5th-6th Sept 2018 Dublin, Ireland

The eternal significance of microRNAs (7)

Sales of human pheromone-enhanced fragrance products have been virtually eliminated by the pseudoscientific nonsense touted by neo-Darwinian theorists and Big Bang cosmologists. I may revisit their ridiculous claims at ScentofEros.com and Pheromones.com, but prefer to continue moving forward via my other domains: RNA-mediated.com and Autophagy.pro.

Summary: 2018 Update: Sympatric speciation has been linked to species diversity as an example of an ecologically validated proof-of-concept in all living genera.

Theorists, other psedoscientists and nearly all so-called science journalists have failed to use common sense in their ridiculous representations.
See for example: Beating the Odds for Lucky Mutations: If DNA repair makes useful mutations more likely, it could accelerate cells’ adaptations to harsh environments (8/16/17) by Jordana Cepelewicz
See: 4/18/18 Nutrient-dependent Pheromone-Controlled Ecological Adaptations: From Angstroms to Ecosystems by James V. Kohl
My model of ecological adaptations was placed into the context of this article in Quanta Magazine by Jordana Cepelewicz — less than one year after she published her article on “lucky mutations” in Aeon.
5/10/18 A Thermodynamic Answer to Why Birds Migrate

…research makes a forceful argument that energy supply and demand is a driving ecological principle shaping the global structure of biodiversity.

See for comparison: 10/12/16 Virus-mediated archaeal hecatomb in the deep seafloor

We show here for the first time the crucial role of viruses in controlling archaeal dynamics and therefore the functioning of deep-sea ecosystems, and suggest that virus-archaea interactions play a central role in global biogeochemical cycles.

Evolutionary theorists and Big Bang cosmologists are forced to plagiarize the intellectual property of others like me and pretend that they are saying something new about the origin of all energy-dependent biophysically constrained biodiversity.
Jordana Cepelewicz is among the most serious offenders. I wonder why she thinks she can get away with directly contradicting the claims she made less than one year ago.
I have neglected some of the domains I established during the past 7 years because it became clear that pseudoscientists were not going to let people know that all aspects of sympatric speciation have been detailed in the context of food energy-dependent pheromone-controlled reproduction, which is required to biophysically constrain viral latency.
That fact was placed into the context of the cell biology game “Cytosis,” which was delivered to backers in October 2017.

A board game taking place inside a human cell! Players compete to build enzymes, hormones and receptors and fend off attacking Viruses!

See also: A transmissible RNA pathway in honey bees (2018)
The authors link my model of food energy-dependent pheromone-controlled biophysically constrained sympatric speciation from atoms to ecosystems in all living genera via my 2013 published review and my unpublished invited review of nutritional epigenetics.

Nutrient-dependent/pheromone-controlled adaptive evolution: a model (2013)

…the epigenetic ‘tweaking’ of the immense gene networks that occurs via exposure to nutrient chemicals and pheromones can now be modeled in the context of the microRNA/messenger RNA balance, receptor-mediated intracellular signaling, and the stochastic gene expression required for nutrient-dependent pheromone-controlled adaptive evolution. The role of the microRNA/messenger RNA balance (Breen, Kemena, Vlasov, Notredame, & Kondrashov, 2012; Duvarci, Nader, & LeDoux, 2008; Griggs et al., 2013; Monahan & Lomvardas, 2012) in adaptive evolution will certainly be discussed in published works that will follow.

For a historical perspective, see: Nutrient-dependent pheromone-controlled ecological adaptations: from atoms to ecosystems (2014 preprint)

Ideas from population genetics, which exclude ecological factors, are integrated with an experimental evidence-based approach that establishes what is currently known. This is known: Olfactory/pheromonal input links food odors and social odors from the epigenetic landscape to the physical landscape of DNA in the organized genomes of species from microbes to man during their development.

The facts about sympatric speciation for comparison to the neo-Darwinian pseudoscientific nonsense about mutation-driven evolution have been placed in to the context of 3 more recently published works.
A 360 degrees view of circular RNAs: From biogenesis to functions (2018)
Circular RNAs: Unexpected outputs of many protein-coding genes (2017)
The Output of Protein-Coding Genes Shifts to Circular RNAs When the Pre-mRNA Processing Machinery Is Limiting (2017)
It is no longer possible to successfully put the facts about sympatric speciation back into the context of ridiculous theories about the emergence of energy and evolution of all life on Earth. Anyone who returns to the links or to the published works I have posted here, will realize that pseudoscientists and most so-called science journalists know virtually nothing about food energy-dependent RNA-mediated cell type differentiation in any species.

5th-6th Sept 2018 Dublin, Ireland

Let there be anti-entropic virucidal light

Summary: This is a lie!

…theories are too detailed to be included in models that study host-phage interactions in the long term, which hinders our understanding of systems that range from pathogens infecting gut bacteria to marine phage shaping present and future oceans.

Fuelling the future

In his short story ‘Let There Be Light’, the science-fiction author Robert A Heinlein introduced the energy source that would power his Future History series of stories and novels.

In The Darwin Code, Greg Bear helped to explain how he linked biophysically constrained light energy to the creation of a superior human species in “Darwin’s Radio” (1999) and “Darwin’s Children” (2003).
On June 21, 2017, Philip C. Ball ignored the science fiction and all facts that link the quantized energy of sunlight to biophysically constrained viral latency.
See: Quantum common sense

To turn quantum to classical, we don’t need a conscious mind to measure or look; we just need an environment full of stuff. With or without us, the Universe is always looking.

His pseudoscientific nonsense led me to ridicule him on June 24, 2017.
See:

See for comparison: Genesis 1:3

And God said, “Let there be light,” and there was light.

For a historical perspective on the creation of anti-entropic virucidal light see Schrodinger’s claims in “What is LIfe?” (1944),

Indeed, in the case of higher animals we know the kind of orderliness they feed upon well enough, viz. the extremely well-ordered state of matter in more or less complicated organic compounds, which serve them as foodstuffs. After utilizing it they return it in a very much degraded form -not entirely degraded, however, for plants can still make use of it. (These, of course, have their most power supply of ‘negative entropy’ the sunlight.) (pp. 73 and 74)

See for comparison: Ecological and evolutionary consequences of viral plasticity 3/27/18

For bacteriophages, this host-viral performance link has been characterized empirically and with intracellular theories. Such theories are too detailed to be included in models that study host-phage interactions in the long term, which hinders our understanding of systems that range from pathogens infecting gut bacteria to marine phage shaping present and future oceans.

My comment on the preprint:

The “importance of viral plasticity to unravel host-phage interactions” has been modeled in the context of everything known about the creation of anti-entropic virucidal light (e.g., ultraviolet light), and how sunlight is linked from the creation of ATP synthase to the creation of ATP and to the creation of RNA and fixation of RNA-mediated amino acid substitutions that biophysically constrain viral latency in all cell types of all living genera.

A google search for “virus-driven energy theft” would be a good place to start looking for information that you appear to have missed in its entirety.

See also, for example: Virus-mediated archaeal hecatomb in the deep seafloor http://advances.sciencemag.org/content/2/10/e1600492.full

“We show here for the first time the crucial role of viruses in controlling archaeal dynamics and therefore the functioning of deep-sea ecosystems, and suggest that virus-archaea interactions play a central role in global biogeochemical cycles.”

See for comparison: Riding the Evolution Paradigm Shift With Eugene Koonin May 7, 2015

…the new understanding of evolution needs to integrate what we now know about viruses and virus-host interactions which, from my own perspective, has been absolutely one of the key factors of all evolution since the emergence of cells — well, actually even before the emergence of cells.

Israeli Middle Schools School to Include Theory of Evolution

…learning about evolution is not the primary function of the decision, but rather to use it as a building block for students to learn more about their ecology.

To learn more about ecology and dismiss the pseudoscientific nonsense touted by neo-Darwinian theorists and Big Bang cosmologists, see:
Phase Transitions in the Assembly and Function of Human miRISC March 16, 2018

…may explain how miRISC silences mRNAs … and provide[s] experimental evidence that protein-mediated phase separation…

Probably facilitates biophysically constrained RNA-mediated achiral glycine-controlled energy processing in all jawless vertebrates.

Virus-mediated archaeal hecatomb in the deep seafloor

Carl Zimmer refutes theistic evolution (2)

Carl Zimmer refutes theistic evolution (1)
Carl Zimmer recognizes the need for a new definition of what heredity is. But he refuses to tell others what he knows about the role that viruses play in the transgenerational epigenetic inheritance of all pathology.
Examples of inherited pathology typically include his misrepresentations among others who fail to link ecological variation to ecological adaptation in the context of energy-dependent biophysically constrained viral latency.
See: Ancient Viruses Are Buried in Your DNA  by Carl Zimmer
His conclusion:

In other words, early embryos may have come to depend on the tricks viruses use to manipulate them. “We’re exploiting a property that has evolved for the virus’s benefit,” Dr. Katzourakis said.

No experimental evidence of biologically-based cause and effect suggests anything except virus-driven pathology has evolved.
See: Virus-mediated archaeal hecatomb in the deep seafloor

We show here for the first time the crucial role of viruses in controlling archaeal dynamics and therefore the functioning of deep-sea ecosystems, and suggest that virus-archaea interactions play a central role in global biogeochemical cycles.

We estimated that viral infections were responsible for the abatement of 1.0 to 2.2% day−1 (on average 1.6% day−1) of the bacterial abundance and 2.3 to 4.3% day−1 (on average 3.2% day−1) of the archaeal abundance in deep-sea sediments (Fig. 6).

The amount of virus-driven degradation of messenger RNA in archaea is clearly biophysically constrained via the energy-dependent physiology of the pheromone-controlled reproduction in bacteria. Neo-Darwinian theorists and so-called science journalists misrepresent the facts about how the virus-driven theft of quantized energy as information is biophysically constrained.
They trick people into believing that viruses and organisms evolve by failing to to mention that viral replication is not possible outside the context of energy theft from the host. Zimmer, for example, has consistently led others to believe in anything except how viral latency is biophysically constrained by what organisms eat and how metabolism is linked to reproduction.
Others like Zimmer are directly to blame for the level of ignorance reported in the context of this project.
The Global Virome Project

Our ability to mitigate disease emergence is undermined by our poor understanding of the diversity and ecology of viral threats, and of the drivers of their emergence.

The diversity and ecology of viral threats has always been linked to stress-induced changes in endogenous substrates. Light activation of endogenous substrates has been linked from the physiology of pheromone-controlled reproduction to biophysically constrained viral latency and healthy longevity in species from bacteria to humans.
Nutrient-stress and social stress have been linked from the degradation of messenger RNA in bacteria to the creation of archaea and L-forms, in which the membrane required for biophysically constrained viral latency is missing.
Zimmer and many other biologically uninformed journalists ignore this threat: Beware ‘Disease X’: the mystery killer keeping scientists awake at night 
The threat would not exist if de Vries 1902 definition of mutation had not been accepted by people with not enough common sense to know that food energy must be linked to heredity via biophysical constrained viral latency.
See: Polymaths and paradigm shifts: from Asimov to Bear (in prep)