APS 2018

From photons to the proton motive force (2)

If you know someone who has linked differences in the energy of photons from the proton motive force to the physiology of reproduction and all biophysically constrained biodiversity, ask if they will attend Schrödinger at 75-The Future of Biology
For contrast, touting genetic evolution is not the future of biology.
See: Abstract: K06.00013 : A Path Integral Method for Analytically Tractable Inference of Evolutionary Dynamics

Understanding the forces that shape genetic evolution is a subject of fundamental importance in biology and one with numerous practical applications. Modern experimental techniques give insight into these questions, but inferring evolutionary parameters from sequence data, such as how an organism’s genotype affects its fitness, remains challenging. Here we present a method to infer selection from genetic time-series data using a path integral approach based in statistical physics. Through extensive numerical tests we find that our method exceeds the current state of the art in the successful classification of mutations as beneficial or deleterious in a variety of scenarios, while also yielding orders of magnitude improvements in run time. Our approach can also be extended to jointly infer other evolutionary parameters such as the effective population size and mutation rates.

Serious scientists do not infer evolutionary parameters using sequence data. They link natural selection for energy-dependent codon optimality to biophysically constrained viral latency. Virus-driven energy theft is linked from mutations to all pathology. There is no such thing as a beneficial mutation.
See also: Abstract: K06.00001 : Coarse-grained models coupling cell cycle and gene expression*

During a cell cycle, cells grow and divide. Recent single-cell experiments show that gene expression levels depend on the cell cycle. Particularly important is the proportion of the number of mRNA and protein to the cell volume. It is not clear how cells maintain a constant mRNA and protein concentration as the cells grow. Here we propose a coarse-grained gene expression model incorporating ribosomes and RNA polymerases, which captures the exponential growth of mRNA and protein number. We show that the homeostasis of mRNA and protein concentrations during the cell cycle can be achieved in a robust manner independent of cell shape. Furthermore, we show that the fluctuations in ribosome and polymerase numbers do not propagate to protein concentrations while the fluctuation in cell density does. Furthermore, our model reconciles the discrepancy between the experimentally observed negligible correlations between mRNA and protein levels, and the predicted positive correlations from previous models

Energy-dependent changes in the microRNA/messenger RNA balance have been linked from RNA-mediated cell cycles to gene expression in more than 70,000 published works. See: microRNA
See also: Applications of ligation-mediated PCR

A nick in a strand is any place where there’s a missing covalent bond between a sugar and the next adjacent phosphate. Nicks can arise from DNA damage, during normal DNA replication, or from the action of nuclease enzymes. Since a nick breaks the continuity of the backbone of one strand, it must be repaired by re-forming the missing covalent bond in order to make the DNA molecule intact again. This job of sealing nicks (specifically, nicks that occur between a sugar 3′ -OH group and the adjacent phosphate attached to the preceding sugar’s 5′ -OH group) is the function of DNA ligase. Using a molecular energy source (which differs depending on the enzyme source organism), DNA ligase reforms the missing covalent bond and the strand is whole again. Two aspects of this are critical:

The nick to be repaired occurs on a single strand but in the context of a double-stranded molecule.

The bases of the nicked strand, and particularly those directly flanking the nick site, must be properly base-paired to the opposite (un-nicked) strand.

It’s not hard to imagine why this is: the base pairing is required to hold the two parts (sugar 3′ -OH and the next phosphate) in place for the ligase enzyme active site to catalyze joining them. If either one of these isn’t base-paired down and is flopping about with thermal motion, the reaction geometry doesn’t occur, and no new bond can be made.

Simply put: It’s all about that base and energy-dependent RNA-mediated DNA repair.
If you are still trying to put what is known about DNA repair and cell type differentiation back into the context of neo-Darwinian evolution, you are not a winner.
See: Kalevi Kull: Censorship & Royal Society Evo Event

Nobody wants to belong to the party of losers. One of the best strategies in such a case is evidently an interpretation of the change as a gradual accumulation of knowledge while their work has always been at the cutting edge. — Kalevi Kull

See also: The spread of true and false news online
Reported as: Researchers call for large-scale scientific investigation into fake news

Additionally, the article’s authors point out that false information affects not only the political sphere but also areas not previously regarded as political, such as public health topics like nutrition and vaccinations, as well as the stock market.

Do you know someone who has consistently touted the use of vaccinations compared to nutrition? Are they paid to do that or are they biologically uninformed?

5th-6th Sept 2018 Dublin, Ireland

From photons to the proton motive force (1)

Conclusion: If you would like to learn how to link quantized energy-dependent changes in atoms to ecosystems in all living genera via the physiology of reproduction, join others age 10+ who will be playing this game in September 2018.
Fly’s Blood-Brain Barrier Has Circadian Rhythms

“the anatomic characteristics of insect and vertebrate BBB structures are quite distinct.”

The molecular mechanisms are conserved.
My comment to The Scientist:

Feedback of the Drosophila period gene product on circadian cycling of its messenger RNA levels (1990)

The levels of complexity have since been placed into the context of how energy-dependent changes in the microRNA/messenger RNA balance link atoms to ecosystems in all living genera via feedback loops.

For instance, see: Feedback loops link odor and pheromone signaling with reproduction

When theorists fail to start with energy-dependent changes they are forced to use de Vries 1902 definition of mutation in attempts to link the virus-driven theft of quantized energy to evolution. Two forthcoming conferences will place that pseudoscientific nonsense into its proper perspective.

Evolution – Genetic Novelty/Genomic Variations by RNA Networks and Viruses

Schrödinger at 75 – The Future of Biology – September 2018

See also:  Here Comes Single-Cell Optogenetics

.. two-photon excitation with computer-generated holography (a way to precisely sculpt light in 3D) allow light to be focused tightly enough  to hit one cell.

OLYMPUS experiment sheds light on structure of protons

…most of the time, only one of the photons has high energy….

Permeability transition in human mitochondria persists in the absence of peripheral stalk subunits of ATP synthase

Production of ATP depends on the oxidation of energy-rich compounds to produce a chemical potential difference for hydrogen ions, the proton motive force (pmf), across the inner mitochondrial membrane (IMM).

Researchers who have not linked differences in the energy of photons to the proton motive force are not likely to be among those who are presenting in September: Schrödinger at 75 – The Future of Biology
See for comparison: Subatomic

Subatomic is a deck building game where players are competing to build a number of available Elements, which score them points. Each player starts with the same small deck of cards that consist of Proton, Neutron, and Electron Cards. They use these cards to build upon their current Atom (by playing these cards face-up as Subatomic Particles) in an attempt to construct one of the available Element Cards. Or players may use their hand of cards to purchase more powerful cards for later use (by playing them in combinations of face-down as energy and face-up as Subatomic Particles!) Subatomic introduces a unique variation on deck building with a highly accurate chemistry theme, with the ultimate goal of building Elements to score points, but allowing many varying types of strategies.

If you would like to learn how to link quantized energy-dependent changes in atoms to ecosystems in all living genera via the physiology of reproduction, join others age 10+ who will be playing this game in September 2018.

5th-6th Sept 2018 Dublin, Ireland

Light-activated carbon fixation did not evolve (4)

Summary: Dobzhansky was joking about the time it would take for the creation of light to cause the energy-dependent fixation of RNA-mediated amino acid substitutions, which link food energy to the creation of enyzmes that metabolized food. His joke extends from the creation of sunlight — as the “light of evolution” — to the species-specific pheromone-controlled physiology of reproduction and cell type differentiation in chimpanzees and humans compared to gorillas via one amino acid substitution. The joke was played on theorists who, in 1973, still believed that mutations could be linked to evolution despite the claims in Schroedinger: What is Life? (1944).
See: Light-activated carbon fixation did not evolve (3),(2),(1) and RNA mediated molecular epigenetics and virus driven entropy and The origin of information (2)
For comparison, see: Genome editor CRISPR’s latest trick? Offering a sharper snapshot of activity inside the cell

…this tool can record exposure to light, antibiotics, and viral infection or document internal molecular events.

The “tool” links the anti-entropic virucidal energy of sunlight to the creation of enzymes, which link the metabolism of food energy to the physiology of reproduction in the context of autophagy and viral latency.

The facts about autophagy and biophysically constrained viral latency have been placed into the context of phage-activated continuous evolution (PACE) by people who do not want others to learn the facts about how autophagy protects all organized genome from the virus-driven degradation of messenger RNA.
See: Evolution in Action – Literally

The idea is that you use bacteriophage as your vehicle for evolving proteins, because of their extremely short generation time. These infect E. coli bacteria, and the two of them are modified in this system so that you can use selection pressure to get to a protein with specific binding properties. It’s been used to look at protease inhibitor resistance and DNA-binding specificity, and now it’s put to work for a protein-protein interaction.

All protein-protein interactions are energy-dependent, RNA-mediated and biophysically constrained in the context of the physiology of reproduction and transgenerational epigenetic inheritance.
See for contrast: Church Speaks George Church [2.14.18]

  1. Maybe it would help if the very top scientists believed in neo-Darwinism or something.
  2. We found the enzymes that occur in nature, which was not obvious, and both companies have patents on making those alkanes.

Top scientists who believe in neo-Darwinism are more likely to believe Church’s claim that the anti-entropic energy of sunlight was not the obvious link to the creation of enzymes and all biophysically constrained life on Earth. The creation of enzymes was required to biophysically constrain viral latency.

Cytosis: A Cell Biology Board Game: A board game taking place inside a human cell! Players compete to build enzymes, hormones and receptors and fend off attacking Viruses!

See: Regulation of the unfolded protein response by noncoding RNA
See: Endoplasmic reticulum stress signaling: the microRNA connection
See also: ER homeostasis and autophagy

The endoplasmic reticulum (ER) is a key site for lipid biosynthesis and folding of nascent transmembrane and secretory proteins. These processes are maintained by careful homeostatic control of the environment within the ER lumen. Signalling sensors within the ER detect perturbations within the lumen (ER stress) and employ downstream signalling cascades that engage effector mechanisms to restore homeostasis. The most studied signalling mechanism that the ER employs is the unfolded protein response (UPR), which is known to increase a number of effector mechanisms, including autophagy.

Place the unfolded protein response (UPR) into the context of how virus-driven energy theft links the degradation of messenger RNA from mutations to all pathology. Link femotosecond blasts of ultraviolet light to the creation of enzymes and energy-dependent RNA-mediated DNA repair to complete the picture of creation vs neo-Darwinism.
See: UV-Induced Charge Transfer States in DNA Promote Sequence Selective Self-Repair
If you are a top scientist who believes in neo-Darwinism, retire as soon as possible to avoid the ridicule that will be linked to the lack of funding for your so-called research.
See also: miRs-103/107 regulate autophagy in the epidermis

We found that antagomir-107 treatment in epidermis: (i) depleted endogenous miR-107; (ii) increased GFP-LC3 puncta in epidermal basal layers of GFP-LC3 transgenic mice, indicative of an accumulation of autophagosomes; (iii) inhibited LC3 turnover and increased p62, suggesting an inhibition of autophagy flux; and (iv) increased phosphorylated dynamin (p-dynamin, an inactive form), a key enzyme in end-stage autophagy. Conversely, miR-107 mimic treatment in mouse epidermis: decreased GFP-LC3 puncta in basal layer as well as p62 protein levels; and diminished p-dynamin, indicative of activation of this enzyme.

See also: CCPG1: A new breed of autophagy cargo receptor: 3:00pm GMT / 10:00am EST / 7:00am PST on Thursday 1st March
The anti-entropic energy-dependent creation of receptors is enzyme-dependent and RNA-mediated in the context of the physiology of reproduction and autophagy, which biophysically constrains viral latency.
The overwhelming complexity prevents most attempts to link quantum physics from quantum chemistry to the molecular mechanisms of epigenetically-effected cancer prevention and treatment. Despite that fact, prevention and effective treatments will continue to link the speed of light on contact with water from hydrogen-atom transfer in DNA base pairs in solution via the creation of microRNAs linked to biophysically constrained viral latency.
Do you remember what Barry J. Marshall did to link H. pylori to prevention of gastric cancer?
See: Neutrons identify critical details in bacterial enzyme implicated in gastric cancer

Ronning’s team focused on H. pylori’s use of a unique biosynthetic pathway to synthesize vitamin K2, which aids in the electron transfer processes, or chemical reactions, of all organisms.

Ronning’s team linked Barry J. Marshall’s energy-dependent changes (e,g., hydrogen-atom transfer in DNA base pairs in solution) from electrons to ecosystems and healthy longevity in all living genera via the physiology of pheromone-controlled reproduction in species from microbes to humans.
I asked the evolutionary theorist, John Hewitt (a so-called science journalist): “Are you still planning to do that by starting with the magical creation of selenocysteine?”
I’ve heard nothing from him, since then.
See also: Is Maternal Food Security a Predictor of Food and Drink Intake Among Toddlers in Oregon? (2012)

CDC Disclaimer: The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention.

The 35-year-old author works as a team lead for the CDC’s Division of Population Health.

Authorities say he called in sick on February 12, 2018 and has not been heard from since.

In 2014 he was the first author of: Sex-specific relationships between adverse childhood experiences and chronic obstructive pulmonary disease in five states

This work adds to a growing body of research suggesting that ACEs may contribute to health problems later in life and suggesting a need for program and policy solutions.

The link from the anti-entropic virucidal energy of sunlight to healthy longevity and the link from stress-induced biophysical constraint-breaking mutations reaffirms that suggestion.
Cunningham’s brother, Anterio Cunningham, does not want to assume the worst, yet he is worried something horrible has happened for him to leave his family and prized job with no notice.
The CDC did not immediately respond to ABC News’ request for comment.

Anyone with information is urged to call 911 or the Atlanta Police Homicide/Adult Missing Persons Unit at 404-546-4235.

The need for program and policy solutions at the CDC could bring the current practice of medicine to an end. The end requires all practitioners to acknowledge the facts about disease control. The facts link the creation of sunlight from fixation of light in cyanobacteria to the physiology of reproduction in humans and to all biodiversity via biophysically constrained viral latency.
See also: Nothing in Biology Makes Any Sense Except in the Light of Evolution (1973)

 I am a creationist and an evolutionist. Evolution is God’s, or Nature’s, method of Creation.

Dozhansky supposedly assumed that:

Creation is not an event that happened in 4004 B.C.; it is a process that began some 10 billion years ago and is still under way.

But he may also have been joking. He wrote:

…the so-called alpha chains of hemoglobin have identical sequences of amino acids in man and the chimpanzee, but they differ in a single amino acid (out of 141) in the gorilla.

Dobzhansky was joking about the time it would take for the creation of light to cause the energy-dependent fixation of RNA-mediated amino acid substitutions, which link food energy to the creation of enyzmes that metabolized food. His joke extends from the creation of sunlight — as the “light of evolution” — to the species-specific pheromone-controlled physiology of reproduction and cell type differentiation in chimpanzees and humans compared to gorillas via one amino acid substitution. The joke was played on theorists who, in 1973, still believed that mutations could be linked to evolution despite the claims in Schroedinger: What is Life? (1944).
Anyone who places Dobzhansky’s claims from 1964 and the claims of McEwen et al. (1964) into the context of Frohlich’s assertions in 1968 would close the door on evolutionists in three steps.
Dobzhansky compared theorists to bird watchers and butterfly collectors.
McEwen et al., (1964) linked the creation of ATP to the creation of RNA.
Frohlich (1968) linked the creation of RNA to all biophysically constrained biodiversity.
The cell biology game “Cytosis” can be used to teach people like George Church about cell biology. Alternatively, Church could ask a serious scientist what was known about the energy-dependent creation of naturally occurring enzymes.
For comparison, retracted works by Jack Szostak’s group are the only works that might make that fact not obvious (e.g., to other theorists). Serious scientists know that all enzymes naturally occur in the context of their energy-dependent microRNA-mediated creation. If George Church shared Dobzhanky’s creationist beliefs, he might have avoided the shame that comes from his claim that it was not obvious where all naturally occurring enzymes come from.
See: Retraction Watch Also reported as: Oops! Scientific retraction a major blow to evolution theory

Szostak’s study reopens what is perhaps the largest hole in evolutionary theory, as scientists remain unable to explain how the building blocks of life were “spontaneously” created.

Jack W. Szostak—a professor of chemistry and chemical biology at Harvard University,  shared the 2009 Nobel Prize in Physiology or Medicine. It seems likely that he influenced the works by George Church — also at Harvard, and the claims Church made about the “not obvious” creation of naturally created enzymes.
See for comparison: Common origins of RNA, protein and lipid precursors in a cyanosulfidic protometabolism
Reported as: Researchers may have solved origin-of-life conundrum

…the conditions that produce nucleic acid precursors also create the starting materials needed to make natural amino acids and lipids. That suggests a single set of [light activated] reactions could have given rise to most of life’s building blocks simultaneously.

The difference between George Church’s neo-Darwinian approach, and the approach that serious scientists have taken, may be as simple as the difference between a creationist and an evolutionary theorist.
 
For comparison, see: What is life when it is not protected from virus driven entropy Published on 30 Mar 2016

Poster: The anti-entropic force of virucidal ultraviolet light links guanine–cytosine (G⋅C) Watson–Crick base pairing from hydrogen-atom transfer in DNA base pairs in solution to supercoiled DNA, which protects the organized genomes of all living genera from virus-driven entropy. For example, protection of DNA from permanent UV damage occurs in the context of photosynthesis and nutrient-dependent RNA-directed DNA methylation, which links RNA-mediated amino acid substitutions to DNA repair. In the context of thermodynamic cycles of protein biosynthesis and degradation, DNA repair enables the de novo creation of G protein coupled receptors (GPCRs). Olfactory receptor genes are GPCRs. The de novo creation of olfactory receptor genes links chemotaxis and phototaxis from foraging behavior to social behavior in species from microbes to humans. Foraging behavior links ecological variation to ecological adaptation in the context of this atoms to ecosystems model of biophysically constrained energy-dependent RNA-mediated protein folding chemistry. Protein folding chemistry links nutrient-dependent microRNAs from microRNA flanking sequences to energy transfer and cell type differentiation in the context of adhesion proteins, and supercoiled DNA that protects all organized genomes from virus-driven entropy.

Cytosis can be used to teach everything from base editing to RNA editing to everyone over age 10. They will learn how to link the creation of energy to biophysically constrained viral latency via the physiology of pheromone-controlled reproduction.

A Mathematical Model Links Quantum Physics to Quantum Souls (1)

Historical facts: All energy-dependent cell type differentiation is biophysically constrained by the de novo creation of microRNAs and enzymes that metabolize food and drugs. All food energy-dependent metabolism occurs in the context of microRNA-mediated cause and effect and the physiology of pheromone-controlled reproduction. The food energy-dependent pheromone controlled physiology of reproduction in bacteria links what organisms eat to the transgenerational epigenetic inheritance of their morphological and behavioral phenotypes. The virus-driven degradation of messenger RNA has been linked to all pathology in the context of the National Microbiome Initiative, the Precision Medicine Initiative, Alpha Genomix profiling of pathways linked to the creation of CYP enzymes and test results that differentiate the most likely response to some medications based on fixation of  RNA-mediated amino acid substitutions in the organized genomes of different people and different populations of modern humans.
See: Nutrient-dependent pheromone-controlled ecological adaptations: from atoms to ecosystems (2014)
The ingestion of sago palm-like leaves linked increased endogenous vitamin C from the stability of the mouse genome to the stability of the organized genome in a modern human population via one base pair change and the fixation of one RNA-mediated amino acid substitution.
See also: Towards a systemic paradigm in carcinogenesis: linking epigenetics and genetics (2015)

The SMT’s [Somatic mutation theory’s] fundamental assumption is that there is no cancer without genetic or chromosomal harm.

See for comparison: Stem cell divisions, somatic mutations, cancer etiology, and cancer prevention
Watch as 2 of 3 co-authors of the article about can prevention tell the world that cancer is caused by “bad luck.”

Now see one of the 3 co-authors admit to his overwhelming ignorance in: Why Is This Bacterium Hiding in Human Tumors?

“The whole idea of bacteria in tumors is fascinating and unexpected,” said Dr. Bert Vogelstein, a colon cancer researcher at Johns Hopkins.

  1. The fundamental assumption that there is no cancer without genetic or chromosomal harm links the virus-driven degradation of messenger RNA in bacteria to the food energy-dependent pheromone-controlled physiology of reproduction in bacteria and healthy longevity via error-free DNA repair.
  2. The fundamental assumption that there is no cancer without genetic or chromosomal harm links virus-driven pathology to cell type-specific and species-specific pathology in all cell types of all individuals of all living genera via the failure of microRNA-mediated error-free DNA repair.

There is now a mathematical model of top-down causation that links the sun’s anti-entropic virucidal energy on contact with water to the physiology of pheromone-controlled reproduction and all biodiversity via RNA-mediated error-free DNA repair. The mathematical model refutes the pseudoscientific nonsense touted by neo-Darwinian theorists because it starts with the creation of the sun, which biophysically constrains viral latency. The importance of linking this mathematical model to all models of biologically-based cause and effect cannot be overstated.
See: Quantum Vacuum Dynamics, Coherence, Superluminal Photons and Hypercomputation in Brain Microtubules

After the Schrodinger’s intuition, expressed in his book “What is life?” [12], the first systematic approach to a quantum interpretation of biological process dated back to the model proposed by Frohlich [13] several years ago. He suggested the occurrence, in biological matter, of macroscopic quantum phenomena able to explain the energy transport without loss in the living organisms and signal transfer based on collective coherent oscillations associated to a branch of longitudinal
electric modes in the frequency range [ ] also known as Frohlich frequency. So in living systems, according to Frohlich’s model, energy could be stored in a thin two – dimensional layer placed beneath the cell membrane, that in this way would act as a biological superconducting medium, under dipolar propagating waves without thermal loss [13].

The ridiculous assumptions about thermal loss and evolution were placed into the context of other ridiculous assumptions that failed to start from the creation of the sun and link the anti-entropic virucidal energy of the sun from food energy to all biodiversity via the physiology of pheromone-controlled reproduction.
For comparison see: Reversing the thermodynamic arrow of time using quantum correlations

We observe a spontaneous heat flow from the cold to the hot system. This process is enabled by a trade off between correlations and entropy that we quantify with information-theoretical quantities.

Reported as: Experiment shows that arrow of time is a relative concept, not an absolute one

The second law of thermodynamics says that entropy, or disorder, tends to increase over time, which is why everything in the world around us appears to unfold forward in time. But it also explains why hot tea grows cold rather than hot. In this new effort, the researchers found an exception to this rule that works in a way that doesn’t violate the rules of physics as they have been defined.
The idea of entangled particles has been in the news a lot lately as researchers around the world attempt to use it for various purposes—but there is another lesser-known property of particles that is similar in nature, but slightly different. It is when particles become correlated, which means they become linked in ways that do not happen in the larger world. Like entanglement, correlated particles share information, though it is not as strong of a bond. In this new experiment, the researchers used this property to change the direction of the arrow of time.

Succinctly stated as:

This observation did not violate the second law of thermodynamics, the group explains, because the second law assumes there are no correlations between particles.

The ridiculous assumption that there are no correlations between subatomic particles led to assumptions that energy emerged and that all life evolved in the context of mutations and natural selection, which led to the “bad luck” theory of cancer.
Frohlich’s model was dismissed and so was the the fact that “…energy could be stored in a thin two – dimensional layer placed beneath the cell membrane, that in this way would act as a biological superconducting medium, under dipolar propagating waves without thermal loss [13].
[13.] Long-range coherence and energy storage in biological systems (1968)

Biological systems are expected to have a branch of longitudinal electric modes in a frequency region between 1011 and 1012 sec−1. They are based on the dipolar properties of cell membranes; of certain bonds recurring in giant molecules (such as H bonds) and possibly on pockets of non-localized electrons. In Section 2 it is shown quit generally that if energy is supplied above a certain mean rate to such a branch, then a steady state will be reached in which a single mode of this branch is very strongly excited. The supplied energy is thus not completely thermalized but stored in a highly ordered fashion. This order expresses itself in long-range phase correlations; the phenomenon has considerable similarity with the low-temperature condensation of a Bose gas. General consequences and proposals of experiments are discussed in section 3.

Four years earlier, McEwen et al., (1964) linked the creation of the sun’s anti-entropic virucidal energy to the creation of ATP and the creation of RNA.
See: Dependence of RNA synthesis in isolated thymus nuclei on glycolysis, oxidative carbohydrate catabolism and a type of “oxidative phosphorylation”

The synthesis of RNA in isolated thymus nuclei is ATP dependent.

That same year, Dobzhansky (1964) first asserted this claim:

The notion has gained some currency that the only worthwhile biology is molecular biology. All else is “bird watching” or “butterfly collecting.” Bird watching and butterfly collecting are occupations manifestly unworthy of serious scientists! I have heard a man whose official title happens to be Professor of Zoology declare to an assembly of his colleagues that “a good man cannot teach zoology. A good man can teach, of course, only molecular biology.

In 1973, Dobzhansky again mocked all the pseudoscientists whose mathematical model failed to link the creation of the sun’s anti-entropic energy from the physiology of pheromone-controlled reproduction to RNA-mediated fixation of amino acid substitutions that differentiate all cell types in all living genera.
See: Nothing in Biology Makes Any Sense Except in the Light of Evolution
He assumed that all serious scientists would recognize that the light of evolution linked Schrodinger’s claims about sunlight to all biodiversity via the food energy-dependent pheromone-controlled fixation of RNA-mediated amino acid substitutions.
He claimed

“…one can calculate the minimum numbers of single mutations needed to change the cytochrome C of one organism into that of another.”

He linked that calculation to this fact:

…the so-called alpha chains of hemoglobin have identical sequences of amino acids in man and the chimpanzee, but they differ in a single amino acid (out of 141) in the gorilla.

The levels of complexity that must be addressed by the calculations have since been addressed and reported in: Quantum Vacuum Dynamics, Coherence, Superluminal Photons and Hypercomputation in Brain Microtubules
Nothing has changed about the facts that all serious scientists have linked from biophysically constrained viral latency to all biodiversity via the physiology of pheromone-controlled reproduction.
For example, see: Substitutions Near the Receptor Binding Site Determine Major Antigenic Change During Influenza Virus Evolution

The major antigenic changes of the influenza virus are primarily caused by a single amino acid near the receptor binding site.

See also Cytosis:A board game taking place inside a human cell! Players compete to build enzymes, hormones and receptors and fend off attacking Viruses!

Cytosis can be used to teach everything from base editing to RNA editing to everyone over age 10. They will learn how to link the creation of energy to biophysically constrained viral latency via the physiology of pheromone-controlled reproduction.

Darwinian adaptation: a clear evolutionary trail?

Summary: The light harvesting occurs in the ocean and on land. It links the creation of sunlight from food energy to the physiology of pheromone-controlled viral latency in all living genera, and all serious scientists know that.
 

Origins of photosynthesis in plants dated to 1.25 billion years ago

The world’s oldest algae fossils are a billion years old, according to a new analysis by earth scientists. Based on this finding, the researchers also estimate that the basis for photosynthesis in today’s plants was set in place 1.25 billion years ago.

A universal trend of amino acid gain and loss in protein evolution

Amino acid composition of proteins varies substantially between taxa and, thus, can evolve.

See for comparison:  Energy as information and constrained endogenous RNA interference (video)
For contrast, Philip Ball separates the origin of photosynthesis in plants from the origin of bioluminescence in bacteria in the ocean.
See: Water is an active matrix of life for cell and molecular biology

1) Water is a complex fluid in its own right (4, 5), and Darwinian adaptation to a complex milieu might be expected to generate much the same kind of enmeshing and interplay of the biological and environmental at the molecular scale that we find at higher levels of life’s organizational hierarchy.

Higher levels of organization are no different than other levels of organization. Organization is organization. But Philip Ball is a deceptive journalist. Neo-Darwinian evolution becomes Darwinian adaptation, which links the sun’s anti-entropic virucidal energy from feedback loops and the physiology of pheromone-controlled reproduction to microRNA-mediated autophagy and biophysically constrained viral latency in species from microbes to human. That causes the biologically uniformed journalist to claim:

2) All of this touches on the astrobiological question mentioned at the outset: should we, like Henderson (88) in 1913, regard water as uniquely “biophilic” and “fit” to act as life’s matrix?

There is no astrobiological question.  See the comments section on Understanding and accounting for relational context is critical for social neuroscience
George F R Ellis This is absolutely correct and forms part of the larger concept that top-down causation is a key factor not just in the way the brain works but in broader contexts in biology and even physics. This is explored here: http://rsfs.royalsocietypublishing.org/content/2/1.toc 25 Apr 2014 at 07:49am
I wrote:  Socioaffective neuroscience and psychology may progress more quickly by keeping these apparent facts in mind: Olfaction and odor receptors provide a clear evolutionary trail that can be followed from unicellular organisms to insects to humans (Keller et al., 2007; Kohl, 2007; Villarreal, 2009; Vosshall, Wong, & Axel, 2000).
Philip Ball has since changed the clear evolutionary trail that links the sense of smell to ecological adaptation. Ecological variation links the creation of enzymes that metabolize food and drugs to his claim about  Darwinian adaptation.
See also for a recent representation of his word-play: Quantum common sense

We don’t need a conscious mind to measure or look. With or without us, the Universe is always looking

There are stark difference in his claims about a Universe that is always looking that can be compared via claims about the creation of a universe in which viral latency is biophysically constrained by feedback loops. The feedback loops link food odors and pheromones from the physiology of reproduction in all living genera to all biodiversity via autophagy and the microRNA-mediated creation of supercoiled DNA.
In the spirit of the Christmas season and an attempt to stop the pseudoscientific nonsense touted by biologically uniformed theorists and journalists like Philip Ball, see: Quantized Energy Links Olfaction from Angstroms to Ecosystems Part 2 (video excerpt <2 minutes long)
Remember, Santa Claus (or someone like him) is coming soon. Philip Ball may not be prepared for that. He has been a very bad boy. At the same time that President Trump, who tries his best to be good, has been accused of censorship and compared to Hitler.  I do not think that President Trump would try to change neo-Darwinian evolution to Darwinian adaptation without mentioning how the speed of light on contact with water changes everything.
Common origins of RNA, protein and lipid precursors in a cyanosulfidic protometabolism
Reported as: … the conditions that produce nucleic acid precursors also create the starting materials needed to make natural amino acids and lipids. That suggests a single set of [light activated] reactions could have given rise to most of life’s building blocks simultaneously.
All the theories can be linked via facts to creationist science that has been supported with experimental evidence of biophysically constrained viral latency as presciently foretold by
1) Schrodinger,
2) Feynman,
3) Dobzhansky
4) McEwen,
and by
5) Eshel Ben-Jacob, who wrote: Bacterial self-organization: co-enhancement of complexification and adaptability in a dynamic environment 
Note his use of the term adaptability. It may have led Philip Ball to change Darwinian evolution to Darwinian adaptation.
See also: Learning from Bacteria about Natural Information Processing

Focusing on the energy, matter, and thermodynamic imbalances provided by the environment, Schrodinger proposed that life required the consumption of negative entropy, that is, the use of thermodynamic imbalances in the environment. From the perspective of thermodynamics, each bacterium can be viewed as a complex system that is composed of an “engine” that uses imbalances in the environment to do work, and a “machine” that uses this energy (to act against the natural course of entropy increase) for the synthesis of organic substances.13 A third information-processing system is also needed for the coordination and synchronization of the functioning of the engine and the machine. Namely, a living cell is analogous to a complex man-made cybernetic system, or a “chimera,” composed of information processing systems and of at least two thermodynamic elements. In addition, using the outer membrane, cells sense the environment.

We proposed that, besides “negative entropy,” organisms sense the environment to extract latent embedded information.13 By latent information we refer to data embedded in the environment that, once processed cognitively, initiates change in the organism’s function or behavior. Information induces changes; hence it can be used to generate an internal condensed description (model or usable information) of the environment, which guides the organism’s functioning.

See also: QuEBS 2018: Workshop on Quantum Effects in Biological Systems  has established itself as an outstanding stage to present the research in the intersection of physics, chemistry and biology. This field has… established excitons in biology as the “must-talk-language” when describing the quantum effects in biological light-harvesting systems.
The light harvesting occurs in the ocean and on land. It links the creation of sunlight from food energy to the physiology of pheromone-controlled viral latency in all living genera, and all serious scientists know that. If Philip Ball just realized that, he knows he has a long-standing problem with misrepresentations of  top-down causation. In any case, it is important to know that he has forced all theorists and journalists to acknowledge the likelihood that Santa Claus is not just a figment of a child-like imagination, and that the creation of sunlight must be linked from its contact with water to the physiology of pheromone-controlled reproduction and biophysically constrained viral latency in all living genera.
 

Cytosis can be used to teach everything from base editing to RNA editing to everyone over age 10. They will learn how to link the creation of energy to biophysically constrained viral latency via the physiology of pheromone-controlled reproduction.

The tipping point (revisited): 68,000 publications

MicroRNA  Items: 1 to 20 of 68011 (earlier today, on 12/21/17)

See for example: In Vitro Validation of miRNA-Mediated Gene Expression Linked to Drug Metabolism 12/20/17

The approaches described can be employed broadly for the validation of miRNA-mediated negative regulation of any gene. Determining miRNA-mediated regulation of enzymes and transporters affecting drug metabolism is a critical step in designing personalized therapy and for understanding the mechanisms responsible for variations in the responses to therapeutic agents.

The “…miRNA-mediated regulation of enzymes and transporters affecting drug metabolism…” links the National Microbiome Initiative to the Precision Medicine Initiative and to all healthy longevity or to all virus-driven pathology in all living genera via differences in energy as information.
For review, see: Energy as information and constrained endogenous RNA interference

Feedback loops link quantized energy as information to biophysically constrained RNA-mediated protein folding chemistry. Light induced energy-dependent changes link angstroms to ecosystems from classical physics to chemistry/chirality and to molecular epigenetics/autophagy. The National Microbiome Initiative links microbial quorum sensing to the physiology of reproduction via endogenous RNA interference and chromosomal rearrangements. The rearrangements link energy-dependent fixed amino acid substitutions to the Precision Medicine Initiative via genome wide inferences of natural selection. This detailed representation of energy-dependent natural selection for codon optimality links biologically- based cause and effect from G protein-coupled receptors to RNA-mediated amino acid substitutions and the functional structure of supercoiled DNA. Energy-dependent polycombic ecological adaptations are manifested in supercoiled DNA. Chromosomal inheritance links the adaptations from morphological phenotypes to healthy longevity via behavioral phenotypes. For contrast, virus-driven energy theft is the link from messenger RNA degradation to negative supercoiling, constraint breaking mutations, and hecatombic evolution. The viral hecatomb links transgenerational epigenetic inheritance from archaea to Zika virus-damaged DNA, which typically is repaired by endogenous RNA interference and fixation of RNA-mediated amino acid substitutions in organized genomes.

For a historical perspective on what is known about energy-dependent RNA-mediated (aka microRNA-mediated) cell type differentiation, see:
The quantum / classical RNA-mediated ‘tipping point’ 3/26/15
The tipping point? 50, 000 publications 5/16/16
The tipping point? 50, 000 publications (2) 5/16/16
The tipping point? 50,000 publications (3) 5/17/16
The tipping point? 50,000 publications (4) 5/26/16
The tipping point? 50,000 publications (5) 7/27/16
The tipping point (revisited): 60,000 4/20/17
By May 16, 2016, the innate antiphage defense strategy was linked from quantum physics to classical physics by 50,000 publications that mentioned microRNAs. Nineteen months later, every aspect of the microRNA-mediated gene expression that had already been linked to drug metabolism attests to the fact that not all scientists have followed the extant literature.
Many scientists are still among the pseudoscientists who who failed to notice the most obvious links from the antiphage defense strategy to healthy longevity. Perhaps they were also too busy to notice the most obvious links from the virus-driven degradation of messenger RNA to the need for drug therapies.
If so, that may explain why the drug therapies have been largely ineffective. The drug therapies may be like vaccinations. They appear to link the virus-driven degradation of messenger RNA to more mutations, which clearly link the virus-driven theft of quantized energy to all pathology.
With more than 18,000 published works in the past 19 months, (8,000 in the past 8 months) it is time to again address the tipping point between quantum physics and classical physics in the context of food energy-dependent pheromone-controlled microRNA-mediated cell type differentiation via what is known about autophagy.
In the context of drug metabolism, the energy-dependent microRNA-mediated creation of enzymes was linked from the metabolism of food to all biodiversity on Earth via pheromone-controlled physiology of reproduction.
See for example page 19 of the sample report from Alpha Genomix that you can download as a pdf here. The food energy-dependent creation of the CYP enzymes protects our organized genome by biophysically constraining viral latency.

See for comparison: Our Top 17 in ’17: The Year in Science at PLOSBLOGS 

…the far-reaching war on science being conducted by the Trump administration, an assault on facts which, as several of our bloggers have noted, constitutes a removal of scientific evidence from the formation and discussion of public policy and an evisceration of funding and communication of vital research in medical research and regulation, public health, climate, energy, agriculture and education.

The only war on science that I know about, is the one in which serious scientists are Combating Evolution to Fight Disease. To place that claim into the context of what has happened during 2017, see the retraction of this article.
Biomechanical Characteristics of Hand Coordination in Grasping Activities of Daily Living [retracted]
It was retracted because the authors mentioned the creator of the hand. The creation of the hand occurs only in the context of biophysically constrained viral latency.

See for comparison: Retraction Watch

In retrospect, we were totally blinded by our belief [in our findings]…we were not as careful or rigorous as we should have been (and as Tivoli was) in interpreting these experiments.

Where else besides PLOS have you seen a retraction for the mention of a creator? Where did PLOS report on the retraction for misrepresentations in “Nature Chemistry?” Who still believes that microRNA and messenger RNAs created each other so that they could automagically constrain viral latency?
Who else besides PLOS is waging a far-reaching war on science?
See: Nutrient-dependent pheromone-controlled ecological adaptations: from atoms to ecosystems 4/10/14

This atoms to ecosystems model of ecological adaptations links nutrient-dependent epigenetic effects on base pairs and amino acid substitutions to pheromone-controlled changes in the microRNA / messenger RNA balance and chromosomal rearrangements. The nutrient-dependent pheromone-controlled changes are required for the thermodynamic regulation of intracellular signaling, which enables biophysically constrained nutrient-dependent protein folding; experience-dependent receptor-mediated behaviors, and organism-level thermoregulation in ever-changing ecological niches and social niches. Nutrient-dependent pheromone-controlled ecological, social, neurogenic and socio-cognitive niche construction are manifested in increasing organismal complexity in species from microbes to man. Species diversity is a biologically-based nutrient-dependent morphological fact and species-specific pheromones control the physiology of reproduction. The reciprocal relationships of species-typical nutrient-dependent morphological and behavioral diversity are enabled by pheromone-controlled reproduction. Ecological variations and biophysically constrained natural selection of nutrients cause the behaviors that enable ecological adaptations. Species diversity is ecologically validated proof-of-concept. Ideas from population genetics, which exclude ecological factors, are integrated with an experimental evidence-based approach that establishes what is currently known. This is known: Olfactory/pheromonal input links food odors and social odors from the epigenetic landscape to the physical landscape of DNA in the organized genomes of species from microbes to man during their development.

Obama Advisers Urge Action Against CRISPR Bioterror Threat 11/17/16

Scientific advisers to President Obama warn that the U.S. urgently needs a new biodefense strategy and should regularly brief President-elect Donald Trump on the dangers posed by new technologies like CRISPR, gene therapy, and synthetic DNA, which they say could be coöpted by terrorists.

See for comparison:  2017 Global Infectious Diseases Threats to the United States 12/22/16

Flu.  Influenza remains one of the greatest threats to the US population killing on average 3,000-49,000 Americans annually.  People at the greatest risk of severe flu and death are pregnant women, residents of long-term care facilities, the very old (adults over the age of 65), the very young (children less than 2), Native American populations, and those with underlying chronic conditions such as asthma, COPD, heart disease, obesity, and other conditions.  Timely vaccination remains the most proven and effective way to avoid serious injury from influenza.

The new Trump Administration will face a formidable array of global and indigenous infectious disease threats in 2017.  A Global Health Security Agenda will help provide a framework for tackling some of these tough issues, but enhanced efforts will be needed to prevent new epidemics, especially from vector-borne and zoonotic neglected tropical diseases, measles, and the ever-constant threats from AMR and flu.

The biggest threat that the Trump administration has faced in the first year is the fake news. The most recent example accused him of censorship at the CDC for his director’s efforts to biophysically constrain energy-dependent viral latency. The CDC director’s efforts to help others with budget concerns were linked to censorship, and the President of the United States was compared to Hitler. Wake up and “Remember the Alamo.”
SARCASM ALERT: No, that was a different war. Wake up and remember the Manhattan Project, which also linked censorship about energy to the winning of a war.

Alternative splicing of pre-mRNA

The Scientist reports Szostak's "honest error"

Top 10 Retractions of 2017

…Szostak’s lab could not reproduce the findings, which the group attributes to honest error.

Please put the “honest error” into the perspective of what was reported in: Retraction Watch
In retrospect, we were totally blinded by our belief [in our findings]…
The claim that scientists were blinded by their belief in their findings attests to the likelihood that they may not be serious scientists. Instead, they may exemplify what Richard Feynman placed into the context of human idiocy.
See: Food energy (video) My summary: All organisms must eat or they die.
For details, see: Dependence of RNA synthesis in isolated thymus nuclei on glycolysis, oxidative carbohydrate catabolism and a type of “oxidative phosphorylation”
McEwen et al., (1964) presciently linked quantized energy as information to all biophysically constrained biodiversity via the physiology of pheromone-controlled reproduction. Serious scientists now know that feedback loops link food odors to viral latency via changes in base pairs and RNA-mediated amino acid substitutions.
The beliefs of Szostak, and others like him, do not fit with the facts about the energy-dependent creation of supercoiled DNA. That fact has prevented others from examining facts about food energy-dependent autophagy, which biophysically constrains viral latency.
See: Modern diversification of the amino acid repertoire driven by oxygen
Simply put, the sudden emergence of life’s anti-entropic virucidal energy and the magical creation of enzymes did not lead to the evolution the amino acid repertoire. Energy-dependent changes in base pairs linked changes in the microRNA/messenger balance to RNA-mediated amino acid substitutions and the creation of enzymes that organize the genomes of all extant species on Earth.
The damage to science that has been done by those whose beliefs are not based on experimental evidence or common sense, which could have been applied to examples from model organisms, has been placed into the context of how enzymes metabolize food and drugs.
See: Alphagenomix  and download a sample report that links the quantized energy dependent creation of enzymes from single nucleotide polymorphisms to RNA-mediated amino acid substitutions. The substitutions typically biophysically constrain viral latency and all pathology in the context of the physiology of pheromone-controlled reproduction and feedback loops. The facts about feedback loops make claims about mutations, natural selection (e.g., for anything except energy-dependent codon optimality) and claims about evolution appear to have automagically arisen from the life-ending thought processes of biologically uninformed theorists, who ignored Darwin’s “conditions of life.”
See for comparison: Nutrient-dependent pheromone-controlled ecological adaptations: from atoms to ecosystems
If it is not obvious to you that the ingestion of sago palm-like leaves links endogenous Vitamin C from the mouse model to the human example of biophysically constrained viral latency in a modern human population in China, you may need to review the extant literature that has been published by serious scientists since 1994, or earlier.
[Pheromonal regulation of genetic processes: research on the house mouse (Mus musculus L.)]

A study of the influence of pheromone stressor(s) on proliferating germ and somatic cells was performed on laboratory lines of house mouse in the context of the physiological hypothesis of mutation process, proposed by M.E. Lobashev in 1947. Data from experiments are presented, and results obtained during last 10-15 years are discussed. The adaptive role of cytogenetic and other observed pheromonal effects is considered. The possible existence of interorganism systems of genetic regulation is discussed, the search for and study of which may help in more complete understanding of the regularities of functioning of genetic material.

See for comparison: Session 10: Viral Evolution (iBiology supports the evolution industry)
See for comparison:  The major antigenic changes of the influenza virus are primarily caused by a single amino acid near the receptor binding site.
 
 

For God and Country

Trump challenges the CDC to remember 9/11

Synopsis: If you do not understand the experimentally established facts… use caution if you attempt to compare the President of the USA to Hitler. If you tell me I am being disrespectful or condescending,  you may be more embarrassed than Nobel Laureate, Jack Szostak, and be subjected to more ridicule than Neil deGrasse Tyson, who was politely called a big ass by the research group that published Structural diversity of supercoiled DNA (2015)
Federal Officials and Scientists Respond to Purported CDC Word Ban

…it seems that The Scientist has been highjacked by people that believes that science is fighting Republicans and promoting liberal ideas, right or wrong. For those that were not even born then, most of the advances in medicine and biology occurred during the war of cancer that President Richard Nixon initiated and supported. –dmarciani

Since then, the evolved use of meaningless words, such as evolved, and the use of meaningless phrases by the Center for Disease Control (CDC) has left the citizens of the United States of America (USA) comparatively unprotected from the forthcoming world-wide viral apocalypse. The last one (in 1918) killed ~50 million people.
See: Bill Gates warns that a new kind of terrorism could be coming, and the ‘potential damage is very, very huge’
The biologically uninformed masses know nothing about how viruses kill, or how fast they kill.  Most people know little or nothing about viruses in vaccines, which may be slow killers. That explains why, on the eve of the 100th anniversary of the year of the 1918 viral terror, the Trump administration is being criticized by non-scientists and pseudoscientists. Researchers who are biologically uniformed science idiots have helped to bankrupt the economy of the USA by submitting proposals for research that include meaningless words and phrases. The biologically uninformed masses (who are not idiots) have not learned the difference between pseudoscience and science, because they have been taught to believe in mutation-driven evolution. The difference between a scientific truth about ecological varaiation and ecological adaptation for comparison to pseudoscientific nonsense can be placed into the context of words, such as: “vulnerable,” “entitlement,” “diversity,” “transgender,” “fetus,” “evidence-based” “science-based” “fetus” and “transgender”
With one exception, none of these words or phrases has anything to do with the purpose of the CDC, which is largely to protect the USA from virus-driven pathology. For comparison, the difference between food energy-dependent amino acid substitutions and mutations, which are caused by the virus-driven theft of quantized energy-as-information, clearly shows why USA Patriots for Donald Trump want to change what’s happening at the CDC.
See also: Trump administration forbids CDC officials from using 7 words and phrases

The claims of Trump-haters cut to the heart of the disrespect some people show for the President of the USA — and also the disrespect they show for the serious scientists who support him. As a medical laboratory scientist, I can point out the difference that one letter in one word makes to help other USA Patriots for Donald Trump understand what is known about how to protect us all from the next viral apocaplyse.
 
 
WORD→WORE→GORE→GONE→GENE. Implicit in this analogy is the idea that epistasis constrains evolution—for example, the original parent sequence does not tolerate three of the four eventual changes, as GORD, WERD and WOND are not words.
 
Serious scientists know that proteins do not evolve and that viruses do not automagically mutate! Similarly, the serious scientists known that new words, such as GORD, WERD and WOND are not created outside the context of biophysically constrained viral latency. Simply put, new words are not created, and new genes are not created from changes in base pairs outside the context of biophysically constrained viral latency at the level of energy-dependent base editing of food energy-dependent ACTG-linked changes in amino acid substitutions.
 
 
Trump knows that the CDC has virtually ignored the facts about food energy-dependent amino acid substitutions via the use of these meaningless words: “vulnerable,” “entitlement,” “diversity,” “transgender,” “fetus,” “evidence-based” “science-based” “fetus” and “transgender.”

In the language of serious scientists, these words cannot be linked to what happens when the virus-driven theft of quantized energy causes a change in one base pair that leads to one amino acid substitution in a virus. Simply put, the change in the virus is linked to constraint breaking mutations. And the change in a virus causes all pathology in all cells of all hosts. Eventually, all human hosts die from the virus-driven degradation of messenger RNA.

Trump knows that. He also knows that viruses cause suicide and glioblastoma in veterans who have served overseas. (SARCASM ALERT: That does not mean he is required to tell John McCain.)  But, the facts have been discussed in the context of articles published in the American Legion Magazine.

It is a wonder that everyone does not know about the virus-driven activation of the death gene, since the death gene was discovered about 20 years ago by researchers at Abcam. Since then the discovery has been linked to this report:  Redox-sensitive alteration of replisome architecture safeguards genome integrity.

See also: Reduced expression of brain-enriched microRNAs in glioblastomas permits targeted regulation of a cell death gene.

Whose going to explain how John McCain gets cured — if he is not sacrificed for the sake of the CDC?

If you are easily bored by details but want to learn about what science advisors are telling President Trump, see: Epigenetic modifications poster (Just kidding. If you are bored by the details you won’t look at the details in the poster.) Instead, you are more likely to compare the President of the United States to Hitler, when Trump knows enough about epigenetics to try and help all serious scientists to protect us from the next viral apocalypse, and to protect us from the practice of corporate medicine, which is an assault on our freedom.

Epistasis biophysically constrains viral latency. The constraints are food energy-dependent and pheromone-controlled. All serious scientists have known that since this article was published in 1994. [Pheromonal regulation of genetic processes: research on the house mouse (Mus musculus L.)]

Two of Eugene Daev’s subsequent works cited my award-winning publications, yet I have been unfriended on Facebook by many who will continue to not face the facts known to Trump and to all serious scientists in the world.

See for example: Chemosignals from isolated females have antimutagenic effect in dividing the cells of bone marrow from male mice of the CBA strain (2014)

Humans also have various pheromone-induced physiological effects, especially those associated with reproduction [46, 47]. This suggests that the human olfactory system is still an effective pathway for influencing environmental factors on the human nervous system.

[46] is Kohl, J.V., Atzmueller, M., Fink, B., and Grammer, K., Human pheromones: integrating neuroendocrinology and ethology, Neuroendocrinol. Lett., 2001, vol. 22, pp. 309–321.
See also:  Effect of two pyrazine-containing chemosignals on cells of bone marrow and testes in male house mice (Mus musculus L.)

The induction of genetic instability leading to a higher genetic heterogeneity in cells of vital tissues and organs may differentially change
the fitness of animals and their progeny. Such olfactory effects can affect rates of microevolutionary transformations [5]. With regard to the conservatism and the significant role of the chemical communication in a wide range of mammals, including Homo sapiens [25], we believe extremely promising the study of genetic mechanisms underlying regulation of reproduction and immunity by volatiles that work through the olfactory system.

25 is Kohl, J.V., The Mind’s Eyes, J. Psychol. Human Sexual., 2007, vol. 18, pp. 313–369. (Concurrently published as this award-winning book chapter from the Handbook of the Evolution of Human Sexuality: The Mind’s Eyes: Human pheromones, neuroscience, and male sexual preferences.)
My former FB friends and others have the freedom to claim that I am a crank, because veterans suffered and died to protect your freedom.
See for contrast:  One crank dies, another rises to take his place
I have the freedom to continue to defend the country from the claims of biologically uniformed science idiots (i.e., PZ Myers) and anyone who compares Trump to Hitler.

BANNED: CDC Gets List Of ‘Forbidden Words’ From The Trump Administration

Activists immediately accused the Administration of censorship, even hysterically comparing the Administration’s move to Orwell’s “1984” and Adolf Hitler’s efforts to control information in Nazi Germany.

Despite the CDC’s own director, Dr. Brenda Fitzgerald, insisting the ban did not extend beyond the scope of a handful of budget documents, it was immediately clear to Democrats that the Trump Administration was moving to throttle all scientific research.

Find out who might benefit from a move to throttle all scientific research.
See: Alphagenomix.com and download this sample report. On page 19, the interpretation of results is placed into the context of the food energy-dependent creation of enzymes that are altered by drug therapies. The Trump administration was virtually forced to alter the funding process at CDC by the fact that Jack Szostak’s works with others led to retractions. They thought enzymes could create themselves. Two retractions in 10 years led to the embarrassment of all biologically uninformed theorists.
See “Retraction watch”

  1. A Nobel Laureate has retracted a 2016 paper in Nature Chemistry that explored the origins of life on earth, after discovering the main conclusions were not correct.
  2. In retrospect, we were totally blinded by our belief [in our findings]…we were not as careful or rigorous as we should have been (and as Tivoli was) in interpreting these experiments.

The problem with ridiculous complacency-based beliefs has plagued serious scientists for decades. It was recently placed into the context of claims made by the former President of the USA.

Obama warns of complacency, notes rise of Hitler

Despite the democracy of the Weimar Republic, Adolph Hitler rose to power, he continued.

“Sixty million people died. … So, you’ve got to pay attention. And vote.”

While some could see the remark as a veiled jab at President Trump, Obama did not mention Trump by name during the event, according to the newspaper.

Now, the claims others are making link Obama’s claims to complaints about the fact that Trump took actions against the misinformation coming from the CDC. The complaints are predictably linked to Hitler’s censorship via: Godwin’s Law 

(or Godwin’s rule of Hitler analogies)[1][2] is an Internet adage that asserts that “As an online discussion grows longer, the probability of a comparison involving Hitler approaches 1”;[2][3] that is, if an online discussion (regardless of topic or scope) goes on long enough, sooner or later someone will compare someone or something to Adolf Hitler or his deeds.

The former President of the USA was caught in a thinly veiled attack on President Trump, and that attack was based on Obama’s ignorance — or based on his motives. What motives? Godwin’s Law existe only the context of pseudoscientific nonsense. That nonsense includes nothing known to the serious scientists who are physicists, chemists, biologists, or polymaths ( e.g., some medical laboratory scientists).
See for comparison: Caught in the act: Papillomaviruses promote non-melanoma skin cancer November 30, 2017

…papillomaviruses associated with UV light promote the development of non-melanoma skin cancer. The investigators provide an explanation why the viruses can be detected in benign human cancer precursors but not in advanced carcinoma.

Everyone is infected with skin-typical (“cutaneous”) human papillomaviruses (HPV) at some point in their lives, usually in early childhood already. In healthy people, the immune system can fight off the viruses, but this often changes in older age.

Those claims about biophysically constrained viral latency were used as the basis for development and use of the HPV vaccine at a time when all serious scientists knew this: “The major antigenic changes of the influenza virus are primarily caused by a single amino acid near the receptor binding site.” Did I mention that before more than 60 times? See: Search Results for “The major antigenic changes of the influenza virus are primarily caused by a single amino acid near the receptor binding site”
The anti-entropic effect of virucidal sunlight links RNA-mediated amino acid substitutions to healthy longevity. That fact was presciently detailed in “What is Life?” (1944).

Indeed, in the case of higher animals we know the kind of orderliness they feed upon well enough, viz. the extremely well-ordered state of matter in more or less complicated organic compounds, which serve them as foodstuffs. After utilizing it they return it in a very much degraded form -not entirely degraded, however, for plants can still make use of it. (These, of course, have their most power supply of ‘negative entropy’ the sunlight.) (pp. 73 and 74)

The fact that virucidal light links the food energy-dependent biophysically constrained pheromone-controlled physiology of reproduction to epistasis was placed into the context of this 2016 video representation:
What is life when it is not protected from virus driven entropy (6:37) Published on 30 Mar 2016

Abstract:

The anti-entropic force of virucidal ultraviolet light links guanine–cytosine (G⋅C) Watson–Crick base pairing from hydrogen-atom transfer in DNA base pairs in solution to supercoiled DNA, which protects the organized genomes of all living genera from virus-driven entropy. For example, protection of DNA from permanent UV damage occurs in the context of photosynthesis and nutrient-dependent RNA-directed DNA methylation, which links RNA-mediated amino acid substitutions to DNA repair. In the context of thermodynamic cycles of protein biosynthesis and degradation, DNA repair enables the de novo creation of G protein coupled receptors (GPCRs). Olfactory receptor genes are GPCRs. The de novo creation of olfactory receptor genes links chemotaxis and phototaxis from foraging behavior to social behavior in species from microbes to humans. Foraging behavior links ecological variation to ecological adaptation in the context of this atoms to ecosystems model of biophysically constrained energy-dependent RNA-mediated protein folding chemistry. Protein folding chemistry links nutrient-dependent microRNAs from microRNA flanking sequences to energy transfer and cell type differentiation in the context of adhesion proteins, and supercoiled DNA that protects all organized genomes from virus-driven entropy.

If you do not understand the experimentally established facts from this presentation, please use caution if you attempt to compare the President of the USA to Hitler. If you tell me I am being disrespectful or condesending,  you may be more embarrassed than Nobel Laureate, Jack Szostak, and be subjected to more ridicule than Neil deGrasse Tyson, who was politely called a big ass by the research group that published Structural diversity of supercoiled DNA.
All structural diversity is energy-dependent and the pheromone-controlled physiology of reproduction links feedback loops from biophysically constrained viral latency to healthy longevity in all living genera.

See also:
Workshop on Quantum Effects in Biological Systems has established itself as an outstanding stage to present the research in the intersection of physics, chemistry and biology. This field has… established excitons in biology as the “must-talk-language” when describing the quantum effects in biological light-harvesting systems.
The CDC has failed to link light-harvesting in biological systems from excitons to protection of organized genomes from the virus-driven degradation of messenger RNA in species from bacteria to humans.
That is why Trump is again being compared to Hitler. The biologically uninformed masses failed to perceive the CDC’s censorship. The CDC censorship of works published by serious scientists who have linked physics, chemistry and biology to healthy longevity via the anti-entropic energy-dependent creation of RNA and enzymes has nearly bankrupted the USA due to the costs of health care.
Who will admit that they were fooled by the use of words? Most people think they are more intelligent than that. But most intelligent people can be fooled by pseudoscientists if the pseudoscientists claim to have reached a consensus. But, what other countries base their healthcare policies on the consensus about theories of neo-Darwinists and “Big Bang” cosmologists? What other agencies can be compared to the CDC and our NIH?
See also: Science’s credibility crisis: why it will get worse before it can get better 

Several other instances of bad science have gained attention in the media. The problems in “priming research”, relevant to marketing and advertising, prompted Nobel Prize winner Daniel Kahneman to issue a publicised statement of concern about the wave of failed replication.

And a study on “power poses”, which claimed that body posture influences a person’s hormones level and “feelings of power” went first viral on TED when it was published – then again when its replication failed.

We are observing two new phenomena. On the one hand doubt is shed on the quality of entire scientific fields or sub-fields. On the other this doubt is played out in the open, in the media and blogosphere.

I dedicate this effort from the blogosphere to an attempt to reduce the tensions among those who have offered their overwhelming support for the efforts of the American Legion and the American Legion Riders who ride for God and Country.
See also The American Legion Magazine. The December 2017 issue contains another article about the stress-linked reactivation of viruses. This time its about the virus that causes shingles. When the issue is available online, see “Reactivation” by Beth W. Orenstein, and link biophysically constrained viral latency to healthy longevity via the food you eat and the pheromone-controlled physiology of reproduction.  Ask yourself “What would President Trump do?” And remember, your donations to the American Legion don not support corporate medical practices. They are used to help those who served their country and lived to continue protecting your freedom. Remember them, and everyone who has ever died trying to protect others.
 
–by Wade Youmans (Read 9/09/17 before the 9/11 Memorial Ride of the American Legion Riders–pictured above)
Remembrance
It is a moral obligation, yea indeed, a most solemn moral and spiritual duty.
To remember.
To remember is to hold fast to that which is truly important, that which is precious in the wisdom of the heart and mind.
By remembering and reflecting, upon things, objects, individual persons, anything material and physical, Which is no more, that which is no more in the mortal sense is yet sustained and can endure.
Far better to remember and reflect, even if that is painful for the heart and mind.
To forget, to blissfully disregard and discard, is a disservice to that which is gone, and ’tis a disservice to one’s own heart and mind.
For remembrance is a needful, essential endeavor for the vitality of the heart and mind, for the whole of the human spirit.

See also: ‘Whatever it took to save lives’ 

Black chicken wire over the bus windows. The odor, the heat, the tropical humidity.

“All the wounded are in the emergency room. They’re sending these sick guys to my unit. They were dehydrated. They were dirty. There was vomit. Wounds weren’t visible, but their suffering was acute and there wouldn’t be any Purple Hearts passed out for their near-death experience.

Nature’s magic helps veterans in transition

Nature’s magic” was placed into the context of the evolution of differences in H2. See: https://phys.org/news/2017-11-chemists-reveal-mechanism-dihydrogen-production.html

 
Excerpt: “This work is a critical step toward a mechanistic understanding of the nitrogenase enzyme. There is still work to be done to understand the mechanism of the other H2 evolution process that leads to N2 binding, activation, and reduction to NH3.”
 
Please help serious scientists stop those who are still touting the magic of evolution by learning how autophagy helps to protect all organized genomes from the virus-driven degradation of messenger RNA.
 

Autophagy is the link from the sun’s anti-entropic virucidal energy to the creation of enzymes and the physiology of pheromone-controlled reproduction, which has been linked to all biophysically constrained biodiversity.  For example, food energy links error-free DNA repair to all healthy longevity and the virus-driven theft of quantized energy links mutations to all pathology.

Keep in mind that as a member of the American Legion Riders, I ride for God and Country, not for Nature’s magic. Also, with 40 years experience as a medical laboratory scientist, I learned enough about the potential of hydrogen (pH) to realize that the potential did not “evolve.”

See also: https://aeon.co/essays/science-and-metaphysics-must-work-together-to-answer-lifes-deepest-questions
Metaphysics of metamorphosis

The swarming, ever-changing character of the living world challenges our deepest assumptions about the nature of reality

Excerpt: …‘physiologists in general never trouble themselves about such things because they suppose themselves to be above “metaphysics” when in fact they are only a very little above it – being up to the neck in it’.
Those who have failed to link the metaphysics of energy to biophysically constrained viral latency, have failed to link the virus-driven theft of quantized energy to the death gene by what is known to serious scientists.
For example, see: Reduced expression of brain-enriched microRNAs in glioblastomas permits targeted regulation of a cell death gene https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3166303/
When a member of the American Legion suffers and prematurely dies from the same virus-caused pathology that has not yet claimed the life of John McCain, ask yourself what is known about the life and death of all veterans who served overseas. Stop letting politics kill more veterans.
Support the Trump administrations efforts to make America great, again. They can do it without your support, but that probably will not end well for you. This is not about Trump’s behavior or about the behavior of anyone else.

An antagonist from Canada complained about Trump’s so-called censorship of the CDC and said his “tactics” didn’t work in Canada. I claim that similar tactics are always effective. The truth hurts but it only hurts those who believed they could keep touting pseudoscientific nonsense. Not only did Canadians get rid of the “transgender” nonsense, they helped to nearly stop James Cantor from promoting pedophilia as another form of sexual orientation.
 

See: Infamous Reparative Therapy Clinic For Transgender Youth Set To Close
Two years ago, I wrote:

The misrepresentations of the issues are out of control.

Excerpt: GIC’s “developmental model” was backwards. It blamed symptoms like depression and anxiety on the gender non-conforming behavior itself, rather than on the stigma attached to it or the conflict of not being able to fulfill one’s gender identity. This philosophy allowed the clinic to claim it was treating these negative mental health outcomes without affirming the trans behavior.”

My comment: They never had a developmental model. At best they had a philosophy based on ridiculous theories that never included anything known to serious scientists about the biological basis of cell type differentiation. These clinicians, like most sex researchers, never learned anything about links from nutrient-dependent RNA-mediated events to behavior.

For example, RNA-directed DNA methylation and RNA-mediated amino acid substitutions link sexual orientation in yeasts to sex differences in the morphological and the behavioral phenotypes of humans via conserved molecular mechanisms. We detailed that fact in the context of our 1996 Hormones and Behavior review.

Despite the extension of our molecular epigenetics section and the model of hormone-organized and hormone-activated developmental differences across species from insects to other primates, psychologists and many psychiatrists continued to link their philosophies and theories to damaging practices.

Like the practice of medicine, outcomes are more predictable if they are based on what is known about RNA-mediated cell type differences. Fixation of nutrient-dependent RNA-mediated amino acid substitutions in some patient populations compared to others allows clinicians to predict whether a medication will do more harm than good in the context of what is known about pharmacogenomics and precision medicine. Fixation of RNA-amino acid substitutions in individuals of different species is also linked to their nutrient-dependent pheromone-controlled physiology of reproductive sexual behavior in species from microbes to man.

That fact has been known to serious scientists for several decades. It is the reason that other careers will be ruined until people like Ken Zucker accept the our model of RNA-mediated cell type differentiation instead of continuing to ignore details of the biologically-based development of personal preferences published in From Fertilization to Adult Sexual Behavior (1996).

 

 

 
 
 
 

 

 

Cases of Cytosis

Narcissistic egomaniacal and deadly denial of autophagy

Summary: Viral latency is food energy-dependent and pheromone-controlled in the context of autophagy, which protects organisms from the virus-driven degradation of messenger RNA.

Workshop on Quantum Effects in Biological Systemshas established itself as an outstanding stage to present the research in the intersection of physics, chemistry and biology. This field has… established excitons in biology as the “must-talk-language” when describing the quantum effects in biological light-harvesting systems.

Pseudoscientists refuse to speak the “must-talk language” of biological light-harvesting systems. When was the last time you heard a theorist mention excitons?

Light-harvesting systems link the creation of the sun’s anti-entropic virucidal energy (Schrodinger’s negentropy, 1944 ) from the creation of food energy to the physiology of pheromone-controlled reproduction in all living genera via autophagy, which protects all organized genomes from virus-driven entropy.

See: Structural diversity of supercoiled DNA

…DNA supercoiling strongly affects DNA metabolism. Despite its importance, however, much about supercoiled DNA (positively supercoiled DNA, in particular) remains unknown. Here we use electron cryo-tomography together with biochemical analyses to investigate structures of individual purified DNA minicircle topoisomers with defined degrees of supercoiling. Our results reveal that each topoisomer, negative or positive, adopts a unique and surprisingly wide distribution of three-dimensional conformations. Moreover, we uncover striking differences in how the topoisomers handle torsional stress. As negative supercoiling increases, bases are increasingly exposed. Beyond a sharp supercoiling threshold, we also detect exposed bases in positively supercoiled DNA. Molecular dynamics simulations independently confirm the conformational heterogeneity and provide atomistic insight into the flexibility of supercoiled DNA. Our integrated approach reveals the three-dimensional structures of DNA that are essential for its function.

They linked energy-dependent changes in base pairs from supercoiled DNA to all biodiversity via cryo-ET, which helped to support their atomistic insight.

See for comparison: Structural Dynamics and Mechanochemical Coupling in DNA Gyrase

Gyrase… harnesses the free energy of ATP hydrolysis to perform mechanical work on DNA. The enzyme specifically introduces negative supercoiling in a process that must coordinate fuel consumption with DNA cleavage and religation and with numerous conformational changes in both the protein and DNA components of a large nucleoprotein complex.

Simply put, gyrase introduces the pathology of virus-driven negative supercoiling. Discussion with one of the co-authors, namely A.C. Parente, led me to make this claim in frustration:

No one who places “Plant Energy Biology” into the context of “Evolutionary Biology” will understand my model of the Mechanisms and Functional Diversity of Macromolecular Remodeling by ATP-Dependent Motors [autophagy]. It starts with the creation of energy and explains how virus-driven energy theft is linked to all pathology via conserved molecular mechanisms in species from microbes to humans. The mechanisms link energy-dependent changes in angstroms to ecosystems via what is known about autophagy. The energy is not destroyed. Viruses use it to replicate.

Parente, and other like her, have tried to present their findings in the context of evolution, which is why their experimental evidence makes no sense to serious scientists. Nothing except natural selection for energy-dependent codon optimality can link the energy-dependent physiology of pheromone-controlled reproduction from feedback loops to autophagy, which biophysically constrains viral latency.  Simply put, viral latency is food energy-dependent and pheromone-controlled.

Serious scientists have detailed that fact since 1994. See: [Pheromonal regulation of genetic processes: research on the house mouse (Mus musculus L.)]

A study of the influence of pheromone stressor(s) on proliferating germ and somatic cells was performed on laboratory lines of house mouse in the context of the physiological hypothesis of mutation process, proposed by M.E. Lobashev in 1947. Data from experiments are presented, and results obtained during last 10-15 years are discussed. The adaptive role of cytogenetic and other observed pheromonal effects is considered. The possible existence of interorganism systems of genetic regulation is discussed, the search for and study of which may help in more complete understanding of the regularities of functioning of genetic material.

See also: Combinatorial effects of odorants on mouse behavior

In summary, our findings indicate that the innate effect of an odorant on behavior can be context-dependent and subject to modification by other odorants. It is conceivable that signals derived from a single receptor can elicit innate behavioral attraction or aversion and involve hard-wired neural circuits. However, our studies indicate that these behavioral responses can be modulated by sensory inputs from other receptors via the interactions of signals derived from the different receptors within the brain. In short, innate behavioral output can be influenced by interactions within the brain among signals derived from different receptors in the nose.

See also my refutation of neo-Darwinian pseudoscientific nonsense: Nutrient-dependent/pheromone-controlled adaptive evolution: a model

See for comparison, on 7/25/13, psychiatrist Jay R. Feierman wrote:

“Variation is not nutrient availability and the something that is doing the selecting is not the individual organism. A feature of an educated person is to realize what they do not know. Sadly, you don’t know that you have an incorrect understanding [of] Darwinian biological evolution.”

In my opinion, Jay R. Feierman goes far beyond the claims of other narcissistic egomaniacs, like Parente, who think they can use evolution as an explanation for all biophysically constrained biodiversity. Other egomaniacs also attempt to beat serious scientists into submission with ridiculous claims that the serious scientists do not understand Darwinian biological evolution. But see the 2009 and 2017 retractions of Jack Szostak’s claims about the evolution of amino acids. Please use the retractions to help stop the pseudoscientific nonsense touted by biologically uninformed theorists.

I am a medical laboratory scientist who knows that Darwin started with his food energy-dependent “conditions of life.” He presciently linked natural selection for energy-dependent codon optimality from the “conditions of life” to the physiology of pheromone-controlled reproduction and all biodiversity in every species he examined. He could have done no better if he knew anything about genetics and focused on one model organism of fixed amino acid substitutions, but that fact has changed.

See for example: Associative Mechanisms Allow for Social Learning and Cultural Transmission of String Pulling in an Insect

My comment: RNA-mediated associative mechanisms Posted by jvkohl on 14 Dec 2016 at 16:36 GMT

Two more articles have been reported that link the energy-dependent RNA-mediated supercoiling of DNA to all healthy longevity. The two articles also link virus-driven energy theft to negative supercoiling in bacteria and all pathology in species from archaea to humans via the transgenerational epigenetic inheritance of Zika virus-damaged DNA.

See: DNA Supercoiling Combats Environmental Challenges

See also: Honeybee memories: another piece of the Alzheimer’s puzzle?

The honeybee model organism links nutrient energy-dependent supercoiling to the pheromone-controlled physiology of reproduction in species from microbes to humans via the conserved molecular mechanisms that link autophagy to chromosomal rearrangements and all biodiversity. See the works of Nobel Laureates Thomas Hunt Morgan, Erwin Schrodinger, Linda Buck, Yoshinori Ohsumi, and Ben Feringa to help establish the facts about cell type differentiation in your future publications.

Competing interests declared: I own these domains: Pheromones.com, RNA-mediated.com and Autophagypro.com They are among others that I own and they collectively link what is currently known about energy-dependent cell type differentiation to all biodiversity via conserved molecular mechanisms.

With the launch of Autophagy.pro, I am considering the sale of the domain Autophagypro.com to someone with commercial interests.  Let the bidding begin, based on the claims of others with commercial interests who have failed to link pheromones to the prevention of pathology.
See for example: Pheromones and the luteinizing hormone for inducing proliferation of neural stem cells and neurogenesis
See also: Obligatory role of hypothalamic neuroestradiol during the estrogen-induced LH surge in female ovariectomized rhesus monkeys
reported as:  Estrogen discovery could shed new light on fertility problems

Estradiol builds in the bloodstream until it reaches a concentration that causes a surge of the hypothalamic and pituitary hormones, including one called luteinizing hormone, which in turn trigger an ovary to release an egg.

“It’s a feedback loop…

See also: Feedback loops link odor and pheromone signaling with reproduction
See also: Olfaction Warps Visual Time Perception

…we show in healthy human adults that odors modulate object visibility around critical flicker-fusion frequency (CFF)-the limit at which chromatic flickers become perceived as a stable color-and effectively alter CFF in a congruency-based manner, despite that they afford no clear environmental temporal information. The behavioral gain produced by a congruent relative to an incongruent odor is accompanied by elevated neural oscillatory power around the object’s flicker frequency in the right temporal region ~150-300 ms after object onset, and is not mediated by visual awareness. In parallel, odors bias the subjective duration of visual objects without affecting one’s temporal sensitivity. These findings point to a neuronal network in the right temporal cortex that executes flexible temporal filtering of upstream visual inputs based on olfactory information. Moreover, they collectively indicate that the very process of sensory integration at the stage of object processing twists time perception, hence casting new insights into the neural timing of multisensory events.

See also: Formulation and evaluation of anti-suicidal nasal spray of Thyrotropin releasing hormone
Re: The deadly denial of theorists who failed to examine the stress-linked activation of the death gene to glioblastoma.
See: Reduced expression of brain-enriched microRNAs in glioblastomas permits targeted regulation of a cell death gene
and A Concise Review of MicroRNA Exploring the Insights of MicroRNA Regulations in Bacterial, Viral and Metabolic Diseases 
Also, please note: I purchased the domain name: Subatomic.pro because the microRNA regulation of metabolic diseases links electrons to ecosystems in all living genera by protecting individuals and species from the degradation of their messenger RNA, which links mutations to all pathology.

See also: Combating Evolution to Fight Disease

Cytosis can be used to teach everything from base editing to RNA editing to everyone over age 10. They will learn how to link the creation of energy to biophysically constrained viral latency via the physiology of pheromone-controlled reproduction.

Light activated error-free DNA repair (3)

The vibrational theory of olfaction for the win

…he and his co-authors delve into more of the specifics of olfactory receptors, including particular amino acid motifs, metal binding capacities, and disulphide bridge redox status. It turns out that amino acid side chains alone frequently pull off some rather interesting electron transfer effects without the need for fancy co-enzymes or prosthetic groups.

See for an example of what one enzyme can do:

Energy-dependent pumping in cytoplasm

High magnification of the slime mold Physarum polycephalum shows the cytoplasm pumping furiously through its huge single cell.

See also this example of how the energy-dependent creation of one enzyme can biophysically constrained viral latency
An example of biophysically constrained viral latency

This cytoplasmic streaming allows the slime mold to push forward toward nutrients and potentially carpet a surface.

For the logical extension of what is known to all serious scientists about how to link the sun’s anti-entropic virucidal energy to the creation of different enzymes and from quantum physics to quantum souls, see:

…to believe that you are, right now, thinking with anything other than a hive of independently living neurons is naive in the extreme…” — Robert Karl Stonjek

To believe that Robert Karl Stonjek does not understand the fact that every aspect of neo-Darwinian evolution has been refuted in its entirety by this model, makes you an example of human idiocy.

Nutrient-dependent/pheromone-controlled adaptive evolution: a model

The honeybee model organism exemplifies what has been learned from the study of invertebrates (De Loof, Lindemans, Liu, De Groef, & Schoofs, ). This includes what has been learned about the epigenetic effects of nutrients and pheromones on juvenile hormone (JH). However, the molecular biology of cause and effect that is common to all species was left behind, and the epigenetic effects of human pheromones have not typically been considered in the same context as epigenetic effects of food odors and insect pheromones or the epigenetic effects of pheromones on other mammals.

To believe that Jay R. Feierman is not an example of human idiocy makes you an example of human idiocy.
On 11/20/17, Feierman wrote:
Science is about predicting, not post hoc explaining except under the conditions stated above.
I agree. That’s why this claim stands out as an example of pseudoscience.
Amino acid composition of proteins varies substantially between taxa and, thus, can evolve. –Jordan et al., (2005) A universal trend of amino acid gain and loss in protein evolution
The pervasive nature of pseudoscientific nonsense probably led to this claim:
7/25/13
Jay R. Feierman: Variation is not nutrient availability and the something that is doing the selecting is not the individual organism. A feature of an educated person is to realize what they do not know. Sadly, you don’t know that you have an incorrect understanding [of] Darwinian biological evolution.

See also: Published on 19 Nov 2017

Excess alcohol caused a flare-up of diverticulitis that led to several days of hospitalization in ICU. The patient was the only person who ever asked me: “What is an amino acid?”
 
He learned from a horrid, almost deadly, experience that the energy-dependent creation of base pairs and the pheromone-controlled fixation of RNA-mediated amino acid substitutions protect all organized genomes from the virus-driven degradation of messenger RNA.
 
He learned enough to practice the concept of “everything in moderation”. He does not need to learn anything else about the links from mutations to all pathology in species from microbes to humans. But, he is back in the hospital for surgery to remove the part of his colon that is most inflamed (the part that contains the most bacteriophages (viruses in bacteria) that almost killed him.
 
Thank God, He’s alive!