Mammalian-wide interspersed repeats (MIRs)

MIR retrotransposon sequences provide insulators to the human genome


Human MIR-derived insulators are characterized by distinct sequence, expression, and chromatin features that provide clues as to their potential mechanisms of action.

See also: The Un-Junk Industry


Wang et al. predicted that RTEs act as “insulators” that “help to organize eukaryotic chromatin via enhancer-blocking and chromatin barrier activity.” Of the 1,178 mammalian-wide interspersed repeats (MIRs, a form of RTE) they predicted would be functional, they found that 58 percent of them do, indeed, function as insulators (the rest may have so-far-unknown functions). The news item calls them a form of “punctuation”:

This “punctuation” can be linked to the language of cell type differentiation, which is RNA-mediated.  For example: Life is physics and chemistry and communication, links this analogy: WORD→WORE→GORE→GONE→GENE to the language of God metaphor.

Implicit in this analogy is the idea that epistasis constrains evolution—for example, the original parent sequence does not tolerate three of the four eventual changes, as GORD, WERD and WOND are not words.

See: The Language of God: A Scientist Presents Evidence for Belief.“He offers an inspiring tour of the human genome to show the miraculous nature of God’s instruction book.”
See for comparison: Mutation-Driven Evolution “…genomic conservation and constraint-breaking mutation is the ultimate source of all biological innovations and the enormous amount of biodiversity in this world. In this view of evolution there is no need of considering teleological elements” (p. 199).
My comment: Without “punctuation” written words are more difficult to understand. Mutations make nonsense out of the “words” before they can be used as language even without punctuation.
The idea that an unintelligible mess of nonsensical misspelled “words” could be the language of God, or the idea that the language could link mutations to the evolution of biodiversity seem equally ridiculous. The ridiculous misrepresentations of what is currently known about biologically-based cause and effect can be viewed in the context of what is currently known about nutrient-dependent RNA-mediated gene duplication and RNA-mediated amino acid substitutions that differentiate the cell types of all individuals of all living genera.

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