Watering Young Plant - Vintage Effect

A single base change refutes theistic evolution

Everyone who failed to learn how light-activated endogenous substrates biophysically constrain viral latency is playing “catch up” to serious scientists. The serious scientists know how quantized energy-dependent RNA-mediated cell type differentiation occurs in the context of the physiology of reproduction in all living genera. Rather than accept the fact that the innate immune system of bacteria (CRISPR) linked the pheromone-controlled physiology of reproduction from autophagy to biophysically constrained viral latency, theorists decided to waste money on virus-assisted gene-editing attempts to repair virus-damaged DNA.

Mammoth Biosciences launches a CRISPR-powered search engine for disease detection

Jennifer Doudna, George Church and many others still refuse to admit that they have refuted theistic evolution. They are just beginning to accurately portray the how detection of changes in the microRNA/messenger RNA balance links virus-driven energy theft to the degradation of messenger RNA. Clearly, however, they know how the degradation of messenger RNA is linked to all pathology.

Had they followed the works of Christ et al. (2013), The Pharmacology of Regenerative Medicine and Christ et al., (2018) Western Diet Triggers NLRP3-Dependent Innate Immune Reprogramming, they could intelligently interact with those who are scheduled to present during Schrödinger at 75 – The Future of Biology – September 2018.

(Nick Lane excepted.) He appears to be a biologically uninformed theorist who does not realize that Fast food makes the immune system more aggressive in the long term

Unhealthy eating causes some of these normally hidden pieces of DNA to unwind, similar to a loop hanging out of a ball of wool. This area of the genetic material can then be read much easier as long as this temporary unwrapping remains active. Scientists call these phenomena epigenetic changes. “The inflammasome triggers such epigenetic changes,” explains Dr. Latz. “The immune system consequently reacts even to small stimuli with stronger inflammatory responses.”

The immune system reacts to the proliferation of viruses. The viruses cause the inflammation, which has been linked to all pathology in more than 72,500 published works. See microRNA.

See also: Field-deployable viral diagnostics using CRISPR-Cas13

…the Cas13-based SHERLOCK (specific high-sensitivity enzymatic reporter unlocking) platform can detect Zika virus (ZIKV) and dengue virus (DENV) in patient samples at concentrations as low as 1 copy per microliter. We developed HUDSON (heating unextracted diagnostic samples to obliterate nucleases), a protocol that pairs with SHERLOCK for viral detection directly from bodily fluids, enabling instrument-free DENV detection directly from patient samples in <2 hours. We further demonstrate that SHERLOCK can distinguish the four DENV serotypes, as well as region-specific strains of ZIKV from the 2015–2016 pandemic. Finally, we report the rapid (<1 week) design and testing of instrument-free assays to detect clinically relevant viral single-nucleotide polymorphisms.

Pardis C. Sabeti’s group already linked the anti-entropic virucidal energy of sunlight from the creation of enzymes to natural selection for energy-dependent codon optimality via the pheromone-controlled stability of organized genomes in a human population in what is now Central China.
See this report from 2013 on fixation of the EDAR V370A substitution.
Following the footprints of positive selection February 15th, 2013.
For comparison to positive selection for food and fixation of the EDAR V370A amino acid substitution, the pseudoscientific nonsense about evolution touted by Pardis C. Sabeti’s group appears in this YouTube video report: 2 Cell Studies Reveal Genetic Variation Driving Human Evolution
In the mouse model of food energy-dependent pheromone-controlled ecological adaptations, they replaced the valine normally found in mouse EDAR with the alanine that’s under selection in humans. They got mice with thicker hair, changes in mammary tissue, and and increased  number of eccrine sweat glands. Those changes parallel phenotypic changes in humans. The phenotypic changes in humans link the quantized energy-dependent creation of microRNAs to biophysically constrained viral latency in all living genera.
In humans, the changes are linked to visual perception of mass and energy and the perception of physical features that are sexually selected.
See: Olfaction Warps Visual Time Perception
A single base change results in the valine to alanine substitution, which changes the ancient mammalian gene EDAR and the EDAR encoded protein.
That fact was reported in the context of links from subatomic particles and all levels of biophysically constrained viral latency and biological organization in my 2014 invited review of nutritional epigenetics.
See: Nutrient-dependent pheromone-controlled ecological adaptations: from atoms to ecosystems (unpublished)

The ecological adaptations, which appear to be manifested in the human population are detailed in these two reports [162-163]. The ecological adaptations are likely to be nutrient-dependent and pheromone-controlled. If so, ecological variation probably leads to ecological, social, neurogenic, and socio-cognitive niche construction, which is manifested in increasing organismal complexity and species diversity. If not, there may be something as yet unknown about mutations and evolution that makes sense in the light of what is known about nutritional epigenetics and the molecular biology of species from microbes to man

162. Kamberov, Yana G.; Wang, S.; Tan, J.; Gerbault, P.; Wark, A.; Tan, L.; Yang, Y.; Li, S.; Tang, K.; Chen, H., et al., Modeling Recent Human Evolution in Mice by Expression of a Selected EDAR Variant. Cell 2013, 152 (4), 691-702. doi: 10.1016/j.cell.2013.01.016
163. Grossman, Sharon R.; Andersen, Kristian G.; Shlyakhter, I.; Tabrizi, S.; Winnicki, S.; Yen, A.; Park, Daniel J.; Griesemer, D.; Karlsson, Elinor K.; Wong, Sunny H., et al., Identifying Recent Adaptations in Large-Scale Genomic Data. Cell 2013, 152 (4), 703-713. doi: 10.1016/j.cell.2013.01.035
See also:
161. Rosenberg, S. M.; Queitsch, C., Combating Evolution to Fight Disease. Science 2014, 343 (6175), 1088-1089. doi: 10.1126/science.1247472
Kalevi Kull: Censorship & Royal Society Evo Event

Nobody wants to belong to the party of losers. One of the best strategies in such a case is evidently an interpretation of the change as a gradual accumulation of knowledge while their work has always been at the cutting edge. — Kalevi Kull

Serious scientists from South Korea are the winners. Two recent publications forced the denuclearization of North Korea.
Emergence of Human G2P[4] Rotaviruses in the Post-vaccination Era in South Korea: Footprints of Multiple Interspecies Re-assortment Events

Compared to the G2 RotaTeq vaccine strain, 17-24 amino acid changes, specifically A87T, D96N, S213D, and S242N substitutions in G2 epitopes, were observed. These results suggest that multiple interspecies re-assortment events might have contributed to the emergence of G2P[4] rotaviruses in the post-vaccination era in South Korea.

A Single Amino Acid at the Polymerase Acidic Protein Determines the Pathogenicity of Influenza B Viruses

When analyzed using reverse-genetically rescued viruses, it was shown that PA K338R alone could increase the pathogenicity of both IBVs in mice and viral replication property in the respiratory tracts of ferrets. In a subsequent mini-replicon assay, the effect of PA K338R was highlighted by the enhancement of viral polymerase complex activity of both Vc_BR60 and Ym_WI01 viruses. These results suggest that the PA K338R mutation may be a molecular determinant of IBV pathogenicity via modulating the viral polymerase function of IBVs.

Mutations are known to be the molecular determinants of all pathology in species from microbes to humans. See:  Virus-mediated archaeal hecatomb in the deep seafloor
Watch as Hashem Al-Ghaili puts everything known to serious scientists about the virus-mediated archaeal hecatomb back into the context of neo-Darwinian evolution.

See also: Study offers new approach to starve p53 deficient tumors

One major hallmark of cancer cells is their ability to adapt to stressful conditions such as nutrient deprivation. Rapidly growing tumor cells must compete for the ever-diminishing supply of nutrients in the surrounding environment to survive and proliferate. Targeting these adaptive mechanisms represents a promising approach for cancer therapeutics.

It’s a little late to claim that the virus-driven theft of quantized energy is linked from autophagy to adaptations in viruses. All serious scientists know that food energy-dependent pheromone-controlled biophysically constrained autophagy has been linked to viral latency and to ecological adaptations in all living genera. Intelligent people know that viruses have been linked to all pathology.
See also: From Istanbul, Turkey. Respect for all human life has been placed into the context of the energy-dependent de novo creation of microRNAs and the works of an Islamic creationist in Turkey.

Autophagy-Regulating microRNAs and Cancer
Cancer researchers in other countries clearly are approaching the cure for all pathology from a scientific creationist perspective despite being forced to place their claims into the context of evolution to get their works past peer review.
The Trump administration has been working towards world peace with other leaders for more than a year. See for example:
May 3, 2017
LIVE: President Donald J. Trump and Palestinian President Mahmoud Abbas make a joint statement at the White House.
Who does not want World Peace? Why The End of the Korean War Is Bad News for the United States
A rendering of how changes in an electron's motion (bottom view) alter the scattering of light (top view), as measured in a new experiment that scattered more than 500 photons of light from a single electron. Previous experiments had managed to scatter no more than a few photons at a time. Credit: Extreme Light Laboratory|University of Nebraska-Lincoln

Evolutionary congruence (losers) vs ecological adaptation (winners)

This is the first DNA-sequence based phylogeographic assessment of Salvadora in the world. Sequence based phylogeographic assessment of tropical tree species is a relative rarity and in India, such investigations are almost non-existent.

Kalevi Kull: Censorship & Royal Society Evo Event

Nobody wants to belong to the party of losers. One of the best strategies in such a case is evidently an interpretation of the change as a gradual accumulation of knowledge while their work has always been at the cutting edge.

In a rapidly changing world of post-censorship, the losers tout “DNA-sequence based phylogeographic assessment.” All serious scientists have linked energy-dependent RNA-mediated protein folding chemistry from changes in angstroms to ecosystems via supercoiled DNA, which protects all organized genomes from the virus-driven degradation of messenger RNA.

Each time you see a term like evolutionary congruence, ask for a definition that links it to what is currently known to all serious scientists about biophysically constrained energy-dependent RNA-mediated biologically based cause and effect.

You will learn There is no such thing as an evolutionary congruence. Molecular Phylogeography is not examined (e.g., by serious scientists) outside the context of the anti-entropic virucidal energy of the sun.

The virucidal energy links the creation of microRNAs in plants to the food energy-dependent creation of microRNAs in animals and all biophysically constrained biologically-based cause and effect on Earth via the physiology of pheromone-controlled reproduction in bacteria.
See: The phylogenetic utility and functional constraint of microRNA flanking sequences

See also: Cystosis

A board game taking place inside a human cell! Players compete to build enzymes, hormones and receptors and fend off attacking Viruses!

Food energy links the de novo creation of microRNA flanking sequences to the creation of enzymes, hormones and receptors that link ecological variation to ecological adaptation via the physiology of pheromone-controlled reproduction in species from microbes to humans. The pheromone-controlled physiology of reproduction biophysically constrains the transgenerational epigenetic inheritance of virus-driven energy theft, which has been linked from mutations to all pathology –except by Greg Bear, who linked biophysically constrained viral latency to the pheromone-controlled creation of a new human subspecies.

See: The Darwin Code by Greg Bear

Bacteriophages–phages for short–can either kill large numbers of host bacteria, reproducing rapidly, or lie dormant in the bacterial chromosome until the time is right for expression and release. Lytic phages almost invariably kill their hosts. But these latter types–known as lysogenic phages–can actually transport useful genes between hosts, and not just randomly, but in a targeted fashion.

See for comparison: A Crack in Creation review – Jennifer Doudna, Crispr and a great scientific breakthrough

Jennifer Doudna’s work began with organisms even further out on the Palin scale: bacteriophages, tiny viruses that prey on bacteria.

Conclusion: The difference between the works of science fiction novelist Greg Bear, and people like Jennifer Doudna, is clear. Greg Bear’s works (and the works of the late Eshel Ben-Jacob) predicted that, if viral latency was not biophysically constrained, the virus-driven degradation of messenger RNA would be linked to all pathology.
The works of biologically uninformed researchers tout the benefits of the virus-driven degradation of messenger RNA, which is used in their gene-editing technology, as if the concept of gene-editing exemplified a “Crack in Creation.” For comparison, natural selection for energy-dependent codon optimality links the pheromone-controlled physiology of reproduction from energy-dependent changes in chirality to autophagy, which protects all organized genomes from the virus-driven degradation of messenger RNA that Doudna and others have linked to all pathology.
See also: Codon identity regulates mRNA stability and translation efficiency during the maternal-to-zygotic transition

The bias between codons or amino acids, and mRNA expression levels has been previously recognized across species and is thought to result from selection for efficient, accurate translation, and folding of highly expressed genes (Ikemura,
1982; Akashi, 1994; Akashi & Gojobori, 2002; Drummond & Wilke, 2008; Kudla et al, 2009; Novoa & Ribas de Pouplana, 2012). The amino acid optimality code (Fig 6) provides an alternative perspective on sequence changes between paralogs in evolution and human disease.

See also:
The Origin of Information (3) If they do not know where the quantized energy in a hydrogen atom came from, they cannot discuss a Crack in Creation in the context of the virus-driven degradation of messenger RNA that is their key to gene editing.
See also: NgAgo Paper Retracted

[W]hen it comes to biology, answers are often not definitive. And when it comes to replication studies, the one thing we know is that it takes time,” it says. “In the case of NgAgo, the time has come and the data have spoken.

Next we will learn that “Nothing in Biology Makes Sense…” outside the context of food energy-dependent pheromone-controlled RNA-mediated ecological adaptations.


Did “Nature” kill Steve Jobs? (3)

So Many Research Scientists, So Few Openings as Professors


Even someone as brilliant as Emmanuelle Charpentier, who in 2015 became head of the Max Planck Institute for Infection Biology after a momentous discovery in gene editing, spent the previous 25 years moving through nine institutions in five countries.

My comment: Why did she move around so much when in the same year, on 07/02/2015, George Church and colleagues filed a patent application for “RNA-Guided Human Genome Engineering.”

Repetitive elements or endogenous viral elements can be targeted with engineered Cas+gRNA systems in microbes, plants, animals, or human cells to reduce deleterious transposition or to aid in sequencing or other analytic genomic/transcriptomic/proteomic/diagnostic tools (in which nearly identical copies can be problematic).

My comment: I suspect that Emmanuelle Charpentier was forced to move around and that others are now going to link virus-driven energy theft to all pathology and take credit for discoveries people like Emmanuelle Charpentier reported. If successful, those with successfull patent applications typically make the money that goes with the credit for taking others works and hiding information that would help others put an end to virus-driven pathology.

See also:  What does it mean for researchers, journalists and the public when secrecy surrounds science?


…some observers were concerned that the organizers’ decisions – which included seeking industry partners and private funding – were quiet moves towards “privatiz[ing] the current conversation about heritable genetic modification.”

My comment: What does it cost others in terms of their health or their careers when only a few key people control the release of information about how energy-dependent genetic modifications could be used to benefit humanity? If a few key people continue reporting their works in terms used by theorists, such as mutations and evolution, what must serious scientists do to try to stop them?

See for example: RNA sequencing uncovers antisense RNAs and novel small RNAs in Streptococcus pyogenes

My comment: Emmanuelle Charpentier is the senior author. You could ask her about the role RNA-guided genetic engineering plays in microbes for comparison to the role that RNA-mediated genetic engineering plays in humans.

See for example:  The Mechanisms of Virulence Regulation by Small Noncoding RNAs in Low GC Gram-Positive Pathogens


In order for pathogens to successfully infect and colonize a host, strict control of virulence is critical. Recently, a group of noncoding RNAs called small RNAs (sRNAs) has been recognized as an essential factor of virulence control in many pathogens. These bacterial sRNAs have become the most abundant class of post-transcriptional regulators [1].

My comment: Energy-dependent control of cell type differentiation is RNA-mediated. If viral latency is not controlled by nutrient energy-dependent microRNAs, the proliferation of viruses may cause unrepaired DNA damage that can be epigenetically inherited across generations. With Zika virus damage as an example, why have so few serious scientists called attention to the facts about cell type differentiation?

See also: Voices of biotech Published online 10 March 2016

My comment: Both these researchers obviously understand the need to detail how energy-dependent RNA-mediated DNA repair typically prevent virus-driven mutations and pathology. If patents prevent others from using the technology that is available, only the wealthy will benefit from research funded by your tax dollars, which are funneled through the gatekeepers of the evolution industry and, to a lesser extent, the gatekeepers of the big bang cosmology industry.

Jennifer Doudna: Exciting opportunities in genome engineering include curing human genetic disease, creating disease-resistant crops and trees, and developing fungi capable of sustainable chemical production. To advance fundamental knowledge and applications of genome engineering, new technologies for delivering editing molecules into cells and tissues are needed, as well as ways of controlling DNA repair and chemical modification pathways.

Feng Zhang: Being able to modify the genome and to modulate gene expression precisely has enormous potential for advancing our understanding of biology, treatment of diseases and development of important agricultural products. The efficiency of making precise genetic changes needs to be increased. We need to advance our understanding of DNA damage and repair processes and to explore and harness the diversity of DNA-acting molecular mechanisms in nature.

Please revisit: What is life when it is not protected from virus driven entropy Published to YouTube on 30 Mar 2016


The anti-entropic force of virucidal ultraviolet light links guanine–cytosine (G⋅C) Watson–Crick base pairing from hydrogen-atom transfer in DNA base pairs in solution to supercoiled DNA, which protects the organized genomes of all living genera from virus-driven entropy. For example, protection of DNA from permanent UV damage occurs in the context of photosynthesis and nutrient-dependent RNA-directed DNA methylation, which links RNA-mediated amino acid substitutions to DNA repair. In the context of thermodynamic cycles of protein biosynthesis and degradation, DNA repair enables the de novo creation of G protein coupled receptors (GPCRs). Olfactory receptor genes are GPCRs. The de novo creation of olfactory receptor genes links chemotaxis and phototaxis from foraging behavior to social behavior in species from microbes to humans. Foraging behavior links ecological variation to ecological adaptation in the context of this atoms to ecosystems model of biophysically constrained energy-dependent RNA-mediated protein folding chemistry. Protein folding chemistry links nutrient-dependent microRNAs from microRNA flanking sequences to energy transfer and cell type differentiation in the context of adhesion proteins, and supercoiled DNA that protects all organized genomes from virus-driven entropy.

My presentation placed the invention of neo-Darwinian theory into its proper context.

See Schrodinger (1944)

“…about forty years ago the Dutchman de Vries discovered that in the offspring even of thoroughly pure-bred stocks, a very small number of individuals, say two or three in tens of thousands, turn up with small but ‘jump-like’ changes, the expression ‘jump-like’ not meaning that the change is so very considerable, but that there is a discontinuity inasmuch as there are no intermediate forms between the unchanged and the few changed. De Vries called that a mutation. The significant fact is the discontinuity. It reminds a physicist of quantum theory -no intermediate energies occurring between two neighbouring energy levels. He would be inclined to call de Vries’s mutation theory, figuratively, the quantum theory of biology. We shall see later that this is much more than figurative. The mutations are actually due to quantum jumps in the gene molecule. But quantum theory was but two years old when de Vries first published his discovery, in 1902. Small wonder that it took another generation to discover the intimate connection! (page 33-34).”

Excerpt from the forward to the reprint:

How often do we still hear that quantum effects can have little relevance in the study of biology, or even that we eat food in order to gain energy? — Roger Penrose
My comment: De Vries called the energy-dependent changes “mutations” and neo-Darwinists assumed that the changes could be linked to the evolution of one species from another. Only recently have serious scientists tried to force the biologically uninformed theorists to acknowledge that virus-driven energy theft prevents beneficial mutations from being considered in the context of all the links from angstroms to ecosystems that must be considered in the context of ecological variation.

When Roger Penrose asks about the quantum effects of food energy, he presents a direct challenge to people like George FR Ellis who ignore the facts about food energy and the facts about virus-driven energy theft, and the fact that the physiology of reproduction links top-down causation from angstroms to ecosystems in all living genera.

See my review: Energy vs virus-driven energy theft must be considered in the context of adaptive changes in the brain, June 12, 2016

My comment: Energy-dependent changes in cell types and in all tissues of all individuals of all living genera have been considered by serious scientists, but ignored by pseudoscientists and other theorists, who simply put have killed people like Steve Jobs with their ignorance.

Pancreatic cancer ‘breakthrough’ hailed

This was reported as if it was a “medical miracle.”


…treatment options for someone with pancreatic cancer are “limited”, with the surgical removal of tumors possible in less than one fifth of patients. Apple co-founder and former CEO Steve Jobs died of the disease in 2011.

My comment: The facts about RNA-mediated protein folding chemistry and biophysically constrained cell type differentiation that link the innate immune system to supercoiled DNA via the physiology of reproduction have been known for at least two decades. Virus-driven energy theft has been linked to all pathology for more than three decades. Medical miracles should be linked to those who survived the past few decades of ignorance that clearly should have linked energy to RNA-mediated gene duplication.

See for example: RNA-mediated gene duplication: the rat preproinsulin I gene is a functional retroposon (1985)

For comparison, see: RNA-Mediated Gene Duplication and Retroposons: Retrogenes, LINEs, SINEs, and Sequence Specificity (2013)

See also: RNA-mediated gene duplication, fixation, and ecological adaptation (2015)

See also: JBC Thematic Minireview Series RNA-mediated Regulation and Noncoding RNAs (2007)

Excerpt with my emphasis on their emphasis:

Ten research articles in the collection cover topics ranging from mechanisms of post-transcriptional gene regulation by microRNAs to activation of the RNA-dependent protein kinase, PKR, by double-stranded viral RNA in a process critical to the innate immune response. Additional results of recent investigations of microRNA biogenesis and mechanism of action are distilled in a minireview with a specific emphasis on the roles of microRNAs in viral infection and oncogenesis.

For specific information on the role of microRNAs in different types of pancreatic cancers, see: microRNA “pancreatic cancer”

My comment: Many researchers have failed to link any of the biomarkers from pathology in neuroscience to the pathology of cancer.

See for example: Neurons Form Synapse Clusters


“The existence of these clusters suggests that the synapses interact with each other to control the strength of the combined signal,” explains Onur Gökçe, author of the study. This is the first anatomical explanation for the disproportionate strength of clustered synapse signals in comparison to the individual signals – a finding known from activity measurements.

My comment: It is not the first anatomical explanation. It links energy-dependent changes in morphological and behavioral phentotypes to RNA-mediated cell type differentiation in every neuronal system that is linked via feedback loops to the gonadotropin releasing hormone neuronal system of all vertebrates. We did that in our 1996 Hormones and Behavior review: From Fertilization to Adult Sexual Behavior. See our section on molecular epigenetics.

The existence of these “clusters” also links virus-driven energy theft to all pathology. That fact refutes every claim made by neo-Darwinian theorists who are still trying to convince you that they correctly linked mutations from natural selection to increasing organismal complexity in species from microbes to humans.  Mutations in the “clusters” link energy-dependent changes from hydrogen-atom transfer in DNA base pairs in solution to RNA-mediated cell type differentiation in all living genera. All serious scientists know that, especially those who have linked angstroms to ecosystems via energy-dependent changes in the immune system, which are clearly linked to supercoiled DNA. The supercoiled DNA links RNA-mediated cell type differentiation to all morphological and behavioral phenotypes via the physiology of reproduction. It’s time to look at the facts from the perspective of ethics and the suffering and death caused by researchers who are willing to delay reporting results that clearly link virus-driven energy theft to all pathology. They are waiting to cash in.
I reiterate: What does it mean for researchers, journalists and the public when secrecy surrounds science?


The global market for synthetic DNA is estimated at nearly US$1 billion annually, and does not typically draw much ethical scrutiny. Indeed, both Drs. Church and Endy are co-founders of a DNA synthesis company called Gen9. 

See also: Get Well in the RNAi Way-RNAi, A Billion Dollar Baby in Therapy
George Church and others appear to be waiting to deliver their billion dollar baby until their patent is granted. However, there is still time for others to force them to disclose the basis for their patent application and also admit that the information on RNA-mediated cause and effect has been known to many others for at least two decades.
Unfortunately, the devil is in the details of what is known.
For example: The miRacle in Pancreatic Cancer by miRNAs: Tiny Angels or Devils in Disease Progression

…it is important to identify biomarkers that can detect early stages of this devastating disease with high sensitivity and specificity. Among these biomarkers, microRNAs (miRNAs) have supplied a profitable recourse and become an attractive focus of research.

My comment: If you still cannot find how “devil” is linked from virus-driven energy theft to all pathology, it is probably because you were not taught where to look. If you were taught to link mutations and natural selection to the evolution of increasing organismal complexity, you never learned about the difference between energy-dependent healthy longevity and virus-driven pathology during life history transitions that link biophysically constrained protein folding to the physiology of reproduction and all biodiversity in species from microbes to humans.
See also: Is Schizophrenia a Disorder of the Immune System?

They conclude that schizophrenia does not appear to be an autoimmune disease and that the illness could be caused by environmental risk factors which activate the immune response, like infections or stress, although further research is needed.

My comment: Further research is always needed, but not to link nutrient-stress and/or social stress to pathology via changes in pH in specific tissues of organs, like the liver, pancreas, or brain. The stress-induced changes in pH have been linked to all pathology via the immune system and energy-dependent histones that are called oncohistones in what appears to be an attempt to confuse people about the role that energy-dependent amino acid substitutions play in healthy longevity. The oncohistones are amino acid substitutions that link virus-driven energy theft to all pathology.  Calling amino acid substitutions “oncohistones” blurs the defined boundaries between epigenetics and genetics at a time when most serious scientists have already realized there is no boundary between epigenetics and genetics. Pseudoscientists took the definition of “mutation” and used it in their assumptions about biologically-based cause and effect, which they thought explained how one species evolved into another species. No experimental evidence of biologically-based cause and effect ever supported their ridiculous claims, so “oncohistones” must link mutations to healthy longevity and to virus-driven pathology in the context of ridiculous theories.
In the context of what is known about biophysically constrained energy-dependent RNA-mediated protein folding chemistry and cell type differentiation a different story has emerged and evolved.
See also: Gen9 Our Founders
Excerpts (with my emphasis):

Joseph Jacobson

He has authored over 70 peer reviewed papers and conference proceedings in the fields of femotosecond lasers, quantum optics, molecular electronics, nano-chemistry and synthetic DNA. In the private sector Joe was co-founder of E Ink, Kovio and Gen9 and was a founding board member of One Laptop Per Child (OLPC).

George Church

Professor of Genetics, Harvard Medical School, Director of the Center for Computational Genetics. 1984 Harvard PhD included the first direct genomic sequencing method, molecular multiplexing tags, which lead to automation & software used at Genome Therapeutics Corp. for the first commercial genome sequence — pathogen, Helicobacter in 1994. This multiplex solid-phase sequencing evolved into polonies (1999), ABI-SOLiD (2005) & open-source Polonator.org (2007). Innovations in DNA reading, writing & allele replacement in cells lead to current research & commercialization in human genomics (Complete Genomics, PersonalGenomes.org, 23andme, Knome), synthetic biology (SynBERC, Joule, LS9) & new ethics/security strategies.

My comment: Femtosecond blasts of ultraviolet light link the sun’s anti-entropic virucidal energy to DNA repair and they link the physiology and reproduction of soil bacteria from the bull sperm microRNAome to microRNAs in breast milk, which protect against further DNA damage from the Zika virus. Helicobacter pylori and other bacteria link virus-driven energy theft in the bacteria to cancer.  By the time human genomics is fully commercialized, the billions of dollar spent on research will be used to line the pockets of those who deliver their billion dollar babies to the people who have not yet suffered and died from virus-driven pathology. Those who remain will receive better treatment, but no one will be told anything more about preventing the virus-driven pathology. Greed is the nature of all human suffering, and it will always link either the angels or the devils from microRNA flanking sequences to RNA-guided human genome editing via what is known about RNA-mediated protein folding chemistry and virus-driven pathology compared to nutrient energy-dependent healthy longevity.
What should serious scientists who want to help people avoid unnecessary suffering and death do? How can they make more people realize that the commercialization in human genomics  synthetic biology and new ethics/security strategies are killing us all?