5th-6th Sept 2018 Dublin, Ireland

The eternal significance of microRNAs (7)

Sales of human pheromone-enhanced fragrance products have been virtually eliminated by the pseudoscientific nonsense touted by neo-Darwinian theorists and Big Bang cosmologists. I may revisit their ridiculous claims at ScentofEros.com and Pheromones.com, but prefer to continue moving forward via my other domains: RNA-mediated.com and Autophagy.pro.

Summary: 2018 Update: Sympatric speciation has been linked to species diversity as an example of an ecologically validated proof-of-concept in all living genera.

Theorists, other psedoscientists and nearly all so-called science journalists have failed to use common sense in their ridiculous representations.
See for example: Beating the Odds for Lucky Mutations: If DNA repair makes useful mutations more likely, it could accelerate cells’ adaptations to harsh environments (8/16/17) by Jordana Cepelewicz
See: 4/18/18 Nutrient-dependent Pheromone-Controlled Ecological Adaptations: From Angstroms to Ecosystems by James V. Kohl
My model of ecological adaptations was placed into the context of this article in Quanta Magazine by Jordana Cepelewicz — less than one year after she published her article on “lucky mutations” in Aeon.
5/10/18 A Thermodynamic Answer to Why Birds Migrate

…research makes a forceful argument that energy supply and demand is a driving ecological principle shaping the global structure of biodiversity.

See for comparison: 10/12/16 Virus-mediated archaeal hecatomb in the deep seafloor

We show here for the first time the crucial role of viruses in controlling archaeal dynamics and therefore the functioning of deep-sea ecosystems, and suggest that virus-archaea interactions play a central role in global biogeochemical cycles.

Evolutionary theorists and Big Bang cosmologists are forced to plagiarize the intellectual property of others like me and pretend that they are saying something new about the origin of all energy-dependent biophysically constrained biodiversity.
Jordana Cepelewicz is among the most serious offenders. I wonder why she thinks she can get away with directly contradicting the claims she made less than one year ago.
I have neglected some of the domains I established during the past 7 years because it became clear that pseudoscientists were not going to let people know that all aspects of sympatric speciation have been detailed in the context of food energy-dependent pheromone-controlled reproduction, which is required to biophysically constrain viral latency.
That fact was placed into the context of the cell biology game “Cytosis,” which was delivered to backers in October 2017.

A board game taking place inside a human cell! Players compete to build enzymes, hormones and receptors and fend off attacking Viruses!

See also: A transmissible RNA pathway in honey bees (2018)
The authors link my model of food energy-dependent pheromone-controlled biophysically constrained sympatric speciation from atoms to ecosystems in all living genera via my 2013 published review and my unpublished invited review of nutritional epigenetics.

Nutrient-dependent/pheromone-controlled adaptive evolution: a model (2013)

…the epigenetic ‘tweaking’ of the immense gene networks that occurs via exposure to nutrient chemicals and pheromones can now be modeled in the context of the microRNA/messenger RNA balance, receptor-mediated intracellular signaling, and the stochastic gene expression required for nutrient-dependent pheromone-controlled adaptive evolution. The role of the microRNA/messenger RNA balance (Breen, Kemena, Vlasov, Notredame, & Kondrashov, 2012; Duvarci, Nader, & LeDoux, 2008; Griggs et al., 2013; Monahan & Lomvardas, 2012) in adaptive evolution will certainly be discussed in published works that will follow.

For a historical perspective, see: Nutrient-dependent pheromone-controlled ecological adaptations: from atoms to ecosystems (2014 preprint)

Ideas from population genetics, which exclude ecological factors, are integrated with an experimental evidence-based approach that establishes what is currently known. This is known: Olfactory/pheromonal input links food odors and social odors from the epigenetic landscape to the physical landscape of DNA in the organized genomes of species from microbes to man during their development.

The facts about sympatric speciation for comparison to the neo-Darwinian pseudoscientific nonsense about mutation-driven evolution have been placed in to the context of 3 more recently published works.
A 360 degrees view of circular RNAs: From biogenesis to functions (2018)
Circular RNAs: Unexpected outputs of many protein-coding genes (2017)
The Output of Protein-Coding Genes Shifts to Circular RNAs When the Pre-mRNA Processing Machinery Is Limiting (2017)
It is no longer possible to successfully put the facts about sympatric speciation back into the context of ridiculous theories about the emergence of energy and evolution of all life on Earth. Anyone who returns to the links or to the published works I have posted here, will realize that pseudoscientists and most so-called science journalists know virtually nothing about food energy-dependent RNA-mediated cell type differentiation in any species.

5th-6th Sept 2018 Dublin, Ireland

2018 March for Science vs microRNAs

Summary: Only biologically uninformed theorists and other pseudoscientists do not seem to know that all carbon-based life is quantized energy-dependent and that biophotonic energy as information comes from the sun. It is obvious to all serious scientists that proton gradients link photons from quantized energy as information to the proton motive force, which is how the potential of hydrogen (pH) is linked to changes in the microRNA/messenger RNA balance that biophysically constrain viral latency in the context of hydrogen-atom transfer in DNA base pairs in solution that must be linked to supercoiled DNA.
The Second March for Science a Smaller Affair

…the events are not devoid of politics—either on signs or in rhetoric.

“It is a remarkable outpouring of scientists to talk about the marvelous accomplishments of science, the amazing relevance of science, and a call for defending the conditions under which science can thrive.” — Rush Holt, the CEO of the American Association for the Advancement of Science
Science is not thriving. See for comparison: All in the (bigger) family (2015)

…at a special symposium of the annual meeting of the Society for Integrative and Comparative Biology, researchers reported new parallels between these two very successful groups of animals and new insights about what it took for an ancient crustacean to give rise to insects.

Energy-dependent microRNA-mediated biophysically constrained viral latency was required. The scientific facts about food energy-dependent pheromone-controlled biophysically constrained viral latency and microRNA-mediated sympatric speciation probably contributed most to the reduced turnout at the ridiculous Marches for Science. All serious scientists know that science is not thriving, and pseudoscientists are finding out.
This is serious science: miRNA regulation of innate immunity

In this review, we discuss the contributory pathways and mechanisms by which several miRNAs influence the development of innate immunity and fine-tune immune response. Moreover, we discuss the consequence of deregulated miRNAs and their pathogenic implications.

Who needs more proof that neo-Darwinian theorists and Big Bang cosmologists are biologically uninformed science idiots?
When George Church reported in this interview that cyanobacteria fix light, he left no room for ridiculous claims about the emergence of energy or claims about mutation-driven evolution. Two months later, most theorists skipped the Marches.
I believe they probably stayed home and attempted to rewrite their grant proposals. But what I believe doesn’t matter. I can’t prove that they’ve been forced by serious scientists to eliminate “evolution” and/or their automagical “evolutionary processes” from the content/context.
But see at 15:10

“…the cyanobacteria turn out that they fix light ah as well or better than land plants…”

See for comparison, from the transcript:

The cyanobacteria fix [carbon via] light as well or better than land plants. Under ideal circumstances, they can be maybe seven to ten times more productive per photon.

Only biologically uninformed theorists and other pseudoscientists do not seem to know that all carbon-based life is quantized energy dependent and that biophotonic energy as information comes from the sun. It is obvious to all serious scientists that proton gradients link photons from quantized energy as information to the proton motive force, which is how the potential of hydrogen (pH) is linked to changes in the microRNA/messenger RNA balance that biophysically constrain viral latency in the context of hydrogen-atom transfer in DNA base pairs in solution that must be linked to supercoiled DNA.
Theorists have been left behind and anyone who participated in the 2018 March for Science has revealed their overwhelming ignorance. Why didn’t George Church warn them? Richard Feynman did:
See: Food energy  for Feynman’s claim about human idiocy.
Alternatively, see: Energy as information and constrained endogenous RNA interference
See also: A 360 degrees view of circular RNAs: From biogenesis to functions

The pre-mRNA splicing machinery generates circRNAs via backsplicing reactions, which are often facilitated by intronic repeat sequences that base pair to one another and bring the intervening splice sites into close proximity.

See also: Dr. Gene Nelson wrote:  “This year, I printed 500 copies of the handout that I wrote regarding CGNP’s battle with the CPUC and the plant’s owner. I returned with about 490 handouts.”
On April 19, 2018 “From Layout to Multi-Physics: Integrating Thermal and Photonics Simulation into the PIC Design Flow” will link the creation of the sun’s anti-entropic virucidal energy to thermal cycling.
The thermal cycles have been linked to cracks in the Vietnam Memorial Wall. This free Webinar will almost undoubtedly place the eternal significance of “The Wall” into the context of the eternal significance of microRNAs, which repair DNA damage in carbon-based life forms. Damage repair via the food energy-dependent creation of microRNAs is linked to the eternal significance of differences between organic and inorganic chemistry.
For instance, quantum physics can be linked to the biophysically constrained production of uranium isotopes by the physiology of reproduction in bacteria. And, the use of uranium isotopes in therapy attests to the fact that the unconstrained energy causes cracks in the human genome. The “cracks” are manifested in radiation-induced pathologies.
Treating glioblastoma with radiation may be ill-advised. For comparison, microRNA-mediated therapy has emerged as an effective treatment regimen based on naturally occurring prevention of all pathology.

Pseudoscientists are willing to let Vietnam Veterans and others with glioblastoma suffer unnecessarily and die prematurely. The pseudoscientists won’t admit that food energy-dependent changes in microRNAs have been linked to the stability of all organized genomes via sympatric speciation in all living genera.
 
 
 
There is no such thing as a de novo mutation. The virus-driven degradation of messenger RNA has been linked from mutations to all pathology via the death gene, which was discovered during the early 1990s by researchers who worked for Abcam.
See: Epigenetic modifications poster
See for comparison: A Crack in Creation: Gene Editing and the Unthinkable Power to Control Evolution

Why is Jennifer Doudna still touting controlled evolution at a time when other serious scientists have linked every aspect of the quantized energy-dependent creation of microRNAs to the epigenetically modified physiology of reproduction and all ecological adaptations? What hasn’t she learned about biophysically constrained microRNA-mediated cell type differentiation in species from microbes to humans?
See: When the Most Potent Combination of Antibiotics Selects for the Greatest Bacterial Load: The Smile-Frown Transition (April 23, 2013)

Finding the most potent combinations of antibiotics in the lab can be a challenge if antibiotic interactions are not robust to evolutionary adaptation.

For nearly 5 years serious scientists have watched theorists try to escape from the traps that were set by their predecessors. All intelligent people now realize that there is no such thing as evolution of a new species. There is only ecological variation and quantized energy-dependent ecological adaptations to the virus-driven theft of quantized energy that comes from sunlight and sustains the physiology of pheromone-controlled reproduction in all living genera.
Reported as: The XV Collection: What Happens when the Antibiotic 1-2 Punch Backfires? (April 13, 2018)

Antibiotic-resistant mutants readily arise within almost any population of bacteria. If a population containing both susceptible and resistant mutants is treated with two antibiotics, the susceptible majority is, as expected, rapidly wiped out. But this also removes any competition for the resistant minority, enabling them to quickly grow and proliferate.

The food energy-dependent pheromone-controlled physiology of reproduction in bacteria biophysically constrains the virus-driven degradation of messenger RNA that links antibiotic resistance from mutations to all pathology.
Reported on June 14, 2013 as: Nutrient-dependent/pheromone-controlled adaptive evolution: a model

That extension of the vertebrate/mammalian model to invertebrates occurred as researchers integrated what was known about human pheromones and their effects on neuroendocrine systems during the development of human behavior (Kohl et al., ). Invertebrate research rapidly progressed to include the epigenetic effects of nutrients and pheromones on gene expression and on hormone-organized and hormone-activated behavioral transitions throughout life (Elekonich & Roberts, ), which is consistent with their epigenetic effects throughout the life of vertebrates, including mammals.

The honeybee model organism exemplifies what has been learned from the study of invertebrates (De Loof, Lindemans, Liu, De Groef, & Schoofs, ). This includes what has been learned about the epigenetic effects of nutrients and pheromones on juvenile hormone (JH).

See also: Pursuing Preprints, Preventing Pandemics: How pre-peer review posting can accelerate outbreak science

Preprints are scientific manuscripts posted online prior to or concurrent with submission for peer review and publication in a scientific journal. They offer opportunities to share data and findings sooner and to get broader community feedback before publication. During outbreaks, decisions that can save lives must often be made quickly and with little information. The fast, open nature of preprint posting can help address these needs.

The posting of most preprints on the bioRxiv server obfuscates what is known to serious scientists about biophysically constrained energy-dependent microRNA-mediated sympatric speciation. The consistent focus of most preprints places the findings into the context of evolution because that is what biologically uninformed theorists have been taught to believe in.

Until everyone admits that the creation of microRNAs is food energy-dependent and biophysically constrained by the physiology of pheromone-controlled reproduction, the ability to respond to urgent and complex health challenges will be placed into the ridiculous context of evolutionary processes.

See for exception:  A transmissible RNA pathway in honey bees

…RNA extracted from worker and royal jellies harbor differential naturally occurring RNA populations. Some of these RNAs corresponded to honey bee protein-coding genes, transposable elements, non-coding RNA and exogenous viruses. These results reveal an inherent property of honey bees to share RNA among individuals and generations. Thus, our findings suggest a transmissible RNA pathway, playing a role in social immunity and epigenetic dynamics among honey bees and potentially other closely interacting organisms.

See for comparison: SLC6A4 binding site and acute prosocial effects of (+/-)-3,4-methylendioxymethamphetamine (MDMA) are evolutionarily conserved in Octopus bimaculoides

Human and octopus lineages are separated by over 500 million years of evolution, and show divergent anatomical patterns of brain organization.

No experimental evidence of top-down causation or energy-dependent RNA interference suggests separation of the lineages by 500 million years of evolution.

See for comparison: Role of olfaction in Octopus vulgaris reproduction

From the concluding paragraph:

Future work on O. vulgaris olfaction must also consider how animals acquire the odours detected by the olfactory organ and what kind of odour the olfactory organ perceives. The OL acting as control centre may be target organ for metabolic hormones such as leptin like and insulin like peptides, and olfactory organ could exert regulatory action on the OL via epigenetic effects of nutrients and pheromones on gene expression (Kohl, 2013; Elekonich and Robinson, 2000).

See also: See Diamond et al., 1996: From Fertilization to Adult Sexual Behavior

Elekonich and Robinson (2000) linked our 1996 Hormones and Behavior review of RNA-mediated cell type differentiation to the honeybee model of food energy-dependent biophysically constrained biodiversity.

Effects of hormones on brain and behavior occur through three mechanisms: (1) behaviors both organized and activated by hormones, (2) behaviors only organized by hormones, and (3) behaviors only activated by hormones (reviewed in Arnold and Breedlove, 1985; Diamond et al., 1996).”

See also: Honey bees as a model for understanding mechanisms of life history transitions

In this review we discuss the physiological and genetic mechanisms of this behavioral transition, which include large scale changes in hormonal activity, metabolism, flight ability, circadian rhythms, sensory perception and processing, neural architecture, learning ability, memory and gene expression.

See also: IAPV, a bee-affecting virus associated with Colony Collapse Disorder can be silenced by dsRNA ingestion (2009)

Here we report on RNAi-silencing of IAPV infection by feeding bees with double-stranded RNA, as an efficient and feasible way of controlling this viral disease. The association of CCD with IAPV is discussed, as well as the potential of controlling CCD.