5th-6th Sept 2018 Dublin, Ireland

Nutrient-dependent pheromone-controlled feedback loops

Summary: The link from positive selection to one food energy-dependent base pair change and fixation of the mouse-model-to-human-specific EDAR V370A allele in populations on different continents attests to sympatric speciation at every level of examination that refutes the pseudoscientific nonsense of neo-Darwinian mutation-driven evolution.

Reported on 5/3/18 as: SWAT team of immune cells found in mother’s milk 

1)

“There is a feedback loop,” says Yu. It’s known that some immune cells like leucocytes, another white blood cell that fights infection, increase in the milk in response to an infection in the baby.

2)

…the largest immune cell population in breast milk is macrophages, which ILCs are known to direct. Macrophages, which literally means ‘big eaters,” are the largest of the white blood cells and much-better studied than ILCs. They are known for their ability to envelop unwanted items like bacteria, viruses…

Environmental selection during the last ice age on the mother-to-infant transmission of vitamin D and fatty acids through breast milk 4/23/18

The frequency of the human-specific EDAR V370A allele appears to be uniquely elevated in North and East Asian and New World populations due to a bout of positive selection likely to have occurred circa 20,000 y ago. The dental pleiotropic effects of this allele suggest an even higher occurrence among indigenous people in the Western Hemisphere before European colonization. We hypothesize that selection on EDAR V370A occurred in the Beringian refugium because it increases mammary ductal branching, and thereby may amplify the transfer of critical nutrients in vitamin D-deficient conditions to infants via mothers’ milk. This hypothesized selective context for EDAR V370A was likely intertwined with selection on the fatty acid desaturase (FADS) gene cluster because it is known to modulate lipid profiles transmitted to milk from a vitamin D-rich diet high in omega-3 fatty acids.

Reported as: Gene linked to breastfeeding may have boosted survival of earliest Americans (4/23/18)

…they carried a genetic mutation—revealed in ancient teeth—that boosted the development of milk ducts in women’s breasts, which may have helped nursing mothers pass more nutrients to their infants.

The obvious link from infant nutrition to healthy longevity was reported in the context of a ridiculous gene-centric theory of species survival. Gene-centric theories are all that pseudoscientists have left. They use them to hold back the scientific progress made by serious scientists like those who reported this:
Feedback loops link odor and pheromone signaling with reproduction (2005)

These results may reflect a strategy wherein GnRH neurons can modify diverse functions in order to coordinate the internal state of the animal and its behavior with reproduction in order to optimize reproductive success.

5th-6th Sept 2018 Dublin, Ireland

2018 March for Science vs microRNAs (2)

The anti-entropic virucidal energy of sunlight on contact with water has been linked from the creation of ATP synthase to the creation of ATP and to the creation of RNA. Energy-dependent RNA-mediated DNA repair has been linked to biophysically constrained viral latency via the creation of microRNAs and feedback loops linked to the food energy-dependent microRNA-mediated physiology of reproduction. The physiology of energy-dependent pheromone-controlled reproduction biophysically constrains viral latency in the context of the creation of the innate immune system and autophagy.
See: miRNA regulation of innate immunity (4/14/18)
None of the facts about the energy-dependent creation of the microRNAs or the microRNA-mediated regulation of innate immunity are included in: The Transcription Factor Runx3 Establishes Chromatin Accessibility of cis-Regulatory Landscapes that Drive Memory Cytotoxic T Lymphocyte Formation (4/17/18)
The regulatory landscape that drive memory cytotoxic T lymphocyte formation might just as well be framed in the context of magic or in the equally ridiculous context of gene-centric theories.
See this report: Your immune system holds the line against repeat invaders, thanks to this molecule

Runx3’s control of T cell differentiation is important because when our bodies fight off viruses and cancers—and our T cells burst into action—the vast majority tend to become effector cells. These effector cells are short-lived and do not persist once the infection resolves.

The control of all cell type differentiation is energy-dependent, RNA-mediated and biophysically constrained by the physiology of reproduction in all living genera. The cell biology game “Cytosis” for ages 10+ teaches the facts that link Schrödinger (1944) What is Life? to Schrödinger at 75 – The Future of Biology – September 2018
In 1944, Schrödinger wrote:

Indeed, in the case of higher animals we know the kind of orderliness they feed upon well enough, viz. the extremely well-ordered state of matter in more or less complicated organic compounds, which serve them as foodstuffs. After utilizing it they return it in a very much degraded form -not entirely degraded, however, for plants can still make use of it. (These, of course, have their most power supply of ‘negative entropy’ the sunlight.)

See for comparison (this gene-centric pseudoscientific nonsense):
– Part I: FINDING THE CODE (Run time: 12:10
The race to sequence the human genome was also billed as a race to end disease. What happened?

– Part II: FIXING THE CODE (Run time: 13:07)
CRISPR — and the promise and pain of gene therapy that came before it. 

– Part III: SELLING THE CODE (Run time: 10:55)
Genetic testing has moved out of the labs into the masses. But even with your genome in hand, what can you believe?
The gene-centric pseudoscientific nonsense does not start with the creation of energy.  But every aspect of biophysically constrained life on Earth starts with the quantized energy-dependent creation of microRNAs. The epigenetically effected energy-dependent microRNA-mediated creation of the “Code” and the microRNA-mediated fixing of the “Code” is missing from the claims of biologically uninformed theorists who link beneficial mutations from natural selection to evolution. They have sold their gene-centric pseudoscientific nonsense to many people.
For example, some gene-centric biologically uninformed theorists share beliefs about abiogenesis for comparison to quantized energy-dependent microRNA biogenesis in articles like this: DNA Denaturing through UV-C Photon Dissipation: A Possible Route to Archean Non-enzymatic Replication
Conclusion:

Many of the fundamental molecules of life, those common to all three domains; bacteria, eukaryote, and archea, including RNA and DNA, amino acids, enzymes, vitamins, cofactors, and protoporphyrins, absorb photons in the UV-C 1. RNA or DNA in complexes with these molecules act as acceptor quenchers, providing the electronically excited pigment donor molecule with an extremely rapid (sub picosecond) non-radiative dexcitation channel, through internal conversion into vibrational energy of the nucleic acid and surrounding water molecules2.

See John Hewitt’s comment: You have just described the founding principle and thermodynamic function of life
In a classic example of human idiocy (See Feynman: food energy), biologically uninformed science idiots linked the dissipation of quantized energy to the origin of life via abiogenesis. The creation of biophysically constrained biophotonicaly based life in the context of the energy-dependent creation of microRNAs was reported in the context of photon dissipation and entropy as: Abiogenesis: A Theory on The Origins of Life

By now, we all know how evolution works. At least, most of us have a basic understanding of how it functions. At its most fundamental level, evolution is change over time. More specifically, it is changes within a biological population over successive generations.

Ultimately, biological complexity is one of the most important things to come out of evolution. Things started simple. Then genes mutated, cells interacted with their environment, mitochondria stopped being living organisms and started being part of a cell and—Tada—complex life.

A conflict arose between John Hewitt’s accurate representations of biophysically constrained life in The vibrational theory of olfaction for the win  and few months ago, Hewitt blocked me from seeing his tweets.

The same kinds of amino acid substitutions that control the separations and interactions of side chains in fluorescent proteins also play an essential role in tuning the proposed mechanism for vibration detection—inelastic electron tunneling. Life literally runs on electron tunneling through the respiratory chain complexes in mitochondria. These proteins employ complicated mechanisms including esoteric-soundings things like electron bifurcation and confurcation to pump protons across the mitochondrial inner membrane. When mitochondria go dark, cells can often continue to run for a short while, but it is only in the dim glow of the battery backup metabolism.

Here are some links to the reason for the conflict. Simply put, John Hewitt put everything known to serious scientists about energy-dependent microRNA biogenesis back into the context of abiogenesis.
2005 MicroRNA biogenesis: coordinated cropping and dicing
2015 Dysregulation of microRNA biogenesis and gene silencing in cancer
2015 RNA-mediated degradation of microRNAs: A widespread viral strategy?
Claims about abiogenesis exemplify what Richard Feynman referred to as human idiocy. So does John Hewitt and anyone else who believes in Michaelian’s pseudoscientific nonsense.
See other examples of Michaelian’s pseudoscientific nonsense and human idiocy by clicking here.
The energy-dependent creation of one domain of life links the physiology of reproduction in bacteria to biophysically constrained viral latency. The virus-driven degradation of messenger RNA is linked to the destruction of all life on Earth.
The degradation of messenger RNA links mutations to the creation of archaea and L-forms via entropy, which clearly links the weakening of the proton motive force to the elimination of the cell wall in L-forms (the last remnants of creation).
See also: Past 5,000 years prolific for changes to human genome
If you cannot link the miRNA regulation of innate immunity to all extant biodiversity via the physiology of pheromone-controlled reproduction and fixation of energy-dependent microRNA-mediated amino acid substitutions, thank a biologically uniformed science idiot.
 

An evolutionary theory killer

Conceptual critique: Innateness vs the death gene (2)

Excerpt: Martie Haselton notes

“…there’s a hidden adaptive intelligence that has been shaped over eons. Martie Haselton places that ecological adaptation into the context of the claim that “…our bodies are designed to fight off invaders, whether they take the form of a cold virus… (p 73.) and she mentions the link from the designer to one theory about menstruation: “female bleeding serves to flush out “bad” sperm that may carry bacteria, viruses and other pathogens.” (p. 84)

See also: Conceptual critique: Innateness vs the death gene (1)
Re: Far-UVC light: A new tool to control the spread of airborne-mediated microbial diseases

This approach may help limit seasonal influenza epidemics, transmission of tuberculosis, as well as major pandemics.

See for comparison: Subatomic

…is a deck building game where players are competing to build a number of available atoms. Each player starts with the same small deck of cards that consist of Proton Cards, Neutron Cards, Electron Cards and Energy Cards and a beginning hand limit of 5 cards. They use these cards to build upon their current Atom, in an attempt to construct one of the available Atom Cards, and/or use their hand of cards to purchase more powerful atom building cards for later use, or increase their hand limit. The deck building cards are simple and clean, but offer a number of interesting combinations. Players also have an energy track that allows them to store energy, which introduces a “push-their-luck” type of mechanic…

See also: Cytosis: A Cell Biology Board Game

Players start out with a number of workers and on their turn, they will place one of their workers on any available location within that cell. Some of the locations provide players with resources (e.g., mRNA, ATP); some with actions (e.g., convert resources, collect cards). Resources are used to build enzymes, hormones, and/or receptors, which score Health Points.

Science Concepts: cell biology, nucleus, free ribosomes, smooth ER, rough ER, golgi apparatus, plasma membrane, mitochondria, enzymes, hormones, receptors, cell detoxification, antibodies and viruses
Alternatively, theorists may continue to ignore the Science Concepts: in the context of  The Hidden Intelligence of Hormones — How They Drive Desire, Shape Relationships, Influence Our Choices, and Make Us Wiser (Feb 13, 2018) for comparison to From Fertilization to Adult Sexual Behavior (1996)

Martie Haselton notes

“…there’s a hidden adaptive intelligence that has been shaped over eons. Martie Haselton places that ecological adaptation into the context of the claim that “…our bodies are designed to fight off invaders, whether they take the form of a cold virus… (p 73.) and she mentions the link from the designer to one theory about menstruation: “female bleeding serves to flush out “bad” sperm that may carry bacteria, viruses and other pathogens.” (p. 84)

See for comparison: Conditional expression of women’s desires and men’s mate guarding across the ovulatory cycle (2006)In 2006, it became clear to most serious scientists that Martie Haselton knew nothing about biophysically constrained RNA-mediated viral latency. Now, she places everything known back into the context of neo-Darwinian pseudoscientific nonsense and eons of evolution. Fortunately,  you can read and discuss her book in the context of what other pseudoscientists have been doing for the past two decades. Simply copy and paste from Wikipedia in attempts to promote ridiculous theories.

See for comparison: Evolution: Genetic Novelty/Genomic Variations by RNA-Networks and Viruses 2018 >

Preliminary List of Confirmed Speakers (41)
Chantal Abergel >
Aix-Marseille University, Centre National de la Recherche Scientifique, Information Génomique & Structurale, Marseille, France
Gustavo Caetano Anolles >
Department of Crop Sciences, Evolutionary Bioinformatics Laboratory, University of Illinois at Urbana-Champaign Urbana, USA.
Marlene Belfort >

Department of Biological Sciences and RNA Institute, University at Albany, New York, USA
Felix Broecker >
Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, USA
Department of Chemistry & Biochemistry, University of California, Santa Barbara, USA
Julian Chen >
Department of Chemistry and Biochemistry, Arizona State University, Tempe, USA
Jean-Michel Claverie >
Centre National de la Recherche Scientifique & Aix-Marseille University, Marseille, France
Bryan Cullen >
Department of Molecular Genetics and Microbiology and Center for Virology, Duke University Medical Center, Durham, USA
Valerian Dolja >

Department of Botany and Plant Pathology, Oregon State University, Corvallis, USA
Cedric Feschotte >
Department of Human Genetics, University of Utah, School of Medicine, Salt Lake City, USA
Matthias Fischer >
Max Planck Institute for Medical Research, Department of Biomolecular Mechanisms, Heidelberg, Germany
David Gilmer >
Institut de biologie moléculaire des plantes, Integrative virology, Strasbourg, France
Reynald Gillet >
Université de Rennes 1, Translation and Folding Team, Rennes cedex, France Institut Universitaire de France
Jordi Gomez >
Instituto de Parasitología y Biomedicina ‘López-Neyra’ (CSIC), Granada, Spain
Matti Jalasvuori >

Centre of Excellence in Biological Interactions, Department of Biological and Environmental Science, University of Jyväskylä, Finland
I.King Jordan >
School of Biological Sciences, Georgia Institute of Technology, Atlanta, Georgia, USA
Eugene Koonin >
National Center for Biotechnology Information, National Library of Medicine, Bethesda, USA.
Dusan Kordis >
Department of Molecular and Biomedical Sciences, Josef Stefan Institute, Ljubljana, Slovenia
Mart Krupovic >

Unit BMGE, Department of Microbiology, Institut Pasteur, Paris, France
Erez Levanon >
Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat Gan, Israel
German Martinez >
Dept. of Plant Biology, Swedish University of Agricultural Sciences, Uppsala, Sweden
John Mattick >
Garvan Institute of Medical Research, Darlinghurst, Australia
Jeff Miller >
California NanoSystems Institute, University of California, Los Angeles, USA
Karin Moelling >
Max Planck Institute for molecular Genetics, Berlin, Germany
Sabine Müller >
Universität Greifswald, Institut für Biochemie , Greifswald , Germany
Ulrich Müller >
Department of Chemistry & Biochemistry, University of California, San Diego, USA
Mariusz Nowacki >
Institute of Cell Biology, University of Bern, Baltzerstrasse 4, 3012 Bern, Switzerland
David Prangishvili >
Department of Microbiology, BMGE, Institut Pasteur, Paris, France
Lennart Randau >
Max Planck Institute for Terrestrial Microbiology, Marburg, Germany
Forest Rohwer >
Department of Biology, San Diego State University, San Diego, CA, USA
Corrado Spadafora >
Institute of Translational Pharmacology, CNR, Rome, Italy
James Shapiro >
Department of Biochemistry and Molecular Biology , University of Chicago , IL , USA
Jason Shepherd >
Biochemistry and Ophthalmology & Visual SciencesUniversity of Utah, School of Medicine Salt Lake City, USA
Ravindra Singh >
Department of Biomedical Sciences, Iowa State University, Ames, USA
Keizo Tomonaga >
Laboratory of RNA Viruses, Department of Virus Research, Institute for Frontier Life and Medical Sciences, Kyoto University, Japan
Peter Unrau >
Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, Canada
Luis P. Villarreal >
Center for Virus Research, University of California, Irvine, Irvine, CA, USA
Andreas Werner >
RNA biology group, Institute for Cell and Molecular Biosciences, Newcastle University, UK
Eric Westhof >
Architecture and Reactivity of RNA, Institute of Molecular and Cellular Biology of the CNRS, University of Strasbourg, France
Bojan Zagrovic >
Department of Structural and Computational Biology, Max F. Perutz Laboratories, Vienna, Austria

Steven Zimmerly >
Department of Biological Sciences, University of Calgary, Calgary, Canada

For comparison to Martie Haselton’s February 13, 2018 publication of her pseudoscientific nonsense about hormonal women, see: Energy as information and constrained endogenous RNA interference from my February 15, 2017 virtual conference presentation on Precision Medicine.

Feedback loops link quantized energy as information to biophysically constrained RNA-mediated protein folding chemistry. Light induced energy-dependent changes link angstroms to ecosystems from classical physics to chemistry/chirality and to molecular epigenetics/autophagy. The National Microbiome Initiative links microbial quorum sensing to the physiology of reproduction via endogenous RNA interference and chromosomal rearrangements. The rearrangements link energy-dependent fixed amino acid substitutions to the Precision Medicine Initiative via genome wide inferences of natural selection. This detailed representation of energy-dependent natural selection for codon optimality links biologically- based cause and effect from G protein-coupled receptors to RNA-mediated amino acid substitutions and the functional structure of supercoiled DNA. Energy-dependent polycombic ecological adaptations are manifested in supercoiled DNA. Chromosomal inheritance links the adaptations from morphological phenotypes to healthy longevity via behavioral phenotypes. For contrast, virus-driven energy theft is the link from messenger RNA degradation to negative supercoiling, constraint breaking mutations, and hecatombic evolution. The viral hecatomb links transgenerational epigenetic inheritance from archaea to Zika virus-damaged DNA, which typically is repaired by endogenous RNA interference and fixation of RNA-mediated amino acid substitutions in organized genomes

5th-6th Sept 2018 Dublin, Ireland

The MicroRNAome Strikes Back: A Sokalian hoax (10)

Linda Buck, Ben Feringa, Michael Gazzaniga, Christof Koch, Nick Lane and Svante Paabo are among the presenters who will almost undoubtedly discuss some or all of my claims.
Prepare to ask questions or intelligently discuss accurate representations of top-down causation by watching this:

The energy-dependent creation of the microRNAome protects the organized genomes of all living genera from the virus-driven degradation of messenger RNA that links mutations to all pathology.
See: The Bull Sperm MicroRNAome and the Effect of Fescue Toxicosis on Sperm MicroRNA Expression

MicroRNA present in mature sperm appears to not only be left over from spermatogenic processes, but may actually serve important regulatory roles in fertilization and early developmental processes. Further, our results indicate the possibility that environmental changes may impact the expression of specific miRNA.

See also: Dynamic control of chirality and self-assembly of double-stranded helicates with light
See for comparison: A Bioenergetic Basis for Membrane Divergence in Archaea and Bacteria (2014)

We conclude that the enzymes involved took these alternatives by chance in independent populations that had already evolved distinct ion pumps. Our model offers a quantitatively robust explanation for why membrane bioenergetics are universal, yet ion pumps and phospholipid membranes arose later and independently in separate populations. Our findings elucidate the paradox that archaea and bacteria share DNA transcription, ribosomal translation, and ATP synthase, yet differ in equally fundamental traits that depend on the membrane, including DNA replication.

The microRNA-mediated creation of enzymes is quantized energy-dependent and biophysically constrained by phosphorylation in the context of food energy and the transgenerational epigenetic inheritance of all morphological and behavioral phenotypes in species from bacteria to primates. Membrane divergence in archaea occurs via the virus-driven degradation of messenger RNA, which links the loss of quantized energy from mutations to all pathology. The degradation of the cell membrane links archaea to L-forms, the last remnant of the life of a cell. See: The Inner Life of the Cell (video)
See also: Virus-mediated archaeal hecatomb in the deep seafloor (2016)

We show here for the first time the crucial role of viruses in controlling archaeal dynamics and therefore the functioning of deep-sea ecosystems, and suggest that virus-archaea interactions play a central role in global biogeochemical cycles.

So far as I know, none of the people who are presenting at “The Future of Biology” meeting have linked Schroedinger’s claims from the past to what is known about the conserved molecular mechanisms of energy-dependent biophysically constrained RNA-mediated cell type differentiation in species from microbes to humans. Even if they are not evolutionary theorists, most have not linked the energy-dependent fixation of RNA-mediated amino acid substitutions to increasing organismal complexity and some have even reversed what is known about top-down causation. For example, Nick Lane, like Gunter P. Wagner have used mathematical models of correlations.
See: Pervasive correlated evolution in gene expression shapes cell and tissue type transcriptomes
They start with this admission”

A major challenge for interpreting this data is that cell type transcriptomes may not evolve independently…

They seem to think they can use statistics and interpretations to address the challenge of facts about increasing organismal complexity.

Our study provides a statistical method to measure and account for correlated gene expression evolution when interpreting comparative transcriptome data.

See for comparison: From Fertilization to Adult Sexual Behavior and Nutrient-dependent/pheromone-controlled adaptive evolution: a model
The fact that what organisms eat has been linked from the food energy-dependent creation of enzymes, receptors, and hormones to the affect of hormones on behavior in all invertebrates and vertebrates was placed into the context of the cell biology game, Cytosis.

A board game taking place inside a human cell! Players compete to build enzymes, hormones and receptors and fend off attacking Viruses!

During the month of January (2018), 2831 people learned from my twitter profile about the domains RNA-mediated.com and Autophagy.pro and some of them learned from more than 100,000 impressions how energy must be linked to RNA-mediated biophysically constrained viral latency by autophagy.
Jan 2018 Summary
Tweets
1,199
Tweet impressions
102,000
Profile visits
2,831
Mentions
71
New followers
29
 

Why do I have only 29 new followers? Are theorists really that scared? If so, how will they help to prevent the next viral apocalypse, if it has not already started before September, 2018?

See also:

If my claims about biophysically constrained energy-dependent RNA-mediated cell type differentiation are not discussed by Linda Buck, Ben Feringa, Michael Gazzaniga, Christof Koch, Nick Lane, and Svante Paabo others will have another example of what happens after a paradigm shift.

 In the past nothing happened because serious scientists failed to acknowledge this fact: Feedback loops link odor and pheromone signaling with reproduction. The article was co-authored by LInda Buck. There is no mention of mutations or evolution and Linda Buck is scheduled to present what can best be described as a refutation of neo-Darwinian evolution.

Alternative splicing of pre-mRNA

Schrodinger's answer to Schrodinger's question (2)

Summary: Neo-Darwinian pseudoscientific nonsense should never have achieved any level of acceptance — even among scientists who are biologically uninformed science idiots.
Beyond blanket terms: Challenges for the explanatory value of variational (neuro-)ethology: Comment on “Answering Schrödinger’s question: A free-energy formulation” by Maxwell James Désormeau Ramstead et al
Paywalled
My summary: The commenters complain that the answer to Schrödinger’s question is framed in the context of a “Just-So” story. The theoretical construct places a “… spatio-temporal Markov blanket around the entire species of Homo Sapiens.”
Simply put, the free energy formulation does not start with the creation of the free energy. Instead the formulation invites a creationist foot to be place into the doorway of the time-space continuum without emerging on another planet. There is no other way to explain free energy-dependent changes that have already been explained by olfactory researchers who exist in the context of the space-time continuum on this planet.
See: The vibrational theory of olfaction for the win

The same kinds of amino acid substitutions that control the separations and interactions of side chains in fluorescent proteins also play an essential role in tuning the proposed mechanism for vibration detection—inelastic electron tunneling. Life literally runs on electron tunneling through the respiratory chain complexes in mitochondria

For comparison to this energy-dependent approach, evolution via natural selection has been reported to be a continuous “process.” The “process” must occur in the context of biophysically constrained food energy-dependent population-wide changes.
In my model, changes in the evolutionary “process” are biophysically constrained by the pheromone-controlled physiology of reproduction, which constrains viral latency. Outside the context of the energy-dependent constraints on viral latency, others are force to extend Nei’s textbook claims about all mutations in all species to the evolution of humans by including every species in the entire evolutionary tree. See: Mutation-Driven Evolution
Others have done the math. The mathematical models don’t work. No experimental evidence of biologically-based cause and effect supports the ridiculous theories.
See for comparison: Learning from Bacteria about Natural Information Processing

…not all the information required for efficient responses to all environmental conditions is stored. To solve newly encountered problems, they assess the problem via collective sensing, recall stored information of past experience, and then execute distributed information processing of the 109–1012 bacteria in the colony—transforming the colony into a “super-brain.” I show illuminating examples of swarming intelligence of live bacteria in which they solve optimization problems that are beyond what human beings can solve. This will lead to a discussion about the special nature of bacterial computational principles compared to Turing algorithm computational principles, in particular about the role of distributed information processing.

The extension from the food energy-dependent pheromone-controlled physiology or reproduction via what is known to serious scientists about the links from quantum physics to quantum computing and quantum souls involved changes in electrons to ecosystems that can now be observed via cryo-EM technology.
Even if that was not possible, theories based on mathematical models seem ridiculous at a time when serious scientists have linked multisensory integration to this report:  Olfaction Warps Visual Time Perception
The added advantage that all serious scientists have is the fact that they use facts in their models, not math.
See: Physiology is rocking the foundations of evolutionary biology

Perhaps the elegant mathematics and the extraordinary reputation of the scientists involved blinded us to what now seems obvious: the organism should never have been relegated to the role of mere carrier of its genes.

If humans are nothing more than gene carriers, experimental evidence suggests that we have not been on Earth long enough to evolve from other primates.
See: Analysis of 6,515 exomes reveals the recent origin of most human protein-coding variants
Reported as: Past 5,000 years prolific for changes to human genome

The findings confirm their earlier work suggesting that the majority of variants, including potentially harmful ones, were picked up during the past 5,000–10,000 years.

Other primates appear to have been on Earth long enough to be representatives of what happens due to the virus-driven degradation of messenger RNA. That also seems to be exemplified in the changes from bacteria to archaea and L-forms.
See: Virus-mediated archaeal hecatomb in the deep seafloor
Watch this incredible actual footage of dividing cells as seen under microscope.
See also: Mitosis

As mitosis progresses, the microtubules attach to the chromosomes, which have already duplicated their DNA and aligned across the center of the cell. The spindle tubules then shorten and move toward the poles of the cell. As they move, they pull the one copy of each chromosome with them to opposite poles of the cell. This process ensures that each daughter cell will contain one exact copy of the parent cell DNA.

SARCASM ALERT: At what point do theorists claim that mutations lead to the evolution of differentiated cell types?
See for comparison, from The Evolution Institute:

Researchers at several [government] agencies have been censored, silenced, and otherwise intimidated; public documents on climate change have been targeted for deletion; fringe ideas in public health and the environment have been getting traction.

— Daniel Engber, Columnist at Slate Magazine

 

See also this 2014 invited review of nutritional epigenetics that was returned without review.

Nutrient-dependent pheromone-controlled ecological adaptations: from atoms to ecosystems

A rendering of how changes in an electron's motion (bottom view) alter the scattering of light (top view), as measured in a new experiment that scattered more than 500 photons of light from a single electron. Previous experiments had managed to scatter no more than a few photons at a time. Credit: Extreme Light Laboratory|University of Nebraska-Lincoln

Long-term adaptation replaces evolution (3)

Summary: Koonin thinks that serious scientists who have linked the creation of energy to all biodiversity via the physiology of pheromone-controlled reproduction in species from microbes to humans must prove that everything the serious scientists know did not occur randomly after the sun’s anti-entropic virucidal energy emerged from nothing.
Other pseudoscientists have taken a step towards refuting Koonin’s moronic claim with publication of:
A mammalian blood odor component serves as an approach-avoidance cue across phylum border – from flies to humans

Feedback loops link odor and pheromone signaling with reproduction

The odor of E2D is sufficient to elicit approach response in blood-seeking animals. (A) Chemical structure of trans-4,5-epoxy-(E)-2-decenal (E2D). (B) Schematic drawing of the Y maze olfactory assay used for the fly behavioral experiment. (C) Mean percentage of flies choosing between E2D in a background of host odor and host odor only (left) and between E2D and cattle blood both in a host background. (D) A wolf displaying biting on the scented log, one of the eleven behaviors present in the ethogram. (E) Mean total number of interactions during a session with the four odor stimuli for the wolf pack. Error bars indicate standard error of the mean (SEM). *p < 0.05, ***p < 0.001.

Conclusion:

Taken together, our results strongly suggest that E2D is a blood signature substance that serves as an approach-avoidance cue across phylum borders; it elicits approach responses in blood-feeding invertebrates as well as in mammalian predators, while eliciting avoidance behavior in mammalian prey species. These results demonstrate the existence of a cross-species food- and alarm cue that affects behavior in both human and non-human animals alike.

Reported as: A universal food and alarm cue found in mammalian blood

The omnipresent adaptation to E2D indicates that the selection pressure for this chemical cue is preserved through evolution. This can shed light on human evolution, our formation as a species. “Our finding in humans fits in with the paleontological data showing that early primates were small-bodied insectivores. There is no question that humans are opportunistic predators, but we probably evolved from a prey species and some aspects of this trait lingers on,” says principal investigator Johan Lundström, associate professor at the Karolinska Institutet in Sweden.

Ecological variations are linked to ecological adaptations via what is known to serious scientists about quantum physics, which recently were placed into the context of observations that link electrons to ecosystems in all living genera via the 2017 Nobel Prize-winning cryo-EM technology. With the help of many others and also via my monographs and my presentations during the past 25 years this fact has become perfectly clear. The human ability to detect DNA differences in tissue type via the sense of smell is the link to biophysically constrained viral latency and all biodiversity.
There is no question that the passive-aggressive behavior of researchers like Johan Lundström is displayed as their failure to cite any of my published works.
See also: Smelling DNA with Joseph Orkin
Our ability to smell DNA arises only after the quantized energy-dependent creation of G protein-coupled receptors.
See also, from 1985: THE QUANTAL NATURE OF CONTROLLING STIMULUS-RESPONSE RELATIONS AS MEASURED IN TESTS OF STIMULUS GENERALIZATION

…the quantal interpretation, proposes that a stimulus-response relation functions as a unit that may or may not occur. From the latter viewpoint, the continuity typically obtained during generalization tests is deemed to be artifactual and to result from averaging across multiple controlling stimulus-response relations.

The “omnipresent adaptation to E2D” links multiple controlling stimulus-response relations from the energy-dependent de novo creation of G protein-coupled receptors to the foraging behavior of bacteria and to the physiology of pheromone-controlled human reproduction. Without the ability to sense differences in the fixation of amino acid substitutions in organized genomes DNA, biologically uninformed science idiots have no way to explain omnipresent pathology. Simply put, they have failed to link our choices to all pathology.
Clearly, serious scientists have linked the physiology of pheromone-controlled human reproduction from food energy to the ability to reproduce in all living genera. That is how the omnipresent pathology links the virus-driven degradation of messenger RNA from bacteria to the creation of archaea and L-forms. The L-forms are the last representation of what happens to all life forms that cannot find enough food energy to biophysically constrain viral latency.
See: Virus-mediated archaeal hecatomb in the deep seafloor

We show here for the first time the crucial role of viruses in controlling archaeal dynamics and therefore the functioning of deep-sea ecosystems, and suggest that virus-archaea interactions play a central role in global biogeochemical cycles.

For comparison, see: A universal trend of amino acid gain and loss in protein evolution

Amino acid composition of proteins varies substantially between taxa and, thus, can evolve.

Eugene Koonin knows that: “The entire evolution of the microbial world and the virus world, and the interaction between microbes and viruses and other life forms have been left out of the Modern Synthesis…”
That fact forces him to fight against the claims of adaptationists who have refuted his pseudoscientific nonsense about mutations and evolution.
See: Splendor and misery of adaptation, or the importance of neutral null for understanding evolution
Koonin thinks that serious scientists who have linked the creation of energy to all biodiversity via the physiology of pheromone-controlled reproduction in species from microbes to humans must prove that everything the serious scientists know did not occur randomly after the sun’s anti-entropic virucidal energy emerged from nothing.

See for comparison:
“Light Unshackled” will be shown in its entirety during a special screening at 527 Forge Mill Road in Morganton, GA on Tuesday, October 24, at 6 p.m.
 
The game “Cytosis” is also already being distributed. Everyone over age 10 can learn to link the creation of anti-entropic virucidal light to all biophysically constrained biodiversity via what is known about the molecular mechanisms that link the physiology of pheromone-controlled reproduction to RNA-mediated viral latency.
 

No one I know expects you to understand the overwhelming complexity of the links from quantum physics to chemistry and molecular epigenetics to quantum souls. Many people I know expect you to be able to understand the claims about “Light Unshackled.”

2/4: Lighting a Flame – Light Unshackled – English

Episode 3 has been released, and Episode 4 will be released on October 27.
See: Light Unshackled Film

See also: Melanoma-specific MHC-II expression represents a tumour-autonomous phenotype and predicts response to anti-PD-1/PD-L1 therapy

In this study, across 60 melanoma cell lines, we find bimodal expression patterns of MHC-II, while MHC-I expression was ubiquitous. A unique subset of melanomas are capable of expressing MHC-II under basal or IFNγ-stimulated conditions. Using pathway analysis, we show that MHC-II(+) cell lines demonstrate signatures of ‘PD-1 signalling’, ‘allograft rejection’ and ‘T-cell receptor signalling’, among others.

UV light induced changes in the microRNA/messenger RNA balance have been linked to healthy longevity via the food energy-dependent RNA-mediated fixation of pheromone-controlled amino acid substitutions in organized genomes. Differences in the amino acid substitutions have been found in the organized genomes of all species.

The virus-driven theft of quantized energy such as UV light has been linked from the degradation of messenger RNA to all pathology.

See also: Medical Breakthroughs: Cancer

During clinical trials, the medication was famously used to treat former President Jimmy Carter, who two years ago announced he had cancer in his brain and liver and said his fate was “in the hands of God, whom I worship.” Four months later, his cancer was gone.

Was it God who caused the cancer, or did God cause its demise? From my perspective on light energy as information and energy-dependent RNA-mediated DNA repair, it is clear that  melanoma-specific MHC-II expression represents a link from the virus-driven degradation of messenger RNA to a predicatable response from the innate immune system. That response has been made somewhat more predictable in the context of the phenotype that predicts the response to anti-PD-1/PD-L1 therapy.

See also:  New Dancing Couple: PD-L1 and MicroRNA

MicroRNAs are regulatory molecules (~20 nt in length) with the ability to regulate the expression of genes. The recently described PD-1 and PD-L1 molecules have great importance for potential use in immunotherapy of many cancers. These molecules are associated with immune checkpoints and provide an opportunity for the treatment of advanced NSCLC patients with synthetic monoclonal antibodies. PD-L1 expression is strictly associated with microRNA function in lung cancer cells. The group of microRNAs related to PD-L1 includes, among others, miR-200, miR-197 or miRNA-34. Expression of these molecules may be useful in lung cancer diagnosis, qualification to anti-PD-1 or anti-PD-L1 antibody therapy and could be a potential therapeutic target. However, studies on PD-L1-related microRNAs are necessary to develop advanced targeted molecular therapies.

Studies of studies on PD-L1-related microRNAs and other microRNAs link the changes in electrons to ecosystems in all living genera. Focus on prevention and effective treatments of all pathology has been delayed by the focus on the CRISPR/Cas 9 gene editing technology. That focus is much more closely linked to the pseudoscientific nonsense touted by neo-Darwinian theorists who failed to link the virus-driven degradation of messenger RNA to all pathology.

A rendering of how changes in an electron's motion (bottom view) alter the scattering of light (top view), as measured in a new experiment that scattered more than 500 photons of light from a single electron. Previous experiments had managed to scatter no more than a few photons at a time. Credit: Extreme Light Laboratory|University of Nebraska-Lincoln

Energy-dependent physical and biophysical constraints (3)

See first: Energy-dependent physical and biophysical constraints (2)
Emily Balskus Pins Down the Chemistry and Metabolism of Human Microbiomes
Summary: The chemistry and metabolism of all microbiomes is food energy-dependent and pheromone-controlled via the physiology of reproduction.
See: Feedback loops link odor and pheromone signaling with reproduction

My comment to The Scientist:

…trans-4-hydroxy-L-proline (Hyp) dehydratase, a newly discovered member of an abundant family of proteins, produced by gut bacteria, known as the glycyl radical enzymes, helps in metabolizing trans-Hyp, an amino acid that is rare in bacteria but is common in eukaryotes.

The de novo creation of energy-dependent RNA-mediated amino acid substitutions in supercoiled DNA protects the organized genomes of all living genera from the virus-driven degradation of messenger RNA, which has been linked from mutations to all pathology via the claims Schrodinger made in “What is Life?” (1944).

Indeed, in the case of higher animals we know the kind of orderliness they feed upon well enough, viz. the extremely well-ordered state of matter in more or less complicated organic compounds, which serve them as foodstuffs. After utilizing it they return it in a very much degraded form -not entirely degraded, however, for plants can still make use of it. (These, of course, have their most power supply of ‘negative entropy’ the sunlight.) (pp. 73 and 74)

See also: The Bull Sperm MicroRNAome and the Effect of Fescue Toxicosis on Sperm MicroRNA Expression

Natural selection for food energy-dependent codon optimality links the sense of smell in bacteria to the biophysically constrained viral latency that links ecological variation to ecological adaptations in species from microbes to humans via the conserved molecular mechanisms of RNA-mediated cell type differentiation.

Sunlight has since been placed into the context of quantized energy as information, which links our visual perception of mass and energy from the space-time continuum to the concept of the energy-dependent creation of quantum souls.
See also: Codon identity regulates mRNA stability and translation efficiency during the maternal-to-zygotic transition (2016) and From Fertilization to Adult Sexual Behavior (1996)
 

human-evolution

Food Energy-Dependent Cell Type Differentiation

A Crack in Creation: Gene Editing and the Unthinkable Power to Control Evolution

Not since the atomic bomb has a technology so alarmed its inventors that they warned the world about its use.

Not since the time of his work on the Manhattan Project has a serious scientist like the late Richard Feynman presciently advised biologists on how to “get” theoretical physicists. Ask them who decided to use different terms for food energy and other source of the same quantized energy, which comes from sunlight.
Clearly, anyone who accepts the use of different terms for the same thing will accept the obfuscation of cause and effect that theorists must use to confuse intelligent people.
For example: “How often do we still hear that quantum effects can have little relevance in the study of biology, or even that we eat food in order to gain energy?” (Roger Penrose 8 August 1991)
See for comparison:

In her introduction to the interview, J.A. Parker mentions this news article:
Evolution Not Only About Natural Selection but Also Improvisation, Says Israeli Scientist

Prof. Yoav Soen sounds almost angry when he talks about the evolutionary concept of natural selection – or, more precisely, its total acceptance – suggesting it blinds people to thinking more broadly. Instead, they simply embrace the theory of evolution developed more than 150 years ago by Charles Darwin.

See also: Food Energy-Dependent Cell Type Differentiation (2) — in prep
I will start with a report on this conceptualization of the microbial metabolism of food energy to the biophysically constrained pheromone-controlled creation of at least one uranium isotope.
Figure 4: Conceptual model of uranium roll-front deposit formation.
Figure 4
Precursors and conditions favouring the formation of uraninite, biogenic uraninite and non-crystalline U(IV) are illustrated.

Cytosis

From E. coli to monkeys and mankind: Theories vs models (5)

From E. coli to monkeys and mankind: Theories vs models (4)
CRISPR Is Taking Over Science, Breaks Out Of Labs And Invades Schools (5/29/17)

…used mathematical models to reveal that even in a uniform environment, metabolic competition generally leads to the steady coexistence of distinct microbes, collectively called a “consortium”. In a consortium, distinct microbes organize themselves to create a community-level metabolism that best exploits the nutrients present. The models showed that while growing, a consortium depletes the available pool of nutrients to such low levels that only members of the consortium can survive. The findings suggest that the benefit of metabolic diversity stems from the ability of a consortium to automatically deplete nutrients to levels at which no other microbes can invade.

Taillefumier et al. propose that consortia that arise naturally under conditions where there is a steady supply of nutrients produce the maximum mass of microbes. Future experiments that analyze the impact of fluctuating nutrient supply may help us to understand the benefit of metabolic diversity in real-world microbial communities.

Microbes do not organize themselves into consortia via the automatic depletion of nutrients. Natural selection for food energy-dependent codon optimality links quantum physics to the pheromone-controlled physiology of biophysically constrained viral latency. That is how metabolic networks must link ecological variation to ecological adaptation in all living genera.

Pseudoscientists who know nothing about energy-dependent quorum sensing and RNA-mediated cell type differentiation in microbial consoritia have wasted billions of dollars and nearly all the time that humans have existed on Earth. Now they tout automagically evolved consortia in attempts to subvert what is known about the nutrient energy-dependent protection from virus-driven energy theft, which is built into the molecular essence of all cell types. The pseudoscientists have led us to the brink of a viral apocalypse.

See: CRISPR gene editing can cause hundreds of unintended mutations (5/29/17)

…the genomes of two independent gene therapy recipients had sustained more than 1,500 single-nucleotide mutations and more than 100 larger deletions and insertions. None of these DNA mutations were predicted by computer algorithms that are widely used by researchers to look for off-target effects.

Division of labor

Competition causes microbes to organize themselves into communities that make the most of the available nutrients.

Where do viruses come from? (2004)

…when virus-infected bacterial cells burst, their energy-rich cell contents spill into the water for other bacteria to scavenge. ‘Viruses tend to keep nutrients away from the big stuff and keep them going around in the little stuff,’ says Fuhrman. If so, viruses have shaped the entire structure of the ecosystem.”9

Virus-driven energy theft causes the degradation of messenger RNA that links mutations to all pathology.

Virus-mediated archaeal hecatomb in the deep seafloor (2016)

We show here for the first time the crucial role of viruses in controlling archaeal dynamics and therefore the functioning of deep-sea ecosystems, and suggest that virus-archaea interactions play a central role in global biogeochemical cycles.

People who believe in mutation-driven evolution are not likely to link virus-driven energy theft in archaea to the morphological and behavioral phenotype of bacteria or from the nutrient-dependent pheromone-controlled physiology of reproduction in bacteria to Alzheimer’s disease. People who believe in mutation-driven evolution may not be capable of understanding how the conserved molecular mechanisms detailed in the published works of serious scientists must be linked from viruses to the the degradation of messenger RNA that links the mutation-driven evolution of pathology to the increase in Alzheimer’s Deaths.

U.S. Alzheimer’s Deaths Jump 54 Percent

In the video that accompanies this report, the image from a brain scan is paired with the mention of biomarkers. microRNAs are the biomarkers. The changes in energy-dependent microRNA biosynthesis clearly predict the onset and severity of all pathology.

That’s why most people will not seek the most effective and least invasive treatment for Alzheimer’s. They won’t link the loss of olfactory acuity and specificity to the virus-driven degradation of messenger RNA and neurodegenerative diseases, because their physicians don’t understand enough about the creation of G protein-coupled receptors to link chemotaxis and phototaxis to all biodiversity via the physiology of reproduction.

See for comparison: microRNA Alzheimer

See also: Search Results for “alzheimer’s”

Reports about an article that I have not yet seen published in “Nature Methods” attest to facts about cell type differentiation that have been placed into this context:

Crack in CRISPR Façade after Unanticipated In Vivo Mutations Arise

“Researchers… may be missing potentially important mutations,” Dr. Tsang remarked. “Even a single nucleotide change can have a huge impact.”

That fact is not just a “Crack in the CRISPR Facade.” It dismisses all claims about mutation-driven evolution. Those ridiculous claims have been replaced by what is known to serious scientists about how viral latency must be biophysically constrained. It must be constrained by a light-activated endogenous substrate in all cell types of all living genera. The light comes from the sun. For example, the anti-entropic energy of ultraviolet light kills viruses.

SARCASM ALERT: Ask your doctor if sunlight could save your life.

Until the publication of “Unexpected mutations after CRISPR-Cas9 editing in vivo” is available to all serious scientists, watch how the prescient claims about food energy that have been made by people like Richard Feynman have forced theorists to do what they have always done. Expect that some of the censorship will end when the news about the unexpected mutations is linked to what all serious scientists have expected since the time that Thomas Hunt Morgan linked energy-dependent chromosomal inheritance to all biodiversity on Earth and virus-driven energy theft was linked to antibiotic resistance.

Kalevi Kull: Censorship & Royal Society Evo Event

Nobody wants to belong to the party of losers. One of the best strategies in such a case is evidently an interpretation of the change as a gradual accumulation of knowledge while their work has always been at the cutting edge. —  Kalevi Kull

See: Nature Methods May 2017, Volume 14 No 5 pp457-540

For example:

Systems biology guided by XCMS Online metabolomics pp461 – 462

See also: Research Highlights

Defining developmental grammar p465

An iterative clustering approach finds the few genes that mark discrete cell states and their transitions during early mouse development.

It takes two to make an embryo pp466 – 467

In vitro culture of mouse embryonic and extra-embryonic stem cells recapitulates embryogenesis.

A light switch for kinases pp466 – 467

A photodissociable dimer of the Dronpa fluorescent protein can cage kinases, making these important signal transducers controllable by light.

A proteome-wide view of thermal stability p468

Proteome thermal stability is probed using limited proteolysis and mass spectrometry.

Dynamic measurement of membrane charges p471

A FRET sensor enables quantitative characterization of electrostatic potential of membranes in living cells.


See for comparison: 2012 Genome evolution: Unexpected relationship between mutation rate and genome complexity

Contrary to expectation, species that have experienced recently accelerated mutation rates have the largest genomes…

Biophysically constrained food energy-dependent pheromone-controlled viral latency protects the organized genomes of all living genera from the degradation of messenger RNA, which links virus-driven energy theft from mutations to all pathology regardless of the size of the organized genome. The measurement of membrane charges in the context of cryo-EM makes it possible to link virus-driven energy theft in bacteria to the degradation of messenger RNA in archaea and the degradation of messenger RNA in archaea to L-forms, which represent the virus-driven destruction of all created cell types. So far as is currently known, only the anti-entropic virucidal energy of sunlight can prevent the virus-driven death of all life on Earth.

L-form bacteria

Bacterial morphology is determined by the cell wall. Since the L-form has no cell wall, its morphology is different from that of the strain of bacteria from which it is derived.

The cell wall is important for cell division, which, in most bacteria, occurs by binary fission. This process usually requires a cell wall and components of the bacterial cytoskeleton such as FtsZ. The ability of L-form bacteria to grow and divide in the absence of both of these structures is highly unusual, and may represent a form of cell division that was important in early forms of life.[1]

The failure to recognize the fact that virus-driven degradation of the cell wall is an example of how cell type destruction occurs in all cells that contain a light-activated endogenous substrate, is also an example of pervasive ignorance among all theorists and other pseudoscientists.

See also: Cytosis:

A board game taking place inside a human cell! Players compete to build enzymes, hormones and receptors and fend off attacking Viruses!

Dispensing with all pseudoscientific nonsense about evolution (1)

No experimental evidence of biophysically constrained biologically-based cause and effect supports claims that the mammalian placenta “evolved.”
All experimental evidence of biophysically constrained biologically-based cause and effect supports claims that the mammalian placenta is an energy-dependent pheromone-controlled ecological adaptation.
See also: Discovery of chemoautotrophic symbiosis in the giant shipworm Kuphus polythalamia (Bivalvia: Teredinidae) extends wooden-steps theory
Chemoautotrophic symbiosis is nutrient energy-dependent and pheromone-controlled. Nothing about life involves autotrophy. Everything known to serious scientists links chirality to autophagy, which protects the supercoiled DNA of all organized genomes from virus-driven energy theft and genomic entropy that links extinction to the fossil record. Claims about the last known common ancestor of shipworms are the clearest indicator that pseudoscientists do not realize no last known common ancestor has ever been found for any form of energy-dependent RNA-mediated life.
See “March for Science: Dispatches from Washington, DC

“We made history!” marchers chanted at the terminus of a mile-and-a-half walk from the Washington Monument to Capitol Hill in Washington, DC.

See “March for Science: Dispatches from Berlin

“We just watched a documentary on Charles Darwin the other night, and my older daughter, when I told her that in some countries—Turkey, Russia, and parts of the United States—evolutionary theory is taken out of the school curricula, she said, ‘We have to make a sign!’ And we [created] these ones.” —Percy Rohde

See “March for Science: Dispatches from Chicago

The science march in Chicago was was a blend of scientists and nonscientists alike. Peggy Mikros, a caterer, came up from the south side of the city because she said she cares about the environment and “science is everything.” The event has inspired her to continue to advocate for science.KERRY GRENS

“I’ve never done this and I am so excited to be here.” —Peggy Mikros, caterer from Chicago

See “Science March Sights and Signs

Here’s a sampling of sights and signs from the Marches for Science in Berlin, Chicago, and Washington, DC.

Here is the scientific support for what my sign would have said;
See: A novel strategy to dissect endogenous gene transcriptional regulation in live cells (2017)

The ARID1A gene, encoding a subunit of the ATP-dependent chromatin remodeling complex SNF/SWI, has recently been identified as a tumor suppressor in multiple cancers. Despite studies that elucidate the mechanism of ARID1A’s tumor suppressor function, little is known of the genes/events that regulate ARID1A expression. Using the HEK293 cells as a model, we discovered novel aspects of ARID1A transcription regulation in response to cell cycle progression, DNA damage, and microRNAs, exemplifying the potential of our strategy in providing new insight to the mechanism of gene transcription regulation.

I don’t know any serious scientist who has ever started with a claim about evolution, mutation, or natural selection. All serious scientists know they must start with the energy-dependent de novo creation of ATP, and link it to cell type differentiation in all living genera via the physiology of pheromone-controlled reproduction.
See for a historical perspective: Dependence of RNA synthesis in isolated thymus nuclei on glycolysis, oxidative carbohydrate catabolism and a type of “oxidative phosphorylation” (1964)

The synthesis of RNA in isolated thymus nuclei is ATP dependent.

Connecting energy as information to ATP-dependent synthesis of RNA and healthy longevity is not difficult unless you do not know where the energy comes from. If you do not know or fail to acknowledge the creation of energy as the source that links the anti-entropic virucidal effects of sunlight to all biodiversity via what is known to serious scientists, you will not understand what serious scientists know about how to prevent all virus-driven energy theft from linking mutations to all pathology in all living genera
See also: Individual Bromodomains of Polybromo-1 Contribute to Chromatin Association and Tumor Suppression in Clear Cell Renal Carcinoma

The architecture of chromatin is governed, in part, by adenosine triphosphate (ATP)-dependent chromatin remodelers. These multi-protein complexes contain targeting domains that recognize posttranslational marks on histones. One such targeting domain is the bromodomain (BD), which recognizes acetyl-lysines and recruits proteins to sites of acetylation across the genome. Polybromo1 (PBRM1), a subunit of the polybromo-associated BRG1- or hBRM-associated factors (P-BAF) chromatin remodeler, contains six tandem BDs and is frequently mutated in Renal Clear Cell Carcinoma (ccRCC). Mutations in the PBRM1 gene often lead to loss of protein expression; however, missense mutations in PBRM1 have been identified and tend to cluster in the BDs, particularly BD2 and BD4, suggesting that individual BDs are critical for PBRM1 function. To study the role of these six BDs, we inactivated each of the six BDs of PBRM1 and re-expressed these mutants in Caki2 cells (ccRCC cells with loss of function mutation of PBRM1). Four of the six BDs abrogated PBRM1 tumor suppressor, gene regulation, and chromatin affinity with degree of importance correlating strongly to rate of missense mutations in patients. Furthermore, we identified BD2 as the most critical for PBRM1 and confirmed BD2 mediated association to histone H3 peptides acetylated at lysine 14 (H3K14Ac), validating the importance of this specific acetylation mark for PBRM1 binding. From these data we conclude that four of the BDs act together to target PBRM1 to sites on chromatin; when a single BD is mutated, PBRM1 no longer controls gene expression properly, leading to increased cell proliferation.

See also: From Fertilization to Adult Sexual Behavior

Yet another kind of epigenetic imprinting occurs in species as diverse as yeast, Drosophila, mice, and humans and is based upon small DNA-binding proteins called “chromo domain” proteins, e.g., polycomb. These proteins affect chromatin structure, often in telomeric regions, and thereby affect transcription and silencing of various genes (Saunders, Chue, Goebl, Craig, Clark, Powers, Eissenberg, Elgin, Rothfield, and Earnshaw, 1993; Singh, Miller, Pearce, Kothary, Burton, Paro, James, and Gaunt, 1991; Trofatter, Long, Murrell, Stotler, Gusella, and Buckler, 1995). Small intranuclear proteins also participate in generating alternative splicing techniques of pre-mRNA and, by this mechanism, contribute to sexual differentiation in at least two species, Drosophila melanogaster and Caenorhabditis elegans (Adler and Hajduk, 1994; de Bono, Zarkower, and Hodgkin, 1995; Ge, Zuo, and Manley, 1991; Green, 1991; Parkhurst and Meneely, 1994; Wilkins, 1995; Wolfner, 1988). That similar proteins perform functions in humans suggests the possibility that some human sex differences may arise from alternative splicings of otherwise identical genes.

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microRNA hecatomb No documents match your search terms
Epidemic hecatomb in the New World (1992)

The American population developed, during thousands of years, free of epidemics that had been attacking Europe, Asia and Africa. The European and African migrations, after Columbus’s first trip, produced an epidemic invasion of influenza, smallpox, measles, yellow fever, malaria, diphtheria, typhus, and other diseases that attacked the immunologically virgin populations and produced a very high mortality, with a diminution of the indigenous population of more than 90% in many places. According to historical evidence, the first epidemic was influenza, produced by swine strain of virus, immediately followed by smallpox. The Spaniards mated freely with the Indians producing a mixed race called the Mestizo, who were immunologically more capable of defending themselves against various viruses, bacteria, and parasites brought over from the Old World. Marriage between the races also was sanctioned by Queen Isabella (1503) and Fernando I (1515). With these new genetic immunologic defenses against infections, the Mestizo eventually made up the majority of the population of Indians in the New World.

Virus-mediated archaeal hecatomb in the deep seafloor (2016)

Viruses are the most abundant biological entities in the world’s oceans, and they play a crucial role in global biogeochemical cycles. In deep-sea ecosystems, archaea and bacteria drive major nutrient cycles, and viruses are largely responsible for their mortality, thereby exerting important controls on microbial dynamics. However, the relative impact of viruses on archaea compared to bacteria is unknown, limiting our understanding of the factors controlling the functioning of marine systems at a global scale. We evaluate the selectivity of viral infections by using several independent approaches, including an innovative molecular method based on the quantification of archaeal versus bacterial genes released by viral lysis. We provide evidence that, in all oceanic surface sediments (from 1000- to 10,000-m water depth), the impact of viral infection is higher on archaea than on bacteria. We also found that, within deep-sea benthic archaea, the impact of viruses was mainly directed at members of specific clades of Marine Group I Thaumarchaeota. Although archaea represent, on average, ~12% of the total cell abundance in the top 50 cm of sediment, virus-induced lysis of archaea accounts for up to one-third of the total microbial biomass killed, resulting in the release of ~0.3 to 0.5 gigatons of carbon per year globally. Our results indicate that viral infection represents a key mechanism controlling the turnover of archaea in surface deep-sea sediments. We conclude that interactions between archaea and their viruses might play a profound, previously underestimated role in the functioning of deep-sea ecosystems and in global biogeochemical cycles.

See: Dispensing with all pseudoscientific nonsense about evolution (2)