The bounce rate here has more than doubled (from 20% to 44%) during the past week at the same reports continue to support all the claims I have made about RNA-mediated cell type differentiation.
Obviously, pseudoscientists are not willing to examine any evidence of biologically-based cause and effect that refutes their ridiculous claims about mutations and evolution. For comparison, serious scientists will want to read this:
In conclusion, we report a leveling off of the correlation between DNAm age and chronological age in old cohorts, which is likely to reflect that individuals reaching advanced ages have a more healthy aging profile. The association with mortality risk seen in the old twins when adjusting for familial factors adds considerable evidence to support the hypothesis that DNAm age can discriminate between slow and fast agers, consistent with the hypothesis that DNAm age is a proxy for underlying mechanisms of aging.
See also: rna directed dna methylation
DNA methylation is nutrient-dependent. It is also RNA directed.
RNA-directed DNA methylation (RdDM) provides a system for targeting DNA methylation to asymmetric CHH (H = A, C, or T) sites.
RNA-directed DNA methylation links the conserved mechanisms of molecular epigenetics to cell type differentiation via amino acid substitutions that differentiate all cell types of all individuals all living genera.
Molecular epigenetics. It is now understood that certain genes undergo a process called “genomic or parental imprinting.” Early in embryonic development attached methyl groups become removed from most genes. Several days later, methyl groups are reattached in appropriate sites. Fascinatingly, some such genes reestablish methylation patterns based upon whether the chromosomal segment carrying the gene came from maternal or paternal chromosomes. These sexually dimorphic patterns are labeled genomic or parental imprinting, and these imprintings are inheritable but non-genetic modifications of specific genes (Razin and Shemer, 1995; Reik, 1989; Surani, 1991; Zuccotti and Monk, 1995).
Unconscious affects that are manifested during the development of diversified life and human behavior are, by their very nature, part of life that few people think about (Kohl et al., 2001). Therefore, the largest contributor to the development of our personal preferences may be the unconscious epigenetic effects of food odors and pheromones on hormones that organize and activate behavior. If so, the model represented here is consistent with what is known about the epigenetic effects of ecologically important nutrients and pheromones on the adaptively evolved behavior of species from microbes to man. Minimally, this model can be compared to any other factual representations of epigenesis and epistasis for determination of the best scientific ‘fit’.
This atoms to ecosystems model of ecological adaptations links nutrient-dependent epigenetic effects on base pairs and amino acid substitutions to pheromone-controlled changes in the microRNA / messenger RNA balance and chromosomal rearrangements. The nutrient-dependent pheromone-controlled changes are required for the thermodynamic regulation of intracellular signaling, which enables biophysically constrained nutrient-dependent protein folding; experience-dependent receptor-mediated behaviors, and organism-level thermoregulation in ever-changing ecological niches and social niches. Nutrient-dependent pheromone-controlled ecological, social, neurogenic and socio-cognitive niche construction are manifested in increasing organismal complexity in species from microbes to man. Species diversity is a biologically-based nutrient-dependent morphological fact and species-specific pheromones control the physiology of reproduction. The reciprocal relationships of species-typical nutrient-dependent morphological and behavioral diversity are enabled by pheromone-controlled reproduction. Ecological variations and biophysically constrained natural selection of nutrients cause the behaviors that enable ecological adaptations. Species diversity is ecologically validated proof-of-concept. Ideas from population genetics, which exclude ecological factors, are integrated with an experimental evidence-based approach that establishes what is currently known. This is known: Olfactory/pheromonal input links food odors and social odors from the epigenetic landscape to the physical landscape of DNA in the organized genomes of species from microbes to man during their development.