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Environmental selection is natural selection

Environmental selection during the last ice age on the mother-to-infant transmission of vitamin D and fatty acids through breast milk was published on April 23, 2018

The ectodysplasin A receptor (EDAR) gene has a range of pleiotropic effects, including sweat gland density, incisor shoveling, and mammary gland ductal branching. The frequency of the human-specific EDAR V370A allele appears to be uniquely elevated in North and East Asian and New World populations due to a bout of positive selection likely to have occurred circa 20,000 y ago. The dental pleiotropic effects of this allele suggest an even higher occurrence among indigenous people in the Western Hemisphere before European colonization. We hypothesize that selection on EDAR V370A occurred in the Beringian refugium because it increases mammary ductal branching, and thereby may amplify the transfer of critical nutrients in vitamin D-deficient conditions to infants via mothers’ milk. This hypothesized selective context for EDAR V370A was likely intertwined with selection on the fatty acid desaturase (FADS) gene cluster because it is known to modulate lipid profiles transmitted to milk from a vitamin D-rich diet high in omega-3 fatty acids.

The authors placed my claims about the mouse-to-human model of the EDAR V370A variant back into the context of an evolutionary adaptation. They seem unwilling to accept the fact that the  EDAR V370A variant is a nutrient-dependent pheromone-controlled ecological adaptation in mice and in humans. It links energy-dependent changes from angstroms to ecosystems in all living genera via natural selection for energy-dependent codon optimality.
The EDAR V370A allele is also known as rs3827760, 1540T/C, 370A, or Val370Ala. It is a SNP in the ectodysplasin A receptor EDAR gene on chromosome 2.
See the author’s copy of my invited review of nutritional epigenetics, which was returned without review :
Nutrient-dependent pheromone-controlled ecological adaptations: from atoms to ecosystems (2014)

In the context of climate change and changes in diet, the story began with what probably was a nutrient-dependent base pair change and a variant epiallele that arose in a human population in what is now central China. Apparently, the effect of the epiallele was adaptive and it was manifested in the context of an effect on sweat, skin, hair, and teeth. In another mammal, such as the mouse, the effect on sweat, skin, hair, and teeth is probably due to a nutrient-dependent epigenetic effect on hormones responsible for the tweaking of immense gene networks that metabolize nutrients to pheromones. The pheromones appear to control the nutrient-dependent epigenetically-effected hormone-dependent organization and hormone-activation of reproductive sexual behavior in mammals such as mice and humans, but also in invertebrates and in microbes as previously indicated.

The ecological adaptations, which appear to be manifested in the human population are detailed in these two reports [162-163]. The ecological adaptations are likely to be nutrient-dependent and pheromone-controlled. If so, ecological variation probably leads to ecological, social, neurogenic, and socio-cognitive niche construction, which is manifested in increasing organismal complexity and species diversity. If not, there may be something as yet unknown about mutations and evolution that makes sense in the light of what is known about nutritional epigenetics and the molecular biology of species from microbes to man.

More than four years later, biologically uninformed theorists have again tried to make natural selection something different than environmental selection. Nina G. Jablonski is one of the co-authors. I’m tempted to think that all the others also are biologically uninformed science idiots who cannot link physical and chemistry from subatomic particles to ecosystems via what organisms eat and the physiology of pheromone-controlled reproduction, which biophysically constrains viral latency in all living genera.
See also: microRNA and ADAR1 microRNA
For example:
Combinatory RNA-Sequencing Analyses Reveal a Dual Mode of Gene Regulation by ADAR1 in Gastric Cancer (April 25, 2018)
Virus-encoded miRNAs in Ebola virus disease (April 24, 2018)

An evolutionary theory killer

MicroRNA-mediated denuclearization (6)

Summary: The EDAR V370A isoform links one quantized energy-dependent base pair change from changes in ultraviolet light (UV) exposure to fixation of one amino acid substitution. The substitution differentiates the cell types of mice and humans in the context of a mouse-to-human model of nutritional epigenetics and microRNA-mediated denuclearization in North Korea.

Environmental selection during the last ice age on the mother-to-infant transmission of vitamin D and fatty acids through breast milk

…a genetically isolated population living in this environment during the LGM ∼20,000 y ago experienced selection for polymorphisms in the FADS gene cluster and for EDAR V370A because of the advantage these genetic variants likely confer in transmitting nutrients from mother to infant through breast milk under conditions of extremely low UV.

Nina G. Jablonski (a co-author), is known for her research into the evolution of skin color in humans. Her neo-Darwinian pseudoscientific nonsense is refuted in this representation of natural selection for food energy-dependent codon optimality.
Codon identity regulates mRNA stability and translation efficiency during the maternal-to-zygotic transition

The amino acid optimality code (Fig 6) provides an alternative perspective on sequence changes between paralogs in evolution and human disease.

The food energy-dependent pheromone-controlled amino acid optimality code has been linked to biophysically constrained viral latency in all living genera via the physiology of pheromone-controlled reproduction.
The EDAR V370A isoform links one quantized energy-dependent base pair change from changes in ultraviolet light (UV) exposure to fixation of one amino acid substitution. The substitution differentiates the cell types of mice and humans in the context of a mouse-to-human model of nutritional epigenetics and microRNA-mediated denuclearization in North Korea.

Nutrient-dependent pheromone-controlled ecological adaptations: from atoms to ecosystems

The scientific creationists in South Korea know how to protect organized genomes from the virus-driven degradation of messenger RNA. Atheistic communists believed vaccines would protect their supercoiled DNA in their organized genomes.
The communists and other atheists lost their battle to promote atheism and vaccines because serious scientists in South Korea liked the accurate representations of the creationists. The serious scientists proceeded to support scientific creationism and Americanism with experimental evidence of top-down causation and biophysical constraints.
Pseudoscientists still tout their nonsense about constraint-breaking mutations.  See: Mutation-Driven Evolution
Kalevi Kull: Censorship & Royal Society Evo Event 

Nobody wants to belong to the party of losers. One of the best strategies in such a case is evidently an interpretation of the change as a gradual accumulation of knowledge while their work has always been at the cutting edge. — Kalevi Kull

The links from particle physics to biophysically constrained viral latency will be placed into the context of the game “Subatomic,” which should be available by the end of this year.

5th-6th Sept 2018 Dublin, Ireland

MicroRNA-mediated denuclearization (5)

Summary: The quantized energy linked to RNA synthesis (1964) is biophysically constrained (1968) in the context of RNA-directed DNA methylation and the physiology of reproduction that links food energy-dependent fixation of amino acid substitutions to cell type differentiation in all cell types of all individuals of all living genera.
Dependence of RNA synthesis in isolated thymus nuclei on glycolysis, oxidative carbohydrate catabolism and a type of “oxidative phosphorylation” (1964)

The synthesis of RNA in isolated thymus nuclei is ATP dependent.

Long-range coherence and energy storage in biological systems (1968)

…if energy is supplied above a certain mean rate to such a branch, then a steady state will be reached in which a single mode of this branch is very strongly excited. The supplied energy is thus not completely thermalized but stored in a highly ordered fashion.

Simply put, the quantized energy that is linked to RNA synthesis is biophysically constrained in the context of RNA-directed DNA methylation and the physiology of reproduction, which links food energy-dependent fixation of amino acid substitutions to cell type differentiation in all cell types of all individuals of all living genera.
See also: A comprehensive and quantitative exploration of thousands of viral genomes

Noncoding DNA is an umbrella term for … functional RNAs such as micro RNAs (miRNA), regulatory elements… as well as transposons and pseudogenes.

The anti-entropic energy-dependent creation of microRNAs links biophysically constrained viral latency to sympatric speciation not to the evolution of one species from another.
See for comparison: The evolving landscape of epigenomics: Measuring and manipulating methylation
One of the presenters published: Dissecting the Functional Consequences of De Novo DNA Methylation Dynamics in Human Motor Neuron Differentiation and Physiology, which was reported as: DNA methylation plays key role in stem cell differentiation

…patients with ALS exhibit a high rate of genetic variants associated with the DMNT3A enzyme—another puzzling link.

The link from the energy-dependent creation of microRNAs to the creation of the enyzme and to RNA-methylation and DNA methylation is not a puzzling link. The puzzling link is portrayed in the context of de novo methylation. Methylation is nutrient-energy-dependent. It does not automagically occur outside the context of the energy that is required for enyzyme-dependent RNA biogenesis.
Another presenter published Multiple Recurrent De Novo CNVs, Including Duplications of the 7q11.23 Williams Syndrome Region, Are Strongly Associated with Autism
De novo CNVs do not exist in the world of serious scientists. All CNVs and all duplications are food energy-dependent and RNA-mediated in the context of the physiology of pheromone-controlled reproduction, which biophysically constrains viral latency.
See also, presenter Sean Sanders is a co-author of Partial Depletion of Intracellular ATP Mediates the Stress-Survival Function of the PCPH Oncoprotein

Consistent with its intrinsic ATP diphosphohydrolase activity, expression of the PCPH oncoprotein in cultured cells has now been shown to result in partial depletion of intracellular ATP and consequent inhibition of the c-JUN NH2-terminal kinase-mediated stress signaling pathway.

He is the only one of the three presenters during this Webinar who is likely to link the anti-entropic virucidal quantized energy of sunlight from the creation of ATP synthase to the creation of ATP and the creation of enzymes via the creation of microRNAs that biophysically constrain RNA in the context of the first two works cited above, which were published in 1964 and in 1968.
50 years of research reports that established the links from energy-dependent cell type differentiation to healthy longevity are consistently missing from Webinars that supposedly exist to teach what is known about biologically-based cause and effect. The webinars often are presented by those who have learned nothing about the molecular mechanisms of energy-dependent RNA-mediated recombination.
But see: Mechanisms of Recombination conference

Understanding precisely how recombination occurs is of interest to workers in the fields of meiosis, DNA repair, replication, chromosome architecture and interactions, and chromatin biology.

See for comparison: Three years ago, I was traveling and visiting friends. I posted links to these articles on my personal FB page, but did not elaborate on the significance of the information in blog posts about the links from the creation of sunlight and the creation of RNA to energy storage in biological systems.
Investigators show how immune cells are ‘educated’ not to attack beneficial bacteria

…once they leave the thymus, T cells are again educated in the , or gut, to leave beneficial bacteria alone. This dual education strategy is vital to supporting healthy immune function…

This claim supports the claims about biophysically constrained RNA-mediated cell type differentiation from 1964 and 1968. Without a model of biophysically constrained viral latency and cell type differentiation, these other studies cannot be linked to any explanation of biologically-based cause and effect.
Study sheds new light on brain’s source of power

Our digestive system converts carbohydrates found in food into glucose, a sugar molecule that is the body’s main source of energy, which is then transported throughout the body via the blood system. Once inside cells, the mitochondria, which serve as tiny cellular power plants, combine these sugars with oxygen to generate energy.

Unlike the rest of the body, the brain maintains its own unique ecosystem.

The brain’s source of power is quantized energy within the context of its unique ecosystem

Antibiotics Found to Have Unexpected Effects on Mitochondria

…these molecules have a significant effect on mitochondria, the cell’s “powerhouses.”

“It’s not that surprising, given that mitochondria are historically bacteria that evolved within our cells,” says Mouchiroud.

Anti-entropic virucidal energy from the sun is the source of the cell’s “powerhouse.” The claim that mitochondria are historically bacteria that evolved within our cells is a regurgitation of pseudoscientific nonsense.
Study describes brain circuitry for selecting among sensations

These studies showed that the frequency-dependent switching of thalamic cells between inhibition and excitation was associated with different balances of activity among all three of these receptors.

See: Olfaction Warps Visual Time Perception
The anti-entropic virucidal energy of sunlight was linked from the physiology of reproduction in bacteria to our visual perception of energy and mass across the time-space continuum.
 
Major depression leaves a metabolic mark

“Our most notable finding is that the amount of mitochondrial DNA changes in response to stress,” says Professor Jonathan Flint of the University of Oxford.

Mitochondria are compartments in cells responsible for generating energy. An increase in mitochondrial DNA suggests a change in mitochondria and cellular energetics, Flint explains.

“We see an unexpected link between cellular energetics and , which has always been seen as a mood disorder.”

Why would a link from cellular energetics to major depression be unexpected in the context of what is known about the virus-driven degradation of messenger RNA?
Fat signals control energy levels in the brain

An enzyme secreted by the body’s fat tissue controls energy levels in the brain…

The claim about the enzyme do not fit the claim about the control of energy levels in the brain by fat tissue. Obviously, the enzyme is linked to metabolism, which is how energy levels in the brain are controlled.
Each of these reports serves only to confuse those who would otherwise learn that the sun’s anti-entropic virucidal energy controls every aspect of the molecular mechanisms of cell type differentiation that are linked from the creation of microRNAs to all biodiversity on Earth via the physiology of reproduction.

Caption: Contemporary analyses of cell metabolism have called out three metabolites: ATP, NADH, and acetyl-CoA, as sentinel molecules whose accumulation represent much of the purpose of the catabolic arms of metabolism and then drive many anabolic pathways. Such analyses largely leave out how and why ATP, NADH, and acetyl-CoA (Figure 1) at the molecular level play such central roles. Yet, without those insights into why cells accumulate them and how the enabling properties of these key metabolites power much of cell metabolism, the underlying molecular logic remains mysterious. Four other metabolites, S-adenosylmethionine, carbamoyl phosphate, UDP-glucose, and Δ2-isopentenyl-PP play similar roles in using group transfer chemistry to drive otherwise unfavorable biosynthetic equilibria. This review provides the underlying chemical logic to remind how these seven key molecules function as mobile packets of cellular currencies for phosphoryl transfers (ATP), acyl transfers (acetyl-CoA, carbamoyl-P), methyl transfers (SAM), prenyl transfers (IPP), glucosyl transfers (UDP-glucose), and electron and ADP-ribosyl transfers (NAD(P)H/NAD(P)+) to drive metabolic transformations in and across most primary pathways. The eighth key metabolite is molecular oxygen (O2), thermodynamically activated for reduction by one electron path, leaving it kinetically stable to the vast majority of organic cellular metabolites

MicroRNA-mediated denuclearization (4)

Summary: Christ’s lab showed that in vivo formation of I-motif structures is pH dependent and helped to put the “fear of God” into atheistic communists.

I-motif DNA structures are formed in the nuclei of human cells (4/23/18)

Reported as: In human cells, scientists find DNA that looks like a twisted knot instead of a double helix (4/23/18)

Also reported as: New Twisted ‘Knot’ Human DNA Structure Discovered—and It Looks Nothing Like the Double Helix (4/23/18)

Christ’s lab showed that in vivo formation of I-motif structures is pH dependent. Clearly, the potential of hydrogen (pH) and pH-dependent cell cycles link the quantized energy of virucidal sunlight to protection from the degradation of messenger RNA that links mutations to all pathology.
In that context, denuclearization has been forced on North Korea and other communist countries by scientific creationists in South Korea. The creationists have indirectly revealed that they could decimate human populations in China via the creation of a virus with one base pair change linked to one amino acid substitution.
See also: Virus-mediated archaeal hecatomb in the deep seafloor

We show here for the first time the crucial role of viruses in controlling archaeal dynamics and therefore the functioning of deep-sea ecosystems, and suggest that virus-archaea interactions play a central role in global biogeochemical cycles.

Until recently, the pseudoscientific nonsense about vaccines that could protect human populations from the forthcoming viral apocalypse was tightly linked from communism to atheism. For comparison, Christ’s lab appears to have put the fear of God into its proper context; the 1918 Spanish flu.
Previously reported as: Structural diversity of supercoiled DNA (2015) and parodied in:

See also: The Pharmacology of Regenerative Medicine (2013)
See also: Energy as information and constrained endogenous RNA interference (2017)

Feedback loops link quantized energy as information to biophysically constrained RNA-mediated protein folding chemistry. Light induced energy-dependent changes link angstroms to ecosystems from classical physics to chemistry/chirality and to molecular epigenetics/autophagy.

The National Microbiome Initiative links microbial quorum sensing to the physiology of reproduction via endogenous RNA interference and chromosomal rearrangements. The rearrangements link energy-dependent fixed amino acid substitutions to the Precision Medicine Initiative via genome wide inferences of natural selection.

This detailed representation of energy-dependent natural selection for codon optimality links biologically- based cause and effect from G protein-coupled receptors to RNA-mediated amino acid substitutions and the functional structure of supercoiled DNA. Energy-dependent polycombic ecological adaptations are manifested in supercoiled DNA.

Chromosomal inheritance links the adaptations from morphological phenotypes to healthy longevity via behavioral phenotypes. For contrast, virus-driven energy theft is the link from messenger RNA degradation to negative supercoiling, constraint breaking mutations, and hecatombic evolution.

The viral hecatomb links transgenerational epigenetic inheritance from archaea to Zika virus-damaged DNA, which typically is repaired by endogenous RNA interference and fixation of RNA-mediated amino acid substitutions in organized genomes.

5th-6th Sept 2018 Dublin, Ireland

MicroRNA-mediated denuclearization (2)

Summary:
The virus-driven theft of quantized energy creates a cellular environment that promotes the survival and self-proliferation of viruses by encoding viral miRNAs or miRNA-like molecules. The viral miRNAs or miRNA-like molecules target different types of host cells.
The sun’s anti-entropic virucidal energy biophysically constrains viral latency in the context of global control of human ES cell differentiation via circRNAs derived from lncRNAs. That fact refutes all neo-Darwinian gene-centric pseudoscientific nonsense. That fact also attests to the link from Chinese philosophy to scientific creationism in South Korea.
Scientific creationism appears to have defeated communism in the context of the electron cloud superimposed over the yin yang symbol of constrained energy.
For scientific support of the claims that appear to have defeated communism, see:
Analysis of human ES cell differentiation establishes that the dominant isoforms of the lncRNAs RMST and FIRRE are circular

Surprisingly, circRNAs derived from long non-coding RNAs (lncRNAs) were found to account for a significantly larger proportion of transcripts from their loci of origin than circRNAs from coding genes.

CONCLUSIONS:

Our results suggest that during human ES cell differentiation, changes in circRNA levels are primarily globally controlled.

Global control of human ES cell differentiation via circRNAs derived from lncRNAs refutes neo-Darwinian gene-centric pseudoscientific nonsense. The level of control comes as no surprise to serious scientists who start with the energy-dependent creation of microRNAs and link the energy to the RNA-mediated creation from genome assembly to the creation of all cell types.

The global control-based refutation is merely one more example of pattern recognition.

See: Three invariant Hi-C interaction patterns: applications to genome assembly

We suggest that simultaneously considering all three invariant patterns may lead to better Hi-C-based genome assembly methods.

Schrödinger suggested that genome assembly was energy-dependent in What is Life? (1944)

Indeed, in the case of higher animals we know the kind of orderliness they feed upon well enough, viz. the extremely well-ordered state of matter in more or less complicated organic compounds, which serve them as foodstuffs. After utilizing it they return it in a very much degraded form -not entirely degraded, however, for plants can still make use of it. (These, of course, have their most power supply of ‘negative entropy’ the sunlight.)

See also: What is life when it is not protected from virus driven entropy (video)

See also: Rotavirus-encoded virus-like small RNA triggers autophagy by targeting IGF1R via the PI3K/Akt/mTOR pathway

Examining virus-host cell interaction is important for elucidating mechanisms of virus proliferation in host cells. Viruses can create an environment that promotes their survival and self-proliferation by encoding miRNAs or miRNA-like molecules that target various host cell.

See also: Base-pair opening dynamics of the microRNA precursor pri-miR156a affect temperature-responsive flowering in Arabidopsis

…fine-tuning of the base-pair stability at the cleavage site is essential for efficient processing of pri-miR156a at a low temperature and for reduced flowering sensitivity to ambient temperature changes.

See also: Emergence of Human G2P[4] Rotaviruses in the Post-vaccination Era in South Korea: Footprints of Multiple Interspecies Re-assortment Events

…17-24 amino acid changes, specifically A87T, D96N, S213D, and S242N substitutions in G2 epitopes, were observed. These results suggest that multiple interspecies re-assortment events might have contributed to the emergence of G2P[4] rotaviruses in the post-vaccination era in South Korea.

See also: A Single Amino Acid at the Polymerase Acidic Protein Determines the Pathogenicity of Influenza B Viruses

Several amino acid mutations were identified in PB2, PB1, PA, BM2, and/or NS1 protein coding regions, and one concurrent lysine (K)-to-arginine (R) mutation in PA residue 338 (PA K338R) was found in both maVc_BR60 and maYm_WI01 viruses. When analyzed using reverse-genetically rescued viruses, it was shown that PA K338R alone could increase the pathogenicity of both IBVs in mice and viral replication property in the respiratory tracts of ferrets.

The energy-dependent fine-tuning of the base-pair stability in plants prevents the emergence of rotaviruses via multiple interspecies re-assortment events linked to healthy longevity in post-vaccination era South Korea.

See for comparison: Engineered virus has artificial amino acid allowing it to serve as a vaccine

A team of researchers at Peking University has developed a new type of vaccine that they claim may allow for a new approach to generating live virus vaccines which could conceivably be adapted to any type of virus. In their paper published in the journal Science, the team outlines the means by which they modified an influenza virus causing it to incite an immune response without a risk of infection.

Scientific creationists in South Korea have showed that the Chinese cannot protect themselves from a viral apocalypse via vaccinations. The viruses adapt too quickly.

Knowing that also allows the scientific creationists to create a virus that damages the DNA of specific human populations who are less well-adapted to their food energy-dependent pheromone-controlled ecological, social, neurogenic, and socio-cognitive niches.

Would you threaten nuclear war after you learn that the population of your country could be decimated by a genetically engineered virus produced in a neighboring country. Or, would you denuclearize and de-escalate the tensions as soon as you learned that all niche construction is food energy-dependent and that the pheromone-controlled physiology of reproduction biophysically constrains viral latency.

That fact cannot be placed back into the context of atheism or communism. It is a neo-Darwinian theory killer and is the most likely reason for denuclearization in a reasonable world.

The facts about biophysically constrained viral latency and energy-dependent life will be discussed during Schrödinger at 75 – The Future of Biology – September 2018

See for comparison: Organ-specific metastases obtained by culturing colorectal cancer cells on tissue-specific decellularized scaffolds

…lung and liver decellularized scaffolds retained their tissue-specific tropism when injected in mice.

Reported as: Scientists create better laboratory tools to study cancer’s spread

The hypothesis is this is caused by both ‘seed and soil’ – that the cancer cells have something in them that drive them to a particular organ, and the soil has to be right for them to grow. Most of the focus has been on studying the cancer cell, or the seed, and not as closely looking at the soil, which is the organs that they go to. Our models will help us understand to better understand the conditions of the soil that help promote cancer metastasis.

The use of Schrödinger’s sunlight-to-soil metaphor of degraded organic matter and biophysically constrained viral latency is not likely to be a coincidence. It also appears in the context of the energy-dependent weekend resurrection of the bacterial flagellum and in the context of the weekend Resurrection of Christ.

See also:  Evolutionary resurrection of flagellar motility via rewiring of the nitrogen regulation system

See also:  Thou fool, that which thou sowest is not quickened, except it die:”

See also: Science, state, and spirituality: Stories of four creationists in South Korea

Scientific creationism in South Korea supposedly began with the support of the US government in their attempt to fight against communism and atheism. Pseudoscientists have not linked energy-dependent RNA-mediated biophysically constrained viral latency to all healthy longevity in the context of Communism and atheism.

For comparison, all serious scientists who understand the role that the creation of energy plays in the creation of supercoiled DNA have won the war against communism by combating evolution to fight disease.

All disease has been linked to the virus-driven energy theft that causes the degradation of messenger RNA, which has been linked to all pathology.

The energy-dependent creation of microRNAs has been linked from the creation of the innate immune system to all biophysically constrained behaviors via what is known about how the physiology of pheromone-controlled reproduction must be linked from soil bacteria to the growth of seeds and all food energy-dependent life on Earth.

5th-6th Sept 2018 Dublin, Ireland

MicroRNA-mediated denuclearization

Kim Says North Korea Is Stopping Nuclear and Missile Tests

Early today, he said the country was stopping nuclear and missile tests and shuttering its atomic test site, which has “done its job.” Those concessions were long demanded by the U.S., lifting hopes that next Friday’s planned summit between Kim and South Korean President Moon Jae-in will be conducted in good faith.

Added Perspective
Emergence of Human G2P[4] Rotaviruses in the Post-vaccination Era in South Korea: Footprints of Multiple Interspecies Re-assortment Events
Viruses do not emerge. They adapt in the context of proton gradients and microRNA-mediated changesin energy-dependent protein folding chemistry. The food energy-dependent fixation of RNA-mediated amino acid substitutions links interspecies re-assortment events to healthy longevity.
See for comparison: A Single Amino Acid at the Polymerase Acidic Protein Determines the Pathogenicity of Influenza B Viruses
The ability of researchers in South Korea to create genetically modified viruses with increased pathogenicity links quantum physics from virus-driven energy theft to the degradation of messenger RNA and extinctions in many different populations of extinct organisms during the past 6,000 years.
See: Virus-mediated archaeal hecatomb in the deep seafloor

We show here for the first time the crucial role of viruses in controlling archaeal dynamics and therefore the functioning of deep-sea ecosystems, and suggest that virus-archaea interactions play a central role in global biogeochemical cycles.

The population of North Korea could have been the next to be decimated by a genetically engineered virus if Kim Jong Un had not agreed to denuclearization.
See also: Reappraising the human mitochondrial DNA [mtDNA] recombination dogma

…studies dealing with human variation and evolution have assumed that human mtDNA does not recombine and should be considered as pathological or very infrequent. Using both direct and indirect approaches, we provide consistent evidence of mtDNA recombination in humans.

Food energy-dependent mtDNA recombination in humans appears to protect all organized genomes in all extant human populations. mtDNA recombination may be the best protection from extinction that any species already has.  Given what is known to serious scientists about cell type differentiation, the link from light-activated endogenous substrates and the physiology of reproduction in all living genera causes many people to ridicule the assumptions still touted in the context of theories invented by neo-Darwinian theorists.
See also: Mechanisms of Recombination conference

High-throughput sequencing and analysis of microbial community cDNA (#metatranscriptomics) are providing valuable insight into in situ microbial activity and metabolism in the oceans.

The eternal significance of microRNAs (4)

Conclusion: Conserved energy biophysically constrains viral latency.
Metatranscriptomics

High-throughput sequencing and analysis of microbial community cDNA are providing valuable insight into in situ microbial activity and metabolism in the oceans.

When faced with the eternal significance of quantized energy-dependent natural selection for codon optimality, theorists must attack the basics of what is known to serious scientists about biophysically constrained life on Earth.
See for example: Virus-mediated archaeal hecatomb in the deep seafloor
By starting with “raw assemblies” instead of the energy from sunlight that must be linked to the “Assemblies Trinity,” pseudoscientists link “data” to codon optimality. They fail to link the creation of virucidal light from differential gene expression before they link the data to results that are meaningless outside the context of an energy source.
All results can be predicted only in the context of the energy-dependent biophysical constraints that prevent the virus-driven degradation of messenger RNA from destroying the supercoiled DNA that is required to maintain viral latency and healthy longevity.
Nutrition, microRNAs, and Human Health (2017)

MicroRNAs (miRs) hybridize with complementary sequences in mRNA and silence genes by destabilizing mRNA or preventing translation of mRNA.

The authors recapitulate the claims from my 2014 invited review of nutritional epigenetics but fail to address the most important aspect of biophysically constrained viral latency, which requires the energy-dependent creation of microRNAs that prevent the translation of mRNA. The destabilizing effects of viruses are eliminated when enough food energy is available to support RNA-directed DNA methylation and fixation of amino acid substitutions in organized genomes.
See:  Nutrient-dependent pheromone-controlled ecological adaptations: from atoms to ecosystems

This atoms to ecosystems model of ecological adaptations links nutrient-dependent epigenetic effects on base pairs and amino acid substitutions to pheromone-controlled changes in the microRNA / messenger RNA balance and chromosomal rearrangements. The nutrient-dependent pheromone-controlled changes are required for the thermodynamic regulation of intracellular signaling, which enables biophysically constrained nutrient-dependent protein folding; experience-dependent receptor-mediated behaviors, and organism-level thermoregulation in ever-changing ecological niches and social niches. Nutrient-dependent pheromone-controlled ecological, social, neurogenic and socio-cognitive niche construction are manifested in increasing organismal complexity in species from microbes to man.

See for comparison: Prediction of 5-Fluorouracil Toxicity Associated With Dihydropyrimidine Dehydrogenase Gene (DPYD) Polymorphism Using the Secondary Structure Prediction Programs
The predicted toxicity must be linked from the energy-dependent creation of dehydrogenase gene polymorphisms. The failure to do that has led to class action litigation.
See also:  DPYD dihydropyrimidine dehydrogenase [ Homo sapiens (human) ]

The protein encoded by this gene is a pyrimidine catabolic enzyme and the initial and rate-limiting factor in the pathway of uracil and thymidine catabolism. Mutations in this gene result in dihydropyrimidine dehydrogenase deficiency, an error in pyrimidine metabolism associated with thymine-uraciluria and an increased risk of toxicity in cancer patients receiving 5-fluorouracil chemotherapy. Two transcript variants encoding different isoforms have been found for this gene.

Finding isoforms is of little use if researchers do not know how the isoforms are created.
medical Definition of isoform.:

any of two or more functionally similar proteins that have a similar but not identical amino acid sequence and are either encoded by different genes or by RNA transcripts from the same gene which have had different exons removed.

Most researchers know nothing about energy-dependent biophysical constraints on the creation of amino acid substitutions in the isoforms.
See for example: NSF’s Big Ideas: Understanding the Rules of Life and The Quantum Leap
The rules of life that include fixation of amino acid substitutions in organized genomes could have been linked from the quantum leap to biophysically constrained viral latency and healthy longevity in all living genera. Instead the presenters failed to answer any of my questions.

1) Has anyone place the rules of Life and the Quantum Leap into the context of food energy-dependent biophysically constrained viral latency and sympatric speciation?
2) Do you think that this parody accurately represents what was known in 2014 about the importance of energy-dependent base pair changes to biophysically constrained protein folding chemistry? All About that Base (Meghan Trainor Parody) 12/10/14
3) Do you agree that questions about genome adaptations compared to the evolution of organized genome are ambiguous in the context of what is known about natural selection for quantized energy-dependent codon optimality?
4) Has the difference in the energy of two photons been linked from altered proton gradients to the protential of hydrogen (pH) and RNA-mediated DNA repair via the creation of microRNAs and enzymes?
NSF funding is largely used to support theories about the emergence of energy and evolution of all biodiversity.
This work would be funded by NSF: The evolutionary history of vertebrate RNA viruses
They claim that the evolutionary history of vertebrates matches the history of the RNA viruses, which they claim is because the viruses evolved. Viruses must steal the quantized energy of sunlight from cell types or they cannot replicate. Does that sound like vertebrate viruses are capable of evolution?
That nonsense was reported as: New study transforms understanding of virus origins and evolution
See also: Estimating evolutionary rates in giant viruses using ancient genomes

…this suggests that these viruses could have diverged at least hundreds of thousands of years ago, and hence have evolved over longer time-scales than previously suggested. We propose that the evolutionary rate and time-scale of pithovirus evolution should be reconsidered in the light of these observations and that future estimates of the rate of giant virus evolution should be carefully examined in the context of their biological plausibility.

All their suggestions have become more ridiculous as more facts about the creation of microRNAs have been placed into the context of biophysically constrained viral latency.
See: MicroRNAs in neural development: from master regulators to fine-tuners

The proper formation and function of neuronal networks is required for cognition and behavior. Indeed, pathophysiological states that disrupt neuronal networks can lead to neurodevelopmental disorders such as autism, schizophrenia or intellectual disability. It is well-established that transcriptional programs play major roles in neural circuit development. However, in recent years, post-transcriptional control of gene expression has emerged as an additional, and probably equally important, regulatory layer. In particular, it has been shown that microRNAs (miRNAs), an abundant class of small regulatory RNAs, can regulate neuronal circuit development, maturation and function by controlling, for example, local mRNA translation. It is also becoming clear that miRNAs are frequently dysregulated in neurodevelopmental disorders, suggesting a role for miRNAs in the etiology and/or maintenance of neurological disease states. Here, we provide an overview of the most prominent regulatory miRNAs that control neural development, highlighting how they act as ‘master regulators’ or ‘fine-tuners’ of gene expression, depending on context, to influence processes such as cell fate determination, cell migration, neuronal polarization and synapse formation.

See also: Learning-dependent chromatin remodeling highlights noncoding regulatory regions linked to autism
They identified a single nucleotide polymorphism known as rs6010065. It is associated with differences in microRNAs linked to autism spectrum disorder.
See also: A Common Allele in FGF21 Associated with Sugar Intake Is Associated with Body Shape, Lower Total Body-Fat Percentage, and Higher Blood Pressure
A single nucleotide polymorphism known as rs838133 was linked from food energy-dependent changes in microRNAs to biophysically constrained viral latency and healthy longevity in the mouse-primate-human model of pheromone-controlled reproduction.
I reiterate: Nutrient-dependent pheromone-controlled ecological adaptations: from atoms to ecosystems

In the context of quantized energy as information-driven changes in the microRNA/messenger RNA balance, a single nucleotide polymorphism known as rs3827760, 1540T/C, 370A, V370A, and/or Val370Ala was linked to conserved morphological and behavioral phenotypes in mice and humans.

See: Epigenetics and Autism Spectrum Disorder: Is There a Correlation?

At a time when all serious scientists have linked energy-dependent changes in electrons to ecosystems, questions about correlations are irrelevant.

See: Oppositional COMT Val158Met effects on resting state functional connectivity in adolescents and adults

Functional connectivity is energy dependent and biophysically constrained by by the energy-dependent physiology of reproduction.

It is time for all biologically uniformed science idiots to admit that the source of all energy-dependent changes in every organism on Earth is sunlight.

See: Resolving sub-cellular miRNA trafficking and turnover at single-molecule resolution

Regulation of microRNA (miRNA) localization and stability is critical for their extensive cytoplasmic RNA silencing activity and emerging nuclear functions. Here, we have developed single-molecule fluorescence-based tools to assess the subcellular trafficking, integrity, and activity of miRNAs.

The regulation of microRNA (miRNA) localization and stability is quantized energy-dependent and pheromone controlled in the context of everything known to serious scientists about biophysically constrained protein folding chemistry and supercoiled DNA, which protects all organized genomes from virus-driven energy theft and genomic entropy.
Why symmetry gets really interesting when it is broken

Energy is conserved…because the laws of physics are the same now as they were a millennium ago…

Long-range coherence and energy storage in biological systems (1968)

The supplied energy is thus not completely thermalized but stored in a highly ordered fashion.

Conserved energy biophysically constrains viral latency.

5th-6th Sept 2018 Dublin, Ireland

Abiogenesis vs microRNA biogenesis (3)

 

My comment to

Thank you for helping to show what has been missing from neo-Darwinian theories and other claims that were based on de Vries 1902 definition of mutation. Theorists may now want to learn more about the energy-dependent molecular mechanisms of recombination.

Most of them will not like the findings you have provided. The peer-review process is especially deadly to those who challenge the current dogma. But since you have made the quantum leap see also:

Mechanisms of Recombination conference  Start: Sunday, May 20, 9.00am Finish: Tuesday, May 22, 6.45pm

Natural selection for codon optimality link quantized energy-dependent RNA-mediated DNA repair from biophysically constrained viral latency to sympatric speciation and all biodiversity.

When people who you thought were your peers reject your findings, you need only wait until after “Schrödinger at 75 – The Future of Biology” – September 2018 to resubmit and publish in a top-tier journal (if you have not already done so).

Until then, see also: Systematic analysis of complex genetic interactions

Reported as: How Many Genes Do Cells Need? Maybe Almost All of Them
Theorists failed to note that the creation of genes in yeasts is quantized energy-dependent and biophysically constrained by the physiology of reproduction. Most of their ridiculous claims try to link abiogenesis to genome evolution.
See for example:  Genome evolution across 1,011 Saccharomyces cerevisiae isolates
The origin of the yeast species in China has been linked to all biophysically constrained sympatric speciation via the section on molecular epigenetics from this 1996 review of RNA-mediated cell type differentiation.
From Fertilization to Adult Sexual Behavior

Small intranuclear proteins also participate in generating alternative splicing techniques of pre-mRNA and, by this mechanism, contribute to sexual differentiation in at least two species, Drosophila melanogaster and Caenorhabditis elegans…

From the Discussion:

Parenthetically it is interesting to note even the yeast Saccharomyces cerevisiae has a gene-based equivalent of sexual orientation (i.e., a-factor and alpha-factor physiologies). These differences arise from different epigenetic modifications of an otherwise identical MAT locus (Runge and Zakian, 1996; Wu and Haber, 1995).

See also: Correction of β-thalassemia mutant by base editor in human embryos
See for comparison: Nothing in Biology Makes Any Sense Except in the Light of Evolution (1973)

…the so-called alpha chains of hemoglobin have identical sequences of amino acids in man and the chimpanzee, but they differ in a single amino acid (out of 141) in the gorilla.

Theorists must now face the facts about mitochondrial DNA that also attest to their ignorance. They will be forced to link the creation of anti-entropic virucidal energy to the creation of ATP synthase, the creation of ATP, and the creation of RNA, which links microRNA biogenesis from naturally occurring energy-dependent base editing and the origin of microbial yeasts in China to morphological and behavioral phenotypes in humans via biophysically constrained changes in the microRNA/messenger RNA balance.
After comparison to these “Levels of Biological Organization” (See slide # 6) and the examples from all species, anyone left touting ridiculous theories will be dismissed.

For God and Country

Abiogenesis vs microRNA biogenesis (2)

All serious scientists learned about Schrödinger’s claims in “What is Life?” (1944).  All serious scientists have since linked the creation of the sun’s anti-entropic virucidal energy to “negentropy” and healthy longevity.

See also: Reappraising the human mitochondrial DNA recombination dogma

…paving the way for the definitive rejection of the non-recombination dogma for human mtDNA.
 

Recombination is quantized energy-dependent and biophysically constrained by the physiology of reproduction.

See the works of those who are scheduled to present during Schrödinger at 75 – The Future of Biology – September 2018

Duane Gish never published anything that is indexed on the PubMed database. If you claim that he or anyone else like him, including Henry M. Morris (1918–2006)  is a bonafide scientist, please try to support your ridiculous claims in the context of the historical record of more than 72,000 published works that mention “microRNA.”

If you do not start with the creation of microRNAs (microRNA biogenesis), do not try to explain how natural selection for beneficial mutations links evolution to biodiversity. All serious scientists will make fun of you.

See:

Some will continue to use you as an example of human idiocy.

See why: Signatures of negative selection in the genetic architecture of human complex traits

Reported as: Natural selection still at work in humans

“In natural selection, or ‘survival of the fittest’, characteristics that improve survival are more likely to be passed on to the next generation,” Professor Yang said.

“The opposite also occurs, when DNA mutations with a detrimental effect on fitness are less likely to be passed on, by a process called negative selection.

Mutations link virus-driven energy theft to all pathology, not from negative selection to evolution.
Case report: detection of the identical virus in a patient presenting with severe fever with thrombocytopenia syndrome encephalopathy and the tick that bit her (April 17, 2018)

Phylogenetic analyses indicated that the SFTSV from the patient and the tick was identical. The patient gradually recovered with treatments of corticosteroids and immunoglobulin.

CONCLUSION:

These findings provide further evidence of SFTS viral transmission from H. longicornis to human.

Researchers in South Korea may already know how to protect human populations from the transmission of viruses, which has been linked from the transgenerational epigenetic inheritance of pathology to the viral hecatomb in the deep sea.
See also: virus south korea
After the USA fought two land-wars in Asia, the uselessness of vaccine in South Korea and the senseless loss of life has been linked from the “creationist capital of the world” to denuclearization via seemingly futile cycles of protein biosynthesis and the virus-driven driven degradation of messenger RNA.
The facts about energy-dependent RNA-mediated DNA repair extend across species in the context of hearing loss and all other pathology via the cell biology game “Cytosis” for ages 10+

Players compete to build enzymes, hormones and receptors and fend off attacking Viruses!

Science, state, and spirituality: Stories of four creationists in South Korea

Supposedly, Duane Gish and Henry M. Morris (1918–2006) were responsible for making South Korea the “creationist capital of the world.”

Hashem Al-Ghaili pits all creationsts claims against his pseudoscientific nonsense in Memories can pass between generations through DNA (video)

If you wish to pit the claims about evolved instincts against my claims about microRNA biogenesis and biophysically constrained viral latency against the the claims of serious scientists from South Korea, start by explaining how Duane Gish linked the creation of the sun’s anti-entropic virucidal energy to all biodiversity. 

All serious scientists learned about Schrödinger’s claims in “What is Life?” (1944).  All serious scientists have since linked the creation of the sun’s anti-entropic virucidal energy to “negentropy” and healthy longevity.

See also: Reappraising the human mitochondrial DNA recombination dogma

…paving the way for the definitive rejection of the non-recombination dogma for human mtDNA.
 

Recombination is quantized energy-dependent and biophysically constrained by the physiology of reproduction.

See the works of those who are scheduled to present during Schrödinger at 75 – The Future of Biology – September 2018

Duane Gish never published anything that is indexed on the PubMed database. If you claim that he or anyone else like him, including Henry M. Morris (1918–2006)  is a bonafide scientist, please try to support your ridiculous claims in the context of the historical record of more than 72,000 published works that mention “microRNA.”

If you do not start with the creation of microRNAs (microRNA biogenesis), do not try to explain how natural selection for beneficial mutations links evolution to biodiversity. All serious scientists will make fun of you.

See:

Some will continue to use you as an example of human idiocy.

See why: Signatures of negative selection in the genetic architecture of human complex traits

Reported as: Natural selection still at work in humans

“In natural selection, or ‘survival of the fittest’, characteristics that improve survival are more likely to be passed on to the next generation,” Professor Yang said.

“The opposite also occurs, when DNA mutations with a detrimental effect on fitness are less likely to be passed on, by a process called negative selection.

Mutations link virus-driven energy theft to all pathology, not from negative selection to evolution.
Case report: detection of the identical virus in a patient presenting with severe fever with thrombocytopenia syndrome encephalopathy and the tick that bit her (April 17, 2018)

Phylogenetic analyses indicated that the SFTSV from the patient and the tick was identical. The patient gradually recovered with treatments of corticosteroids and immunoglobulin.

CONCLUSION:

These findings provide further evidence of SFTS viral transmission from H. longicornis to human.

Researchers in South Korea may already know how to protect human populations from the transmission of viruses, which has been linked from the transgenerational epigenetic inheritance of pathology to the viral hecatomb in the deep sea.
See also: virus south korea
After the USA fought two land-wars in Asia, the uselessness of vaccine in South Korea and the senseless loss of life has been linked from the “creationist capital of the world” to denuclearization via seemingly futile cycles of protein biosynthesis and the virus-driven driven degradation of messenger RNA.
The facts about energy-dependent RNA-mediated DNA repair extend across species in the context of hearing loss and all other pathology via the cell biology game “Cytosis” for ages 10+

Players compete to build enzymes, hormones and receptors and fend off attacking Viruses!

Indeed, the role of quantized energy as information in information-dependent naturally occurring RNA interference may soon be linked to denuclearization in North Korea (and everywhere else) by the factual representations of researchers from the Republic of South Korea.

See: A Single Amino Acid at the Polymerase Acidic Protein Determines the Pathogenicity of Influenza B Viruses (2018)
The looming threat of the next viral apocolypse is far greater than the nuclear threat, and researchers in South Korea are probably prepared to defend their population of modern humans.
Bill Gates, for comparison, is still touting the use of relatively useless vaccines.
See: Emergence of Human G2P[4] Rotaviruses in the Post-vaccination Era in South Korea: Footprints of Multiple Interspecies Re-assortment Events (April 16, 2018)

Compared to the G2 RotaTeq vaccine strain, 17-24 amino acid changes, specifically A87T, D96N, S213D, and S242N substitutions in G2 epitopes, were observed. These results suggest that multiple interspecies re-assortment events might have contributed to the emergence of G2P[4] rotaviruses in the post-vaccination era in South Korea.

If researchers in the so-called “creationist capital of the world” decide to genetically engineer a virus and wipe out the less-well ecologically adapted population of modern humans in North Korea, there would be virtually no loss of physical resources. The population of Seoul would benefit most by expanding into more rural areas.
Although this could lead to the futility of another land-war in Asia, it has become clear that everything ends badly. If that was not true, nothing would end. The current threat to anything that might otherwise be considered eternally significant was predicted in the science fiction novel “Quantico” by Greg Bear. It’s not funny any more, but see: Jon Stewart interviews Greg Bear
See also: Substitutions Near the Receptor Binding Site Determine Major Antigenic Change During Influenza Virus Evolution (2013) This author’s comment was recently removed:

The major antigenic changes of the influenza virus are primarily caused by a single amino acid near the receptor binding site.

But see the editor’s summary:  Koel et al. (p. 976) show that major antigenic change can be caused by single amino acid substitutions.
The energy-dependent fixation of single amino acid substitutions in viruses has since been linked to all pathology in all living genera via the failure of virus-infected cell types to repair their damaged supercoiled DNA. The late Timothy J. Cunningham knew that as well as anyone. Sadly, he vanished without a trace and was found dead a river near his home several weeks later.

Since then, I was asked to comment on the eternal significance of the Vietnam Memorial Wall. I did not yet mention that thermal cycles have been linked to cracks in the Vietnam Memorial Wall because the article was about the American Veterans Traveling Tribute’s Wall.

I wrote:

The Vietnam Veterans Memorial wall (The Wall) was built with private contributions from the American people. It stands as a symbol of America’s honor, and to recognize the men and women who served and sacrificed their lives in the Vietnam War. The Wall was designed by the daughter of Chinese intellectuals who fled their homeland before the 1949 Communist takeover. She lives in Athens, Ohio.

The Wall is made up of two panels 246 feet 9 inches long. At it’s highest point the wall is over 10 feet tall. The names of more than 58,000 men and women who gave their lives or remain missing are inscribed on the black granite walls. Names are added when more remains are found.

The Vietnam Veterans Memorial wall stirs emotion. It can even be somewhat overwhelming to visit. When people looks into the polished volcanic rock of the wall, it reportedly “looks back:” It envelops its visitors in the names of those who lost their lives in a war which lasted nearly two decades.

For the hundreds of thousands of Vietnam veterans who are still alive, it is a place of eternal significance.

The Traveling Vietnam Veterans wall is a 80% sized replica of the Vietnam Veterans Memorial Wall in Washington, D.C.

Whether or not you have visited The Wall in Washington, D.C. and/or visited other places of ‘eternal significance,’ you may want to take advantage of the opportunity to see the American Veterans Traveling Tribute’s Traveling Vietnam Wall from May 16-20, 2018 at the Lions Club Fairgrounds 1729 S. Main Street, Ellijay, Georgia 30540.

American Legion Post 82 and the Ellijay Lions Club are the sponsors. American Legion Post 82 will have guides, counselors, and security 24 hrs a day and a computer list to locate where the veterans names are inscribed.

There is no cost to see The Traveling Vietnam Veterans wall. Pencil rubbing of the names can be made just as it can be with the Wall in D.C.

Donations to the American Legion Post 82 Ellijay will be used to help our Veterans and our community.

Biologically uninformed theorists do not understand how researchers in the “creationist capital of the world” have linked the Laws of Thermodynamics to biophysically constrained viral latency. Virus-driven constraint-breaking mutations or nuclear war will almost undoubtedly lead to the death of us all.

Who do you think might save you in a “worst case” scenario? If not for the American Legion, you probably would not have been warned.

Biology to a Physicist

Abiogenesis vs microRNA biogenesis

Summary: The pseudoscientific nonsense about abiogenesis that has been touted by Karo Michaelian and others like him has caused the unnecessary suffering and premature death of millions to billions of people by placing the pathogenic consequences of deregulated miRNAs into the context of ridiculous theories.
See for comparison: Structural diversity of supercoiled DNA and the parody from the same research group:
——————————-
Abiogenesis (2017)
Microscopic dissipative structuring and proliferation at the origin of life (Oct 13, 2017)

Some fundamental molecules of life are suggested to have been formed, proliferated, and evolved through photochemical microscopic dissipative structuring and autocatalytic proliferation under the UV-C/UV-B solar environment prevalent at Earth’s surface throughout the Archean. Evidence is given in the numerous salient characteristics of these, including their strong absorption in this spectral region and their rapid non-radiative excited state decay through inherent conical intersections. The examples of the dissipative structuring and dissipative proliferation of the purines and of single strand DNA are given. UV-C and UV-B-induced stationary state isomerizations and tautomerizations are shown to be crucial to the formation of the purines from hydrogen cyanide in an aqueous environment under UV-C light, while UV-C induced phosphorylation of nucleosides and denaturing of double helix RNA and DNA are similarly important to the production and proliferation of single strand DNA. This thermodynamic dissipation perspective provides a physical-chemical foundation for understanding the origin and evolution of life.

The suggestion is ridiculous. No serious scientist would claim that some fundamental molecules of life formed, proliferated, and evolved in the context of thermodynamic dissipation after the UV-C induced phosphorylation of nucleosides and denaturing of double helix RNA and DNA.
The functional structure of supercoiled DNA is energy-dependent.
All serious scientists start with the link from the sun’s anti-entropic virucidal energy on contact with water to the creation of ATP synthase; the creation of microRNAs; the creation of all other enzymes; the creation of all receptors; the creation of all hormones. That’s how serious scientists link microRNA biogenesis to all biophysically constrained food energy-dependent pheromone-controlled morphological and behavioral diversity on Earth.
MicroRNA biogenesis (2018)

The tipping point of 72,000 indexed published works that mention microRNAs was reached on 4/18/18
See: microRNA
Example: Arthropod viruses and small RNAs (2013)

Understanding the role of small RNAs in arthropod host-virus molecular interactions will facilitate manipulation of these pathways for both management of arthropod pests of agricultural and medical importance, and for protection of beneficial arthropods such as honey bees and shrimp. This review highlights recent research on the role of small RNAs in arthropod host-virus interactions with reference to other host-pathogen systems.

Example: MicroRNAs as mediators of insect host-pathogen interactions and immunity (2014)

In this review, we will discuss the latest developments in regards to the role of microRNA in insect host-pathogen interactions and provide some insights into this rapidly developing area of research.

Example: miRNA regulation of innate immunity (2018)

MicroRNAs (miRNAs) are small noncoding RNA and are pivotal posttranscriptional regulators of both innate and adaptive immunity. They act by regulating the expression of multiple immune genes, thus, are the important elements to the complex immune regulatory network. Deregulated expression of specific miRNAs can lead to potential autoimmunity, immune tolerance, hyper-inflammatory phenotype, and cancer initiation and progression. In this review, we discuss the contributory pathways and mechanisms by which several miRNAs influence the development of innate immunity and fine-tune immune response. Moreover, we discuss the consequence of deregulated miRNAs and their pathogenic implications.

The pseudoscientific nonsense touted by Karo Michaelian and others like him has caused the unnecessary suffering and premature death of millions to billions of people by placing the pathogenic consequences of deregulated miRNAs into the context of ridiculous theories.
See for comparison: Structural diversity of supercoiled DNA and the parody from the same research group:

See also: Michaelian K
and Retraction: Oligoarginine peptides slow strand annealing and assist non-enzymatic RNA replication (Nov 23, 2017)
The life’s works of all those who have ever touted their ridiculous claims about abiogenesis can now be placed into the context of the eternal significance of microRNAs. The energy dependent de novo creation of microRNA flanking sequences has repeatedly been linked from the physiology of pheromone-controlled reproduction to biophysically constrained viral latency and sympatric speciation in all living genera.
See: Dependence of RNA synthesis in isolated thymus nuclei on glycolysis, oxidative carbohydrate catabolism and a type of “oxidative phosphorylation” (1964)

The synthesis of RNA in isolated thymus nuclei is ATP dependent.

See also: Long-range coherence and energy storage in biological systems (1968)
See also: Cytosis (for ages 10+)

Players take turns placing workers on available organelles within a human cell in order to collect resources (such as Carbohydrates or ATP!) or take actions (such as purchasing Cell Component cards or translating mRNA into Proteins!)

Players use their resources to build Enzymes, Hormones, and Hormone Receptors and also to help detoxify the cell – all of which score health points. The player with the most health points at the end of the game wins!

See for comparison: DNA Denaturing through UV-C Photon Dissipation: A Possible Route to Archean Non-enzymatic Replication (2014)

Many of the fundamental molecules of life, those common to all three domains; bacteria, eukaryote, and archea, including RNA and DNA, amino acids, enzymes, vitamins, cofactors, and protoporphyrins, absorb photons in the UV-C 1. RNA or DNA in complexes with these molecules act as acceptor quenchers, providing the electronically excited pigment donor molecule with an extremely rapid (sub picosecond) non-radiative dexcitation channel, through internal conversion into vibrational energy of the nucleic acid and surrounding water molecules2.

On January 15, 2016 John Hewitt commented:  You have just described the founding principle and thermodynamic function of life
On April 17, 2018, I commented on the ridiculous claim this so-called science journalist made because he blocked me from seeing his tweets a few months ago.