I know you have accomplished much already in the areas of research and discovery toward cures in brain disease. And I am sure at times the progress has felt painfully slow. Do not give up. Trust that a cascade of cures and discovery is imminent in all areas of brain disease and you will be a part of making that happen.
If only Robin could have met you. He would have loved you—not just because he was a genius and enjoyed science and discovery, but because he would have found a lot of material within your work to use in entertaining his audiences, including the troops. In fact, the most repeat character role he played throughout his career was a doctor, albeit different forms of practice.
You and your work have ignited a spark within the region of my brain where curiosity and interest lie and within my heart where hope lives. I want to follow you. Not like a crazed fan, but like someone who knows you just might be the one who discovers the cure for LBD and other brain diseases.
Thank you for what you have done, and for what you are about to do.
See also: Antibiotic Guideline for Central Nervous System Infections
My comment: Someone should tell Robin Williams’ widow that these guidelines could apply to the use of antibiotics to treat gut discomfort before virus-driven energy theft causes Lewy Body Disease to be misdiagnosed and leads to death by suicide. Perhaps she would believe someone like Dr. Jon Lieff.
See: Intelligent Lysosomes Are More than A Waste Disposal
The lysosome is a sensory hub to determine what molecules are available, what has too much and what is needed. This includes all the molecules in metabolism of the cell such as amino acids to make proteins.
My comment: The lysosome links the energy-dependent secreting of a molecule to the sensing of the molecule, which enables the link from epistasis to homeostasis.
The lysosome maintains a particular pH (4.5 to 5.0) as an optimal amount to hydrolyze various molecules. This is similar to the way the stomach maintains a particular acid balance. But, the lysosome maintains in a singular vesicle. It contains a very large number of particular enzymes to break down almost every type of molecule that is found. It breaks down all large molecules (polymers).
See for example: Secreting and Sensing the Same Molecule Allows Cells to Achieve Versatile Social Behaviors with my comment to the Science site.
Re: “Evolution appears to favor efficient circuits and signaling elements that can accomplish many different tasks…”
That was inferred in our 1996 Hormones and Behavior review: From Fertilization to Adult Sexual Behavior. We started with the conserved molecular epigenetics of yeasts and extended nutrient-dependent genetic diversity from the metabolism of nutrients to the pheromone-controlled physiology of reproduction in species from microbes to man.
Four years later our yeast-to-mammalian model was extended by others to hormone-organized and hormone-activated invertebrate behavior, and 5 years after that to the life history transitions of the honeybee model organism.
Since then, “Signaling Crosstalk: Integrating Nutrient Availability and Sex” has linked yeasts to “Feedback loops link odor and pheromone signaling with reproduction” in other species and to “Nutrient-dependent/pheromone-controlled adaptive evolution: a model”
Placing all these published works into the context of evolution as Youk and Lim have done seems somewhat problematic for some evolutionary theorists. The conserved molecular mechanisms appear to represent adaptations to ecological variation via nutrient-dependent secretion of pheromones and the sensing of pheromones.
That links the epigenetic landscape to the physical landscape of DNA in the organized genomes of species from microbes to man.
The fact that ecological adaptations occur via a nutrient-dependent signaling pathway, which regulates a pheromone-controlled signalling pathway shows how unicellular and multicellular organisms produce a coordinated response to multiple stimuli with no consideration for mutations or for natural selection of anything except food.
That does not present a problem in the context of biologically-based food odor- and social odor-driven cause and effect, but it makes mutation-driven evolution appear to be not only biologically implausible but also to not be an ecologically valid approach to species diversity.
More Nobel-Winning Research that challenges neo-Darwinian evolutionary theory was announced today.
From the comments on the 2016 Nobel Prize in Physiology or Medicine.
Malay Saha: Autophagy is an intracellular degradation system that delivers cytoplasmic constituents to the lysosome. Despite its simplicity, recent progress has demonstrated that autophagy plays a wide variety of physiological and pathophysiological roles, which are sometimes complex..
See: Autophagy: process and function
Autophagy is an intracellular degradation system that delivers cytoplasmic constituents to the lysosome. Despite its simplicity, recent progress has demonstrated that autophagy plays a wide variety of physiological and pathophysiological roles, which are sometimes complex. Autophagy consists of several sequential steps—sequestration, transport to lysosomes, degradation, and utilization of degradation products—and each step may exert different function. In this review, the process of autophagy is summarized, and the role of autophagy is discussed in a process-based manner.
My comment: The article is available for free.
Excerpt from the 2007 conclusion:
…although autophagy is generally considered to be a tumor-suppressive process (Hippert et al. 2006; Levine 2007), the relationship between autophagy and cancer is complicated, in part because different steps of autophagy have different roles in tumor generation and tumor survival. A more quantitative view will be required to further understand the net role of autophagy in vivo. Finally, our knowledge of autophagy now seems to be ready for therapeutic application. Indeed, small molecules that can regulate autophagy seem to have great potential to modulate the clinical course of neurodegenerative diseases (Sarkar et al. 2007).
My comment: The small molecules are microRNAs, but the role that they play in linking hydrogen-atom transfer in DNA base pairs in solution to healthy longevity or from virus-driven energy theft to all pathology has not been explained in the context of how the nutrient-dependent pheromone-controlled physiology of reproduction must be linked from quorum-sensing in microbes to all biodiversity.
My comment to the FB page where the announcement of the 2016 Nobel Prize was made.
James Kohl: Let’s not discuss the fact that it must link energy-dependent changes from angstroms to ecosystems in all living genera in the context of their RNA-mediated DNA repair of virus-driven damage as manifested in the transgenerational epigenetic inheritance of Zika virus pathology. If we discuss that fact, neo-Darwinian theorists will attack.
Jon Lieff has stepped ahead of the data and linked it to biologically-based cause and effect in all living genera via the nutrient-dependent pheromone-controlled physiology of reproduction in the yeast model organism.
My comment: Jon Lieff’s timely entry was posted in Blog, Cellular Intelligence, Neuronal Plasticity and tagged Lysosomes work with autophagy, Lysosomes work with mTOR to regulate cellular molecules, Many ways to get lysosome storage diseases.
Unfortunately, it is obvious that most people will not understand the intricacies of the works that led Yoshinori Ohsumi to win the 2016 Nobel Prize for Physiology and Medicine ”for his discoveries of mechanisms for autophagy,” which must be linked to lysosome storage diseases and to healthy longevity.
Most people do not know what autophagy is. It is energy-dependent. That is the most important thing about it. Autophagy is linked to biophysically constrained RNA-mediated protein folding chemistry and cell type differentiation. It links nutrient energy-dependent changes from angstroms to ecosystems in all living genera via the physiology of reproduction. That makes autophagy the link to all biodiversity via the physiology of nutrient-dependent pheromone-controlled reproduction in species from yeasts to humans.
See also: Yoshinori Ohsumi wins Nobel medicine prize
My comment: His works take us from hypothesis-free pseudoscience to facts about RNA-mediated cell type differentiation via experimental evidence of nutrient-dependent pheromone-controlled biophysically constrained biodiversity in species from microbes to humans.
It is hard to escape the conclusion that all biodiversity is energy-dependent in the context of autophagy, and harder still to escape the conclusion that virus-driven energy theft is the cause of all pathology.
Minimally, Yoshinori Ohsumi he has bridged the gaps from physics and chemistry to biology by placing his experimental evidence into the context of molecular epigenetics. The details already were linked from energy-dependent amino acid substitutions to all biodiversity in Dobzhansky (1973).
But now there is new light shed on what Dobzhansky referred to as the light of evolution. It’s what Schrodinger (1944) called sunlight in the context of its anti-entropic virucidal energy.
See for comparison: A reply to Alice Roberts and Mark Maslin: Our ancestors may indeed have evolved at the shoreline – and here is why…
There is literally nothing left of neo-Darwinian pseudoscientific nonsense, and yet the pseudoscientists still make the same ridiculous claims.