A rendering of how changes in an electron's motion (bottom view) alter the scattering of light (top view), as measured in a new experiment that scattered more than 500 photons of light from a single electron. Previous experiments had managed to scatter no more than a few photons at a time. Credit: Extreme Light Laboratory|University of Nebraska-Lincoln

Reporting new scientific truths is not allowed in the USA (2)

Summary: Genetic mutations do not drive evolution.  Energy-dependent RNA-mediated fixation of amino acid substitutions links the physiology of reproduction to biophysically constrained viral latency.
With minimal effort, you can peruse the science news each day to see how many pseudoscientists report their findings outside the context of food energy-dependent pheromone-controlled biophysically constrained RNA-mediated cell type differentiation.
See for example:
Type 2 diabetes has hepatic origins

The researchers are now working on identifying the endogenous ligand produced by the body, or on developing molecules that could mimic its function.

Clearly, they are aware of the fact that they must link food energy to the endogenous substrate without claiming that gene activation and the creation of the protein automagically occur.
Diabetes, obesity behind 800,000 cancers worldwide: study

“Our study shows that diabetes—either on its own or combined with being overweight—is responsible for hundreds of thousands of cancer cases each year across the world.”

Who did not know that?
New study finds mycobacteria can sense presence of proteins that cause disease

The transcription factor regulates the levels of the protein cargo transported by the machinery. When the bacteria sense the machinery is absent, the levels of the protein substrates are reduced.

Fat distribution in women and men provides clues to heart attack risk

“We hypothesized that there are gender-based differences in body composition and ectopic fat depots and that these could be associated with gender-specific risk profiles for diseases like diabetes, heart disease and stroke,” said lead author Miriam A. Bredella, M.D., radiologist at Massachusetts General Hospital and associate professor of radiology at Harvard Medical School in Boston.

Sex-differences in cell types link the food energy-dependent pheromone-controlled physiology of reproduction to RNA-mediated cell type stability in all living genera.
Women may be more vulnerable to concussions because of ‘leaner’ nerve fibers

The paper shows us that there is a fundamental, anatomical difference between male and female axons,” Smith said. “In the male axon, there are a great number of microtubules, which make the entire structure stronger, whereas in female axons, it’s more of a leaner type of architecture, so it’s not as strong.

This representation of energy-dependent RNA-mediated cell type differentiation is sexist. If researchers claimed there were racial differences in biophysically constrained cell type differentiation, the claim would be racist.

That’s the problem that all pseudoscientists have with cryo-EM. It makes everything that will be reported in the context of energy-dependent links from electrons to ecosystems appear to be racist in the context of A Civic Biology: Presented in Problems (New York, 1914)

Whole-transcriptome brain expression and exon-usage profiling in major depression and suicide: evidence for altered glial, endothelial and ATPase activity

Exploratory whole-exome analysis revealed higher expression of humanin-like 8 (MTRNR2L8, or HN8) in both suicide and depression (Figure 1, Supplementary Table 2). MTRNR2L8 is an isoform of the humanin gene (HN) (), a newly discovered mitochondrial-derived 24 amino acid peptide (), which is coded by nuclear DNA.

See also:

These effects appear to be driven primarily by depression, with the exception of genes involved in ‘DNA-dependent ATPase activity’, which appear to be greater in suicide but not depression. Results suggest cortical gene expression related to microglial, endothelial and glial cell functions may contribute toward or be altered in MDD and suicide, and identify the putative genes and pathways which may play a functional role in these disorders.

This claim makes it obvious that the researchers do not know the difference between an epigenetic effect on hormones and the affect of hormones on behavior. That explains their failure to link energy-dependent epigenetic effects from ATPase activity to changes in the microRNA/messenger RNA balance. That means they cannot link RNA-mediated differences in the cell types that protect organized genomes from the virus-driven degradation of messenger RNA to mutations and all pathology.

Heat, Hydrogen, and Togas

Ther­mo­to­gae are strict an­aero­bes and gram ne­ga­ti­ve. Their pep­ti­do­gly­can is uni­que in hav­ing as much D-ly­sine as the usu­al L-ly­sine. And, no LPS (or, at least, no LPS-ma­king en­zym­es), de­spi­te be­ing gram-ne­ga­ti­ve.

The stability of all organized genomes is energy-dependent and biophysically constrained by the fixation of amino acid substitutions in organized genomes. The amount of D-ly­sine compared to the amount of L-ly­sine links the dynamic control of chirality to the quantized energy-dependent creation of supercoiled DNA, which protects all organized genomes from the virus-driven degradation of messenger RNA that links mutations to all pathology.

 

The fact that hydrogen-atom transfer in DNA base pairs in solution links quantized energy as information from the creation of sunlight to the quality of RNA, which must be linked to energy-dependent DNA repair, seems to have escaped the attention of theorists.

Chemists reveal one mechanism of dihydrogen production by nitrogenase (with my emphasis)

There are 2 types of hydrogens in the catalytic cofactor (called FeMo-co): one located in a bridging position where it binds to two iron atoms (a bridging hydride), and one on a nearby sulfur atom ligands (basically a protonated sulfur atom: S-H). It turns out that during H2 evolution, the latter is the active partner. The S-H bond breaks and the resulting H+ moves toward the bridging hydride and protonates it forming H2: The calculations provide an explanation of the experimental observation that only one hydrogen is “active,” while the other is a mere spectator waiting for the arrival of its partner.
 

Can anyone help to link the calculations to the evolution of the two types of hydrogens in the context of Feynman’s claims about food energy and human idiocy?

A correspondent wrote:

Interesting chirality issues, however I know of no biological system where light directly changes polymer helicity, and this paper is not a biological system. Vines can change their macroscopic helicity, incredibly, just by single amino acid substitutions in different cytoskeltal monomer proteins.

Thanks. A single amino acid substitution at position 6 of the GnRH decapeptide in all vertebrates links the sense of smell in bacteria to the pheromone-controlled physiology of reproduction and all biophysically constrained biodiversity via achiral glycine. 

See also: Photoinduced charge transfer occurs naturally in DNA
Scientists identify the segmentation and consolidation mechanism of long-term memories

According to the research, published in the scientific journal Current Biology, the brain identifies context changes as “frontiers” in the flow of our experience and uses them to fragment the course of events into small units of memory that can be stored long-term. The study shows that this process takes place during the identification of a boundary event thanks to the rapid reactivation of the flow of information that precedes it.

The flow of information is energy-dependent and serious scientists have link the energy-dependent changes from RNA-methylation to RNA-directed DNA methylation and all biodiversity via the pheromone-controlled physiology of reproduction.
The article does not mention RNA-methylation, which means it is a compilation of pseudoscientific nonsense.
See for comparison: Experience-Dependent Accumulation of N6-Methyladenosine in the Prefrontal Cortex Is Associated with Memory Processes in Mice

The differential effects of m6A may depend on distinct cis-acting elements that are present on the RNA molecule which may interact with m6A, including micro-RNAs (Alarcón et al., 2015; Chen et al., 2015).

When physics gives evolution a leg up by breaking one

Genetic mutation may drive evolution, but not all by itself.

Genetic mutations do not drive evolution.  Energy-dependent RNA-mediated fixation of amino acid substitutions links the physiology of reproduction to biophysically constrained viral latency.
See Schrodinger (1944): and link the anti-entropic virucidal energy of sunlight to all biodiversity via the creation of RNA and the physiology of pheromone-controlled reproduction.

Indeed, in the case of higher animals we know the kind of orderliness they feed upon well enough, viz. the extremely well-ordered state of matter in more or less complicated organic compounds, which serve them as foodstuffs. After utilizing it they return it in a very much degraded form -not entirely degraded, however, for plants can still make use of it. (These, of course, have their most power supply of ‘negative entropy’ the sunlight.)

See the reprint edition with the forward by Roger Penrose.
“How often do we still hear that quantum effects can have little relevance in the study of biology, or even that we eat food in order to gain energy?”(Roger Penrose 8 August 1991)
‘Mind’s eye blink’ proves ‘paying attention’ is not just a figure of speech

Mind’s eye blink is closely related to “attentional blink” that has been studied by Cornelius Vanderbilt Professor of Psychology David Zald and Professor of Psychology René Marois. Attentional blink is a phenomenon that occurs when a person is presented with a rapid series of images. If the spacing between two images is too short, the observer doesn’t detect the second image. In 2005, Zald determined that the time of temporary blindness following violent or erotic images was significantly longer than it is for emotionally neutral images.

Olfaction spontaneously highlights visual saliency map
Fear-related chemosignals modulate recognition of fear in ambiguous facial expressions
Global Sensory Impairment Predicts Morbidity and Mortality in Older U.S. Adults
 

Alternative splicing of pre-mRNA

Light-activated error free DNA repair (2)

Summary: In the diagram and diatribes that accompany claims about de novo changes in electrons and the production of nucleotides, the amount of pseudoscientific nonsense becomes perfectly clear. Pseudoscientists start with energy-dependent changes but call the changes de novo changes in electrons. That allows the pseudoscientists to dismiss any facts about how the creation of energy must be linked to the creation of enzymes. The creation of enzymes does not automagically occur and the creation of all biodiversity must occur via the enzymatic metabolism of food to pheromones and the physiology of pheromone-controlled reproduction. Use of the phrase de novo changes is a clear indicator that pseudoscientists know nothing about biophysically constrained viral latency and nothing about cell type differentiation. All changes are energy-dependent and virus-driven energy theft links the degradation of messenger RNA from mutations to all pathology.
In Light-activated error free DNA repair, I wrote:

The creation of quantized energy in sunlight links energy as information from electrons to ecosystems via the physiology of reproduction in all living genera.

See also: Endogenous adenosine maintains cartilage homeostasis and exogenous adenosine inhibits osteoarthritis progression

We conclude that adenosine, acting at A2AR, is an important homeostatic regulator of chondrocytes and cartilage and adenosine repletion may represent a novel approach to treating OA (Fig. 6).

The link from exogenous adenosine to the endogenous adenosine that inhibits pathology is food energy-dependent and RNA-mediated.That is why adenosine repletion will almost undoubtedly be effective. Some friends have already found that supplements of curcumin and nicotinamide/niacinamide are helpful.
Science needs reason to be trusted to link the creation of visible light to the creation of the nicotinamide-dependent enzyme known as ketoreductase, which can be transformed from a carbonyl reductase into an initiator of radical species and a chiral source of hydrogen atoms.
If hydrogen-atom transfer in DNA base pairs in solution is not linked to healthy longevity, the virus-driven degradation of messenger RNA will not be linked from mutations to all pathology.
See: Accessing non-natural reactivity by irradiating nicotinamide-dependent enzymes with light
The link from the quantized energy of the sun has been placed into this context:

We demonstrate this new reactivity through a highly enantioselective radical dehalogenation of lactones-a challenging transformation for small-molecule catalysts. Mechanistic experiments support the theory that a radical species acts as an intermediate in this reaction, with NADH and NADPH (the reduced forms of nicotinamide adenine nucleotide and nicotinamide adenine dinucleotide phosphate, respectively) serving as both a photoreductant and the source of hydrogen atoms.

The photoreductant source of hydrogen atoms links the quantized energy of sunlight from quantum physics to quantum souls via error-free RNA-mediated DNA repair in the context of the physiology of pheromone-controlled reproduction and the creation of all morphological and behavioral diversity on Earth via what is known about the stability of the gonadotropin releasing hormone (GnRH) decapeptide. The creation of achiral glycine and its position at position 6 in the GnRH decapeptide is linked from food odors and pheromones to the stability of all vertebrate genomes.
See how easily the facts about the stability of supercoiled DNA in the organized genomes of all vertebrates was placed back into the context of evolution.
A quantum theory for the irreplaceable role of docosahexaenoic acid in neural cell signalling throughout evolution
Explanations from classical physics cannot be used to support the theory and nothing but that facts about chemistry links sunlight to the creation of enzymes that metabolize food and link the food energy to biophysically constrained life via the physiology of pheromone-controlled reproduction, which protects organized genomes from the virus-driven degradation of messenger RNA that links mutations to all pathology.

We suggest that DHA is one Darwin’s “Conditions of Existence” [conditions of life] which made DHA the master of DNA

How Popper killed Particle Physics

Even in his worst moments Popper never said a theory is scientific just because it’s falsifiable. That’s Popper upside-down and clearly nonsense. Unfortunately, upside-down Popper now drives theory-development, both in cosmology and in high energy physics.
It’s not hard to come up with theories that are falsifiable but not scientific. By scientific I mean the theory has a reasonable chance of accurately describing nature.

11/20/17
Jay R. Feierman:

Science is about predicting, not post hoc explaining except under the conditions stated above. I still find Popper’s methods useful for crafting theories in the bio-behavioral sciences. I’m not ready to declare his philosophy as dead.

7/25/13
Jay R. Feierman: Variation is not nutrient availability and the something that is doing the selecting is not the individual organism. A feature of an educated person is to realize what they do not know. Sadly, you don’t know that you have an incorrect understanding [of] Darwinian biological evolution.
Popper’s upside-down theory can be replaced in the context of the inside-out olfactory receptor, which links the epigenetic landscape to the physical landscape of DNA via two epigenetic traps
An Epigenetic Signature for Monoallelic Olfactory Receptor Expression
Nuclear Aggregation of Olfactory Receptor Genes Governs Their Monogenic Expression

We’ve got the evolution of complex cells inside-out

Almost everybody agrees that the complex eukaryotic cell evolved from a simple ancestor. The question is how.

All serious scientists know that the energy-dependent creation of ATP (epigenetic trap #1) must be linked from the creation of RNA (epigenetic trap #2) to all biodiversity on Earth via the physiology of pheromone-controlled reproduction in species from microbes to humans. For example, without the energy-dependent de novo creation of G protein-coupled receptors, there is no way to link any light-induced endogenous substrate to the creation of enzymes and the metabolism of food to the energy that sustains life in electron eating microbes and microbes that “eat” light.

 
“…Golden didn’t set out from school intent on pursuing a career in chronobiology. The field only barely existed when she did her graduate work in the 1980s. Her specialty was, and still is, studying bacteria that use light as a source of energy.

See also: Biogenic non-crystalline U(IV) revealed as major component in uranium ore deposits

The fact that bacteria eat electrons and produce uranium isotopes can now be linked from light-harvesting to all pheromone-controlled biophysically constrained biodiversity on Earth by what was known to Susan S. Golden in the 1980s.

Two Questions remain:

1) Where do the electrons come from?

2) Why doesn’t every serious scientist know how to link energy-dependent changes from electrons to ecosystems via the link from ultraviolet light to the vibrational theory of olfaction and RNA-mediated feedback loops that link food odors and pheromones to the physiology of reproduction in species from microbes to humans?

The vibrational theory of olfaction for the win by John Hewitt

On 11/21/17, John Hewitt alerted me to the fact that the information in this article might be linked from the de novo creation of olfactory receptor genes to all biodiversity on Earth via links from the physiology of pheromone-controlled reproduction in bacteria to human adult hippocampal neurogenesis. The monoallelic disease(s) known as Kallmann’s Syndrome clearly link the transgenerational epigenetic inheritance of virus-driven pathology to deficits in olfactory acuity and specificity. The olfactory deficites link interactions among all neuronal systems in the brain to healthy longevity via the substitution of the achiral amino acid glycine in position 6 of the GnRH decapeptide.

See: Long-Range GABAergic Inputs Regulate Neural Stem Cell Quiescence and Control Adult Hippocampal Neurogenesis

Taken together, these findings delineate a GABAergic network involving long-range GABAergic projection neurons and local PV interneurons that couples dynamic brain activity to the neurogenic niche in controlling NSC quiescence and hippocampal neurogenesis.

See for comparison: Guidelines for Genome-Scale Analysis of Biological Rhythms

1) Genome biology approaches have made enormous contributions to our understanding of biological rhythms, particularly in identifying outputs of the clock, including RNAs, proteins, and metabolites, whose abundance oscillates throughout the day.

2) …we discuss several unmet analytical needs, including applications to clinical medicine, and suggest productive avenues to address them.

This suggests they are going to try to make it appear that Schrodinger’s link from the anti-entropic virucidal effects of sunlight has only recently been discovered to be the key to the prevention of the virus-driven degradation of messenger RNA, which all serious scientists know is the link from mutations to all pathology.
SS Golden is the co-author and they propose 3 broadly applicable “golden rules” of light-activated biological rhythms. The “Golden Rules” do not link more than 66,000 published works on microRNAs to Kohl’s “Laws of Biology” in this 2014 invited review of nutritional epigenetics: Nutrient-dependent pheromone-controlled ecological adaptations: from atoms to ecosystems
The Law’s of Biology are Darwin’s “conditions of life.” Simply put, all organisms must eat and the physiology of pheromone-controlled reproduction must be linked to all morphological and behavioral biodiversity on Earth after the creation of light made life possible. Natural selection for anything that was selected after the creation of energy, should not be viewed in the context of explanations of anything else.
Nothing on Earth exists outside the context of biophysically constrained energy and viral latency. Nothing on Earth exists outside the context of energy-dependent natural selection for codon optimality in the context of fixation of RNA-mediated amino acid substitutions, the creation of enzymes and the interactions among complex systems in humans that link achiral glycine in position 6 of the GnRH decapeptide to all morphological and behavioral phenotypes.

See also: An epigenetics gold rush: new controls for gene expression

‘A-to-I editing’ can alter a protein’s coding sequence, and, in humans, is crucial for keeping the innate immune response in check.

See for comparison: Redox-sensitive alteration of replisome architecture safeguards genome integrity

DNA replication requires coordination between replication fork progression and deoxynucleotide triphosphate (dNTP)–generating metabolic pathways

The safeguards are energy-dependent and they have been linked from light-activated endogenous substrates in all cell types to changes in immune system function. That fact is ignored in the context of a “genome survellance mechanism.”

Studying this genome surveillance mechanism in cancer cells with elevated ROS levels and increased replication adaptability may provide opportunities to specifically target tumors.

Reported as: Redox sensing controls DNA replication!

Redox sensing controls DNA replication!

New DNA is generated in human cells from tiny building blocks called nucleotides produced by an enzyme called RNR (ribonucleotide reductase).

By starting with de novo changes in electrons, the diagram that accompanies the pseudoscientific nonsense of their claim makes the nonsense perfectly clear. They intend to leave out anything known to serious scientists who have linked the creation of energy to the creation of enzymes and to the creation of all biodiversity via the metabolism of food to pheromones and the physiology of pheromone-controlled reproduction.
For comparison, serious scientists have linked energy-dependent changes from atoms to ecosystems via the conserved molecular mechanisms of base editing, microRNA editing, and RNA editing as detailed in Light-activated error free DNA repair.
See for examples:
Nutrient-dependent pheromone-controlled ecological adaptations: from atoms to ecosystems
Reduced adenosine-to-inosine miR-455-5p editing promotes melanoma growth and metastasis

…adenosine-to-inosine (A-to-I) RNA editing occurs in microRNAs (miRNAs)…

Thanks to Dr. Phil Mills for bring this to my attention in the context of more than 40 skin cancer excisions I have had during the past few years. RNA editing by ADAR1 leads to context-dependent transcriptome-wide changes in RNA secondary structure

Our findings imply that the editing effect on RNA secondary structure is context dependent and underline the intricate regulatory role of ADAR1 on global RNA secondary structure.

See: Scientists demonstrate the importance of RNA editing in melanoma development

…a lack of RNA editing, a process by which information inside RNA molecules is transformed, leads to tumor growth and progression through manipulation of proteins.

See also: Study: Vitamin B3 might help against skin cancer

…people who took a specific type of vitamin B3 for a year had a 23 percent lower rate of new skin cancers compared to others…

The link from sun exposure to vitamin C production in plants and vitamin D production in human populations that might be protected from skin cancer by niacinamide, led me to become more focused on prevention. For example, a 23 percent lower rate of skin cancers translates to 10 less excision surgeries if I can achieve a better energy-dependent microRNA/messenger RNA balance.
Energy-dependent base editing has been linked to microRNA editing and linked from RNA editing to the fixation of RNA-mediated amino acid substitutions in the organized genomes of all living genera via the pheromone-controlled physiology of reproduction. Any presentation of data that fails to start with energy-dependent changes in the microRNA/messenger RNA balance implies a deliberate attempt to support the pseudoscientific nonsense of evolutionary theorists and/or big bang cosmologists.
It’s time for pseudoscientists to admit they’ve been wrong about mutation-driven evolution and move forward via consideration of experimental evidence.
See also: Systematic characterization of A-to-I RNA editing hotspots in microRNAs across human cancers
MicroRNA-mediated RNA editing links energy-dependent changes in base pairs from the creation of nucleotides to the stability of organized genome in all living genera via the physiology of pheromone-controlled reproduction in species from microbes to humans.  All serious scientists know that. However, the number of pseudoscientists is more than the serious scientists who will be presenting at this conference.
See: Mechanisms of Recombination conference
For comparison, the pseudoscientists have their own conferences. See for a possible example: Neuroimmunology and Neurological disorders
I’ve already asked the conference organizer “Who will be linking the molecular mechanisms of recombination to neuroimmunology via autophagy or help serious scientists to link the virus-driven degradation of messenger RNA to all pathology?” 
I no longer expect any answer to my questions from those who have not linked the creation of quantized energy to all biodiversity via the pheromone-controlled physiology of reproduction in species from microbes to humans.
See instead, more information on: A-to-I RNA editing

Cytosis can be used to teach everything from base editing to RNA editing to everyone over age 10. They will learn how to link the creation of energy to biophysically constrained viral latency via the physiology of pheromone-controlled reproduction.

A null mutation and healthy longevity?

Summary: Food odors and pheromones biophysically constrain all pathology in species from microbes to humans. What kind of biologically uninformed science idiot leaves out everything known to serious scientists about the virus-driven degradation of messenger RNA and tells others they must falsify the neutral null theory that led to claims about a biophysically constrained beneficial “null mutation” in the Amish population of Berne, Indiana?
Glutamylation Regulates Transport, Specializes Function, and Sculpts the Structure of Cilia
Reported as: How to Control Traffic on Cellular Highways

Intracellular and extracellular traffic control

Reported in: How to control traffic on cellular highways http://neurosciencenews.com/enzyme-transportation-7915/

See for comparison: A null mutation in SERPINE1 protects against biological aging in humans
Reported as: Amish gene can make them live 10 years longer and avoid diabetes

A gene variant that arose decades ago in an Amish group…

All gene variants are quantized energy-dependent and the pheromone-controlled physiology of reproduction protects all organized genomes from the virus-driven degradation of messenger RNA. The degradation of messenger RNA links mutations to all pathology. Any claim that “a gene variant arose” is a claim made by a biologically uninformed science idiot. Gene variants in humans are biophysically constrained by the availability of food energy. Other humans may not know that.
Watch and listen to Richard P. Feynman presciently claim that the “null mutation” theory of healthy longevity is an example of “human idiocy.”

Help others to find any experimental evidence that suggests a “null mutation” can be beneficial and/or protect them from biological aging. See for alternative representations of biologically-based facts: Best matches for “null mutation“: and others.
If you cannot find experimental evidence of a beneficial “null mutation” see: Consciousness in the universe: A review of the ‘Orch OR’ theory They inadvertently linked quantum physics from consciousness to quantum souls.
Reported as: Anesthesia Points to Deeper Level ‘Quantum Channels’ as Origins of Consciousness subtitle “Electron resonance pervades the brain”

“Using molecular modeling, the US-Canadian team of Travis Craddock, Stuart Hameroff and Jack Tuszynski had previously shown anesthetic binding in ‘quantum channels’, non-polar arrays of amino acid pi resonance clouds, winding through microtubules.”

See also: The vibrational theory of olfaction for the win

The same kinds of amino acid substitutions that control the separations and interactions of side chains in fluorescent proteins also play an essential role in tuning the proposed mechanism for vibration detection—inelastic electron tunneling. Life literally runs on electron tunneling through the respiratory chain complexes in mitochondria.

For comparison, see the conclusion to: Quantized Energy Links Olfaction from Angstroms to Ecosystems Part 2
Beneficial “null mutations” can now be placed into the context of the creation of a universe that — with or without us — is always watching, like Santa Claus.
For a historical perspective on that pseudoscientific nonsense, see:
Splendor and misery of adaptation, or the importance of neutral null for understanding evolution

To claim adaptation, the neutral null has to be falsified.

A universal trend of amino acid gain and loss in protein evolution

Amino acid composition of proteins varies substantially between taxa and, thus, can evolve.

The entire evolution of the microbial world and the virus world, and the interaction between microbes and viruses and other life forms have been left out of the Modern Synthesis… — Eugene Koonin
What kind of biologically uninformed science idiot leaves out everything known to serious scientists about the virus-driven degradation of messenger RNA and tells others they must falsify the neutral null theory that led to claims about a biophysically constrained beneficial “null mutation” in the Amish population of Berne, Indiana?
Food odors and pheromones biophysically constrain all pathology in species from microbes to humans.
See for comparison: Chemosignals from isolated females have antimutagenic effect in dividing the cells of bone marrow from male mice of the CBA strain

…specific, volatile, and zoosocial important chemosignals are a promising approach both to modeling posttraumatic stress disorders in humans [36] and to searching for mehods of their treatment.

Humans also have various pheromone-induced physiological effects, especially those associated with reproduction [46, 47]. This suggests that the human olfactory system is still an effective pathway for influencing environmental factors on the human nervous
system.

[46] is Kohl, J.V., Atzmueller, M., Fink, B., and Grammer, K., Human pheromones: integrating neuroendocrinology and ethology, Neuroendocrinol. Lett., 2001, vol. 22, pp. 309–321.
See also: Cytogenetic approaches for determining ecological stress in aquatic and terrestrial biosystems

The assessment of genomes’ integrity plays the key role in the studies of mutagenicity in a polluted environment. We present a step-by-step recommendations for the analysis of the cytogenetic data and discuss the prospects of applying genetic tests for ecological monitoring, based on the example of analysis using crustacean species.

I suspect that the manufacturer of my human pheromone-enhanced fragrance products asked to speak with me next week due to the all-to-obvious link from human pheromones to biophysically constrained viral latency and the prevention of all pathology, which was detailed in the context of the creation of sunlight, which was subsequently linked from the creation of ATP to the creation of RNA.
Pheromones and the luteinizing hormone for inducing proliferation of neural stem cells and neurogenesis
The last time I spoke with him, he asked how to monetize the facts. Bergdhal’s pathology may have prompted renewed interest. Attempts to discuss that fact with other veterans have failed. I think that some of them would rather see him crucified rather than link the energy-dependent weekend resurrection of the bacterial flagellum in P. fluorescens to the the energy-dependent Resurrection of Christ.
Bergdhal’s pathology can also be placed into the context of the problematic transitions from adolescence to adulthood that are altered by fixation of one energy-dependent RNA-mediated amino acid substitution.
See: Oppositional COMT Val158Met effects on resting state functional connectivity in adolescents and adults
The A or Met allele is associated with lower enzymatic activity and the polymorphism is associated with many different personality traits. The USAF is leading the way forward towards effective treatment of mental disorders in veterans, which is something the psychiatrists who evaluated Bergdhal know about.  See for instance: US Air Force Studying Impact of Exome Sequencing in Routine Care
 

Cytosis can be used to teach everything from base editing to RNA editing to everyone over age 10. They will learn how to link the creation of energy to biophysically constrained viral latency via the physiology of pheromone-controlled reproduction.

Light-activated error free DNA repair

Summary: The same set of microRNAs controls expression of the genes for rate-limiting enzymes, which control differences in the hormone production of different hormones in insects and crustaceans. That fact led to this claim in: The secret to safe DNA repair.

…if you don’t have this enzyme, then this error-free repair is stopped. You can’t do it. If you can’t do the error-free repair, among other things that happen is that you expect these cells to be cancer prone.

The Secret to Long Life? It May Lurk in the DNA of the Oldest Among Us

If unusual patterns in their three billion pairs of A’s, C’s, G’s and T’s — the nucleobases that make up all genomes — can be shown to have prolonged their lives and protected their health, the logic goes, it is conceivable that a drug or gene therapy could be devised to replicate the effects in the rest of us.

The unusual patterns exist only in the context of error-free RNA-directed DNA repair. DNA repair is linked from the energy-dependent creation of one enzyme and the metabolism of food to species-specific pheromones.
The secret to safe DNA repair.

…if you don’t have this enzyme, then this error-free repair is stopped. You can’t do it. If you can’t do the error-free repair, among other things that happen is that you expect these cells to be cancer prone.

The pheromones control the physiology of reproduction. In the mouse model, pheromones have repeatedly been linked to epigenetic effects on gene regulation.
See: [Pheromonal regulation of genetic processes: research on the house mouse (Mus musculus L.)] 1994

A study of the influence of pheromone stressor(s) on proliferating germ and somatic cells was performed on laboratory lines of house mouse in the context of the physiological hypothesis of mutation process, proposed by M.E. Lobashev in 1947. Data from experiments are presented, and results obtained during last 10-15 years are discussed. The adaptive role of cytogenetic and other observed pheromonal effects is considered. The possible existence of interorganism systems of genetic regulation is discussed, the search for and study of which may help in more complete understanding of the regularities of functioning of genetic material.
 

The virus-driven degradation of messenger RNA has since been linked to all pathology. Food odors and pheromones biophysically constrain the transgenerational epigenetic inheritance of viral latency via the creation of amino acid substitutions that differentiate all the cell types of all individuals of all individuals of all species.
When all serious scientists fully disclose what is known about the biophysically constrained energy-dependent links from 1) base editing and 2) microRNA editing to 3) RNA editing and RNA-mediated DNA repair, pseudoscientists will be put out of the business of drug development. Medical practice will be based on what is known about Precision Medicine, which specifically links the food energy-dependent creation of enzymes to healthy longevity and to the metabolism of the drugs that often do more harm than good.
1)
Base Editing Now Able to Convert Adenine-Thymine to Guanine-Cytosine

“Nature conveniently provides us with cytosine deaminase enzymes that operate on DNA,” Liu tells The Scientist.

The creation of quantized energy in sunlight links energy as information from electrons to ecosystems via the physiology of reproduction in all living genera. The claim that “Nature” provides us with cytosine deaminase enzymes makes it seem that the enzymes emerged and automagically evolved to become purposeful and meaningful in the context of ridiculous theories about mutation-driven evolution.
2)
Conserved microRNA editing in mammalian evolution, development and disease
MicroRNA (miRNA) editing is a site-specific conserved mechanism that links ecological variation to energy-dependent ecological adaptations via the physiology of pheromone-controlled reproduction, which increases the functional diversity of mammalian miRNA transcriptomes. These authors place microRNA editing into the context of an “evolutionarily stable feature” without explaining how the energy-dependent stability was linked to biophysically constrained viral latency.
3)
RNA Editing Possible with CRISPR-Cas13
Serious scientists moved forward by calling pre-mRNAs “microRNAs.” They linked energy-dependent alternative splicings to all biodiversity via fixation of amino acid substitutions in the context of the pheromone-controlled physiology of reproduction. Now, Zhang and others make the claim that’s akin to saying they rediscovered the innate immune system, which biophysically constrains viral latency.
The so-called secret to the three-step recognition of the pattern linked to longevity may be as simple as this: Learn how anything you eat or drink may be beneficial and do not take drugs that will kill you by stealing the quantized energy as information that McEwen et al. (1964) linked the light-activated creation of ATP to the food energy-dependent creation of RNA.
Dependence of RNA synthesis in isolated thymus nuclei on glycolysis, oxidative carbohydrate catabolism and a type of “oxidative phosphorylation”

Isolated thymus nuclei transport amino acids into an intranuclear pool by a process which seems to depend on energy from nuclear ATP synthesis (20).

See also: Dobzhansky (1964): Biology, molecular and organismic

Ingram and others found that hemoglobin S differs from A in the substitution of just a single amino acid, valine in place of glutamic acid in the beta chain of the hemoglobin molecule.

See also: Dobzhansky (1973) Nothing in Biology Makes Any Sense Except in the Light of Evolution

For example, the so-called alpha chains of hemoglobin have identical sequences of amino acids in man and the chimpanzee, but they differ in a single amino acid (out of 141) in the gorilla.

All serious scientists know that the creation of the sun’s anti-entropic virucidal energy must be linked from ecological variation to ecological adaptations, whether or not they refer to light in the context of evolution. Nothing makes sense when theorists fail to link the speed of light on contact with water from the creation of enzymes to the metabolism of food. And nothing else about food energy makes sense when pseudoscientists fail to link it to the physiology of pheromone-controlled reproduction, which biophysically constrains viral latency.
See: The phylogenetic utility and functional constraint of microRNA flanking sequences (2015)
Reported as:‘Junk DNA’ Used To Sort Species and also as: All in the (bigger) family with my comment:

The 2015 Society for Integrative and Comparative Biology (SICB) presenters may not recognize how much progress has been made since the 2013 ecological epigenetics symposium. For example, since then authors claimed “…ctenophore neural systems, and possibly muscle specification, evolved independently from those in other animals.” http://dx.doi.org/10.1038/nature13400
Six months later, other authors traced signaling factors found in vertebrates to the origin of nerve cell centralization via the diffuse nerve net of animals like the sea anemone. http://dx.doi.org/10.1038/ncomms6536 That fact suggests ecological variation is linked to ecological adaptations in morphological and behavioral phenotypes via signaling protein concentrations that differentiate various cell types in body axes and the central nervous system.
Links across species from the epigenetic landscape to the physical landscape of DNA in organized genomes appear to have their origins in the conserved molecular mechanisms of RNA-directed DNA methylation and RNA-mediated protein folding. Two weeks after the publication that refuted ideas about independently evolved neural systems or muscle specification — and perhaps refuted the independent evolution of anything else, SICB presenters linked crustaceans to insects.
Apparently, they’ve learned that the same set of microRNAs controls expression of the genes for rate-limiting enzymes that control the hormone production of different hormones in insects and crustaceans.
Why were they left with any questions about how crustaceans and insects could all be part of one big family? They linked RNA-mediated cell type differentiation to what we described in our section on molecular epigenetics in our 1996 Hormones and Behavior review. From Fertilization to Adult Sexual Behavior

 

Light-induced-conformer-intercoversion-of-hydrogen-bond

Eating electrons and excreting degraded energy

Summary: The tenacity of energy-dependent life extends from quantum physics to quantum souls via what is known about the birds and the bees (and bacteria). Simply put, if they don’t eat, they die.

Neuroscience—and the new weapons of the mind

Dietary modification also shows increasing promise for the exogenous manipulation of neurotransmitter signaling. Recent research into the effects on brain chemistry of the microbiome—the bacterial flora located in the human gut traditionally thought to aid in digestion—shows significant potential for covert alterations of neurotransmission.

Energy-dependent changes in electrons to ecosystems link the covert alterations of neurotransmission to behavior.

See Schrodinger (1944)

Indeed, in the case of higher animals we know the kind of orderliness they feed upon well enough, viz. the extremely well-ordered state of matter in more or less complicated organic compounds, which serve them as foodstuffs. After utilizing it they return it in a very much degraded form -not entirely degraded, however, for plants can still make use of it. (These, of course, have their most power supply of ‘negative entropy’ the sunlight.) (pp. 73 and 74)

If you do not know where nuclear energy comes from or do not know how it got into the mitochondria of every cell of every eukaryote ever created See: Biogenic non-crystalline U(IV) revealed as major component in uranium ore deposits

Reported as:  Biologists discover electric bacteria that eat pure electrons rather than sugar, redefining the tenacity of life

The tenacity of energy-dependent life extends from quantum physics to quantum souls via what is known about the birds and the bees (and bacteria). Simply put, if they don’t eat, they die.  If they eat right, their pheromone-controlled physiology of reproduction can be linked to survival of every species from archaea to humans. In that context, there is no room for any nonsense about mutations and evolution.

See: What We Can Learn From the Quantum Calculations of Birds and Bacteria

…green sulphur bacteria can synthesize sugar from light by biologically controlling quantum mechanical effects at temperatures up to 80 degrees Fahrenheit.

The physiology of pheromone-controlled reproduction biophysically constrains the virus-driven degradation of messenger RNA that links the facts about vibrations and olfaction from quantum physics to all biologically-based biodiversity on Earth.

In his 1944 book, “What is Life?,” Schrödinger focused on how organisms, such as fruit flies, employ quantum mechanical effects to combat entropy by producing order from disorder.
‘Humans have not yet figured out how it is that nature can stabilize a coherent electronic quantum state in such complex systems for such long periods of time.’

Luca Turin figured that out more than 2 decades ago.
See: The vibrational theory of olfaction for the win
The link from bacteria to our visual perception of energy and mass via food odors and pheromones was established earlier this year by Wen Zhou’s group in China.
Olfaction Warps Visual Time Perception
They placed everything known to serious scientists into the context of the space-time continuum and refuted every aspect of neo-Darwinian pseudoscientific nonsense at the same time they refuted every aspect of “Big Bang” cosmology. Serious scientists start with claims about the creation of light.  They link top-down causation to:

 Light-Induced Opening and Closing of the Intramolecular Hydrogen Bond in Glyoxylic Acid

vibrational energy deposited in the system is also transferred via inter- and intramolecular hydrogen bonds

Luca Turin’s group inadvertently linked everything known about quantum physics to quantum souls with facts about vibrational energy that links intermolecular bonds to intramolecular bonds. He placed the facts into the context of what is known about food odors, pheromones, and hydrogen-atom transfer in DNA base pairs in solution, and RNA interference.
RNA interference has since been linked to our receptor-mediated structure and function of supercoiled DNA and to our behavior via inhalation.
Quark Pharmaceuticals, Inc. to Present Preclinical Efficacy Data on Inhaled siRNA Co-Developed with Biocon for Prevention of Primary Graft Dysfunction following Lung Transplantation at the 6th Annual RNAi China Conference

The presentation will summarize the preclinical efficacy data for inhaled small interfering RNA (siRNA) against an undisclosed target gene on preventing primary graft dysfunction and acute rejection in an animal model of lung transplantation.

For example, if you cannot inhale and exhale, your body will reject energy-dependent RNA-mediated life.

A rendering of how changes in an electron's motion (bottom view) alter the scattering of light (top view), as measured in a new experiment that scattered more than 500 photons of light from a single electron. Previous experiments had managed to scatter no more than a few photons at a time. Credit: Extreme Light Laboratory|University of Nebraska-Lincoln

From base editing to RNA editing

Base Editing Now Able to Convert Adenine-Thymine to Guanine-Cytosine

“Nature conveniently provides us with cytosine deaminase enzymes that operate on DNA,” Liu tells The Scientist.

The creation of quantized energy in sunlight links energy as information from electrons to ecosystems via the physiology of reproduction in all living genera. The claim that “Nature” provides us with cytosine deaminase enzymes makes it seem that the enzymes emerged and automagically evolved to become purposeful and meaningful in the context of ridiculous theories about mutation-driven evolution.
See for comparison: All about that base (video parody)
See also: RNA Editing Possible with CRISPR-Cas13

Introducing specific sequence changes into RNA molecules could allow researchers to answer questions about alternative splicing mechanisms, translation, and even editing, he says. “There’s a lot of scope.”

The entirety of that scope was addressed in the context of energy-dependent RNA-mediated cell type differentiation in our section on molecular epigenetics from this 1996 Hormones and Behavior review. From Fertilization to Adult Sexual Behavior
Small intranuclear proteins also participate in generating alternative splicing techniques of pre-mRNA and, by this mechanism, contribute to sexual differentiation in at least two species, Drosophila melanogaster and Caenorhabditis elegans (Adler and Hajduk, 1994; de Bono, Zarkower, and Hodgkin, 1995; Ge, Zuo, and Manley, 1991; Green, 1991; Parkhurst and Meneely, 1994; Wilkins, 1995; Wolfner, 1988). That similar proteins perform functions in humans suggests the possibility that some human sex differences may arise from alternative splicings of otherwise identical genes.
All biophysically constrained RNA-mediated energy-dependent cell type differentiation has since been linked from the pheromone-controlled physiology of reproduction to supercoiled DNA via the fixation of amino acid substitutions and chromosomal rearrangements.
The facts about the amino acid substitutions in the context of transgenerational epigenetic inheritance link electrons to ecosystems via the cryo-EM technology that won the 2017 Nobel Prize in Chemistry.
See: Chemists know (video parody)
See also:

Feedback loops link quantized energy as information to biophysically constrained RNA-mediated protein folding chemistry. Light induced energy-dependent changes link angstroms to ecosystems from classical physics to chemistry/chirality and to molecular epigenetics/autophagy. The National Microbiome Initiative links microbial quorum sensing to the physiology of reproduction via endogenous RNA interference and chromosomal rearrangements. The rearrangements link energy-dependent fixed amino acid substitutions to the Precision Medicine Initiative via genome wide inferences of natural selection. This detailed representation of energy-dependent natural selection for codon optimality links biologically- based cause and effect from G protein-coupled receptors to RNA-mediated amino acid substitutions and the functional structure of supercoiled DNA. Energy-dependent polycombic ecological adaptations are manifested in supercoiled DNA. Chromosomal inheritance links the adaptations from morphological phenotypes to healthy longevity via behavioral phenotypes. For contrast, virus-driven energy theft is the link from messenger RNA degradation to negative supercoiling, constraint breaking mutations, and hecatombic evolution. The viral hecatomb links transgenerational epigenetic inheritance from archaea to Zika virus-damaged DNA, which typically is repaired by endogenous RNA interference and fixation of RNA-mediated amino acid substitutions in organized genomes

For God and Country

Life and death via chemical effects on photosynthesis

Summay: “…chemosignals are a promising approach both to modeling posttraumatic stress disorders in humans [36] and to searching for mehods of their treatment.”
Serious scientists linked the sense of smell in bacteria from the physiology of pheromone-controlled reproduction in all living genera to our visual perception of energy and mass in the context of the space time continuum.
The fact that food odors and pheromones biophysically constrain cell type differentiation in mammals was first placed into the context of [Pheromonal regulation of genetic processes: research on the house mouse (Mus musculus L.)] (1994)


For evidence of the link from the anti-entropic virucidal energy of sunlight to all biodiversity, see also: 1994 Effect of atrazine herbicide on growth, photosynthesis, protein synthesis, and fatty acid composition in the unicellular green alga Chlorella kessleri

Sublethal atrazine concentrations induced a general inhibition on growth, photosynthesis, and dark respiration in the green alga Chlorella kessleri….. Progressive reduction in protein synthesis was associated with increasing herbicide concentration at all experimental periods. The herbicide had preferential effect on the associated fatty acid composition of total and phospholipids. After 24 and 48 hr the herbicide stimulated fatty acids synthesis at concentrations where photosynthesis was inhibited. Meanwhile, stearic and miristic acids disappeared at 15 μM after 24 hr and the total polyunsaturated fatty acids were not affected after 48 hr. Fatty acid synthesis was sensitive to treatment at 72 hr by 5 and 10 μM atrazine, whereas the total saturated fatty acids were completely inhibited.

Sublethal effects of  chemicals on protein biosynthesis and degradation have been linked to all pathology via the virus-driven degradation of messenger RNA, which links changes in the microRNA/messenger RNA balance to mutations and all pathology. For example, this is what must happen to link the sun’s anti-entropic virucidal energy from electrons to ecosystems via the chemistry and physiology of pheromone-controlled reproduction in all living genera.

A dietary difference in nematodes links their chemistry of metabolism from what they eat to the pheromone-controlled physiology of reproduction in C. elegans and the ecological adaptations manifested in P. pacificus, a predatory nematode with teeth.
See other information on biophysically constrained biologically based cause and effect in Nutrient-dependent/pheromone-controlled adaptive evolution: a model.

The epigenetic effects of nutrients on evolved differences in the diet and starch digestion of dogs and wolves (Axelsson et al., ) were detailed at the same time differences in the socialization of these subspecies were attributed to explorations involving only chemosensory input in 3 to 4-week-old wolf pups. For comparison, differences in starch digestion and exploration involving multisensory input in dogs begin a mere 2 weeks later (Lord, ). The differences in nutrient-dependent pheromone-controlled socialization, however, extend across a life-time of more aggressive behavior in wolves that have not been domesticated because less digested starch from their diet genetically predisposes infants to first respond to olfactory/pheromonal cues as they initially explore their postnatal environment.

See also: Dogs Recognize Themselves in Test Based on Smell, Not Sight

But, she said, her test and the mirror tests “all show that there’s this selective sensory investigation of something that comes from yourself, but is changed.”

The link from a light-induced change in an endogenous substrate — that comes from yourself — to the physiology of reproduction is changed by the pheromone-controlled physiology of reproduction, which is linked to all biodiversity.
That fact and facts about intelligence in different species started to become clear when Schrodinger (1944) wrote:

Indeed, in the case of higher animals we know the kind of orderliness they feed upon well enough, viz. the extremely well-ordered state of matter in more or less complicated organic compounds, which serve them as foodstuffs. After utilizing it they return it in a very much degraded form -not entirely degraded, however, for plants can still make use of it. (These, of course, have their most power supply of ‘negative entropy’ the sunlight.) (pp. 73 and 74)

Perfect clarity was achieved among all intelligent serious scientists when McEwen et al, (1964) wrote; Dependence of RNA synthesis in isolated thymus nuclei on glycolysis, oxidative carbohydrate catabolism and a type of “oxidative phosphorylation

The synthesis of RNA in isolated thymus nuclei is ATP dependent.

Nothing in life happens outside the context of the ATP-dependent creation of RNA.
Decades later, Roger Penrose wrote:

“How often do we still hear that quantum effects can have little relevance in the study of biology, or even that we eat food in order to gain energy?” (Roger Penrose 8 August 1991)

See also: Olfaction Warps Visual Time Perception
The authors linked the sense of smell in bacteria from the physiology of pheromone-controlled reproduction in all living genera to our visual perception of energy and mass in the context of the space time continuum.
The fact that food odors and pheromones biophysically constrain cell type differentiation in mammals was first placed into the context of [Pheromonal regulation of genetic processes: research on the house mouse (Mus musculus L.)] (1994) in Russian
Abstract excerpt (in English)

The adaptive role of cytogenetic and other observed pheromonal effects is considered. The possible existence of interorganism systems of genetic regulation is discussed, the search for and study of which may help in more complete understanding of the regularities of functioning of genetic material.

See also: [Cytogenetic effect of volatile components of urine of sexually mature animals on bone marrow cells of young female house mice Mus musculus L] (1996) in Russian

Effects of volatile components of the urine (VCU) of mature male and female CBA/LacStoRap mice on proliferating bone marrow cells in young females of the same line were analyzed.

In 2005,  a 2004 Nobel Laureate and her co-authors caught up to what researchers in Russia had already been claiming for 20 years. See: Feedback loops link odor and pheromone signaling with reproduction
See also: Chemosignals from isolated females have antimutagenic effect in dividing the cells of bone marrow from male mice of the CBA strain (2014) with my emphasis

Humans also have various pheromone-induced physiological effects, especially those associated with reproduction [46, 47]. This suggests that the human olfactory system is still an effective pathway for influencing environmental factors on the human nervous system. Various psychoemotional states of the human nervous system can, in turn, disrupt the integrity of the chromosomal apparatus of target cells, for instance lymphocytes [41, 42]. Therefore, studies on the oppositely directional modulation of the mutagenic consequences of stress in rodents with the use of specific, volatile, and zoosocial important chemosignals are a promising approach both to modeling posttraumatic stress disorders in humans [36] and to searching for mehods of their treatment.

[46] is Kohl, J.V., Atzmueller, M., Fink, B., and Grammer, K., Human pheromones: integrating neuroendocrinology and ethology, Neuroendocrinol. Lett., 2001, vol. 22, pp. 309–321.
See also: Cytogenetic approaches for determining ecological stress in aquatic and terrestrial biosystems (2015)

Genetic monitoring of the environment is an important component in the analysis of the status of the biosystems. Its efficiency depends on the correct choice of (a) natural bioindicator species; (b) appropriate signs reflecting the state of the environment; and (c) appropriate statistical analysis. The assessment of genomes’ integrity plays the key role in the studies of mutagenicity in a polluted environment. We present a step-by-step recommendations for the analysis of the cytogenetic data and discuss the prospects of applying genetic tests for ecological monitoring, based on the example of analysis using crustacean species.

The nutrient energy-dependent pheromone-controlled ecological adaptations in all invertebrates and vertebrates were reviewed in the context of: Role of olfaction in Octopus vulgaris reproduction

Future work on O. vulgaris olfaction must also consider how animals acquire the odours detected by the olfactory organ and what kind of odour the olfactory organ perceives. The OL acting as control centre may be target organ for metabolic hormones such as leptin like and insulin like peptides, and olfactory organ could exert regulatory action on the OL via epigenetic effects of nutrients and pheromones on gene expression (Kohl, 2013; Elekonich and Robinson, 2000). — p. 61

See for comparison 1): Riding the Evolution Paradigm Shift With Eugene Koonin

“[T]he entire ideology of personalized medicine should be taken with many grains of salt. It’s not useless, it’s useful to sequence thousands of genomes. It’s useful to sequence everyone’s genome. It’s useful and desirable — yet, it’s wrong and to some degree dangerous to think that, by peering into the sequence of the A, G, T, and Cs in your genome, your family doctor is going to tell you how to treat all your conditions and what conditions you are going to develop, and which ones you are not going to develop, and so on.” — Eugene Koonin

See also for comparison 2): Riding the Evolution Paradigm Shift With Eugene Koonin

“The entire evolution of the microbial world and the virus world, and the interaction between microbes and viruses and other life forms have been left out of the Modern Synthesis…” — Eugene Koonin

The entire ideology of personalized medicine is based on what is known about how the anti-entropic virucidal energy of sunlight must be linked from endogenous RNA interference and foraging behavior to the physiology of biophysically constrained pheromone-controlled reproduction in species from microbes to humans. See this 7 minute representation from my Precision Medicine virtual conference presentation. Energy as information and constrained endogenous RNA interference (2017)
Do not be surprised if you cannot track the historical record of scientific advances in nutritional epigenetics from 1994 Effect of atrazine herbicide on growth, photosynthesis, protein synthesis, and fatty acid composition in the unicellular green alga Chlorella kessleri to the current representations of top-down causation and energy-dependent biophysically constrained biologically-based cause and effect. There are many pseudoscientists who will do everything possible to prevent you from learning that their ridiculous theories have never been supported by experimental evidence.
See for example: 7/25/13
Jay R. Feierman: “Variation is not nutrient availability and the something that is doing the selecting is not the individual organism. A feature of an educated person is to realize what they do not know. Sadly, you don’t know that you have an incorrect understanding [of] Darwinian biological evolution.”
See also: One crank dies, another rises to take his place by PZ Myers

I was asked to look at a string of comments left on a science article by a fellow going by the pseudonym JVK, and all the Davison traits were there. Pretentious phrasing. Repetition: if the audience didn’t get it the first time, just say the same thing again, twice. A kind of sneering anger that people don’t understand how smart he is. An obsession with one narrow idea, which is his, which explains all of evolution and proves that everyone else is wrong.
Behold James Vaughn Kohl.

Ecological adaptation occurs via the epigenetic effects of nutrients on alternative splicings of pre-mRNA which result in amino acid substitutions that differentiate all cell types of all individuals of all species. The control of the differences in cell types occurs via the metabolism of the nutrients to chemical signals that control the physiology of reproduction.
These facts do not refute evolution; they simply refute the ridiculous theory of mutation-initiated natural selection that most people here were taught to believe is the theory of evolution.
That theory is far too ridiculous to be anything but a joke in the context of biological-based increasing organismal complexity. But here, we have lots of jokers, don’t we? The proof of ecological variation that appears to refute the theory of evolution, which actually refutes itself, is that ecological adaptations occur too fast for mutations to compete with them as a source of anything but diseases and disorders.

Ecological adaptations are food energy-dependent and biophysically constrained in the context of biologically based chromosomal inheritance via the pheromone-controlled physiology of reproduction. There is only one model for that.
It’s my model:
Nutrient-dependent/pheromone-controlled adaptive evolution: a model
See for comparison: Interactome analysis reveals ZNF804A, a schizophrenia risk gene, as a novel component of protein translational machinery critical for embryonic neurodevelopment
Reported as: Gene associated with schizophrenia risk regulates neurodevelopment

A gene associated with the risk of schizophrenia regulates critical components of early brain development, according to a new study led by researchers from Penn State University. The gene is involved in the translation of proteins from RNA and in the proliferation and migration of neurons in the brain.

Gene regulation is energy-dependent and RNA-mediated. That fact is twisted into this misrepresentation: “The gene is involved in the translation of proteins from RNA and in the proliferation and migration of neurons in the brain.”

What they claim, in the most twisted way possible, is that the energy-dependent RNA-mediated translation of proteins must be linked to ecological adaptations via the proliferation and migration of neurons in the brain.

A board game taking place inside a human cell! Players compete to build enzymes, hormones and receptors and fend off attacking Viruses!

Sunlight, phytochemicals, microRNAs and cancer

A board game taking place inside a human cell! Players compete to build enzymes, hormones and receptors and fend off attacking Viruses!
Summary: If the creation of the uranium isotopes was not biophysically constrained in the context of hydrogen-atom transfer in DNA base pairs in solution, the sun’s anti-entropic virucidal energy would be a less effective treatment for cancer than radiation therapy.
The link from the anti-entropic virucidal energy of sunlight to the de novo creation of microRNAs and prevention of all pathology will become clearer each day until the cell biology game “Cytosis” is available for play by anyone ten years old or older.
Jay R. Feierman continues his attempts to obfuscate that clarity. He failed to post three comments to the Human Ethology Yahoo Group and sent me three private messages: All three claim: “You can only post one message a day as you keep saying the same thing over and over again.”
This research was published yesterday.
Role of phytochemicals in the modulation of miRNA expression in cancer (published in Food & function)

…phytochemicals play an important role in the modulation of miRNA expression, which is related to changes in oncogenes, tumour suppressors, and cancer-related protein expression. Hence, phytonutrients can suppress tumour development, prevent metastasis, reverse the EMT, and improve drug sensitivity via the modulation of miRNA expression.

The research supports what I have been saying since the time I learned that Schrodinger (1944) stated it clearly:

“Indeed, in the case of higher animals we know the kind of orderliness they feed upon well enough, viz. the extremely well-ordered state of matter in more or less complicated organic compounds, which serve them as foodstuffs. After utilizing it they return it in a very much degraded form -not entirely degraded, however, for plants can still make use of it. (These, of course, have their most power supply of ‘negative entropy’ the sunlight.)”

People like Feierman must prevent others from learning facts about the anti-entropic virucidal energy of sunlight. The facts are neo-Darwinian evolutionary theory killers becasue Darwin’s claims began with food energy-dependent “conditions of life.”
See for comparison:
Jay R. Feierman wrote: You can only post one message a day as you keep saying the same thing over and over again. —In human-ethology@yahoogroups.com, he wrote :

Re: This claim is above my level of expertise to refute. — Jay R. Feierman

My response: It is unfortunate that the comment by James Gray about Jay’s understanding cannot be found in this series, and that no one seems interested in discussion of facts that attest to Jay’s claim.

Others who cannot refute the claim that “DNA Begins As a Quantum Wave” may continue to link the anti-entropic virucidal energy of sunlight to mutations, natural selection, and evolution despite my history of published works that led Jay to claim:

7/26/13
“I am absolutely certain that if you showed this statement to any professor of biology or genetics in any accredited university anywhere in the world that 100% of them would say that “Random mutations are the substrate upon which directional natural selection acts” is a correct and true statement.” 

We may never know why others, like Jay, would make claims about random mutations without knowing the origin of DNA, which links energy as information to the biophysically constrained physiology of reproduction in my model of all biologically-based diversity.
Jay R. Feierman wrote: You can only post one message a day as you keep saying the same thing over and over again.

He blocked this comment:

Journal article abstract excerpt: “…isotopic analyses of individuals amino acids offer the opportunity to further examine this hypothesis.”

Food energy-dependent RNA-mediated amino acid substitutions link ecological variation to ecological adaptations in species from microbes to humans in the context of the physiology of pheromone-controlled reproduction. That fact led to a counter-claim by Jay R. Feierman, and he has since limited all discussion of my model.

7/25/13
Jay R. Feierman: Variation is not nutrient availability and the something that is doing the selecting is not the individual organism. A feature of an educated person is to realize what they do not know. Sadly, you don’t know that you have an incorrect understanding [of] Darwinian biological evolution. 

See for comparison:Nutrient-dependent/pheromone-controlled adaptive evolution: a model

MODERATOR NOTE: I’m not going to post more from Kohl until he answers the very direct and simple question posed to him by anon, which is whether he (Kohl) believes that RNA splicing can change DNA.]

See for comparison: From Fertilization to Adult Sexual Behavior
“Small intranuclear proteins also participate in generating alternative splicing techniques of pre-mRNA and, by this mechanism, contribute to sexual differentiation in at least two species, Drosophila melanogaster and Caenorhabditis elegans (Adler and Hajduk, 1994; de Bono, Zarkower, and Hodgkin, 1995; Ge, Zuo, and Manley, 1991; Green, 1991; Parkhurst and Meneely, 1994; Wilkins, 1995; Wolfner, 1988). That similar proteins perform functions in humans suggests the possibility that some human sex differences may arise from alternative splicings of otherwise identical genes.”

My attempts to discuss
facts about food energy-dependent RNA-mediated cell type differentiation have consistently been placed into the context of attempts to discuss beliefs by a moderator who has consistently supported claims that link random mutations from natural selection to the evolution of biodiversity.

Jay R. Feierman wrote: You can only post one message a day as you keep saying the same thing over and over again.
He blocked this comment:

Genes Before DNA

How geneticists around the world struggled to bring the foundation of life’s building blocks to light.

Excerpt: “Information” was about to enter science, but had not done so when Schrödinger gave his lectures. Without that conception of the content of the code, Schrödinger’s insight was merely part of the zeitgeist, a hint of what was to come rather than a breakthrough that shaped all subsequent thinking.

My comment: In 1944, Schrödinger stated: Indeed, in the case of higher animals we know the kind of orderliness they feed upon well enough, viz. the extremely well-ordered state of matter in more or less complicated organic compounds, which serve them as foodstuffs. After utilizing it they return it in a very much degraded form -not entirely degraded, however, for plants can still make use of it. (These, of course, have their most power supply of ‘negative entropy’ the sunlight.) (pp. 73 and 74)

The fact that quantized energy is information seems to have escaped the grasp of many theorists, but virtually all the medical professionals I have encountered realize that organisms die if they do not find some form of quantized energy as information to eat.

Addendum: Arguably, Feierman is right. I do repeat myself. He forces me to repeatedly present my claims about energy as information by ignoring them. Instead, he makes ridiculous claims about mutations, natural selection, and evolution. That is what all pseudoscientists do.
USDA Emails: Don’t Use “Climate Change”

The news report suggested these were political moves to fall in line with the newly installed Trump administration.

The truth is that these moves are consistent with the claims that Schrodinger (1944) made in “What is Life” and the claims made in Role of phytochemicals in the modulation of miRNA expression in cancer.
Weather extremes link changes in the microRNA/messenger RNA balance in soil bacteria to healthy longevity or from the virus-driven degradation of messenger RNA to all pathology. Climate change is comparatively ambiguous, since it does not link the anti-entropic virucidal energy of sunlight to healthy longevity.
The biophysically constrained energy of sunlight also helps to reduce greenhouse gases and to sequester carbon, which links the de novo creation of energy as information to all life on Earth by building organic material in soil.  For example, sunlight has been linked from the metabolism of bacteria to the biophysically constrained creation of uranium isotopes.
See: Biogenic non-crystalline U(IV) revealed as major component in uranium ore deposits
If the creation of the isotopes was not biophysically constrained in the context of hydrogen-atom transfer in DNA base pairs in solution, the sun’s anti-entropic virucidal energy would be a less effective treatment for cancer than radiation therapy.

A rendering of how changes in an electron's motion (bottom view) alter the scattering of light (top view), as measured in a new experiment that scattered more than 500 photons of light from a single electron. Previous experiments had managed to scatter no more than a few photons at a time. Credit: Extreme Light Laboratory|University of Nebraska-Lincoln

Energy-dependent physical and biophysical constraints (10)

Summary: The entire evolution of the microbial world and the virus world, and the interaction between microbes and viruses and other life forms have been left out of the Modern Synthesis…— Eugene Koonin
My comment: Viruses are not life forms. They steal the quantized energy that links sunlight to viral latency in the context of everything known to all serious scientists about the fact that Feedback loops link odor and pheromone signaling with reproduction
See for comparison: Olfaction Warps Visual Time Perception Energy as information links the sense of smell in bacteria to our visual perception of energy and mass in the context of the space-time continuum and food odors that link the physiology of reproduction in bacteria to the pheromone-controlled physiology of reproduction and biophysically constrained viral latency in all living genera.
—————————————————————

Energy-dependent physical and biophysical constraints (9)

2010 A single amino acid substitution confers enhanced methylation activity of mammalian Dnmt3b on chromatin DNA

…the I662N substitution in mammalian Dnmt3b conferred enhanced chromatin DNA methylation activity and contributed to functional adaptation in the epigenetic system.

Energy-dependent amino acid substitutions link what organisms eat to their pheromone-controlled physiology of reproduction and chromosomal rearrangements that have been linked to all biodiversity via the sense of smell in bacteria and quorum sensing.
2013 Nutrient-dependent/pheromone-controlled adaptive evolution: a model

CONCLUSION:

An environmental drive evolved from that of nutrient ingestion in unicellular organisms to that of pheromone-controlled socialization in insects. In mammals, food odors and pheromones cause changes in hormones such as LH, which has developmental affects on pheromone-controlled sexual behavior in nutrient-dependent reproductively fit individuals across species of vertebrates.

2013 The major antigenic changes of the influenza virus are primarily caused by a single amino acid near the receptor binding site.
2017 Stem cell divisions, somatic mutations, cancer etiology, and cancer prevention

There are at least four sources of R mutations in normal cells: quantum effects on base pairing (30), mistakes made by polymerases (31), hydrolytic deamination of bases (32), and damage by endogenously produced reactive oxygen species or other metabolites (33).

2015 Visualizing transient Watson-Crick-like mispairs in DNA and RNA duplexes

…their covalently bonded 13C/15N nuclei were assigned using heteronuclear single/multiple quantum coherence correlation experiments (HSQC or HMQC).

2017 Nature does not rely on long-lived electronic quantum coherence for photosynthetic energy transfer

…/the observed extremely fast decoherence should be viewed as general, bringing to question any significant quantum coherent transport contributions to photosynthesis.

2017 Recent progress on the effects of microRNAs and natural products on tumor epithelial-mesenchymal transition
My summary: Two researches in NATURE denied the role that microRNAs play epithelial-mesenchymal transition in tumors and their denial of everything known about food energy-dependent biophysically constrained pheromone-contolled biodiversity is discussed in this review. See for comparison the section on Regulation of miRNA on EMT in tumors
The role of miRNA/ZEB in head and neck squamous cell carcinoma, in breast cancer, in lung cancer, in pancreatic cancer and in bladder cancer was anticipated in reports by serious scientists such as the late Eshel Ben-Jacob. See: MicroRNA-based regulation of epithelial–hybrid–mesenchymal fate determination, which was reported as:

They found that there is a molecular “on” and “off” switch that cancer cells use to determine their fate. Evidently, there is an on or off state for metastasis (migration), but also a third possibility, according to this recently-discovered molecular data.

The researchers discovered that there was an intermediate function, which is termed a “ternary,” or three-way switch. This function relates to the fact that ZEB has the ability to turn itself on due to a positive feedback system. This allows a cell to keep intermediate levels of all four proteins required for the switch. Ben-Jacob notes that the hybrid, or partially on-off state, also supports cancer metastasis by enabling collective cell migration and by imparting stem-cell properties that help migrating cancer cells evade the immune system and anticancer therapies.

See also: Stability of the hybrid epithelial/mesenchymal phenotype

Our results suggest that partial EMT, i.e. a hybrid E/M phenotype, need not be ‘metastable’, and strengthen the emerging notion that partial EMT, but not necessarily a complete EMT, is associated with aggressive tumor progression.

The food energy-dependent stability of the hybrid epithelial/mesenchymal phenotype has been linked from photosynthesis to the creation of energy-dependent microRNAs in plants and in animals via what has been known to all serious scientists about the physiology of pheromone-controlled reproduction in bacteria.
See:
2003 Bacterial self-organization: co-enhancement of complexification and adaptability in a dynamic environment
2006 Seeking the foundations of cognition in bacteria: From Schrödinger’s negative entropy to latent information
2009 Learning from Bacteria about Natural Information Processing with my emphasis

Focusing on the energy, matter, and thermodynamic imbalances provided by the environment, Schrodinger proposed that life required the consumption of negative entropy, that is, the use of thermodynamic imbalances in the environment. From the perspective of thermodynamics, each bacterium can be viewed as a complex system that is composed of an “engine” that uses imbalances in the environment to do work, and a “machine” that uses this energy (to act against the natural course of entropy increase) for the synthesis of organic substances.13 A third information-processing system is also needed for the coordination and synchronization of the functioning of the engine and the machine. Namely, a living cell is analogous to a complex man-made cybernetic system, or a “chimera,” composed of information processing systems and of at least two thermodynamic elements. In addition, using the outer membrane, cells sense the environment.

We proposed that, besides “negative entropy,” organisms sense the environment to extract latent embedded information.13 By latent information we refer to data embedded in the environment that, once processed cognitively, initiates change in the organism’s function or behavior. Information induces changes; hence it can be used to generate an internal condensed description (model or usable information) of the environment, which guides the organism’s functioning.

Conclusion: Olfaction Warps Visual Time Perception Energy as information links the sense of smell in bacteria to our visual perception of energy and mass in the context of the space-time continuum and food odors that link the physiology of reproduction in bacteria to the pheromone-controlled physiology of reproduction in all living genera.
See for comparison (Koonin is a co-author): On the Origin of Reverse Transcriptase-Using CRISPR-Cas Systems and Their Hyperdiverse, Enigmatic Spacer Repertoires
…another cause of the lack of detectable protospacers is likely to be the existence of a virtually untapped pool of mobile genetic elements that, at any given time, are not represented in a given environment (10). This paucity of spacer matches is conceivably explained by the vastness and diversity of viromes…
Biologically uninformed evolutionary theorists have failed to link the anti-entropic virucidal energy of the sun to all biodiversity and failed to link the virus-driven degradation of messenger RNA to all pathology via changes in the microRNA/messenger RNA balance. The release of the game “Cytosis” in September (2017) will make all theorists appear to be among the biologically uninformed science idiots who invented ridiculous theories in attempts to explain away Darwin’s “conditions of life.”
See: Cytosis: A Cell Biology Board Game 
A board game taking place inside a human cell! Players compete to build enzymes, hormones and receptors and fend off attacking Viruses!
See also the comments on: Stem cell divisions, somatic mutations, cancer etiology, and cancer prevention
For example:  2017 Jul 28 06:45 a.m. (research profile) challenges the “bad luck” theory of cancer.

Cancer etiology: assumptions lead to erroneous conclusion

The authors claim that cancer is caused and driven by mutations, and that two-thirds of the mutations required for cancer are caused by unavoidable errors arising during DNA replication. The first claim is based on the somatic mutation theory. The second claim is based on a highly positive correlation between the lifetime number of stem cell divisions in a tissue and the risk of cancer in that tissue, and on their method for estimating the proportion of mutations that result from heredity (H mutations), environmental factors (E mutations) and unavoidable errors arising during DNA replication (R mutations). These claims raise several questions:

1. Sequencing studies have found zero mutations in the genes of a variable proportion of different cancer types (see, e.g., https://dx.doi.org/10.1093/jnci/dju405 and references therein). If cancer is caused by mutations in driver genes, could the authors explain what causes these cancers with zero mutations? Could the authors use their method for estimating the proportion of cancer risk that is preventable and unpreventable in people with tumors lacking driver gene mutations?

2. Environmental factors are known to affect stem cell division rates. According to IARC, drinking very hot beverages probably causes esophageal cancer (Group 2A). If you drink something hot enough to severely damage the cells lining the esophagus, the stem cells located in deeper layers have to divide to produce new cells to replace the damaged cells. These stem cell divisions, triggered by an environmental factor, will lead to mutations arising during DNA replication. However, these mutations are avoidable if you do not drink very hot beverages. Should these mutations be counted as environmental mutations (H mutations) or as unavoidable mutations arising during DNA replication (R mutations)?

3. The authors’ work is based on the somatic mutation theory. This theory is primarily supported by the idea that cancer incidence increases exponentially with age. Since our cells are known to accumulate mutations throughout life, the accumulation of driver gene mutations in our cells would perfectly explain why the risk of cancer increases until death. However, it is now well established that cancer incidence does not increase exponentially with age for some cancers (acute lymphoblastic leukemia, testicular cancer, cervical cancer, Hodgkin lymphoma, thyroid cancer, bone cancer, etc). It is also well known that cancer incidence decreases late in life for many cancer types (lung cancer, breast cancer, prostate cancer, etc). For example, according to SEER cancer statistics review, 1975-2014, men in their 80s have approximately half the risk of developing prostate cancer than men in their 70s. The somatic mutation theory, which is the basis for this article, does not explain why the lifetime accumulation of driver gene mutations in the cells of many tissues is not translated into an increase in cancer incidence throughout life. Are the authors’ conclusions applicable to all cancers or only to those few cancers in which incidence increases exponentially with age until death?

4. The authors estimate that 23% of the mutations required for the development of pancreatic cancer are associated with environmental and hereditary factors; the rest (77%) are mutations arising during DNA replication. However, Notta et al. recently found that 65.4% of pancreatic tumors develop catastrophic mitotic events that lead to mutations associated with massive genomic rearrangements (https://doi.org/10.1038/nature19823). In other words, Notta et al. demonstrate that cell division not only leads to mutations arising during DNA replication, but also to mutations arising during mitosis. For this cancer type, the authors could introduce a fourth source of mutations, and estimate the proportion of mutations arising during mitosis (M mutations) and re-estimate those arising during DNA replication (R mutations). Alternatively, they could reanalyze their raw data without assuming that the parameters “stem cell divisions” and ”DNA replication mutations” are interchangeable. Cell division, process by which a cell copies and separates its cellular components to finally split into two cells, can lead to mutations occurring during DNA replication, but also to other cancer-promoting errors, such as chromosome aberrations arising during mitosis, errors in the distribution of cell-fate determinants between the daughter cells, and failures to restore physical interactions with other tissue components. Would the authors’ conclusions stand without assuming that the parameters “stem cell divisions” and ”DNA replication mutations” are interchangeable?

5. The authors report a striking correlation between the number of stem cell divisions in a tissue and the risk of cancer in that tissue. They do not report any correlation between the number of mutations in a tissue and the risk of cancer in that tissue; in fact, these parameters are not correlated (see. e.g., https://doi.org/10.1038/nature19768). In addition, the authors discuss that most of the mutations required for cancer are a consequence, not a cause, of the division of stem cells. So, why do the authors use their correlation to say that cancer is caused by the accumulation of mutations in driver genes instead of saying that cancer is caused by the accumulation of cell divisions in stem cells?

For references and additional information see: Comment on ‘Stem cell divisions, somatic mutations, cancer etiology, and cancer prevention’ DOI: 10.13140/RG.2.2.28889.21602 https://www.researchgate.net/publication/318744904; also https://www.preprints.org/manuscript/201707.0074/v1/download

See also: Miguel Lopez-Lazaro
My comment: Like him, others from a new generation of researchers, will no longer tolerate the pseudoscienitfic nonsense touted by evolutionary theorists and “Big Bang” cosmologists who know nothing about natural selection for energy-dependent codon optimality, which links the physiology of reproduction to biophysically constrained viral latency.

A rendering of how changes in an electron's motion (bottom view) alter the scattering of light (top view), as measured in a new experiment that scattered more than 500 photons of light from a single electron. Previous experiments had managed to scatter no more than a few photons at a time. Credit: Extreme Light Laboratory|University of Nebraska-Lincoln

Energy-dependent physical and biophysical constraints (3)

See first: Energy-dependent physical and biophysical constraints (2)
Emily Balskus Pins Down the Chemistry and Metabolism of Human Microbiomes
Summary: The chemistry and metabolism of all microbiomes is food energy-dependent and pheromone-controlled via the physiology of reproduction.
See: Feedback loops link odor and pheromone signaling with reproduction

My comment to The Scientist:

…trans-4-hydroxy-L-proline (Hyp) dehydratase, a newly discovered member of an abundant family of proteins, produced by gut bacteria, known as the glycyl radical enzymes, helps in metabolizing trans-Hyp, an amino acid that is rare in bacteria but is common in eukaryotes.

The de novo creation of energy-dependent RNA-mediated amino acid substitutions in supercoiled DNA protects the organized genomes of all living genera from the virus-driven degradation of messenger RNA, which has been linked from mutations to all pathology via the claims Schrodinger made in “What is Life?” (1944).

Indeed, in the case of higher animals we know the kind of orderliness they feed upon well enough, viz. the extremely well-ordered state of matter in more or less complicated organic compounds, which serve them as foodstuffs. After utilizing it they return it in a very much degraded form -not entirely degraded, however, for plants can still make use of it. (These, of course, have their most power supply of ‘negative entropy’ the sunlight.) (pp. 73 and 74)

See also: The Bull Sperm MicroRNAome and the Effect of Fescue Toxicosis on Sperm MicroRNA Expression

Natural selection for food energy-dependent codon optimality links the sense of smell in bacteria to the biophysically constrained viral latency that links ecological variation to ecological adaptations in species from microbes to humans via the conserved molecular mechanisms of RNA-mediated cell type differentiation.

Sunlight has since been placed into the context of quantized energy as information, which links our visual perception of mass and energy from the space-time continuum to the concept of the energy-dependent creation of quantum souls.
See also: Codon identity regulates mRNA stability and translation efficiency during the maternal-to-zygotic transition (2016) and From Fertilization to Adult Sexual Behavior (1996)