“…a mesmerising, perspective-shaking glimpse at Earth’s life-giving star.” (video)
1) Did the energy in this life-giving star create itself?
2) How is hydrogen-atom transfer in DNA base pairs in solution biophysically constrained.
3) Who created the feedback loops that link the solar analemma from the time-space continuum to representations of biophysically constrained life and free will in the Mobius strip.
4) Was Linda Buck the first Nobel Laureate to establish the link from the food energy-dependent pheromone-controlled physiology of reproduction to biodiversity in all living genera?
5) Are biologically uninformed theorists capable of answering any questions about the energy of life or how virus-driven energy theft causes the degradation of messenger RNA that links constraint-breaking mutations to all pathology?
The Mobius strip and the solar analemma exemplifie biophysical constraints on life history events.
The Mobius strip (above) is a visual aid for those who do not understand the concept of how free will is connected to the conserved molecular mechanisms of biophysically constrained energy-dependent RNA-mediated cell type differentiation in all living genera. If you cannot answer all 5 questions about energy in the context of the visual aid, which links the solar analemma to choices between quantized energy-dependent life and death, please search for microRNA on PubMed. The sun’s anti-entropic virucidal energy is biophysically constrained in microRNAs at every level of examination from angstroms to ecosystems.
If you cannot find the answers to any of the five questions about energy, ask a theorist to answer the first question. Alternatively, see: Computational identification of mutually homologous Zika virus miRNAs that target microcephaly genes
…ZIKV may modulate the action of various miRNAs, and miR-1304 in particular, resulting in microcephaly.
ZIKV – driven degradation of messenger RNA is linked to microcephaly. See also: Absolute Biophysical Characterization with Multi-Angle and Dynamic Light Scattering
A SEC-MALS-RI or UV with DLS system extends the characterization range of biomolecules to glycoproteins, PEGylated proteins, hydrophobic proteins, biopolymers, and other biomolecules.
My summary: The “Brownian” motion of molecules links dynamic light-scattering (DLS) from ecological variation to ecological adaptations via Ultraviolet-visible (UV-Vis) spectroscopy. Detection of energy as information has been placed into the context of virucidal light as energy.
Dynamic light scattering [DLS]
Dynamic light scattering (DLS) is a technique in physics that can be used to determine the size distribution profile of small particles in suspension or polymers in solution. In the scope of DLS, temporal fluctuations are usually analyzed by means of the intensity or photon auto-correlation function (also known as photon correlation spectroscopy or quasi-elastic light scattering).
See also: Detection Limits of DLS and UV-Vis Spectroscopy in Characterization of Polydisperse Nanoparticles Colloids
My summary: Ultraviolet-visible (UV-Vis) spectroscopy links the the food energy-dependent pheromone-controlled physiology of reproduction to the weekend resurrection of the bacterial flagellum in P. fluorescens, which responds to the light-activated chemistry of life with fluorescence even after the “knock-out” of the gene for its mobility, which was resurrected over the weekend as reported in: Evolutionary resurrection of flagellar motility via rewiring of the nitrogen regulation system
The resurrection in this organism, links its fluorescence to quantized energy-dependent exosome-delivered microRNAs, which have been reported to be Ultraconserved Elements in the Human Genome. When theorists use terms like ultraconserved elements outside the context of the conserved energy in microRNAs, it is clear that theorists are attempting to obfuscate this fact: The energy-dependent de novo creation of microRNAs has been linked to all biodiversity in all living genera via the physiology of pheromone-controlled reproduction.
See for example: All in the (bigger) family I wrote:
The 2015 Society for Integrative and Comparative Biology (SICB) presenters may not recognize how much progress has been made since the 2013 ecological epigenetics symposium. For example, since then authors claimed “…ctenophore neural systems, and possibly muscle specification, evolved independently from those in other animals.” http://dx.doi.org/10.1038/nature13400
Six months later, other authors traced signaling factors found in vertebrates to the origin of nerve cell centralization via the diffuse nerve net of animals like the sea anemone. http://dx.doi.org/10.1038/ncomms6536 That fact suggests ecological variation is linked to ecological adaptations in morphological and behavioral phenotypes via signaling protein concentrations that differentiate various cell types in body axes and the central nervous system.
Links across species from the epigenetic landscape to the physical landscape of DNA in organized genomes appear to have their origins in the conserved molecular mechanisms of RNA-directed DNA methylation and RNA-mediated protein folding. Two weeks after the publication that refuted ideas about independently evolved neural systems or muscle specification — and perhaps refuted the independent evolution of anything else, SICB presenters linked crustaceans to insects.
Apparently, they’ve learned that the same set of microRNAs controls expression of the genes for rate-limiting enzymes that control the hormone production of different hormones in insects and crustaceans.
Why were they left with any questions about how crustaceans and insects could all be part of one big family? They linked RNA-mediated cell type differentiation to what we described in our section on molecular epigenetics in our 1996 Hormones and Behavior review. From Fertilization to Adult Sexual Behavior
The interactions of these small noncoding RNAs in such primitive species have wide-reaching effects, from increasing viral and bacterial proliferation, better responses to stress, increased virulence, to manipulation of host immune responses…
The small non-coding RNAs are energy-dependent microRNAs, which are the same thing as Ultraconserved Elements in the Human Genome..
Here’s a way to make that fact perfectly clear. When it becomes available, play this game: Cytosis: A Cell Biology Board Game
A board game taking place inside a human cell! Players compete to build enzymes, hormones and receptors and fend off attacking Viruses!
Stop playing the ridiculous games of theorists who have failed to link the Creation of the sun’s quantized energy to all biodiversity on Earth. Theorists also failed to link the virus-driven degradation of messenger RNA from mutations to all pathology. Instead, they have used definitions of terms and definitions of species that are not limited to that fact that all organisms on Earth must eat or they fail to reproduce.
See for examples of pseudoscientific nonsense: New Research Problem of Species Definitions
Darwin first noted that there is no one definition of species, and not much has changed since then.
All species-specific behavior is food energy-dependent and RNA-mediated cell type differentiation biophysically constrains it in the context of the physiology of pheromone-controlled reproduction in all living genera. Darwin presciently included that fact in his “conditions of life.” He warned others that they could not start with natural selection, but many others have consistently ignored Darwin’s warnings. They also ignore the consistency of biological facts that link what organisms eat to the survival of all species via the pheromone-controlled physiology of reproduction. That forces them to ignore the consequences of virus-driven energy theft.
See: Virus-mediated archaeal hecatomb in the deep seafloor
We show here for the first time the crucial role of viruses in controlling archaeal dynamics and therefore the functioning of deep-sea ecosystems, and suggest that virus-archaea interactions play a central role in global biogeochemical cycles.
See for support of the fact that virus-archaea interactions play a central role in global biogeochemical cycles: Feedback loops link odor and pheromone signaling with reproduction
The feedback loops link natural selection for energy dependent codon optimality from RNA-mediated amino acid substitutions in supercoiled DNA to all biodiversity on Earth via the exosome-mediated delivery of microRNAs.
See also: The phylogenetic utility and functional constraint of microRNA flanking sequences
…the clear identity and easy alignment of these sequences makes them good candidates for estimating phylogeny, and they can reliably be found and identified across all members of a clade of interest. Their relatively slow evolution  also means that they can easily be identified in de novo assemblies of genomes.
The assembly of all organized genomes is food energy-dependent. Without food energy there is no energy for assembly of anything. Exosomes mediated the delivery of the food energy in microRNAs.
See also: Exosome Mediated Delivery of miR-124 Promotes Neurogenesis after Ischemia.
The intrinsic ability of neurogenesis after stroke has been proven weak, which results in insufficient repair of injury in the nerve system. Recent studies suggest multiple microRNAs (miRNAs) are involved in the neuroremodeling process. Targeted miRNAs delivery for amplification of neurogenesis is promising in promoting the prognosis after ischemia. Here, we showed that modified exosomes, with rabies virus glycoprotein (RVG) fused to exosomal protein lysosome-associated membrane glycoprotein 2b (Lamp2b), could efficiently deliver miR-124 to the infarct site. Systemic administration of RVG-exosomes loaded with miR-124 promoted cortical neural progenitors to obtain neuronal identity and protect against ischemic injury by robust cortical neurogenesis. Our study suggests that RVG-exosomes can be utilized therapeutically for the targeted delivery of gene drugs to the brain, thus having great potential for clinical applications.
The fact that “…multiple microRNAs (miRNAs) are involved in the neuroremodeling process…” makes the role of food energy-dependent RNA-mediated DNA repair perfectly clear to all serious scientists. For comparison, use of virus-assisted delivery has been linked to the predictable horror of gene editing technology.
See: Unexpected mutations after CRISPR-Cas9 editing in vivo
See for comparison: Cell proliferation in the subventricular zone by synthetic murine pheromones
The elucidation of the mechanisms by which specific compounds influence cell proliferation and neurogenesis, and eventually reproductive conditions in males and females should provide further insight as to how the odor environment controls and modulates the reproductive activities of animals.
See also: Pheromones and the luteinizing hormone for inducing proliferation of neural stem cells and neurogenesis
Clearly, researchers who use viruses to stimulate neurogenesis have not learned that all cell type differentiation is energy-dependent and controlled by feedback loops. Their use of viruses will continue ot link virus-driven energy theft from the degradation of messenger RNA to all pathology via the constraint breaking mutations the Masatoshi Nei, and many other biologically uninformed theorists have included in their stories about Mutation-Driven Evolution.
See for comparison: Nutrient-dependent/pheromone-controlled adaptive evolution: a model
…the epigenetic ‘tweaking’ of the immense gene networks that occurs via exposure to nutrient chemicals and pheromones can now be modeled in the context of the microRNA/messenger RNA balance, receptor-mediated intracellular signaling, and the stochastic gene expression required for nutrient-dependent pheromone-controlled adaptive evolution. The role of the microRNA/messenger RNA balance (Breen, Kemena, Vlasov, Notredame, & Kondrashov, 2012; Duvarci, Nader, & LeDoux, 2008; Griggs et al., 2013; Monahan & Lomvardas, 2012) in adaptive evolution will certainly be discussed in published works that will follow.
See also: Humans Fit All Of The Government Criteria For ‘Endangered Species’ and Past 5,000 years prolific for changes to human genome
See for comparison: Independent and Stochastic Action of DNA Polymerases in the Replisome
It has been assumed that DNA synthesis by the leading- and lagging-strand polymerases in the replisome must be coordinated to avoid the formation of significant gaps in the nascent strands.
Reported as: Close-Up View of DNA Replication Yields Surprises
What looks like coordination is actually the outcome of a random process of starting, stopping and variable speeds. Over time, any one DNA polymerase will move at an average speed; look at a number of DNA polymerases synthesizing DNA strands over time, and they will have the same average speed.
…the metabolic enzyme, pyruvate kinase muscle (PKM), interacts with sub-pools of endoplasmic reticulum (ER)-associated ribosomes, exerting a non-canonical function as an RNA-binding protein in the translation of ER-destined mRNAs.
Metabolism is food energy-dependent. That fact should have eliminated all the pseudoscientific nonsense about the random process of starting, stopping and variable speeds. For example, autophagy is quantized energy-dependent and the energy from food protects all organized genomes from virus-driven energy theft and the degradation of messenger RNA that links mutations to all pathology.
See also: The evolution of ecosystem ascendency in a complex systems based model
Our findings support the validity of ecosystem ascendency as a meaningful measure of ecosystem organisation, which increases over evolutionary time scales and significantly drops during periods of disturbance. The results suggest a general trend towards both higher integrity and increased stability driven by functional and structural ecosystem coadaptation.
Ecosystem ascendancy is food energy-dependent and biophysically constrained by the pheromone-controlled physiology of reproduction in all living genera.
Attempts to model general trends towards the increased stability of functional and structural ecosystems without linking the anti-entropic virucidal energy of sunlight to the physiology of reproduction are examples of what Richard Feynman referred to as human idiocy.
Richard Feynman was a Nobel prize winning Theoretical Physicist who popularized physics with his entertaining lecture style. This snippet is taken from one of his lectures in the series “The character of Physical Law” where he complains about all the different units that are used to measure the single concept of Energy.
See also: Structural diversity of supercoiled DNA
Six decades after the elucidation of its double helical structure, DNA continues to surprise us by revealing new information. Our cryo-ET, biochemical, and computational studies show the astounding versatility and dynamism of DNA depending on the degree of supercoiling. DNA simultaneously exists in a largely inactive B-form with bases tucked in and protected and an active, highly varied structure with exposed bases. Our data provide relative comparisons of supercoiling-dependent twisted, writhed, curved, and kinked conformations and associated base exposure. Each of these structural features may be differentially recognized by the proteins, nucleic acids, and small molecules that modulate DNA metabolic processes.
See for comparison:
Jay R. Feierman: Variation is not nutrient availability and the something that is doing the selecting is not the individual organism. A feature of an educated person is to realize what they do not know. Sadly, you don’t know that you have an incorrect understanding [of] Darwinian biological evolution.
Jay R. Feierman: I am absolutely certain that if you showed this statement to any professor of biology or genetics in any accredited university anywhere in the world that 100% of them would say that “Random mutations are the substrate upon which directional natural selection acts” is a correct and true statement.
See also:These groups are moderated by Robert Karl Stonjek, who is an example of human idiocy. He knows nothing about biophysically constrained energy-dependent cell type differentiation and consistently displays his ignorance by limiting ability to explain the role that the virus-driven degradation of messenger RNA plays in all pathology.
Psychiatry and Clinical Psychology
Evolutionary Psychology News
Religion: Science and Psychology
Quantum Physics News
On his FB group for discussion of Sensescence on 6/16/17 I wrote:
All death is caused by trauma or the virus driven degradation of messenger RNA
On 6/17/17 Robert Karl Stonjek wrote (with my emphasis):
Or viruses, or bacteria, or degenerative disease, or genetic disease (there are many), or substance abuse (there are many), or obesity, or….the only one I can’t find in the regular literature is virus driven degradation of messenger RNA.
And then: Robert Karl Stonjek turned off commenting for this post. Can you die from old age?
The pervasive ignorance of those who moderate or censor the comments made by serious scientists via social media has overwhelmed all attempts to present what is known about the virus-driven degradation of messenger RNA, which causes the mutations that have been linked to all pathology.
See for comparison:
Theorists will cause the death of us all. Who will be the next of your loved ones to unnecessarily suffer and prematurely die from the ignorance of theorists?
America’s Dominance In The Scientific World Is shrinking
Denise Chen’s student, Wen Zhou did that. See: Olfaction Warps Visual Time Perception
Had she stayed in the United States, she would have been subjected to pseudoscientific nonsense like this:
Still, even in fruit flies, other sensory input besides pheromones — acoustic, tactile, and visual stimuli — play a role in sexual attraction, and sex specific responses to these stimuli appear to be innate rather than learned by association [36.]. We simply don’t know where the boundary between prespecified attraction and learned association lie in our own species, nor do we have compelling evidence for the primacy of one sense over another.” — Simon LeVay (2011) in his comments on my award-winning model – after it won a second award in 2007. See: The Mind’s Eyes: Human pheromones, neuroscience, and male sexual preferences
… chemosignal enthusiasts point to a variety of studies in which sniffing body secretions or substances purified from secretions appears to have some psychological effect…” — Simon LeVay (2016)
He cited the review that won the first award (Kohl et al., 2001). Human pheromones: integrating neuroendocrinology and ethology
The subsecond scales links femtosecond blasts of UV light to DNA repair, which is required to link quantum physics to quantum souls. That is the topic of my next interview with J.A. Parker, who sent me the questions in advance, so that I could try to keep the jargon to a minimum.
Until I am sucessful, see: Analysis sheds light on how metaphors like ‘sheds light’ evolved
Words that originally had only concrete or external meaning have grown to also have meaning in the realms of the abstract and internal.
Who else besides Schrodinger in “What is Life? (1944) and J.A. Parker of Quantum Souls knew that Dobzhansky’s “light of evolution” would be traced back to “Let there be Light” in Biblical Genesis via what is known about the anti-entropic virucidal energy of sunlight?