Human Expression QTLs Are Enriched in Signals of Environmental Adaptation
eQTLs is the term used to link base pair changes via proxies to single-nucleotide polymorphisms (SNPs) associated with complex traits and diseases. The direct link from the epigenetic landscape to the physical landscape of DNA via nutrient-dependent protein folding biochemistry and RNA-mediated gene duplication and RNA-mediated amino acid substitutions goes missing in the context of term use confusion.
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Small intranuclear proteins also participate in generating alternative splicing techniques of pre-mRNA and, by this mechanism, contribute to sexual differentiation in at least two species, Drosophila melanogaster and Caenorhabditis elegans (Adler and Hajduk, 1994; de Bono, Zarkower, and Hodgkin, 1995; Ge, Zuo, and Manley, 1991; Green, 1991; Parkhurst and Meneely, 1994; Wilkins, 1995; Wolfner, 1988). That similar proteins perform functions in humans suggests the possibility that some human sex differences may arise from alternative splicings of otherwise identical genes.