Caption: Contemporary analyses of cell metabolism have called out three metabolites: ATP, NADH, and acetyl-CoA, as sentinel molecules whose accumulation represent much of the purpose of the catabolic arms of metabolism and then drive many anabolic pathways. Such analyses largely leave out how and why ATP, NADH, and acetyl-CoA (Figure 1) at the molecular level play such central roles. Yet, without those insights into why cells accumulate them and how the enabling properties of these key metabolites power much of cell metabolism, the underlying molecular logic remains mysterious. Four other metabolites, S-adenosylmethionine, carbamoyl phosphate, UDP-glucose, and Δ2-isopentenyl-PP play similar roles in using group transfer chemistry to drive otherwise unfavorable biosynthetic equilibria. This review provides the underlying chemical logic to remind how these seven key molecules function as mobile packets of cellular currencies for phosphoryl transfers (ATP), acyl transfers (acetyl-CoA, carbamoyl-P), methyl transfers (SAM), prenyl transfers (IPP), glucosyl transfers (UDP-glucose), and electron and ADP-ribosyl transfers (NAD(P)H/NAD(P)+) to drive metabolic transformations in and across most primary pathways. The eighth key metabolite is molecular oxygen (O2), thermodynamically activated for reduction by one electron path, leaving it kinetically stable to the vast majority of organic cellular metabolites

The eternal significance of microRNAs (5)

Excerpt: Researchers in South Korea, for example, have reminded the God-less Communist dictator of North Korea that one microRNA-mediated amino acid substitution in the influenza B virus could decimate the human populations that he thinks he rules.
Conclusion: Conserved energy biophysically constrains viral latency.

Ridiculously ignorant objections to my publication in what others claim is a predatory journal can be compared to my objection to publication of this article in PNAS.

Environmental selection during the last ice age on the mother-to-infant transmission of vitamin D and fatty acids through breast milk
1) They linked environmental selection to the frequency of the EDAR V370A variant in the mouse model via positive selection for modulation of thermoregulatory sweating.
2) They linked environmental selection to similarities in human populations in North Asia, East Asia, and the New World. But they virtually ignored the mouse model of food energy-dependent pheromone-controlled biophysically constrained ecological adaptation.
I linked the same food energy-dependent pheromone-controlled base pair change and microRNA-mediated fixation of the same amino acid substitution to all biodiversity in all living genera via feedback loops. See: Feedback loops link odor and pheromone signaling with reproduction

Others see what passes peer-review published in journals that support the expense of efforts made by pseudoscientists and other theorists, but they claim that the OMICS journals are predatory. I claim that pseudoscientists and other theorists do not know the difference between predation and sympatric speciation because they place predation into the context of evolved biodiversity.

For comparison see: Whole-genome sequencing of the blue whale and other rorquals finds signatures for introgressive gene flow

Reported as: Baleen Whale Genomes Point to Evolution With Gene Flow

Large baleen whales in the Balaenopteridae family (commonly known as rorqual whales) have undergone sympatric speciation — speciation without clear geographic barriers between them — despite ongoing hybridization, according to new research from investigators in Sweden and Germany.

System-wide Rewiring Underlies Behavioral Differences in Predatory and Bacterial-Feeding Nematodes

Reported as:

“The patterns of synaptic connections perfectly mirror the fundamental differences in the feeding behaviours of P. pacificus and C. elegans”, Ralf Sommer concludes. A clear-cut result like that was not what he had necessarily expected.

Neo-Darwinian theorists and other biologically uniformed pseudoscientists have failed to use any common sense in attempts to link what organisms eat from the physiology of reproduction to biophysically constrained biodiversity.  For comparison, serious scientists have forced the denuclearization of North Korea by reminding others to start with what is known about how food energy-dependent autophagy protects all life on Earth from the virus-driven degradation of messenger RNA.

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

…as a reviewer, it is tiresome to raise the same objections repeatedly, wondering why researchers have not fulfilled some of the basic requirements for establishing the occurrence of an autophagic process.

 …appropriate assays depend in part on the question being asked and the system being used.

Researchers in South Korea, for example, have reminded the God-less Communist dictator of North Korea that one microRNA-mediated amino acid substitution in the influenza B virus could decimate the human populations that he thinks he rules.

See: A Single Amino Acid at the Polymerase Acidic Protein Determines the Pathogenicity of Influenza B Viruses

Caption: Contemporary analyses of cell metabolism have called out three metabolites: ATP, NADH, and acetyl-CoA, as sentinel molecules whose accumulation represent much of the purpose of the catabolic arms of metabolism and then drive many anabolic pathways. Such analyses largely leave out how and why ATP, NADH, and acetyl-CoA (Figure 1) at the molecular level play such central roles. Yet, without those insights into why cells accumulate them and how the enabling properties of these key metabolites power much of cell metabolism, the underlying molecular logic remains mysterious. Four other metabolites, S-adenosylmethionine, carbamoyl phosphate, UDP-glucose, and Δ2-isopentenyl-PP play similar roles in using group transfer chemistry to drive otherwise unfavorable biosynthetic equilibria. This review provides the underlying chemical logic to remind how these seven key molecules function as mobile packets of cellular currencies for phosphoryl transfers (ATP), acyl transfers (acetyl-CoA, carbamoyl-P), methyl transfers (SAM), prenyl transfers (IPP), glucosyl transfers (UDP-glucose), and electron and ADP-ribosyl transfers (NAD(P)H/NAD(P)+) to drive metabolic transformations in and across most primary pathways. The eighth key metabolite is molecular oxygen (O2), thermodynamically activated for reduction by one electron path, leaving it kinetically stable to the vast majority of organic cellular metabolites

EDAR V370A and sympatric speciation

Nick Lane and others like him refuse to reappraise their human mitochondrial DNA recombination dogma. All serious scientists know where the energy for recombination comes from. But, in his latest video clip, he touts the same unsubstantiated theoretical pseudoscientific nonsense.

See the: Aeon Video:

Life on earth – from mushrooms to humans and everything in between – seems enormously diverse. At the cellular level, however, almost all complex lifeforms are surprisingly similar. Why life is this way, though, remains mysterious. In this Aeon interview, the UK biochemist and author Nick Lane discusses his research on the connection between energy and genes, which, he hypothesises, made possible the radical transformation from single-celled organisms to complex life about 4 billion years ago.

See for comparison: Reappraising the human mitochondrial DNA recombination dogma

I’ve asked the authors: Are you prepared to address the comments that you might receive from people like Nick Lane in the context of “peer review?” How will you respond to those who do not accept the fact that the creation of ATP synthase and the creation of ATP must be linked to the creation of RNA and biophysically constrained viral latency in the context of SNPs and fixation of amino acid substitutions? What can be done when biologically uninformed theorists continue to link anything except biophysically constrained viral latency to all biodiversity?

I ask because there are still too many examples of human idiocy that are being considered outside the context of facts about energy-dependent RNA-mediated cell type differentiation.

See: Modeling Recent Human Evolution in Mice by Expression of a Selected EDAR Variant

See the claims about the selection of the EDAR variant placed back into the context of evolution.

Field-deployable viral diagnostics using CRISPR-Cas13

…we report the rapid (<1 week) design and testing of instrument-free assays to detect clinically relevant viral single-nucleotide polymorphisms.

The relevant energy-dependent single-nucleotide polymorphisms clearly protect all living genera from the clinically relevant viral single-nucleotide polymorphisms. The viral single-nucleotide polymorphisms link the virus-driven degradation of messenger RNA to all pathology via what is known to all serious scientists about the energy-dependent creation of the innate immune system in species from bacteria to humans.

Environmental selection during the last ice age on the mother-to-infant transmission of vitamin D and fatty acids through breast milk

The frequency of the human-specific EDAR V370A allele appears to be uniquely elevated in North and East Asian and New World populations due to a bout of positive selection likely to have occurred circa 20,000 y ago.

If any experimental evidence of biophysically constrained viral latency supported the claim about positive selection 20,000 y ago, it could be linked to Nick Lane’s claims about how chimeras and electricity allowed a sterile planet to give way to complex life 4 billion years ago. Since there is no experimental evidence to support his ridiculous theories, intelligent people may want to continue to link environmental selection from food selection to the physiology of reproduction and fixation of RNA-mediated amino acid substitutions such as V370A that stabilize the organized genomes of all species on Earth.

Watering Young Plant - Vintage Effect

Environmental selection is natural selection (5)

Summary: Atheistic Chinese Communists realize that vaccinations cannot protect them. Their attempts to develop a universal vaccine have failed. Bill Gates promotes vaccinations, which led us to the brink of the next pandemic.

Vaccines prevent ecological adaptations in some cell types. Does Bill Gates, a non-scientist, think that people from God-fearing non-communist countries can do better than the atheistic Communists?

Bill Gates calls on U.S. to lead fight against a pandemic that could kill 33 million

Gates and his wife, Melinda, have repeatedly warned that a pandemic is the greatest immediate threat to humanity. Experts say the risk is high, because new pathogens are constantly emerging and the world is so interconnected.

New pathogens do not emerge. Read Quantico. The viruses that cause all pathology ecologically adapt by stealing the quantized energy that all differentiated cell types need to survive.

Bill Gates thinks a coming disease could kill 30 million people within 6 months — and says we should prepare for it as we do for war

If you were to tell the world’s governments that weapons that could kill 30 million people were under construction right now, there’d be a sense of urgency about preparing for the threat, Gates said.

The one time the military tried a sort of simulated war game against a smallpox pandemic, the final score was “smallpox one, humanity zero,” Gates said.

See also: Nov 17, 2016 Obama Advisers Urge Action Against CRISPR Bioterror Threat

…a strategy was developed in 2009, but it’s carried out by several government agencies in an uncoördinated approach…

Bill Gates has been promoting vaccinations as a strategy. The vaccinations led us to the brink of the pandemic. Vaccines prevent ecological adaptations in some cell types. The atheistic Chinese Communists now realize that vaccinations cannot protect them. Their attempts to develop a universal vaccine have failed, miserably. Does Bill Gates, a non-scientist, think that people from non-communist countries can do better than the atheistic Communists?
Perhaps he doesn’t know how South Korea forced the denuclearization of North Korea, which will probably lead to proclamations of world peace.
See: Engineered virus has artificial amino acid allowing it to serve as a vaccine (2016)

A team of researchers at Peking University has developed a new type of vaccine that they claim may allow for a new approach to generating live virus vaccines which could conceivably be adapted to any type of virus.

Their “new approach” failed. The uncoordinated strategy against the CRISPR bioterror threat has failed to address the established scientific facts. All ecological adaptations are quantized energy-dependent and biophysically constrained by the physiology of pheromone-controlled reproduction in species from microbes to humans. That fact is presented in the context of the Holy Bible, which explains why scientific creationists from South Korea were able to force denuclearization on atheistic communists.
Now Gates accuses the US Government (the Trump Administration?) of failing to protect US citizens.
On April 26, 2018, I discussed factual representations of biologically-based cause and effect that probably led to the death of Timothy J. Cunningham. I told a friend that Cunningham’s publication record clearly reveals his ability to link viruses to the failed differentiation of all cell types in all living genera.
See his publications on

1)”Racial Disparities in Age-Specific Mortality”
2) “Sex-specific relationships between adverse childhood experiences”
3) “Associations between antioxidants and all-cause mortality”
and
4) “Health and Safety Issues for Travelers”

What Bill Gates Fears Most may be the revelations of facts about vaccines. Gates seems to be still promoting the live (or dead) virus-containing vaccines that have failed to protect anyone since the time they were supposed to start protecting us all.
Is he aware that An error made in 1925 led to a crisis in modern science?
The error replaced the creation of energy with models of statistical significance as if the answer to the question “What is Life?” was akin to computers that automagically emerged with the energy to run themselves.
See also: Arrowsmith (1925). If Bill Gates had studied US history, he might have learned that the 1925 Scopes Trial in Dayton, Tennessee predicted that teaching neo-Darwinian evolution would cause the next pandemic.
Instead see: Gates Foundation launches $12M Grand Challenge for universal flu vaccine, as Bill Gates urges world to prepare for war on pandemics
When Europeans “invaded” the Americas, indigenous human populations were decimated by the virus-driven degradation of their messenger RNA. Few American Indians had the amino acid substitution that protected them from the virus-driven pathology manifested in the deep sea. The virus-driven pathology has been linked to all physical and mental diseases/disorders on Earth via the 1918 Spanish influenza pandemic.
For comparison, everything known to all serious scientists about quantized energy-dependent RNA-mediated cell type differentiation has been linked to biophysically constrained viral latency.
See: Virus-mediated archaeal hecatomb in the deep seafloor and Cytosis.
See for comparison: Environmental selection during the last ice age on the mother-to-infant transmission of vitamin D and fatty acids through breast milk
The V370A adaptation came from populations in what is now Central China, but dietary changes eliminated the need for the adaptation in the Americas, where indigenous populations had adapted to other viruses. When Europeans introduced the viruses to indigenous populations on other continents, the 6,000 year history of ecological adaptations in species from mice to humans became clear.
See: Modeling Recent Human Evolution in Mice by Expression of a Selected EDAR Variant
The EDAR variant is V370A, which is also known as The ectodysplasin receptor variant (EDARV370A) and as rs3827760, which is also known as 1540T/C, 370A or Val370Ala. It is a SNP in the ectodysplasin A receptor EDAR gene on chromosome 2. The fact that one food energy-dependent variant in one SNP was linked from the creation of a receptor to biophysically constrained RNA-mediated cell type differentiation in species from mice to humans proved that environmental selection links quantized energy-dependent changes in the microRNA/messenger RNA balance from the creation of sunlight to viral latency in all living genera.
See for comparison: Here Are Michelle Wolf’s Boldest Moments At The White House Correspondents’ Dinner
See also the bold moves made by scientific creationists in South Korea, who forced the denuclearization of North Korea (in the same week as the “dinner”) with prior publication of two articles that link viruses to the decimation of populations of atheistic Communists.
Whether or not the US, and/or if South Korea invades, they could decimate the populations of atheists without firing more than one shot to deliver a payload of virus-modified yeasts. The lives of well-nourished troops could be saved for the take-over/occupation.
See:
1) A Single Amino Acid at the Polymerase Acidic Protein Determines the Pathogenicity of Influenza B Viruses 4/13/18

Several amino acid mutations were identified in PB2, PB1, PA, BM2, and/or NS1 protein coding regions, and one concurrent lysine (K)-to-arginine (R) mutation in PA residue 338 (PA K338R) was found in both maVc_BR60 and maYm_WI01 viruses.

2) Emergence of Human G2P[4] Rotaviruses in the Post-vaccination Era in South Korea: Footprints of Multiple Interspecies Re-assortment Events 4/18/18

…17-24 amino acid changes, specifically A87T, D96N, S213D, and S242N substitutions in G2 epitopes, were observed.

See also: South Korea: Kim Seeks U.S. Guarantee Against Invasion

If the only thing atheistic Communists want is to not be invaded, they probably know that vaccines and nuclear weapons cannot protect them from the decimation that could be caused by a single amino acid substitution in a virus.

Why tempt our Creator to show them the error of their ways, when atheistic Communists do not believe in Him? Ask also, “Who killed Timothy J. Cunningham?” — and/or anyone else who is killed or goes missing during the transition to Global Peace.
See also:  [evol-psych] Sorry but Yahoo! groups have blocked all my news items — Robert Karl Stonjek 4/30/18
Wait for this to happen with the Human Ethology Yahoo group, where you can still find the atheistic pseudoscientific nonsense touted by the moderator, Jay R. Feierman.
See for example:
Variation is not nutrient availability and the something that is doing the selecting is not the individual organism. A feature of an educated person is to realize what they do not know. Sadly, you don’t know that you have an incorrect understanding [of] Darwinian biological evolution.
See also: I am absolutely certain that if you showed this statement to any professor of biology or genetics in any accredited university anywhere in the world that 100% of them would say that “Random mutations are the substrate upon which directional natural selection acts” is a correct and true statement.
See for comparison: Tracking niche variation over millennial timescales in sympatric killer whale lineages

  1. Ecological variation is the raw material by which natural selection can drive evolutionary divergence [1–4].
  2. The differences in amino acid composition among different tissues can lead to large differences in trophic discrimination [38].

Many evolutionary theorists and Big Bang cosmologists are among the hate-mongers who would rather combat Christianity than make any efforts towards Combating Evolution to Fight Disease.

(E) KEGG analysis of the common up- and downregulated mRNAs in NDV infection. The left panel shows the KEGG enrichment analysis of each of the top 20 significant differences in the upregulated mRNAs, and the right panel shows the KEGG enrichment analysis of each of the top 20 significant differences in the downregulated mRNAs.

The eternal significance of microRNAs (6)

Accurate representations of how mutations are linked to the ecological adaptations in viruses that kill us are required to end the stranglehold that pseudoscientists have held on medical research. The pseudoscientists and other theorists make claims about mutation-driven evolution or natural selection and evolution as if the effect of virus-driven energy theft was beneficial to species that have somehow evolved from other species.
Neo-Darwinian theories will cause the death of us all. But first they will kill all the chickens.
Common microRNA-mRNA Interactions in Different Newcastle Disease Virus-Infected Chicken Embryonic Visceral Tissues
figure 3 E (above) includes biosynthesis of amino acids but a word search for “amino acid” turns up nothing.

(E) KEGG analysis of the common up- and downregulated mRNAs in NDV infection. The left panel shows the KEGG enrichment analysis of each of the top 20 significant differences in the upregulated mRNAs, and the right panel shows the KEGG enrichment analysis of each of the top 20 significant differences in the downregulated mRNAs.

The pathways for the biosynthesis of amino acids link microRNA biogenesis from energy-dependent changes in base pairs to amino acid substitutions that stabilize or destabilize the organized genomes in the context of everything that could be learned by playing the cell biology game “Cytosis.”
Ages 10+ can learn how to protect all organized genomes from viruses in the context of the food energy-dependent pheromone-controlled physiology of reproduction of humans, which biophysically constrains viral latency in species from microbes to humans.
One base pair change and one amino acid substitution (e.g., EDAR V370A) in a human host may be all that’s required to protect the organized genome from the virus-driven degradation of mRNA that has been linked to all pathology.
That means the virus-driven theft of quantized energy may link the change in the base pair to an amino acid substitution in the virus that stabilizes the virus. The 1918 Spanish flu was one example of what happens next. But no one knew why it happened until more recently.
See:  Substitutions Near the Receptor Binding Site Determine Major Antigenic Change During Influenza Virus Evolution (2013)

Koel et al. (p. 976) show that major antigenic change can be caused by single amino acid substitutions.

See also: A Single Amino Acid at the Polymerase Acidic Protein Determines the Pathogenicity of Influenza B Viruses (2018)

…the PA K338R mutation may be a molecular determinant of IBV pathogenicity via modulating the viral polymerase function of IBVs.

Accurate representations of how mutations are linked to ecological adaptations in viruses are required to end the stranglehold that pseudoscientists have held on medical research. The pseudoscientists and other theorists make claims about mutation-driven evolution or natural selection and evolution as if the effect of virus-driven energy theft was beneficial to species that have somehow evolved from other species.
The most recent example of that nonsense may be the focus of several blog posts here.
See:  Environmental selection during the last ice age on the mother-to-infant transmission of vitamin D and fatty acids through breast milk

…we investigate whether the population occupying Beringia during the LGM represents another example of human adaptation to an extreme environment, this time adapting to very low UV exposure (Fig. 1). There are two lines of genetic evidence for this: variation in the fatty acid desaturase (FADS) gene cluster that modulates the manufacture of polyunsaturated fatty acids and variation in the ectodysplasin A receptor (EDAR) gene that influences ectodermally derived structures, such as teeth, hair, and mammary gland ductal branching. A study on selection on the FADS gene cluster in the ancestral population of Native Americans has been published previously (13), but, here, we shift the emphasis from phenotypic effects on older adults to focus on those that influence fertility via breast milk.

They link the food energy-dependent creation of microRNAs in all mammals from the physiology of reproduction to biophysically constrained viral latency via one base pair change an a single amino acid substitution, EDAR V370A. They refuse to acknowledge the facts that link the creation of the sun’s anti-entropic virucidal energy from the creation of microRNAs to viral latency in the mouse-to-human model, and fail to link what is known about what animals eat from the physiology of reproduction to the transgenerational epigenetic inheritance of healthy longevity and fertility.
See: The Bull Sperm MicroRNAome and the Effect of Fescue Toxicosis on Sperm MicroRNA Expression (2014)

The potential for sperm miRNA affecting zygote development has recently been reported in the literature [18] and has interesting implications for the use of sperm miRNA profiles as indicators of potential male fertility.

See also: Codon identity regulates mRNA stability and translation efficiency during the maternal-to-zygotic transition (2016)

The amino acid optimality code (Fig 6) provides an alternative perspective on sequence changes between paralogs in evolution and human disease.

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The chicken-livered (timid; fearful; cowardly) theorists who refuse to admit that their ridiculous theories have led to the unnecessary suffering and premature death of millions to billions of people and other mammals, have brought us all to the brink of extinction.
Does any intelligent person think that humans will evolve another protective variant allele like the EDAR V370A variant before humanity — as we know it know – ceases to exist?
Environmental selection during the last ice age on the mother-to-infant transmission of vitamin D and fatty acids through breast milk

The frequency of the human-specific EDAR V370A allele appears to be uniquely elevated in North and East Asian and New World populations due to a bout of positive selection likely to have occurred circa 20,000 y ago.

 
 
 
 
 
 

Plenty of Room at the Bottom

Environmental selection is natural selection (2)

I believe that if you put enough biologically uniformed theorists in the same room, they will invent more theories to support the pseudoscientific nonsense they have touted in the past. See for example:

Environmental selection during the last ice age on the mother-to-infant transmission of vitamin D and fatty acids through breast milk

Acknowledgments

The synthesis presented here is a product of the American Association for the Advancement of Science’s 2017 annual meeting, as the ideas came together in the session entitled “Beringia and the Dispersal of Modern Humans to the Americas.”
 

Every aspect of every level of biophysically constrained food energy-dependent biologically-based cause and effect is placed back into the context of a ridiculous theory of human migration and evolution. The theory accurately attests to the link from one food energy-dependent base pair change to biodiversity in human populations via fixation of one amino acid substitution. But then, something goes horribly wrong.

The theory requires the fixation of the amino acid substitution to automagically occur in the context of the sun’s anti-entropic virucidal energy. The theory fails to mention the fact that the physiology of pheromone-controlled reproduction and the microRNA-mediated creation of all cell types in all living genera is required.

See for comparison: Anything published since the time I learned about the importance of microRNAs during the 2012 Society for Neuroscience annual meeting in New Orleans, LA.

From 2000/10/15 to 2012/10/15 microRNA Items: 1 to 20 of 19910

From 2012/10/15 to 2018/04/26 microRNA Items: 1 to 20 of 53458

The number of biologically informed serious scientists who have linked the energy-dependent creation of microRNAs to biophysically constrained viral latency and all biodiversity via the pheromone-controlled physiology of reproduction in bacteria continues to rapidly increase.

This begs the question: When will biologically uninformed science idiots stop attending meetings that facilitate their attempts to invent more ridiculous theories?

An evolutionary theory killer

MicroRNA-mediated denuclearization (6)

Summary: The EDAR V370A isoform links one quantized energy-dependent base pair change from changes in ultraviolet light (UV) exposure to fixation of one amino acid substitution. The substitution differentiates the cell types of mice and humans in the context of a mouse-to-human model of nutritional epigenetics and microRNA-mediated denuclearization in North Korea.

Environmental selection during the last ice age on the mother-to-infant transmission of vitamin D and fatty acids through breast milk

…a genetically isolated population living in this environment during the LGM ∼20,000 y ago experienced selection for polymorphisms in the FADS gene cluster and for EDAR V370A because of the advantage these genetic variants likely confer in transmitting nutrients from mother to infant through breast milk under conditions of extremely low UV.

Nina G. Jablonski (a co-author), is known for her research into the evolution of skin color in humans. Her neo-Darwinian pseudoscientific nonsense is refuted in this representation of natural selection for food energy-dependent codon optimality.
Codon identity regulates mRNA stability and translation efficiency during the maternal-to-zygotic transition

The amino acid optimality code (Fig 6) provides an alternative perspective on sequence changes between paralogs in evolution and human disease.

The food energy-dependent pheromone-controlled amino acid optimality code has been linked to biophysically constrained viral latency in all living genera via the physiology of pheromone-controlled reproduction.
The EDAR V370A isoform links one quantized energy-dependent base pair change from changes in ultraviolet light (UV) exposure to fixation of one amino acid substitution. The substitution differentiates the cell types of mice and humans in the context of a mouse-to-human model of nutritional epigenetics and microRNA-mediated denuclearization in North Korea.

Nutrient-dependent pheromone-controlled ecological adaptations: from atoms to ecosystems

The scientific creationists in South Korea know how to protect organized genomes from the virus-driven degradation of messenger RNA. Atheistic communists believed vaccines would protect their supercoiled DNA in their organized genomes.
The communists and other atheists lost their battle to promote atheism and vaccines because serious scientists in South Korea liked the accurate representations of the creationists. The serious scientists proceeded to support scientific creationism and Americanism with experimental evidence of top-down causation and biophysical constraints.
Pseudoscientists still tout their nonsense about constraint-breaking mutations.  See: Mutation-Driven Evolution
Kalevi Kull: Censorship & Royal Society Evo Event 

Nobody wants to belong to the party of losers. One of the best strategies in such a case is evidently an interpretation of the change as a gradual accumulation of knowledge while their work has always been at the cutting edge. — Kalevi Kull

The links from particle physics to biophysically constrained viral latency will be placed into the context of the game “Subatomic,” which should be available by the end of this year.