Scent of Eros

The eternal significance of microRNAs (8)

May 15, 2018

by James Kohl with No Comment Adaptations Diseases & Disorders Ecology microRNA editing RNA Directed RNA interference RNA-directed DNA methylation RNA-mediated epigenetic regulation of gene expression RNA–Mediated Epigenetic Heredity

Use of definitions in attempts to explain any aspect of species-specific biophysically constrained cell type differentiation and aging has been replaced by the use of model systems of biological processes. Biological processes can be compared to so-ca ...

Caption: Contemporary analyses of cell metabolism have called out three metabolites: ATP, NADH, and acetyl-CoA, as sentinel molecules whose accumulation represent much of the purpose of the catabolic arms of metabolism and then drive many anabolic pathways. Such analyses largely leave out how and why ATP, NADH, and acetyl-CoA (Figure 1) at the molecular level play such central roles. Yet, without those insights into why cells accumulate them and how the enabling properties of these key metabolites power much of cell metabolism, the underlying molecular logic remains mysterious. Four other metabolites, S-adenosylmethionine, carbamoyl phosphate, UDP-glucose, and Δ2-isopentenyl-PP play similar roles in using group transfer chemistry to drive otherwise unfavorable biosynthetic equilibria. This review provides the underlying chemical logic to remind how these seven key molecules function as mobile packets of cellular currencies for phosphoryl transfers (ATP), acyl transfers (acetyl-CoA, carbamoyl-P), methyl transfers (SAM), prenyl transfers (IPP), glucosyl transfers (UDP-glucose), and electron and ADP-ribosyl transfers (NAD(P)H/NAD(P)+) to drive metabolic transformations in and across most primary pathways. The eighth key metabolite is molecular oxygen (O2), thermodynamically activated for reduction by one electron path, leaving it kinetically stable to the vast majority of organic cellular metabolites

Kohl's Laws of Biology (codon-optimality revisited)

May 11, 2018

by James Kohl with No Comment Adaptations Alternative Splicings Autophagy base editing biophotonics Cytosis Diseases & Disorders Ecology Human Brain Human Pheromones Light Energy microRNA editing Model Organisms Neuronal Plasticity Nutrigenomics Physics RNA Directed RNA editing RNA interference RNA methylation RNA-directed DNA methylation RNA-mediated epigenetic regulation of gene expression RNA-mediated gene silencing RNA-mediated toxicity RNA–Mediated Epigenetic Heredity Subatomic Variations What's in the News

Summary: Kohl's Laws help to explain what was missing from Darwin's 'conditions of life.' Darwin knew nothing about genetics, which means he knew nothing about the epigenetic effects of food odors or pheromones. Ancient hepatitis B viruses from the Bronze ...

The eternal significance of microRNAs (7)

May 11, 2018

by James Kohl with No Comment Adaptations Alternative Splicings Cytosis Diseases & Disorders Ecology Model Organisms RNA Directed RNA-directed DNA methylation RNA-mediated epigenetic regulation of gene expression RNA-mediated gene silencing Subatomic

Sales of human pheromone-enhanced fragrance products have been virtually eliminated by the pseudoscientific nonsense touted by neo-Darwinian theorists and Big Bang cosmologists. I may revisit their ridiculous claims at ScentofEros.com and Pheromones.com, ...

The eternal significance of microRNAs (5)

May 10, 2018

by James Kohl with No Comment Adaptations Autophagy Cytosis Diseases & Disorders Ecology RNA Directed RNA–Mediated Epigenetic Heredity

Excerpt: Researchers in South Korea, for example, have reminded the God-less Communist dictator of North Korea that one microRNA-mediated amino acid substitution in the influenza B virus could decimate the human populations that he thinks he rules. Concl ...

ATP and RNA-mediated chromosomal stability

May 9, 2018

by James Kohl with No Comment Adaptations Alternative Splicings base editing biophotonics Cytosis Diseases & Disorders Ecology Light Energy microRNA editing Model Organisms Physics RNA Directed RNA editing RNA interference RNA methylation RNA-directed DNA methylation RNA-mediated epigenetic regulation of gene expression RNA-mediated gene silencing RNA-mediated toxicity RNA–Mediated Epigenetic Heredity Subatomic

Cytosis, a cell biology game for ages 10+ links ATP to viral latency and the protection of all organized genomes from the virus-driven degradation of messenger RNA that serious scientists have linked to all pathology. It is time for a new measure of cell ...

A single base change refutes theistic evolution (2)

May 9, 2018

by James Kohl with No Comment Adaptations Alternative Splicings Autophagy base editing Cytosis Diseases & Disorders Ecology Light Energy microRNA editing Model Organisms Neuronal Plasticity Nutrigenomics Physics RNA Directed RNA editing RNA interference RNA methylation RNA-directed DNA methylation RNA-mediated epigenetic regulation of gene expression RNA-mediated gene silencing RNA-mediated toxicity RNA–Mediated Epigenetic Heredity Subatomic

Announcing publication of a model that links the creation of quantized energy from changes in subatomic particles to biophysically constrained viral latency and sympatric speciation in all living genera. Nutrient-dependent Pheromone-Controlled Ecological ...

Ecological adaptations vs the randomness of evolution (3)

May 8, 2018

by James Kohl with No Comment Adaptations base editing biophotonics Diseases & Disorders Ecology Human Pheromones Light Energy microRNA editing Model Organisms RNA Directed

Summary: Fifty years later, only theorists and other pseudoscientists have failed to recognize the facts that link experimental evidence of differences in the energy of photons to the proton motive force, which links the potential of hydrogen (pH) to biop ...

A single base change refutes theistic evolution

May 3, 2018

by James Kohl with No Comment Adaptations Autophagy base editing biophotonics Cytosis Diseases & Disorders Ecology Light Energy microRNA editing Model Organisms RNA Directed RNA–Mediated Epigenetic Heredity

Everyone who failed to learn how light-activated endogenous substrates biophysically constrain viral latency is playing "catch up" to serious scientists. The serious scientists know how quantized energy-dependent RNA-mediated cell type differentiation o ...

Nutrient-dependent pheromone-controlled feedback loops

May 3, 2018

Summary: The link from positive selection to one food energy-dependent base pair change and fixation of the mouse-model-to-human-specific EDAR V370A allele in populations on different continents attests to sympatric speciation at every level of examinat ...

EDAR V370A and sympatric speciation

May 3, 2018

by James Kohl with No Comment Adaptations Diseases & Disorders Ecology Model Organisms RNA-mediated epigenetic regulation of gene expression RNA–Mediated Epigenetic Heredity Variations

Nick Lane and others like him refuse to reappraise their human mitochondrial DNA recombination dogma. All serious scientists know where the energy for recombination comes from. But, in his latest video clip, he touts the same unsubstantiated theoretical ...