5th-6th Sept 2018 Dublin, Ireland

Nutrient-dependent pheromone-controlled feedback loops

Summary: The link from positive selection to one food energy-dependent base pair change and fixation of the mouse-model-to-human-specific EDAR V370A allele in populations on different continents attests to sympatric speciation at every level of examination that refutes the pseudoscientific nonsense of neo-Darwinian mutation-driven evolution.

Reported on 5/3/18 as: SWAT team of immune cells found in mother’s milk 

1)

“There is a feedback loop,” says Yu. It’s known that some immune cells like leucocytes, another white blood cell that fights infection, increase in the milk in response to an infection in the baby.

2)

…the largest immune cell population in breast milk is macrophages, which ILCs are known to direct. Macrophages, which literally means ‘big eaters,” are the largest of the white blood cells and much-better studied than ILCs. They are known for their ability to envelop unwanted items like bacteria, viruses…

Environmental selection during the last ice age on the mother-to-infant transmission of vitamin D and fatty acids through breast milk 4/23/18

The frequency of the human-specific EDAR V370A allele appears to be uniquely elevated in North and East Asian and New World populations due to a bout of positive selection likely to have occurred circa 20,000 y ago. The dental pleiotropic effects of this allele suggest an even higher occurrence among indigenous people in the Western Hemisphere before European colonization. We hypothesize that selection on EDAR V370A occurred in the Beringian refugium because it increases mammary ductal branching, and thereby may amplify the transfer of critical nutrients in vitamin D-deficient conditions to infants via mothers’ milk. This hypothesized selective context for EDAR V370A was likely intertwined with selection on the fatty acid desaturase (FADS) gene cluster because it is known to modulate lipid profiles transmitted to milk from a vitamin D-rich diet high in omega-3 fatty acids.

Reported as: Gene linked to breastfeeding may have boosted survival of earliest Americans (4/23/18)

…they carried a genetic mutation—revealed in ancient teeth—that boosted the development of milk ducts in women’s breasts, which may have helped nursing mothers pass more nutrients to their infants.

The obvious link from infant nutrition to healthy longevity was reported in the context of a ridiculous gene-centric theory of species survival. Gene-centric theories are all that pseudoscientists have left. They use them to hold back the scientific progress made by serious scientists like those who reported this:
Feedback loops link odor and pheromone signaling with reproduction (2005)

These results may reflect a strategy wherein GnRH neurons can modify diverse functions in order to coordinate the internal state of the animal and its behavior with reproduction in order to optimize reproductive success.

Caption: Contemporary analyses of cell metabolism have called out three metabolites: ATP, NADH, and acetyl-CoA, as sentinel molecules whose accumulation represent much of the purpose of the catabolic arms of metabolism and then drive many anabolic pathways. Such analyses largely leave out how and why ATP, NADH, and acetyl-CoA (Figure 1) at the molecular level play such central roles. Yet, without those insights into why cells accumulate them and how the enabling properties of these key metabolites power much of cell metabolism, the underlying molecular logic remains mysterious. Four other metabolites, S-adenosylmethionine, carbamoyl phosphate, UDP-glucose, and Δ2-isopentenyl-PP play similar roles in using group transfer chemistry to drive otherwise unfavorable biosynthetic equilibria. This review provides the underlying chemical logic to remind how these seven key molecules function as mobile packets of cellular currencies for phosphoryl transfers (ATP), acyl transfers (acetyl-CoA, carbamoyl-P), methyl transfers (SAM), prenyl transfers (IPP), glucosyl transfers (UDP-glucose), and electron and ADP-ribosyl transfers (NAD(P)H/NAD(P)+) to drive metabolic transformations in and across most primary pathways. The eighth key metabolite is molecular oxygen (O2), thermodynamically activated for reduction by one electron path, leaving it kinetically stable to the vast majority of organic cellular metabolites

EDAR V370A and sympatric speciation

Nick Lane and others like him refuse to reappraise their human mitochondrial DNA recombination dogma. All serious scientists know where the energy for recombination comes from. But, in his latest video clip, he touts the same unsubstantiated theoretical pseudoscientific nonsense.

See the: Aeon Video:

Life on earth – from mushrooms to humans and everything in between – seems enormously diverse. At the cellular level, however, almost all complex lifeforms are surprisingly similar. Why life is this way, though, remains mysterious. In this Aeon interview, the UK biochemist and author Nick Lane discusses his research on the connection between energy and genes, which, he hypothesises, made possible the radical transformation from single-celled organisms to complex life about 4 billion years ago.

See for comparison: Reappraising the human mitochondrial DNA recombination dogma

I’ve asked the authors: Are you prepared to address the comments that you might receive from people like Nick Lane in the context of “peer review?” How will you respond to those who do not accept the fact that the creation of ATP synthase and the creation of ATP must be linked to the creation of RNA and biophysically constrained viral latency in the context of SNPs and fixation of amino acid substitutions? What can be done when biologically uninformed theorists continue to link anything except biophysically constrained viral latency to all biodiversity?

I ask because there are still too many examples of human idiocy that are being considered outside the context of facts about energy-dependent RNA-mediated cell type differentiation.

See: Modeling Recent Human Evolution in Mice by Expression of a Selected EDAR Variant

See the claims about the selection of the EDAR variant placed back into the context of evolution.

Field-deployable viral diagnostics using CRISPR-Cas13

…we report the rapid (<1 week) design and testing of instrument-free assays to detect clinically relevant viral single-nucleotide polymorphisms.

The relevant energy-dependent single-nucleotide polymorphisms clearly protect all living genera from the clinically relevant viral single-nucleotide polymorphisms. The viral single-nucleotide polymorphisms link the virus-driven degradation of messenger RNA to all pathology via what is known to all serious scientists about the energy-dependent creation of the innate immune system in species from bacteria to humans.

Environmental selection during the last ice age on the mother-to-infant transmission of vitamin D and fatty acids through breast milk

The frequency of the human-specific EDAR V370A allele appears to be uniquely elevated in North and East Asian and New World populations due to a bout of positive selection likely to have occurred circa 20,000 y ago.

If any experimental evidence of biophysically constrained viral latency supported the claim about positive selection 20,000 y ago, it could be linked to Nick Lane’s claims about how chimeras and electricity allowed a sterile planet to give way to complex life 4 billion years ago. Since there is no experimental evidence to support his ridiculous theories, intelligent people may want to continue to link environmental selection from food selection to the physiology of reproduction and fixation of RNA-mediated amino acid substitutions such as V370A that stabilize the organized genomes of all species on Earth.

(E) KEGG analysis of the common up- and downregulated mRNAs in NDV infection. The left panel shows the KEGG enrichment analysis of each of the top 20 significant differences in the upregulated mRNAs, and the right panel shows the KEGG enrichment analysis of each of the top 20 significant differences in the downregulated mRNAs.

The eternal significance of microRNAs (6)

Accurate representations of how mutations are linked to the ecological adaptations in viruses that kill us are required to end the stranglehold that pseudoscientists have held on medical research. The pseudoscientists and other theorists make claims about mutation-driven evolution or natural selection and evolution as if the effect of virus-driven energy theft was beneficial to species that have somehow evolved from other species.
Neo-Darwinian theories will cause the death of us all. But first they will kill all the chickens.
Common microRNA-mRNA Interactions in Different Newcastle Disease Virus-Infected Chicken Embryonic Visceral Tissues
figure 3 E (above) includes biosynthesis of amino acids but a word search for “amino acid” turns up nothing.

(E) KEGG analysis of the common up- and downregulated mRNAs in NDV infection. The left panel shows the KEGG enrichment analysis of each of the top 20 significant differences in the upregulated mRNAs, and the right panel shows the KEGG enrichment analysis of each of the top 20 significant differences in the downregulated mRNAs.

The pathways for the biosynthesis of amino acids link microRNA biogenesis from energy-dependent changes in base pairs to amino acid substitutions that stabilize or destabilize the organized genomes in the context of everything that could be learned by playing the cell biology game “Cytosis.”
Ages 10+ can learn how to protect all organized genomes from viruses in the context of the food energy-dependent pheromone-controlled physiology of reproduction of humans, which biophysically constrains viral latency in species from microbes to humans.
One base pair change and one amino acid substitution (e.g., EDAR V370A) in a human host may be all that’s required to protect the organized genome from the virus-driven degradation of mRNA that has been linked to all pathology.
That means the virus-driven theft of quantized energy may link the change in the base pair to an amino acid substitution in the virus that stabilizes the virus. The 1918 Spanish flu was one example of what happens next. But no one knew why it happened until more recently.
See:  Substitutions Near the Receptor Binding Site Determine Major Antigenic Change During Influenza Virus Evolution (2013)

Koel et al. (p. 976) show that major antigenic change can be caused by single amino acid substitutions.

See also: A Single Amino Acid at the Polymerase Acidic Protein Determines the Pathogenicity of Influenza B Viruses (2018)

…the PA K338R mutation may be a molecular determinant of IBV pathogenicity via modulating the viral polymerase function of IBVs.

Accurate representations of how mutations are linked to ecological adaptations in viruses are required to end the stranglehold that pseudoscientists have held on medical research. The pseudoscientists and other theorists make claims about mutation-driven evolution or natural selection and evolution as if the effect of virus-driven energy theft was beneficial to species that have somehow evolved from other species.
The most recent example of that nonsense may be the focus of several blog posts here.
See:  Environmental selection during the last ice age on the mother-to-infant transmission of vitamin D and fatty acids through breast milk

…we investigate whether the population occupying Beringia during the LGM represents another example of human adaptation to an extreme environment, this time adapting to very low UV exposure (Fig. 1). There are two lines of genetic evidence for this: variation in the fatty acid desaturase (FADS) gene cluster that modulates the manufacture of polyunsaturated fatty acids and variation in the ectodysplasin A receptor (EDAR) gene that influences ectodermally derived structures, such as teeth, hair, and mammary gland ductal branching. A study on selection on the FADS gene cluster in the ancestral population of Native Americans has been published previously (13), but, here, we shift the emphasis from phenotypic effects on older adults to focus on those that influence fertility via breast milk.

They link the food energy-dependent creation of microRNAs in all mammals from the physiology of reproduction to biophysically constrained viral latency via one base pair change an a single amino acid substitution, EDAR V370A. They refuse to acknowledge the facts that link the creation of the sun’s anti-entropic virucidal energy from the creation of microRNAs to viral latency in the mouse-to-human model, and fail to link what is known about what animals eat from the physiology of reproduction to the transgenerational epigenetic inheritance of healthy longevity and fertility.
See: The Bull Sperm MicroRNAome and the Effect of Fescue Toxicosis on Sperm MicroRNA Expression (2014)

The potential for sperm miRNA affecting zygote development has recently been reported in the literature [18] and has interesting implications for the use of sperm miRNA profiles as indicators of potential male fertility.

See also: Codon identity regulates mRNA stability and translation efficiency during the maternal-to-zygotic transition (2016)

The amino acid optimality code (Fig 6) provides an alternative perspective on sequence changes between paralogs in evolution and human disease.

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The chicken-livered (timid; fearful; cowardly) theorists who refuse to admit that their ridiculous theories have led to the unnecessary suffering and premature death of millions to billions of people and other mammals, have brought us all to the brink of extinction.
Does any intelligent person think that humans will evolve another protective variant allele like the EDAR V370A variant before humanity — as we know it know – ceases to exist?
Environmental selection during the last ice age on the mother-to-infant transmission of vitamin D and fatty acids through breast milk

The frequency of the human-specific EDAR V370A allele appears to be uniquely elevated in North and East Asian and New World populations due to a bout of positive selection likely to have occurred circa 20,000 y ago.