eQTLs and ecological adaptation

Human Expression QTLs Are Enriched in Signals of Environmental Adaptation

eQTLs is the term used to link base pair changes via proxies to single-nucleotide polymorphisms (SNPs) associated with complex traits and diseases. The direct link from the epigenetic landscape to the physical landscape of DNA via nutrient-dependent protein folding biochemistry and RNA-mediated gene duplication and RNA-mediated amino acid substitutions goes missing in the context of term use confusion.

They link the epigenetic landscape to the physical landscape of DNA without the link from nutritional epigenetics to the pheromone-controlled physiology of reproduction and ecological speciation in species from microbes to man. But, they seem to be surprisingly close to realizing the difference between mutations and amino acid substitutions in the context of how ecological variation MUST lead to ecological adaptations via the conserved molecular mechanisms we detailed in our 1996 review of RNA-mediated cell type differentiation. From Fertilization to Adult Sexual Behavior

Small intranuclear proteins also participate in generating alternative splicing techniques of pre-mRNA and, by this mechanism, contribute to sexual differentiation in at least two species, Drosophila melanogaster and Caenorhabditis elegans (Adler and Hajduk, 1994; de Bono, Zarkower, and Hodgkin, 1995; Ge, Zuo, and Manley, 1991; Green, 1991; Parkhurst and Meneely, 1994; Wilkins, 1995; Wolfner, 1988). That similar proteins perform functions in humans suggests the possibility that some human sex differences may arise from alternative splicings of otherwise identical genes.

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