“…an important gap is being filled by molecular understanding of the genesis of variation that confers the ability to evolve.”
The U.S. Department of Veterans Affairs is gathering blood from 1 million veterans to sequence their DNA. This is one of the most ambitious projects ever undertaken to understand our genome.
In January, President Obama announced plans for the Precision Medicine Initiative, which will create a database with over 1 million participants.
My comment: The existing database is already sufficient to link what is currently known about biophysically constrained nutrient-dependent RNA-mediated cell type differentiation to specific amino acid substitutions that predict how many different individuals will respond to many different types of medications. See: Clinically Actionable Genotypes Among 10,000 Patients With Preemptive Pharmacogenomic Testing, which was reported in the context of this video representation.
See also: Evolution of MicroRNA Research Over the Past Decade
More than 20,000 microRNA-Focused Publications Were Assessed as a Means to Characterize the Field
Summary: Nutrient-dependent microRNAs are linked from cell adhesion proteins to supercoiled DNA via an atoms to ecosystems model of protection from virus-driven genomic entropy, which is manifested in all pathology.
The octopus genome and the evolution of cephalopod neural and morphological novelties linked the conserved molecular mechanisms of RNA-mediated gene duplication and RNA-mediated amino acid substitutions from microRNAs and cell adhesion proteins to cell type differentiation in species from microbes to humans.
No new code makes reprogramming cells possible — despite the claims of cancer researchers. Nothing about the code is new. Experience-driven de novo creation of genes is linked to virus-perturbed loss of function and pathology via what is known about cell type differentiation.
Cell type differentiation is nutrient-dependent and the availability of nutrients links ecological variation to ecological adaptation only when virus-driven pathology is controlled by nutrient-dependent microRNAs that link supercoiled DNA to protection against virus-driven genomic entropy.