Thanks to George FR Ellis for recommending this course.
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In conclusion, our dataset (GSE62432, Data Citation 2: Gene Expression Omnibus GSE62432, Supplementary Table 1) is a genetic analysis of how Rx+ tissue responds to Fgf and Wnt/β-catenin signaling pathways as it differentiates towards NR-like and RPE-like tissue. This data may be helpful for future work in optimizing in vitro optic tissue engineering as well as future studies examining the developmental and cellular biology of eye. For instance, with these data, we can ask questions such as:
- What genes change expression levels following the stimulation of competent Day 10 Rx+ tissue with Wnt/β-catenin or Fgf signalling? (Group 1 versus Group 2, Group 1 versus Group 3).
- What genes change expression during the maturation stages (Day 12–15) of in vitro RPE-like and NR-like tissue differentiation? (Group 2 versus Group 4, Group 3 versus Group 5).
- What are the major differences in the transcriptome profiles of similarly aged in vitro generated RPE-like and NR-like differentiating tissues? (Group 2 versus Group 3, Group 4 versus Group 5)
My comment: The idea of self-organized gene expression is borrowed from the pseudoscientific nonsense of evolutionary theory. Theorists are not willing to accept the fact that cell type differentiation links the epigenetic landscape to the physical landscape of DNA via the nutrient-dependent physiology of RNA-mediated reproduction.
Epigenetic regulation of miR-129-2 and its effects on the proliferation and invasion in lung cancer cells
…miR-129 suppressed lung cancer cell proliferation by arresting cell cycle at G2/M phase through inactivation of CDK1 by Wee1, and reduced cell migration and invasion in lung cancer through controlling the protein levels of NF-κB and MMP-2.
My comment: Entropic elasticity is induced by viruses. RNA-mediated cell type differentiation is nutrient-dependent. Fixation of RNA-mediated amino acid substitutions links nutrient-dependent health via nutrient-dependent microRNAs and virus-driven pathology to viral microRNAs that perturb protein folding.