5th-6th Sept 2018 Dublin, Ireland

Nutrient-dependent pheromone-controlled feedback loops

Summary: The link from positive selection to one food energy-dependent base pair change and fixation of the mouse-model-to-human-specific EDAR V370A allele in populations on different continents attests to sympatric speciation at every level of examination that refutes the pseudoscientific nonsense of neo-Darwinian mutation-driven evolution.

Reported on 5/3/18 as: SWAT team of immune cells found in mother’s milk 

1)

“There is a feedback loop,” says Yu. It’s known that some immune cells like leucocytes, another white blood cell that fights infection, increase in the milk in response to an infection in the baby.

2)

…the largest immune cell population in breast milk is macrophages, which ILCs are known to direct. Macrophages, which literally means ‘big eaters,” are the largest of the white blood cells and much-better studied than ILCs. They are known for their ability to envelop unwanted items like bacteria, viruses…

Environmental selection during the last ice age on the mother-to-infant transmission of vitamin D and fatty acids through breast milk 4/23/18

The frequency of the human-specific EDAR V370A allele appears to be uniquely elevated in North and East Asian and New World populations due to a bout of positive selection likely to have occurred circa 20,000 y ago. The dental pleiotropic effects of this allele suggest an even higher occurrence among indigenous people in the Western Hemisphere before European colonization. We hypothesize that selection on EDAR V370A occurred in the Beringian refugium because it increases mammary ductal branching, and thereby may amplify the transfer of critical nutrients in vitamin D-deficient conditions to infants via mothers’ milk. This hypothesized selective context for EDAR V370A was likely intertwined with selection on the fatty acid desaturase (FADS) gene cluster because it is known to modulate lipid profiles transmitted to milk from a vitamin D-rich diet high in omega-3 fatty acids.

Reported as: Gene linked to breastfeeding may have boosted survival of earliest Americans (4/23/18)

…they carried a genetic mutation—revealed in ancient teeth—that boosted the development of milk ducts in women’s breasts, which may have helped nursing mothers pass more nutrients to their infants.

The obvious link from infant nutrition to healthy longevity was reported in the context of a ridiculous gene-centric theory of species survival. Gene-centric theories are all that pseudoscientists have left. They use them to hold back the scientific progress made by serious scientists like those who reported this:
Feedback loops link odor and pheromone signaling with reproduction (2005)

These results may reflect a strategy wherein GnRH neurons can modify diverse functions in order to coordinate the internal state of the animal and its behavior with reproduction in order to optimize reproductive success.

Plenty of Room at the Bottom

Environmental selection is natural selection (2)

I believe that if you put enough biologically uniformed theorists in the same room, they will invent more theories to support the pseudoscientific nonsense they have touted in the past. See for example:

Environmental selection during the last ice age on the mother-to-infant transmission of vitamin D and fatty acids through breast milk

Acknowledgments

The synthesis presented here is a product of the American Association for the Advancement of Science’s 2017 annual meeting, as the ideas came together in the session entitled “Beringia and the Dispersal of Modern Humans to the Americas.”
 

Every aspect of every level of biophysically constrained food energy-dependent biologically-based cause and effect is placed back into the context of a ridiculous theory of human migration and evolution. The theory accurately attests to the link from one food energy-dependent base pair change to biodiversity in human populations via fixation of one amino acid substitution. But then, something goes horribly wrong.

The theory requires the fixation of the amino acid substitution to automagically occur in the context of the sun’s anti-entropic virucidal energy. The theory fails to mention the fact that the physiology of pheromone-controlled reproduction and the microRNA-mediated creation of all cell types in all living genera is required.

See for comparison: Anything published since the time I learned about the importance of microRNAs during the 2012 Society for Neuroscience annual meeting in New Orleans, LA.

From 2000/10/15 to 2012/10/15 microRNA Items: 1 to 20 of 19910

From 2012/10/15 to 2018/04/26 microRNA Items: 1 to 20 of 53458

The number of biologically informed serious scientists who have linked the energy-dependent creation of microRNAs to biophysically constrained viral latency and all biodiversity via the pheromone-controlled physiology of reproduction in bacteria continues to rapidly increase.

This begs the question: When will biologically uninformed science idiots stop attending meetings that facilitate their attempts to invent more ridiculous theories?

Cytosis can be used to teach everything from base editing to RNA editing to everyone over age 10. They will learn how to link the creation of energy to biophysically constrained viral latency via the physiology of pheromone-controlled reproduction.

A Mathematical Model Links Quantum Physics to Quantum Souls (1)

Historical facts: All energy-dependent cell type differentiation is biophysically constrained by the de novo creation of microRNAs and enzymes that metabolize food and drugs. All food energy-dependent metabolism occurs in the context of microRNA-mediated cause and effect and the physiology of pheromone-controlled reproduction. The food energy-dependent pheromone controlled physiology of reproduction in bacteria links what organisms eat to the transgenerational epigenetic inheritance of their morphological and behavioral phenotypes. The virus-driven degradation of messenger RNA has been linked to all pathology in the context of the National Microbiome Initiative, the Precision Medicine Initiative, Alpha Genomix profiling of pathways linked to the creation of CYP enzymes and test results that differentiate the most likely response to some medications based on fixation of  RNA-mediated amino acid substitutions in the organized genomes of different people and different populations of modern humans.
See: Nutrient-dependent pheromone-controlled ecological adaptations: from atoms to ecosystems (2014)
The ingestion of sago palm-like leaves linked increased endogenous vitamin C from the stability of the mouse genome to the stability of the organized genome in a modern human population via one base pair change and the fixation of one RNA-mediated amino acid substitution.
See also: Towards a systemic paradigm in carcinogenesis: linking epigenetics and genetics (2015)

The SMT’s [Somatic mutation theory’s] fundamental assumption is that there is no cancer without genetic or chromosomal harm.

See for comparison: Stem cell divisions, somatic mutations, cancer etiology, and cancer prevention
Watch as 2 of 3 co-authors of the article about can prevention tell the world that cancer is caused by “bad luck.”

Now see one of the 3 co-authors admit to his overwhelming ignorance in: Why Is This Bacterium Hiding in Human Tumors?

“The whole idea of bacteria in tumors is fascinating and unexpected,” said Dr. Bert Vogelstein, a colon cancer researcher at Johns Hopkins.

  1. The fundamental assumption that there is no cancer without genetic or chromosomal harm links the virus-driven degradation of messenger RNA in bacteria to the food energy-dependent pheromone-controlled physiology of reproduction in bacteria and healthy longevity via error-free DNA repair.
  2. The fundamental assumption that there is no cancer without genetic or chromosomal harm links virus-driven pathology to cell type-specific and species-specific pathology in all cell types of all individuals of all living genera via the failure of microRNA-mediated error-free DNA repair.

There is now a mathematical model of top-down causation that links the sun’s anti-entropic virucidal energy on contact with water to the physiology of pheromone-controlled reproduction and all biodiversity via RNA-mediated error-free DNA repair. The mathematical model refutes the pseudoscientific nonsense touted by neo-Darwinian theorists because it starts with the creation of the sun, which biophysically constrains viral latency. The importance of linking this mathematical model to all models of biologically-based cause and effect cannot be overstated.
See: Quantum Vacuum Dynamics, Coherence, Superluminal Photons and Hypercomputation in Brain Microtubules

After the Schrodinger’s intuition, expressed in his book “What is life?” [12], the first systematic approach to a quantum interpretation of biological process dated back to the model proposed by Frohlich [13] several years ago. He suggested the occurrence, in biological matter, of macroscopic quantum phenomena able to explain the energy transport without loss in the living organisms and signal transfer based on collective coherent oscillations associated to a branch of longitudinal
electric modes in the frequency range [ ] also known as Frohlich frequency. So in living systems, according to Frohlich’s model, energy could be stored in a thin two – dimensional layer placed beneath the cell membrane, that in this way would act as a biological superconducting medium, under dipolar propagating waves without thermal loss [13].

The ridiculous assumptions about thermal loss and evolution were placed into the context of other ridiculous assumptions that failed to start from the creation of the sun and link the anti-entropic virucidal energy of the sun from food energy to all biodiversity via the physiology of pheromone-controlled reproduction.
For comparison see: Reversing the thermodynamic arrow of time using quantum correlations

We observe a spontaneous heat flow from the cold to the hot system. This process is enabled by a trade off between correlations and entropy that we quantify with information-theoretical quantities.

Reported as: Experiment shows that arrow of time is a relative concept, not an absolute one

The second law of thermodynamics says that entropy, or disorder, tends to increase over time, which is why everything in the world around us appears to unfold forward in time. But it also explains why hot tea grows cold rather than hot. In this new effort, the researchers found an exception to this rule that works in a way that doesn’t violate the rules of physics as they have been defined.
The idea of entangled particles has been in the news a lot lately as researchers around the world attempt to use it for various purposes—but there is another lesser-known property of particles that is similar in nature, but slightly different. It is when particles become correlated, which means they become linked in ways that do not happen in the larger world. Like entanglement, correlated particles share information, though it is not as strong of a bond. In this new experiment, the researchers used this property to change the direction of the arrow of time.

Succinctly stated as:

This observation did not violate the second law of thermodynamics, the group explains, because the second law assumes there are no correlations between particles.

The ridiculous assumption that there are no correlations between subatomic particles led to assumptions that energy emerged and that all life evolved in the context of mutations and natural selection, which led to the “bad luck” theory of cancer.
Frohlich’s model was dismissed and so was the the fact that “…energy could be stored in a thin two – dimensional layer placed beneath the cell membrane, that in this way would act as a biological superconducting medium, under dipolar propagating waves without thermal loss [13].
[13.] Long-range coherence and energy storage in biological systems (1968)

Biological systems are expected to have a branch of longitudinal electric modes in a frequency region between 1011 and 1012 sec−1. They are based on the dipolar properties of cell membranes; of certain bonds recurring in giant molecules (such as H bonds) and possibly on pockets of non-localized electrons. In Section 2 it is shown quit generally that if energy is supplied above a certain mean rate to such a branch, then a steady state will be reached in which a single mode of this branch is very strongly excited. The supplied energy is thus not completely thermalized but stored in a highly ordered fashion. This order expresses itself in long-range phase correlations; the phenomenon has considerable similarity with the low-temperature condensation of a Bose gas. General consequences and proposals of experiments are discussed in section 3.

Four years earlier, McEwen et al., (1964) linked the creation of the sun’s anti-entropic virucidal energy to the creation of ATP and the creation of RNA.
See: Dependence of RNA synthesis in isolated thymus nuclei on glycolysis, oxidative carbohydrate catabolism and a type of “oxidative phosphorylation”

The synthesis of RNA in isolated thymus nuclei is ATP dependent.

That same year, Dobzhansky (1964) first asserted this claim:

The notion has gained some currency that the only worthwhile biology is molecular biology. All else is “bird watching” or “butterfly collecting.” Bird watching and butterfly collecting are occupations manifestly unworthy of serious scientists! I have heard a man whose official title happens to be Professor of Zoology declare to an assembly of his colleagues that “a good man cannot teach zoology. A good man can teach, of course, only molecular biology.

In 1973, Dobzhansky again mocked all the pseudoscientists whose mathematical model failed to link the creation of the sun’s anti-entropic energy from the physiology of pheromone-controlled reproduction to RNA-mediated fixation of amino acid substitutions that differentiate all cell types in all living genera.
See: Nothing in Biology Makes Any Sense Except in the Light of Evolution
He assumed that all serious scientists would recognize that the light of evolution linked Schrodinger’s claims about sunlight to all biodiversity via the food energy-dependent pheromone-controlled fixation of RNA-mediated amino acid substitutions.
He claimed

“…one can calculate the minimum numbers of single mutations needed to change the cytochrome C of one organism into that of another.”

He linked that calculation to this fact:

…the so-called alpha chains of hemoglobin have identical sequences of amino acids in man and the chimpanzee, but they differ in a single amino acid (out of 141) in the gorilla.

The levels of complexity that must be addressed by the calculations have since been addressed and reported in: Quantum Vacuum Dynamics, Coherence, Superluminal Photons and Hypercomputation in Brain Microtubules
Nothing has changed about the facts that all serious scientists have linked from biophysically constrained viral latency to all biodiversity via the physiology of pheromone-controlled reproduction.
For example, see: Substitutions Near the Receptor Binding Site Determine Major Antigenic Change During Influenza Virus Evolution

The major antigenic changes of the influenza virus are primarily caused by a single amino acid near the receptor binding site.

See also Cytosis:A board game taking place inside a human cell! Players compete to build enzymes, hormones and receptors and fend off attacking Viruses!

Filtering light through a prism to identify tissue type

Light, behavior and autophagy, a gender-specific risk factor

Structure of photosystem II and substrate binding at room temperature

Excerpt:

PS II, a membrane-bound multi-subunit pigment protein complex, couples the one-electron photochemistry at the reaction centre with the four-electron redox chemistry of water oxidation at the Mn4CaO5 cluster in the oxygen-evolving complex (OEC).

New, detailed snapshots capture photosynthesis at room temperature

The living machinery responsible for photosynthesis – while commonplace and essential to life on Earth – is still not fully understood.

It is understood at every level of examination that links quantized energy to healthy longevity and virus-driven energy theft to all pathology. Thomas Hunt Morgan (Physiology or Medicine) and Schrodinger and Dirac (Physics) won Nobel Prizes in 1933 for linking energy-dependent changes from angstroms to ecosystems in all living genera via the physiology of reproduction and chromosomal inheritance. Like Darwin, they did this based on his “conditions of life” without knowing how the experimental evidence of biologically-based cause and effect would soon begin to fill in the missing links.

Only pseudoscientists would link claims about one-electron photochemistry to thermodynamic cycles and the oxygen-evolving complex (OEC) via five intermediate S-states linked to O2 evolution across three billion years. What’s worst is that they think some people are foolish enough to believe them because they are “experts” with academic credentials to prove it. They have proved how foolish all academics can be. Don’t let the fools fool you.

Let’s look at some practical applications of what is known about how to link the sun’s biological energy to life on Earth.

See: Laser used to control mouse’s brain — and speed up milkshake consumption

The ability to control very small groups of neurons could have big implications for brain science.

….conducted their experiments on mice that were genetically engineered to have light-sensitive neurons in a brain region called the orbitofrontal cortex. That area is involved in perceiving, and reacting to, rewards. By shining a laser at specific neurons, the researchers increased the pace at which the mice consumed a high-calorie milkshake.

The link from energy as information via the speed of light on contact with water and hydrogen-atom transfer in DNA base pairs in solution was placed into the context of everything known to serious scientists about biophysically constrained RNA-mediated cell type differentiation (i.e., autophagy) and all biodiversity in this brief presentation.

The link from virus-driven energy theft to all pathology via mRNA degradation in G protein-coupled receptors and receptor-mediated behavior seems unlikely to be considered. Indeed, researchers only recently decided to consider sex as a biological variable.
2016 Multifaceted origins of sex differences in the brain

The pervasive impact of sex on so many aspects of neural functioning in both the healthy and diseased brain demands that as neuroscientists, we incorporate sex as a biological variable…

2016 Addressing sex as a biological variable

Do we continue the status quo and ignore sex as a biological variable, or do we acknowledge that sex influences the brain at all levels and address the major gaps in knowledge? The National Institutes of Health now mandates the inclusion of sex as a biological variable.

Most of the contributors to articles about sexual differentiation still refuse to consider that the role of nutrient-dependent pheromone-controlled reproduction must extend from microbes to humans via the energy-dependent de novo creation of G protein-coupled receptors.

Very few sex researchers can understand the importance of the claims in this published work.: Gender-Specific Association of Galanin Polymorphisms with HPA-Axis Dysregulation, Symptom Severity, and Antidepressant Treatment Response
Excerpt:

Human galanin (GAL) is a 30 amino-acid neuropeptide, proteolytically processed from preprogalanin (PPGAL) (Evans and Shine, 1991; Schmidt et al, 1991). PPGAL is a single-copy gene located on chromosome 11q13.3–13.5, spanning over 6 kb of genomic DNA and organized into six exons (Rokaeus and Brownstein, 1986; Vrontakis et al, 1987).

One energy-dependent base pair change links the single-nucleotide polymorphism, rs948854 in the human galanin gene to sex differences in multiple sclerosis via a single amino acid substitution in the supercoiled DNA of humans, and the base pair change is referred to as a “gender” specific risk factor.
Single-nucleotide polymorphism rs948854 in human galanin gene and multiple sclerosis: a gender-specific risk factor

The associations between rs948854 variants and MS demonstrated in the current study support our hypothesis that polymorphism in the promoter region that are likely to change expression level of the GAL gene affect the cause and the outcome of MS, shifting the balance in favor of either neuroprotection or neurodegeneration.

The microRNA/messenger RNA balance shifts in the context of nutrient energy-dependent base pairs changes and codon optimality that links the base pair changes to RNA-mediated amino acid substitutions and cell type differentiation of all cell types in all living genera via their physiology of reproduction. See what happens when that fact is repeatedly placed into the context of social science and the pseudoscientific nonsense about sex-specific pathology, which is referred to as gender-specific.

rs3827760, also known as 1540T/C, 370A or Val370Ala, is a SNP in the ectodysplasin A receptor EDAR gene on chromosome 2.

Although all SNPs are biological variables that link base pair changes from RNA-mediated amino acid substitutions to energy-dependent cell type variation via the physiology of reproduction in all living genera, Val370Ala (aka rs3827760) was used as an example of how a mutation linked nutrient energy-dependent changes in human morphological and behavioral phenotypes via evolution with one caveat.
Modeling Recent Human Evolution in Mice by Expression of a Selected EDAR Variant

Alternatively, another phenotype, such as mammary gland branching or fat pad size could have been adaptive. The increased branching of 370A mouse mammary glands and the importance of mammary tissue in evolutionary fitness (Anderson et al., 1983; Oftedal, 2002) make this organ an interesting candidate. Alterations in gland structure have been reported to disrupt lactation in mice (Ramanathan et al., 2007), suggesting a functional consequence for this change. Unfortunately, it is not possible to assess mammary gland branching in living humans, highlighting the importance of animal models. Reports of smaller breast size in East Asian women (Maskarinec et al., 2001; Chen et al., 2004) are notable in light of the effects of 370A on fat pad size and the importance of breast morphology in human mate preference (Furnham et al., 1998, 2006; Dixson et al., 2011).

See also: Oppositional COMT Val158Met effects on resting state functional connectivity in adolescents and adults
See also: 23andMe has discovered hundreds of genetic links to traits, and much more is coming
One of 23andMe’s biggest discoveries came this summer with a paper linking 17 genetic tweaks, or SNPs (pronounced “snips”), that appear to be tied to one’s risk of developing Major Depressive Disorder (MDD).
See also: Olfactory organ of Octopus vulgaris: morphology, plasticity, turnover and sensory characterization
See also: Is brain plasticity the key to healing?

There haven’t been many scientists who have paid nearly enough attention to the fact that there is this phenomenon of the noisy dysregulated brain. So one of the themes of this book is the use of energy based interventions to resynchronise the noisy brain.

Filtering light through a prism to identify tissue type

Top-down adaptation vs bottom-up evolution

Who rules the waves? – Viruses might just be bit players in the drama of the seas. Then again, they could be major actors
Excerpt:

Most consider viruses to be a legion of cripples, sterilised by ultraviolet radiation and rendered impotent by hosts that are largely immune to their threat. But a few researchers take the opposite view. And if they turn out to be right, viruses could radically alter the balance of life in the oceans, ripping away huge parts of the food web that supports whales, sea birds and the fisheries on which many people rely.

See the discussion attempt at: What does DNA have to do with the Origin of Life ?
My comment: Supercoiled DNA is the link from energy-dependent changes in angstroms to all ecosystems in all living genera. That fact has been established in the context of experimental evidence that links physics and chemistry to molecular epigenetics and biophysically constrained RNA-mediated cell type differentiation at the level of quantum consciousness.

In an attempt to discuss my model on a Facebook group where Larry Kinser Jr., is an administrator and Taylor Kessinger is an antagonist,

I cited: Structural Dynamics and Mechanochemical Coupling in DNA Gyrase

I wrote: I predict that this group will be the first to link virus-driven energy theft to negative supercoiling in bacteria, but a student from Susan Rosenberg’s lab was on the same track several months ago when she contacted me. I also predict that mathematical models will continue to be as useless as they always have been due to their lack of explanatory power.
Previously, co-author Angelica Parente wrote: Do you have a source on this? I study bacterial supercoiling in the context of topoisomerase II structural biology. I’m assuming in honeybees it’s affecting chromatin dynamics? My lab would be really interested in learning more about this.
See also: Asking the right questions (1)
My comment: The Journal of Molecular Biology topic is “Mechanisms and Functional Diversity of Macromolecular Remodeling by ATP-Dependent Motors.” The authors have linked energy-dependent changes from angstroms to ecosystems via the conserved molecular mechanism of autophagy. The mechanisms link the innate immune system of bacteria to their nutrient-dependent pheromone-controlled physiology of reproduction, which biophysically constrains virus-driven energy theft and all pathology in all living genera.
See: 
1) Larry Kisner Sr. If the sun could kill viruses, you could harness that and win the nobel prizw
2) Larry Kisner Sr. there is no alternate model
3) Larry Kisner Sr. Evolution must be bottom-up
Summary: The anti-entropic energy of virucidal ultraviolet light kills viruses. I have linked that fact from top-down energy-dependent causation in a model that links nutrient-dependent pheromone-controlled biophysically constrained RNA-mediated protein folding chemistry from amino acid substitutions in supercoiled DNA to protection of organized genomes from virus-driven entropy, which is the cause of all pathology.
Although Larry Kinser Sr. did not know that sunlight could kill viruses, he has since learned how I linked that fact to polycombic ecological adaptations in all living genera, and is closing fast on my claims that hecatombic evolution is the cause of all pathology.  If he is motivated by money, he will present the facts I have detailed as if they were his own ideas. Others have been doing that for more than 20 years, but it is especially frustrating when other people who are supposedly young earth creationists do it.
Is someone pretending to be Larry Kinser Sr., the administrator of a “false flag” group [The Battlefield]? I will not know until he either bans me from participation in the group, or admits that he is merely using my detailed model to convince others about the facts of Creation science so that they can dismiss the claims of biologically uniformed theorists.
Until then, Taylor Kessinger, or someone pretending to be Taylor Kessinger, claims to have a model that can be compared to mine.
He is the co-author of Coalescence and genetic diversity in sexual populations under selection
Conclusion:

Our model provides the background on top of which such singular adaptations can be sought, and understanding the statistical patterns of diversity and linkage within this null model is essential for reliable inference.

My comment: Anyone who thinks that this is a model of biologically-based cause and effect need only read the concluding sentence. It is nothing more than a theory of unreliable inferences. There is no claim about what must be selected to get from unicelluar to multicellular organisms or to sex differences in the cell types of yeasts. It is a mathematical model with no explanatory power.
See for comparison:  Nutrient-dependent/pheromone-controlled adaptive evolution: a model
Concluding sentence:

…the model represented here is consistent with what is known about the epigenetic effects of ecologically important nutrients and pheromones on the adaptively evolved behavior of species from microbes to man. Minimally, this model can be compared to any other factual representations of epigenesis and epistasis for determination of the best scientific ‘fit’

Characterization of Genetic Diversity in the Nematode Pristionchus pacificus from Population-Scale Resequencing Data is listed as one of the other papers that cited the paper co-authored by Taylor Kessinger. The paper that Kessinger co-authored was not cited.
If it had been cited, Kessinger could be taken to task for not knowing how his mathematical model must be linked from the nutrient-dependent pheromone-controlled physiology of reproduction in C. elegans to the morphological and behavioral diversity of the predatory nematode P. pacificus.
Instead of his inference of evolutionary history and charaterization of “…coalescence, genetic diversity, and the speed of adaptation in the infinitesimal model of quantitative genetics.” Taylor Kessinger would have a model for comparison to mine.
The two models could then be compared to representations in Natural selection constrains neutral diversity across a wide range of species to show that natural selection for energy-dependent codon optimality is nutrient-dependent.
Excerpt:

…natural selection constrains levels of neutral genetic diversity across many species. This implies that natural selection may provide an explanation for this longstanding paradox of population genetics.

Kessinger may think that he has characterized an evolutionary history of “…coalescence, genetic diversity, and the speed of adaptation in the infinitesimal model of quantitative genetics.” Instead he has merely inferred the evolutionary history that prevents others from comparing ridiculous theories based on population genetics in the context of results like these:
See: Two genetic markers that predict malaria treatment failure found
Excerpt:

“By studying the genomes of these parasites we found two genetic markers that are linked with piperaquine resistance. Not only can we now use these markers to monitor the spread of the drug resistant malaria, they will also help towards understanding as much as possible about the biology and evolution of the parasite.”

Journal article excerpt:

The first marker is a [base pair change. It is referred to as a] single-nucleotide polymorphism, which encodes a glutamic acid-to-glycine aminoacid substitution, in a putative exonuclease gene. This exonuclease marker is associated… a low rate (0·38) of dihydroartemisinin–piperaquine treatment efficacy… in Cambodia but not in other areas of the world…. The second marker is… a strong candidate for causal mutation because plasmepsins encode aspartic proteases, which are involved in the parasite’s haemoglobin degradation pathway…

Summary: Energy-dependent base pair changes and amino acid substitutions in the exonuclease gene are linked to the stability of supercoiled DNA. In all living genera the stability of supercoiled DNA is nutrient-dependent and pheromone-controlled via the physiology of reproduction. Here, the energy-dependent base pair change and RNA-mediated amino acid substitutions are found with the plasmepsin markers, and the aspartic proteases, which should be linked from energy-dependent changes in the microRNA/messenger RNA balance and  mRNA degradation. The mRNA degradation links virus-driven energy theft to kelch13 gene mutations and a single copy of the mdr1 gene, which is associated with cell type differentiation in mosquitoes with decreased piperaquine, but increased mefloquine, susceptibility.

Because these researchers failed to start with energy-dependent changes in hydrogen-atom transfer in DNA base pairs in solution they missed every other step that links nutrient energy-dependent base pair changes to healthy longevity. They also missed every other step that links virus-driven energy-dependent from the loss of quantised energy and loss of information as energy from virus-driven energy theft to all pathology.

If the researchers knew anything about energy-dependent autophagy, they could link nutrient energy-dependent base pair changes to healthy longevity in the populations of different regions via the amino acid substitutions and link virus-driven energy theft to the mutations, which are linked to all pathology in all living genera.

Instead, we have yet another example of how people are being killed by neo-Darwinian theories that link mutations to pathology and to the evolution of new species via natural selection.

See also:  Why bad genes aren’t always bad news

Excerpt:

“We don’t really understand why some people with damaging mutations get the disease and some don’t. Some of this could be due to environment, but a lot of could be due to the presence of other mutations that are suppressing the effects of the first mutation,” said Roth, who is also a Senior Scientist at Sinai Health System’s Lunenfeld-Tanenbaum Research Institute.
Imagine being stuck in a room with a broken thermostat and it’s getting too hot. To cool down, you could fix the thermostat—or you could just break a window. This is how genetic suppression works to keep cells healthy despite damaging mutations. And it opens a new way of understanding, and maybe even treating, genetic disorders.

Excerpt:

“We’ve uncovered fundamental principles of genetic suppression and show that damaging mutations and their suppressors are generally found in genes that are functionally related. Instead of looking for a needle in the haystack, we can now narrow down our focus when searching for suppressors of genetic disorders in humans. We’ve gone from a search area spanning 20,000 genes to hundreds, or even dozens. That’s a big step forward,” said Boone.

My comment: Researchers like this have never made a big step forward, and they probably never will. They obviously do not know enough about energy-dependent RNA-mediated cell type differentiation to link it from virus-driven energy theft and all pathology by as little as one base pair change and one amino acid substitution.