Plenty of Room at the Bottom

Environmental selection is natural selection (2)

I believe that if you put enough biologically uniformed theorists in the same room, they will invent more theories to support the pseudoscientific nonsense they have touted in the past. See for example:

Environmental selection during the last ice age on the mother-to-infant transmission of vitamin D and fatty acids through breast milk

Acknowledgments

The synthesis presented here is a product of the American Association for the Advancement of Science’s 2017 annual meeting, as the ideas came together in the session entitled “Beringia and the Dispersal of Modern Humans to the Americas.”
 

Every aspect of every level of biophysically constrained food energy-dependent biologically-based cause and effect is placed back into the context of a ridiculous theory of human migration and evolution. The theory accurately attests to the link from one food energy-dependent base pair change to biodiversity in human populations via fixation of one amino acid substitution. But then, something goes horribly wrong.

The theory requires the fixation of the amino acid substitution to automagically occur in the context of the sun’s anti-entropic virucidal energy. The theory fails to mention the fact that the physiology of pheromone-controlled reproduction and the microRNA-mediated creation of all cell types in all living genera is required.

See for comparison: Anything published since the time I learned about the importance of microRNAs during the 2012 Society for Neuroscience annual meeting in New Orleans, LA.

From 2000/10/15 to 2012/10/15 microRNA Items: 1 to 20 of 19910

From 2012/10/15 to 2018/04/26 microRNA Items: 1 to 20 of 53458

The number of biologically informed serious scientists who have linked the energy-dependent creation of microRNAs to biophysically constrained viral latency and all biodiversity via the pheromone-controlled physiology of reproduction in bacteria continues to rapidly increase.

This begs the question: When will biologically uninformed science idiots stop attending meetings that facilitate their attempts to invent more ridiculous theories?

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Environmental selection is natural selection

Environmental selection during the last ice age on the mother-to-infant transmission of vitamin D and fatty acids through breast milk was published on April 23, 2018

The ectodysplasin A receptor (EDAR) gene has a range of pleiotropic effects, including sweat gland density, incisor shoveling, and mammary gland ductal branching. The frequency of the human-specific EDAR V370A allele appears to be uniquely elevated in North and East Asian and New World populations due to a bout of positive selection likely to have occurred circa 20,000 y ago. The dental pleiotropic effects of this allele suggest an even higher occurrence among indigenous people in the Western Hemisphere before European colonization. We hypothesize that selection on EDAR V370A occurred in the Beringian refugium because it increases mammary ductal branching, and thereby may amplify the transfer of critical nutrients in vitamin D-deficient conditions to infants via mothers’ milk. This hypothesized selective context for EDAR V370A was likely intertwined with selection on the fatty acid desaturase (FADS) gene cluster because it is known to modulate lipid profiles transmitted to milk from a vitamin D-rich diet high in omega-3 fatty acids.

The authors placed my claims about the mouse-to-human model of the EDAR V370A variant back into the context of an evolutionary adaptation. They seem unwilling to accept the fact that the  EDAR V370A variant is a nutrient-dependent pheromone-controlled ecological adaptation in mice and in humans. It links energy-dependent changes from angstroms to ecosystems in all living genera via natural selection for energy-dependent codon optimality.
The EDAR V370A allele is also known as rs3827760, 1540T/C, 370A, or Val370Ala. It is a SNP in the ectodysplasin A receptor EDAR gene on chromosome 2.
See the author’s copy of my invited review of nutritional epigenetics, which was returned without review :
Nutrient-dependent pheromone-controlled ecological adaptations: from atoms to ecosystems (2014)

In the context of climate change and changes in diet, the story began with what probably was a nutrient-dependent base pair change and a variant epiallele that arose in a human population in what is now central China. Apparently, the effect of the epiallele was adaptive and it was manifested in the context of an effect on sweat, skin, hair, and teeth. In another mammal, such as the mouse, the effect on sweat, skin, hair, and teeth is probably due to a nutrient-dependent epigenetic effect on hormones responsible for the tweaking of immense gene networks that metabolize nutrients to pheromones. The pheromones appear to control the nutrient-dependent epigenetically-effected hormone-dependent organization and hormone-activation of reproductive sexual behavior in mammals such as mice and humans, but also in invertebrates and in microbes as previously indicated.

The ecological adaptations, which appear to be manifested in the human population are detailed in these two reports [162-163]. The ecological adaptations are likely to be nutrient-dependent and pheromone-controlled. If so, ecological variation probably leads to ecological, social, neurogenic, and socio-cognitive niche construction, which is manifested in increasing organismal complexity and species diversity. If not, there may be something as yet unknown about mutations and evolution that makes sense in the light of what is known about nutritional epigenetics and the molecular biology of species from microbes to man.

More than four years later, biologically uninformed theorists have again tried to make natural selection something different than environmental selection. Nina G. Jablonski is one of the co-authors. I’m tempted to think that all the others also are biologically uninformed science idiots who cannot link physical and chemistry from subatomic particles to ecosystems via what organisms eat and the physiology of pheromone-controlled reproduction, which biophysically constrains viral latency in all living genera.
See also: microRNA and ADAR1 microRNA
For example:
Combinatory RNA-Sequencing Analyses Reveal a Dual Mode of Gene Regulation by ADAR1 in Gastric Cancer (April 25, 2018)
Virus-encoded miRNAs in Ebola virus disease (April 24, 2018)

An evolutionary theory killer

MicroRNA-mediated denuclearization (6)

Summary: The EDAR V370A isoform links one quantized energy-dependent base pair change from changes in ultraviolet light (UV) exposure to fixation of one amino acid substitution. The substitution differentiates the cell types of mice and humans in the context of a mouse-to-human model of nutritional epigenetics and microRNA-mediated denuclearization in North Korea.

Environmental selection during the last ice age on the mother-to-infant transmission of vitamin D and fatty acids through breast milk

…a genetically isolated population living in this environment during the LGM ∼20,000 y ago experienced selection for polymorphisms in the FADS gene cluster and for EDAR V370A because of the advantage these genetic variants likely confer in transmitting nutrients from mother to infant through breast milk under conditions of extremely low UV.

Nina G. Jablonski (a co-author), is known for her research into the evolution of skin color in humans. Her neo-Darwinian pseudoscientific nonsense is refuted in this representation of natural selection for food energy-dependent codon optimality.
Codon identity regulates mRNA stability and translation efficiency during the maternal-to-zygotic transition

The amino acid optimality code (Fig 6) provides an alternative perspective on sequence changes between paralogs in evolution and human disease.

The food energy-dependent pheromone-controlled amino acid optimality code has been linked to biophysically constrained viral latency in all living genera via the physiology of pheromone-controlled reproduction.
The EDAR V370A isoform links one quantized energy-dependent base pair change from changes in ultraviolet light (UV) exposure to fixation of one amino acid substitution. The substitution differentiates the cell types of mice and humans in the context of a mouse-to-human model of nutritional epigenetics and microRNA-mediated denuclearization in North Korea.

Nutrient-dependent pheromone-controlled ecological adaptations: from atoms to ecosystems

The scientific creationists in South Korea know how to protect organized genomes from the virus-driven degradation of messenger RNA. Atheistic communists believed vaccines would protect their supercoiled DNA in their organized genomes.
The communists and other atheists lost their battle to promote atheism and vaccines because serious scientists in South Korea liked the accurate representations of the creationists. The serious scientists proceeded to support scientific creationism and Americanism with experimental evidence of top-down causation and biophysical constraints.
Pseudoscientists still tout their nonsense about constraint-breaking mutations.  See: Mutation-Driven Evolution
Kalevi Kull: Censorship & Royal Society Evo Event 

Nobody wants to belong to the party of losers. One of the best strategies in such a case is evidently an interpretation of the change as a gradual accumulation of knowledge while their work has always been at the cutting edge. — Kalevi Kull

The links from particle physics to biophysically constrained viral latency will be placed into the context of the game “Subatomic,” which should be available by the end of this year.

Caption: Contemporary analyses of cell metabolism have called out three metabolites: ATP, NADH, and acetyl-CoA, as sentinel molecules whose accumulation represent much of the purpose of the catabolic arms of metabolism and then drive many anabolic pathways. Such analyses largely leave out how and why ATP, NADH, and acetyl-CoA (Figure 1) at the molecular level play such central roles. Yet, without those insights into why cells accumulate them and how the enabling properties of these key metabolites power much of cell metabolism, the underlying molecular logic remains mysterious. Four other metabolites, S-adenosylmethionine, carbamoyl phosphate, UDP-glucose, and Δ2-isopentenyl-PP play similar roles in using group transfer chemistry to drive otherwise unfavorable biosynthetic equilibria. This review provides the underlying chemical logic to remind how these seven key molecules function as mobile packets of cellular currencies for phosphoryl transfers (ATP), acyl transfers (acetyl-CoA, carbamoyl-P), methyl transfers (SAM), prenyl transfers (IPP), glucosyl transfers (UDP-glucose), and electron and ADP-ribosyl transfers (NAD(P)H/NAD(P)+) to drive metabolic transformations in and across most primary pathways. The eighth key metabolite is molecular oxygen (O2), thermodynamically activated for reduction by one electron path, leaving it kinetically stable to the vast majority of organic cellular metabolites

MicroRNA-mediated denuclearization (4)

Summary: Christ’s lab showed that in vivo formation of I-motif structures is pH dependent and helped to put the “fear of God” into atheistic communists.

I-motif DNA structures are formed in the nuclei of human cells (4/23/18)

Reported as: In human cells, scientists find DNA that looks like a twisted knot instead of a double helix (4/23/18)

Also reported as: New Twisted ‘Knot’ Human DNA Structure Discovered—and It Looks Nothing Like the Double Helix (4/23/18)

Christ’s lab showed that in vivo formation of I-motif structures is pH dependent. Clearly, the potential of hydrogen (pH) and pH-dependent cell cycles link the quantized energy of virucidal sunlight to protection from the degradation of messenger RNA that links mutations to all pathology.
In that context, denuclearization has been forced on North Korea and other communist countries by scientific creationists in South Korea. The creationists have indirectly revealed that they could decimate human populations in China via the creation of a virus with one base pair change linked to one amino acid substitution.
See also: Virus-mediated archaeal hecatomb in the deep seafloor

We show here for the first time the crucial role of viruses in controlling archaeal dynamics and therefore the functioning of deep-sea ecosystems, and suggest that virus-archaea interactions play a central role in global biogeochemical cycles.

Until recently, the pseudoscientific nonsense about vaccines that could protect human populations from the forthcoming viral apocalypse was tightly linked from communism to atheism. For comparison, Christ’s lab appears to have put the fear of God into its proper context; the 1918 Spanish flu.
Previously reported as: Structural diversity of supercoiled DNA (2015) and parodied in:

See also: The Pharmacology of Regenerative Medicine (2013)
See also: Energy as information and constrained endogenous RNA interference (2017)

Feedback loops link quantized energy as information to biophysically constrained RNA-mediated protein folding chemistry. Light induced energy-dependent changes link angstroms to ecosystems from classical physics to chemistry/chirality and to molecular epigenetics/autophagy.

The National Microbiome Initiative links microbial quorum sensing to the physiology of reproduction via endogenous RNA interference and chromosomal rearrangements. The rearrangements link energy-dependent fixed amino acid substitutions to the Precision Medicine Initiative via genome wide inferences of natural selection.

This detailed representation of energy-dependent natural selection for codon optimality links biologically- based cause and effect from G protein-coupled receptors to RNA-mediated amino acid substitutions and the functional structure of supercoiled DNA. Energy-dependent polycombic ecological adaptations are manifested in supercoiled DNA.

Chromosomal inheritance links the adaptations from morphological phenotypes to healthy longevity via behavioral phenotypes. For contrast, virus-driven energy theft is the link from messenger RNA degradation to negative supercoiling, constraint breaking mutations, and hecatombic evolution.

The viral hecatomb links transgenerational epigenetic inheritance from archaea to Zika virus-damaged DNA, which typically is repaired by endogenous RNA interference and fixation of RNA-mediated amino acid substitutions in organized genomes.

5th-6th Sept 2018 Dublin, Ireland

MicroRNA-mediated denuclearization (2)

Summary:
The virus-driven theft of quantized energy creates a cellular environment that promotes the survival and self-proliferation of viruses by encoding viral miRNAs or miRNA-like molecules. The viral miRNAs or miRNA-like molecules target different types of host cells.
The sun’s anti-entropic virucidal energy biophysically constrains viral latency in the context of global control of human ES cell differentiation via circRNAs derived from lncRNAs. That fact refutes all neo-Darwinian gene-centric pseudoscientific nonsense. That fact also attests to the link from Chinese philosophy to scientific creationism in South Korea.
Scientific creationism appears to have defeated communism in the context of the electron cloud superimposed over the yin yang symbol of constrained energy.
For scientific support of the claims that appear to have defeated communism, see:
Analysis of human ES cell differentiation establishes that the dominant isoforms of the lncRNAs RMST and FIRRE are circular

Surprisingly, circRNAs derived from long non-coding RNAs (lncRNAs) were found to account for a significantly larger proportion of transcripts from their loci of origin than circRNAs from coding genes.

CONCLUSIONS:

Our results suggest that during human ES cell differentiation, changes in circRNA levels are primarily globally controlled.

Global control of human ES cell differentiation via circRNAs derived from lncRNAs refutes neo-Darwinian gene-centric pseudoscientific nonsense. The level of control comes as no surprise to serious scientists who start with the energy-dependent creation of microRNAs and link the energy to the RNA-mediated creation from genome assembly to the creation of all cell types.

The global control-based refutation is merely one more example of pattern recognition.

See: Three invariant Hi-C interaction patterns: applications to genome assembly

We suggest that simultaneously considering all three invariant patterns may lead to better Hi-C-based genome assembly methods.

Schrödinger suggested that genome assembly was energy-dependent in What is Life? (1944)

Indeed, in the case of higher animals we know the kind of orderliness they feed upon well enough, viz. the extremely well-ordered state of matter in more or less complicated organic compounds, which serve them as foodstuffs. After utilizing it they return it in a very much degraded form -not entirely degraded, however, for plants can still make use of it. (These, of course, have their most power supply of ‘negative entropy’ the sunlight.)

See also: What is life when it is not protected from virus driven entropy (video)

See also: Rotavirus-encoded virus-like small RNA triggers autophagy by targeting IGF1R via the PI3K/Akt/mTOR pathway

Examining virus-host cell interaction is important for elucidating mechanisms of virus proliferation in host cells. Viruses can create an environment that promotes their survival and self-proliferation by encoding miRNAs or miRNA-like molecules that target various host cell.

See also: Base-pair opening dynamics of the microRNA precursor pri-miR156a affect temperature-responsive flowering in Arabidopsis

…fine-tuning of the base-pair stability at the cleavage site is essential for efficient processing of pri-miR156a at a low temperature and for reduced flowering sensitivity to ambient temperature changes.

See also: Emergence of Human G2P[4] Rotaviruses in the Post-vaccination Era in South Korea: Footprints of Multiple Interspecies Re-assortment Events

…17-24 amino acid changes, specifically A87T, D96N, S213D, and S242N substitutions in G2 epitopes, were observed. These results suggest that multiple interspecies re-assortment events might have contributed to the emergence of G2P[4] rotaviruses in the post-vaccination era in South Korea.

See also: A Single Amino Acid at the Polymerase Acidic Protein Determines the Pathogenicity of Influenza B Viruses

Several amino acid mutations were identified in PB2, PB1, PA, BM2, and/or NS1 protein coding regions, and one concurrent lysine (K)-to-arginine (R) mutation in PA residue 338 (PA K338R) was found in both maVc_BR60 and maYm_WI01 viruses. When analyzed using reverse-genetically rescued viruses, it was shown that PA K338R alone could increase the pathogenicity of both IBVs in mice and viral replication property in the respiratory tracts of ferrets.

The energy-dependent fine-tuning of the base-pair stability in plants prevents the emergence of rotaviruses via multiple interspecies re-assortment events linked to healthy longevity in post-vaccination era South Korea.

See for comparison: Engineered virus has artificial amino acid allowing it to serve as a vaccine

A team of researchers at Peking University has developed a new type of vaccine that they claim may allow for a new approach to generating live virus vaccines which could conceivably be adapted to any type of virus. In their paper published in the journal Science, the team outlines the means by which they modified an influenza virus causing it to incite an immune response without a risk of infection.

Scientific creationists in South Korea have showed that the Chinese cannot protect themselves from a viral apocalypse via vaccinations. The viruses adapt too quickly.

Knowing that also allows the scientific creationists to create a virus that damages the DNA of specific human populations who are less well-adapted to their food energy-dependent pheromone-controlled ecological, social, neurogenic, and socio-cognitive niches.

Would you threaten nuclear war after you learn that the population of your country could be decimated by a genetically engineered virus produced in a neighboring country. Or, would you denuclearize and de-escalate the tensions as soon as you learned that all niche construction is food energy-dependent and that the pheromone-controlled physiology of reproduction biophysically constrains viral latency.

That fact cannot be placed back into the context of atheism or communism. It is a neo-Darwinian theory killer and is the most likely reason for denuclearization in a reasonable world.

The facts about biophysically constrained viral latency and energy-dependent life will be discussed during Schrödinger at 75 – The Future of Biology – September 2018

See for comparison: Organ-specific metastases obtained by culturing colorectal cancer cells on tissue-specific decellularized scaffolds

…lung and liver decellularized scaffolds retained their tissue-specific tropism when injected in mice.

Reported as: Scientists create better laboratory tools to study cancer’s spread

The hypothesis is this is caused by both ‘seed and soil’ – that the cancer cells have something in them that drive them to a particular organ, and the soil has to be right for them to grow. Most of the focus has been on studying the cancer cell, or the seed, and not as closely looking at the soil, which is the organs that they go to. Our models will help us understand to better understand the conditions of the soil that help promote cancer metastasis.

The use of Schrödinger’s sunlight-to-soil metaphor of degraded organic matter and biophysically constrained viral latency is not likely to be a coincidence. It also appears in the context of the energy-dependent weekend resurrection of the bacterial flagellum and in the context of the weekend Resurrection of Christ.

See also:  Evolutionary resurrection of flagellar motility via rewiring of the nitrogen regulation system

See also:  Thou fool, that which thou sowest is not quickened, except it die:”

See also: Science, state, and spirituality: Stories of four creationists in South Korea

Scientific creationism in South Korea supposedly began with the support of the US government in their attempt to fight against communism and atheism. Pseudoscientists have not linked energy-dependent RNA-mediated biophysically constrained viral latency to all healthy longevity in the context of Communism and atheism.

For comparison, all serious scientists who understand the role that the creation of energy plays in the creation of supercoiled DNA have won the war against communism by combating evolution to fight disease.

All disease has been linked to the virus-driven energy theft that causes the degradation of messenger RNA, which has been linked to all pathology.

The energy-dependent creation of microRNAs has been linked from the creation of the innate immune system to all biophysically constrained behaviors via what is known about how the physiology of pheromone-controlled reproduction must be linked from soil bacteria to the growth of seeds and all food energy-dependent life on Earth.

5th-6th Sept 2018 Dublin, Ireland

MicroRNA-mediated denuclearization

Kim Says North Korea Is Stopping Nuclear and Missile Tests

Early today, he said the country was stopping nuclear and missile tests and shuttering its atomic test site, which has “done its job.” Those concessions were long demanded by the U.S., lifting hopes that next Friday’s planned summit between Kim and South Korean President Moon Jae-in will be conducted in good faith.

Added Perspective
Emergence of Human G2P[4] Rotaviruses in the Post-vaccination Era in South Korea: Footprints of Multiple Interspecies Re-assortment Events
Viruses do not emerge. They adapt in the context of proton gradients and microRNA-mediated changesin energy-dependent protein folding chemistry. The food energy-dependent fixation of RNA-mediated amino acid substitutions links interspecies re-assortment events to healthy longevity.
See for comparison: A Single Amino Acid at the Polymerase Acidic Protein Determines the Pathogenicity of Influenza B Viruses
The ability of researchers in South Korea to create genetically modified viruses with increased pathogenicity links quantum physics from virus-driven energy theft to the degradation of messenger RNA and extinctions in many different populations of extinct organisms during the past 6,000 years.
See: Virus-mediated archaeal hecatomb in the deep seafloor

We show here for the first time the crucial role of viruses in controlling archaeal dynamics and therefore the functioning of deep-sea ecosystems, and suggest that virus-archaea interactions play a central role in global biogeochemical cycles.

The population of North Korea could have been the next to be decimated by a genetically engineered virus if Kim Jong Un had not agreed to denuclearization.
See also: Reappraising the human mitochondrial DNA [mtDNA] recombination dogma

…studies dealing with human variation and evolution have assumed that human mtDNA does not recombine and should be considered as pathological or very infrequent. Using both direct and indirect approaches, we provide consistent evidence of mtDNA recombination in humans.

Food energy-dependent mtDNA recombination in humans appears to protect all organized genomes in all extant human populations. mtDNA recombination may be the best protection from extinction that any species already has.  Given what is known to serious scientists about cell type differentiation, the link from light-activated endogenous substrates and the physiology of reproduction in all living genera causes many people to ridicule the assumptions still touted in the context of theories invented by neo-Darwinian theorists.
See also: Mechanisms of Recombination conference

High-throughput sequencing and analysis of microbial community cDNA (#metatranscriptomics) are providing valuable insight into in situ microbial activity and metabolism in the oceans.

The eternal significance of microRNAs (4)

Conclusion: Conserved energy biophysically constrains viral latency.
Metatranscriptomics

High-throughput sequencing and analysis of microbial community cDNA are providing valuable insight into in situ microbial activity and metabolism in the oceans.

When faced with the eternal significance of quantized energy-dependent natural selection for codon optimality, theorists must attack the basics of what is known to serious scientists about biophysically constrained life on Earth.
See for example: Virus-mediated archaeal hecatomb in the deep seafloor
By starting with “raw assemblies” instead of the energy from sunlight that must be linked to the “Assemblies Trinity,” pseudoscientists link “data” to codon optimality. They fail to link the creation of virucidal light from differential gene expression before they link the data to results that are meaningless outside the context of an energy source.
All results can be predicted only in the context of the energy-dependent biophysical constraints that prevent the virus-driven degradation of messenger RNA from destroying the supercoiled DNA that is required to maintain viral latency and healthy longevity.
Nutrition, microRNAs, and Human Health (2017)

MicroRNAs (miRs) hybridize with complementary sequences in mRNA and silence genes by destabilizing mRNA or preventing translation of mRNA.

The authors recapitulate the claims from my 2014 invited review of nutritional epigenetics but fail to address the most important aspect of biophysically constrained viral latency, which requires the energy-dependent creation of microRNAs that prevent the translation of mRNA. The destabilizing effects of viruses are eliminated when enough food energy is available to support RNA-directed DNA methylation and fixation of amino acid substitutions in organized genomes.
See:  Nutrient-dependent pheromone-controlled ecological adaptations: from atoms to ecosystems

This atoms to ecosystems model of ecological adaptations links nutrient-dependent epigenetic effects on base pairs and amino acid substitutions to pheromone-controlled changes in the microRNA / messenger RNA balance and chromosomal rearrangements. The nutrient-dependent pheromone-controlled changes are required for the thermodynamic regulation of intracellular signaling, which enables biophysically constrained nutrient-dependent protein folding; experience-dependent receptor-mediated behaviors, and organism-level thermoregulation in ever-changing ecological niches and social niches. Nutrient-dependent pheromone-controlled ecological, social, neurogenic and socio-cognitive niche construction are manifested in increasing organismal complexity in species from microbes to man.

See for comparison: Prediction of 5-Fluorouracil Toxicity Associated With Dihydropyrimidine Dehydrogenase Gene (DPYD) Polymorphism Using the Secondary Structure Prediction Programs
The predicted toxicity must be linked from the energy-dependent creation of dehydrogenase gene polymorphisms. The failure to do that has led to class action litigation.
See also:  DPYD dihydropyrimidine dehydrogenase [ Homo sapiens (human) ]

The protein encoded by this gene is a pyrimidine catabolic enzyme and the initial and rate-limiting factor in the pathway of uracil and thymidine catabolism. Mutations in this gene result in dihydropyrimidine dehydrogenase deficiency, an error in pyrimidine metabolism associated with thymine-uraciluria and an increased risk of toxicity in cancer patients receiving 5-fluorouracil chemotherapy. Two transcript variants encoding different isoforms have been found for this gene.

Finding isoforms is of little use if researchers do not know how the isoforms are created.
medical Definition of isoform.:

any of two or more functionally similar proteins that have a similar but not identical amino acid sequence and are either encoded by different genes or by RNA transcripts from the same gene which have had different exons removed.

Most researchers know nothing about energy-dependent biophysical constraints on the creation of amino acid substitutions in the isoforms.
See for example: NSF’s Big Ideas: Understanding the Rules of Life and The Quantum Leap
The rules of life that include fixation of amino acid substitutions in organized genomes could have been linked from the quantum leap to biophysically constrained viral latency and healthy longevity in all living genera. Instead the presenters failed to answer any of my questions.

1) Has anyone place the rules of Life and the Quantum Leap into the context of food energy-dependent biophysically constrained viral latency and sympatric speciation?
2) Do you think that this parody accurately represents what was known in 2014 about the importance of energy-dependent base pair changes to biophysically constrained protein folding chemistry? All About that Base (Meghan Trainor Parody) 12/10/14
3) Do you agree that questions about genome adaptations compared to the evolution of organized genome are ambiguous in the context of what is known about natural selection for quantized energy-dependent codon optimality?
4) Has the difference in the energy of two photons been linked from altered proton gradients to the protential of hydrogen (pH) and RNA-mediated DNA repair via the creation of microRNAs and enzymes?
NSF funding is largely used to support theories about the emergence of energy and evolution of all biodiversity.
This work would be funded by NSF: The evolutionary history of vertebrate RNA viruses
They claim that the evolutionary history of vertebrates matches the history of the RNA viruses, which they claim is because the viruses evolved. Viruses must steal the quantized energy of sunlight from cell types or they cannot replicate. Does that sound like vertebrate viruses are capable of evolution?
That nonsense was reported as: New study transforms understanding of virus origins and evolution
See also: Estimating evolutionary rates in giant viruses using ancient genomes

…this suggests that these viruses could have diverged at least hundreds of thousands of years ago, and hence have evolved over longer time-scales than previously suggested. We propose that the evolutionary rate and time-scale of pithovirus evolution should be reconsidered in the light of these observations and that future estimates of the rate of giant virus evolution should be carefully examined in the context of their biological plausibility.

All their suggestions have become more ridiculous as more facts about the creation of microRNAs have been placed into the context of biophysically constrained viral latency.
See: MicroRNAs in neural development: from master regulators to fine-tuners

The proper formation and function of neuronal networks is required for cognition and behavior. Indeed, pathophysiological states that disrupt neuronal networks can lead to neurodevelopmental disorders such as autism, schizophrenia or intellectual disability. It is well-established that transcriptional programs play major roles in neural circuit development. However, in recent years, post-transcriptional control of gene expression has emerged as an additional, and probably equally important, regulatory layer. In particular, it has been shown that microRNAs (miRNAs), an abundant class of small regulatory RNAs, can regulate neuronal circuit development, maturation and function by controlling, for example, local mRNA translation. It is also becoming clear that miRNAs are frequently dysregulated in neurodevelopmental disorders, suggesting a role for miRNAs in the etiology and/or maintenance of neurological disease states. Here, we provide an overview of the most prominent regulatory miRNAs that control neural development, highlighting how they act as ‘master regulators’ or ‘fine-tuners’ of gene expression, depending on context, to influence processes such as cell fate determination, cell migration, neuronal polarization and synapse formation.

See also: Learning-dependent chromatin remodeling highlights noncoding regulatory regions linked to autism
They identified a single nucleotide polymorphism known as rs6010065. It is associated with differences in microRNAs linked to autism spectrum disorder.
See also: A Common Allele in FGF21 Associated with Sugar Intake Is Associated with Body Shape, Lower Total Body-Fat Percentage, and Higher Blood Pressure
A single nucleotide polymorphism known as rs838133 was linked from food energy-dependent changes in microRNAs to biophysically constrained viral latency and healthy longevity in the mouse-primate-human model of pheromone-controlled reproduction.
I reiterate: Nutrient-dependent pheromone-controlled ecological adaptations: from atoms to ecosystems

In the context of quantized energy as information-driven changes in the microRNA/messenger RNA balance, a single nucleotide polymorphism known as rs3827760, 1540T/C, 370A, V370A, and/or Val370Ala was linked to conserved morphological and behavioral phenotypes in mice and humans.

See: Epigenetics and Autism Spectrum Disorder: Is There a Correlation?

At a time when all serious scientists have linked energy-dependent changes in electrons to ecosystems, questions about correlations are irrelevant.

See: Oppositional COMT Val158Met effects on resting state functional connectivity in adolescents and adults

Functional connectivity is energy dependent and biophysically constrained by by the energy-dependent physiology of reproduction.

It is time for all biologically uniformed science idiots to admit that the source of all energy-dependent changes in every organism on Earth is sunlight.

See: Resolving sub-cellular miRNA trafficking and turnover at single-molecule resolution

Regulation of microRNA (miRNA) localization and stability is critical for their extensive cytoplasmic RNA silencing activity and emerging nuclear functions. Here, we have developed single-molecule fluorescence-based tools to assess the subcellular trafficking, integrity, and activity of miRNAs.

The regulation of microRNA (miRNA) localization and stability is quantized energy-dependent and pheromone controlled in the context of everything known to serious scientists about biophysically constrained protein folding chemistry and supercoiled DNA, which protects all organized genomes from virus-driven energy theft and genomic entropy.
Why symmetry gets really interesting when it is broken

Energy is conserved…because the laws of physics are the same now as they were a millennium ago…

Long-range coherence and energy storage in biological systems (1968)

The supplied energy is thus not completely thermalized but stored in a highly ordered fashion.

Conserved energy biophysically constrains viral latency.

Biology to a Physicist

Abiogenesis vs microRNA biogenesis

Summary: The pseudoscientific nonsense about abiogenesis that has been touted by Karo Michaelian and others like him has caused the unnecessary suffering and premature death of millions to billions of people by placing the pathogenic consequences of deregulated miRNAs into the context of ridiculous theories.
See for comparison: Structural diversity of supercoiled DNA and the parody from the same research group:
——————————-
Abiogenesis (2017)
Microscopic dissipative structuring and proliferation at the origin of life (Oct 13, 2017)

Some fundamental molecules of life are suggested to have been formed, proliferated, and evolved through photochemical microscopic dissipative structuring and autocatalytic proliferation under the UV-C/UV-B solar environment prevalent at Earth’s surface throughout the Archean. Evidence is given in the numerous salient characteristics of these, including their strong absorption in this spectral region and their rapid non-radiative excited state decay through inherent conical intersections. The examples of the dissipative structuring and dissipative proliferation of the purines and of single strand DNA are given. UV-C and UV-B-induced stationary state isomerizations and tautomerizations are shown to be crucial to the formation of the purines from hydrogen cyanide in an aqueous environment under UV-C light, while UV-C induced phosphorylation of nucleosides and denaturing of double helix RNA and DNA are similarly important to the production and proliferation of single strand DNA. This thermodynamic dissipation perspective provides a physical-chemical foundation for understanding the origin and evolution of life.

The suggestion is ridiculous. No serious scientist would claim that some fundamental molecules of life formed, proliferated, and evolved in the context of thermodynamic dissipation after the UV-C induced phosphorylation of nucleosides and denaturing of double helix RNA and DNA.
The functional structure of supercoiled DNA is energy-dependent.
All serious scientists start with the link from the sun’s anti-entropic virucidal energy on contact with water to the creation of ATP synthase; the creation of microRNAs; the creation of all other enzymes; the creation of all receptors; the creation of all hormones. That’s how serious scientists link microRNA biogenesis to all biophysically constrained food energy-dependent pheromone-controlled morphological and behavioral diversity on Earth.
MicroRNA biogenesis (2018)

The tipping point of 72,000 indexed published works that mention microRNAs was reached on 4/18/18
See: microRNA
Example: Arthropod viruses and small RNAs (2013)

Understanding the role of small RNAs in arthropod host-virus molecular interactions will facilitate manipulation of these pathways for both management of arthropod pests of agricultural and medical importance, and for protection of beneficial arthropods such as honey bees and shrimp. This review highlights recent research on the role of small RNAs in arthropod host-virus interactions with reference to other host-pathogen systems.

Example: MicroRNAs as mediators of insect host-pathogen interactions and immunity (2014)

In this review, we will discuss the latest developments in regards to the role of microRNA in insect host-pathogen interactions and provide some insights into this rapidly developing area of research.

Example: miRNA regulation of innate immunity (2018)

MicroRNAs (miRNAs) are small noncoding RNA and are pivotal posttranscriptional regulators of both innate and adaptive immunity. They act by regulating the expression of multiple immune genes, thus, are the important elements to the complex immune regulatory network. Deregulated expression of specific miRNAs can lead to potential autoimmunity, immune tolerance, hyper-inflammatory phenotype, and cancer initiation and progression. In this review, we discuss the contributory pathways and mechanisms by which several miRNAs influence the development of innate immunity and fine-tune immune response. Moreover, we discuss the consequence of deregulated miRNAs and their pathogenic implications.

The pseudoscientific nonsense touted by Karo Michaelian and others like him has caused the unnecessary suffering and premature death of millions to billions of people by placing the pathogenic consequences of deregulated miRNAs into the context of ridiculous theories.
See for comparison: Structural diversity of supercoiled DNA and the parody from the same research group:

See also: Michaelian K
and Retraction: Oligoarginine peptides slow strand annealing and assist non-enzymatic RNA replication (Nov 23, 2017)
The life’s works of all those who have ever touted their ridiculous claims about abiogenesis can now be placed into the context of the eternal significance of microRNAs. The energy dependent de novo creation of microRNA flanking sequences has repeatedly been linked from the physiology of pheromone-controlled reproduction to biophysically constrained viral latency and sympatric speciation in all living genera.
See: Dependence of RNA synthesis in isolated thymus nuclei on glycolysis, oxidative carbohydrate catabolism and a type of “oxidative phosphorylation” (1964)

The synthesis of RNA in isolated thymus nuclei is ATP dependent.

See also: Long-range coherence and energy storage in biological systems (1968)
See also: Cytosis (for ages 10+)

Players take turns placing workers on available organelles within a human cell in order to collect resources (such as Carbohydrates or ATP!) or take actions (such as purchasing Cell Component cards or translating mRNA into Proteins!)

Players use their resources to build Enzymes, Hormones, and Hormone Receptors and also to help detoxify the cell – all of which score health points. The player with the most health points at the end of the game wins!

See for comparison: DNA Denaturing through UV-C Photon Dissipation: A Possible Route to Archean Non-enzymatic Replication (2014)

Many of the fundamental molecules of life, those common to all three domains; bacteria, eukaryote, and archea, including RNA and DNA, amino acids, enzymes, vitamins, cofactors, and protoporphyrins, absorb photons in the UV-C 1. RNA or DNA in complexes with these molecules act as acceptor quenchers, providing the electronically excited pigment donor molecule with an extremely rapid (sub picosecond) non-radiative dexcitation channel, through internal conversion into vibrational energy of the nucleic acid and surrounding water molecules2.

On January 15, 2016 John Hewitt commented:  You have just described the founding principle and thermodynamic function of life
On April 17, 2018, I commented on the ridiculous claim this so-called science journalist made because he blocked me from seeing his tweets a few months ago.

5th-6th Sept 2018 Dublin, Ireland

2018 March for Science vs microRNAs (2)

The anti-entropic virucidal energy of sunlight on contact with water has been linked from the creation of ATP synthase to the creation of ATP and to the creation of RNA. Energy-dependent RNA-mediated DNA repair has been linked to biophysically constrained viral latency via the creation of microRNAs and feedback loops linked to the food energy-dependent microRNA-mediated physiology of reproduction. The physiology of energy-dependent pheromone-controlled reproduction biophysically constrains viral latency in the context of the creation of the innate immune system and autophagy.
See: miRNA regulation of innate immunity (4/14/18)
None of the facts about the energy-dependent creation of the microRNAs or the microRNA-mediated regulation of innate immunity are included in: The Transcription Factor Runx3 Establishes Chromatin Accessibility of cis-Regulatory Landscapes that Drive Memory Cytotoxic T Lymphocyte Formation (4/17/18)
The regulatory landscape that drive memory cytotoxic T lymphocyte formation might just as well be framed in the context of magic or in the equally ridiculous context of gene-centric theories.
See this report: Your immune system holds the line against repeat invaders, thanks to this molecule

Runx3’s control of T cell differentiation is important because when our bodies fight off viruses and cancers—and our T cells burst into action—the vast majority tend to become effector cells. These effector cells are short-lived and do not persist once the infection resolves.

The control of all cell type differentiation is energy-dependent, RNA-mediated and biophysically constrained by the physiology of reproduction in all living genera. The cell biology game “Cytosis” for ages 10+ teaches the facts that link Schrödinger (1944) What is Life? to Schrödinger at 75 – The Future of Biology – September 2018
In 1944, Schrödinger wrote:

Indeed, in the case of higher animals we know the kind of orderliness they feed upon well enough, viz. the extremely well-ordered state of matter in more or less complicated organic compounds, which serve them as foodstuffs. After utilizing it they return it in a very much degraded form -not entirely degraded, however, for plants can still make use of it. (These, of course, have their most power supply of ‘negative entropy’ the sunlight.)

See for comparison (this gene-centric pseudoscientific nonsense):
– Part I: FINDING THE CODE (Run time: 12:10
The race to sequence the human genome was also billed as a race to end disease. What happened?

– Part II: FIXING THE CODE (Run time: 13:07)
CRISPR — and the promise and pain of gene therapy that came before it. 

– Part III: SELLING THE CODE (Run time: 10:55)
Genetic testing has moved out of the labs into the masses. But even with your genome in hand, what can you believe?
The gene-centric pseudoscientific nonsense does not start with the creation of energy.  But every aspect of biophysically constrained life on Earth starts with the quantized energy-dependent creation of microRNAs. The epigenetically effected energy-dependent microRNA-mediated creation of the “Code” and the microRNA-mediated fixing of the “Code” is missing from the claims of biologically uninformed theorists who link beneficial mutations from natural selection to evolution. They have sold their gene-centric pseudoscientific nonsense to many people.
For example, some gene-centric biologically uninformed theorists share beliefs about abiogenesis for comparison to quantized energy-dependent microRNA biogenesis in articles like this: DNA Denaturing through UV-C Photon Dissipation: A Possible Route to Archean Non-enzymatic Replication
Conclusion:

Many of the fundamental molecules of life, those common to all three domains; bacteria, eukaryote, and archea, including RNA and DNA, amino acids, enzymes, vitamins, cofactors, and protoporphyrins, absorb photons in the UV-C 1. RNA or DNA in complexes with these molecules act as acceptor quenchers, providing the electronically excited pigment donor molecule with an extremely rapid (sub picosecond) non-radiative dexcitation channel, through internal conversion into vibrational energy of the nucleic acid and surrounding water molecules2.

See John Hewitt’s comment: You have just described the founding principle and thermodynamic function of life
In a classic example of human idiocy (See Feynman: food energy), biologically uninformed science idiots linked the dissipation of quantized energy to the origin of life via abiogenesis. The creation of biophysically constrained biophotonicaly based life in the context of the energy-dependent creation of microRNAs was reported in the context of photon dissipation and entropy as: Abiogenesis: A Theory on The Origins of Life

By now, we all know how evolution works. At least, most of us have a basic understanding of how it functions. At its most fundamental level, evolution is change over time. More specifically, it is changes within a biological population over successive generations.

Ultimately, biological complexity is one of the most important things to come out of evolution. Things started simple. Then genes mutated, cells interacted with their environment, mitochondria stopped being living organisms and started being part of a cell and—Tada—complex life.

A conflict arose between John Hewitt’s accurate representations of biophysically constrained life in The vibrational theory of olfaction for the win  and few months ago, Hewitt blocked me from seeing his tweets.

The same kinds of amino acid substitutions that control the separations and interactions of side chains in fluorescent proteins also play an essential role in tuning the proposed mechanism for vibration detection—inelastic electron tunneling. Life literally runs on electron tunneling through the respiratory chain complexes in mitochondria. These proteins employ complicated mechanisms including esoteric-soundings things like electron bifurcation and confurcation to pump protons across the mitochondrial inner membrane. When mitochondria go dark, cells can often continue to run for a short while, but it is only in the dim glow of the battery backup metabolism.

Here are some links to the reason for the conflict. Simply put, John Hewitt put everything known to serious scientists about energy-dependent microRNA biogenesis back into the context of abiogenesis.
2005 MicroRNA biogenesis: coordinated cropping and dicing
2015 Dysregulation of microRNA biogenesis and gene silencing in cancer
2015 RNA-mediated degradation of microRNAs: A widespread viral strategy?
Claims about abiogenesis exemplify what Richard Feynman referred to as human idiocy. So does John Hewitt and anyone else who believes in Michaelian’s pseudoscientific nonsense.
See other examples of Michaelian’s pseudoscientific nonsense and human idiocy by clicking here.
The energy-dependent creation of one domain of life links the physiology of reproduction in bacteria to biophysically constrained viral latency. The virus-driven degradation of messenger RNA is linked to the destruction of all life on Earth.
The degradation of messenger RNA links mutations to the creation of archaea and L-forms via entropy, which clearly links the weakening of the proton motive force to the elimination of the cell wall in L-forms (the last remnants of creation).
See also: Past 5,000 years prolific for changes to human genome
If you cannot link the miRNA regulation of innate immunity to all extant biodiversity via the physiology of pheromone-controlled reproduction and fixation of energy-dependent microRNA-mediated amino acid substitutions, thank a biologically uniformed science idiot.
 

5th-6th Sept 2018 Dublin, Ireland

2018 March for Science vs microRNAs

Summary: Only biologically uninformed theorists and other pseudoscientists do not seem to know that all carbon-based life is quantized energy-dependent and that biophotonic energy as information comes from the sun. It is obvious to all serious scientists that proton gradients link photons from quantized energy as information to the proton motive force, which is how the potential of hydrogen (pH) is linked to changes in the microRNA/messenger RNA balance that biophysically constrain viral latency in the context of hydrogen-atom transfer in DNA base pairs in solution that must be linked to supercoiled DNA.
The Second March for Science a Smaller Affair

…the events are not devoid of politics—either on signs or in rhetoric.

“It is a remarkable outpouring of scientists to talk about the marvelous accomplishments of science, the amazing relevance of science, and a call for defending the conditions under which science can thrive.” — Rush Holt, the CEO of the American Association for the Advancement of Science
Science is not thriving. See for comparison: All in the (bigger) family (2015)

…at a special symposium of the annual meeting of the Society for Integrative and Comparative Biology, researchers reported new parallels between these two very successful groups of animals and new insights about what it took for an ancient crustacean to give rise to insects.

Energy-dependent microRNA-mediated biophysically constrained viral latency was required. The scientific facts about food energy-dependent pheromone-controlled biophysically constrained viral latency and microRNA-mediated sympatric speciation probably contributed most to the reduced turnout at the ridiculous Marches for Science. All serious scientists know that science is not thriving, and pseudoscientists are finding out.
This is serious science: miRNA regulation of innate immunity

In this review, we discuss the contributory pathways and mechanisms by which several miRNAs influence the development of innate immunity and fine-tune immune response. Moreover, we discuss the consequence of deregulated miRNAs and their pathogenic implications.

Who needs more proof that neo-Darwinian theorists and Big Bang cosmologists are biologically uninformed science idiots?
When George Church reported in this interview that cyanobacteria fix light, he left no room for ridiculous claims about the emergence of energy or claims about mutation-driven evolution. Two months later, most theorists skipped the Marches.
I believe they probably stayed home and attempted to rewrite their grant proposals. But what I believe doesn’t matter. I can’t prove that they’ve been forced by serious scientists to eliminate “evolution” and/or their automagical “evolutionary processes” from the content/context.
But see at 15:10

“…the cyanobacteria turn out that they fix light ah as well or better than land plants…”

See for comparison, from the transcript:

The cyanobacteria fix [carbon via] light as well or better than land plants. Under ideal circumstances, they can be maybe seven to ten times more productive per photon.

Only biologically uninformed theorists and other pseudoscientists do not seem to know that all carbon-based life is quantized energy dependent and that biophotonic energy as information comes from the sun. It is obvious to all serious scientists that proton gradients link photons from quantized energy as information to the proton motive force, which is how the potential of hydrogen (pH) is linked to changes in the microRNA/messenger RNA balance that biophysically constrain viral latency in the context of hydrogen-atom transfer in DNA base pairs in solution that must be linked to supercoiled DNA.
Theorists have been left behind and anyone who participated in the 2018 March for Science has revealed their overwhelming ignorance. Why didn’t George Church warn them? Richard Feynman did:
See: Food energy  for Feynman’s claim about human idiocy.
Alternatively, see: Energy as information and constrained endogenous RNA interference
See also: A 360 degrees view of circular RNAs: From biogenesis to functions

The pre-mRNA splicing machinery generates circRNAs via backsplicing reactions, which are often facilitated by intronic repeat sequences that base pair to one another and bring the intervening splice sites into close proximity.

See also: Dr. Gene Nelson wrote:  “This year, I printed 500 copies of the handout that I wrote regarding CGNP’s battle with the CPUC and the plant’s owner. I returned with about 490 handouts.”
On April 19, 2018 “From Layout to Multi-Physics: Integrating Thermal and Photonics Simulation into the PIC Design Flow” will link the creation of the sun’s anti-entropic virucidal energy to thermal cycling.
The thermal cycles have been linked to cracks in the Vietnam Memorial Wall. This free Webinar will almost undoubtedly place the eternal significance of “The Wall” into the context of the eternal significance of microRNAs, which repair DNA damage in carbon-based life forms. Damage repair via the food energy-dependent creation of microRNAs is linked to the eternal significance of differences between organic and inorganic chemistry.
For instance, quantum physics can be linked to the biophysically constrained production of uranium isotopes by the physiology of reproduction in bacteria. And, the use of uranium isotopes in therapy attests to the fact that the unconstrained energy causes cracks in the human genome. The “cracks” are manifested in radiation-induced pathologies.
Treating glioblastoma with radiation may be ill-advised. For comparison, microRNA-mediated therapy has emerged as an effective treatment regimen based on naturally occurring prevention of all pathology.

Pseudoscientists are willing to let Vietnam Veterans and others with glioblastoma suffer unnecessarily and die prematurely. The pseudoscientists won’t admit that food energy-dependent changes in microRNAs have been linked to the stability of all organized genomes via sympatric speciation in all living genera.
 
 
 
There is no such thing as a de novo mutation. The virus-driven degradation of messenger RNA has been linked from mutations to all pathology via the death gene, which was discovered during the early 1990s by researchers who worked for Abcam.
See: Epigenetic modifications poster
See for comparison: A Crack in Creation: Gene Editing and the Unthinkable Power to Control Evolution

Why is Jennifer Doudna still touting controlled evolution at a time when other serious scientists have linked every aspect of the quantized energy-dependent creation of microRNAs to the epigenetically modified physiology of reproduction and all ecological adaptations? What hasn’t she learned about biophysically constrained microRNA-mediated cell type differentiation in species from microbes to humans?
See: When the Most Potent Combination of Antibiotics Selects for the Greatest Bacterial Load: The Smile-Frown Transition (April 23, 2013)

Finding the most potent combinations of antibiotics in the lab can be a challenge if antibiotic interactions are not robust to evolutionary adaptation.

For nearly 5 years serious scientists have watched theorists try to escape from the traps that were set by their predecessors. All intelligent people now realize that there is no such thing as evolution of a new species. There is only ecological variation and quantized energy-dependent ecological adaptations to the virus-driven theft of quantized energy that comes from sunlight and sustains the physiology of pheromone-controlled reproduction in all living genera.
Reported as: The XV Collection: What Happens when the Antibiotic 1-2 Punch Backfires? (April 13, 2018)

Antibiotic-resistant mutants readily arise within almost any population of bacteria. If a population containing both susceptible and resistant mutants is treated with two antibiotics, the susceptible majority is, as expected, rapidly wiped out. But this also removes any competition for the resistant minority, enabling them to quickly grow and proliferate.

The food energy-dependent pheromone-controlled physiology of reproduction in bacteria biophysically constrains the virus-driven degradation of messenger RNA that links antibiotic resistance from mutations to all pathology.
Reported on June 14, 2013 as: Nutrient-dependent/pheromone-controlled adaptive evolution: a model

That extension of the vertebrate/mammalian model to invertebrates occurred as researchers integrated what was known about human pheromones and their effects on neuroendocrine systems during the development of human behavior (Kohl et al., ). Invertebrate research rapidly progressed to include the epigenetic effects of nutrients and pheromones on gene expression and on hormone-organized and hormone-activated behavioral transitions throughout life (Elekonich & Roberts, ), which is consistent with their epigenetic effects throughout the life of vertebrates, including mammals.

The honeybee model organism exemplifies what has been learned from the study of invertebrates (De Loof, Lindemans, Liu, De Groef, & Schoofs, ). This includes what has been learned about the epigenetic effects of nutrients and pheromones on juvenile hormone (JH).

See also: Pursuing Preprints, Preventing Pandemics: How pre-peer review posting can accelerate outbreak science

Preprints are scientific manuscripts posted online prior to or concurrent with submission for peer review and publication in a scientific journal. They offer opportunities to share data and findings sooner and to get broader community feedback before publication. During outbreaks, decisions that can save lives must often be made quickly and with little information. The fast, open nature of preprint posting can help address these needs.

The posting of most preprints on the bioRxiv server obfuscates what is known to serious scientists about biophysically constrained energy-dependent microRNA-mediated sympatric speciation. The consistent focus of most preprints places the findings into the context of evolution because that is what biologically uninformed theorists have been taught to believe in.

Until everyone admits that the creation of microRNAs is food energy-dependent and biophysically constrained by the physiology of pheromone-controlled reproduction, the ability to respond to urgent and complex health challenges will be placed into the ridiculous context of evolutionary processes.

See for exception:  A transmissible RNA pathway in honey bees

…RNA extracted from worker and royal jellies harbor differential naturally occurring RNA populations. Some of these RNAs corresponded to honey bee protein-coding genes, transposable elements, non-coding RNA and exogenous viruses. These results reveal an inherent property of honey bees to share RNA among individuals and generations. Thus, our findings suggest a transmissible RNA pathway, playing a role in social immunity and epigenetic dynamics among honey bees and potentially other closely interacting organisms.

See for comparison: SLC6A4 binding site and acute prosocial effects of (+/-)-3,4-methylendioxymethamphetamine (MDMA) are evolutionarily conserved in Octopus bimaculoides

Human and octopus lineages are separated by over 500 million years of evolution, and show divergent anatomical patterns of brain organization.

No experimental evidence of top-down causation or energy-dependent RNA interference suggests separation of the lineages by 500 million years of evolution.

See for comparison: Role of olfaction in Octopus vulgaris reproduction

From the concluding paragraph:

Future work on O. vulgaris olfaction must also consider how animals acquire the odours detected by the olfactory organ and what kind of odour the olfactory organ perceives. The OL acting as control centre may be target organ for metabolic hormones such as leptin like and insulin like peptides, and olfactory organ could exert regulatory action on the OL via epigenetic effects of nutrients and pheromones on gene expression (Kohl, 2013; Elekonich and Robinson, 2000).

See also: See Diamond et al., 1996: From Fertilization to Adult Sexual Behavior

Elekonich and Robinson (2000) linked our 1996 Hormones and Behavior review of RNA-mediated cell type differentiation to the honeybee model of food energy-dependent biophysically constrained biodiversity.

Effects of hormones on brain and behavior occur through three mechanisms: (1) behaviors both organized and activated by hormones, (2) behaviors only organized by hormones, and (3) behaviors only activated by hormones (reviewed in Arnold and Breedlove, 1985; Diamond et al., 1996).”

See also: Honey bees as a model for understanding mechanisms of life history transitions

In this review we discuss the physiological and genetic mechanisms of this behavioral transition, which include large scale changes in hormonal activity, metabolism, flight ability, circadian rhythms, sensory perception and processing, neural architecture, learning ability, memory and gene expression.

See also: IAPV, a bee-affecting virus associated with Colony Collapse Disorder can be silenced by dsRNA ingestion (2009)

Here we report on RNAi-silencing of IAPV infection by feeding bees with double-stranded RNA, as an efficient and feasible way of controlling this viral disease. The association of CCD with IAPV is discussed, as well as the potential of controlling CCD.