Scent of Eros

Environmental selection is natural selection

Environmental selection during the last ice age on the mother-to-infant transmission of vitamin D and fatty acids through breast milk was published on April 23, 2018 The ectodysplasin A receptor (EDAR) gene has a range of pleiotropic effects, including sw ...

MicroRNA-mediated denuclearization (6)

Summary: The EDAR V370A isoform links one quantized energy-dependent base pair change from changes in ultraviolet light (UV) exposure to fixation of one amino acid substitution. The substitution differentiates the cell types of mice and humans in the cont ...

MicroRNA-mediated denuclearization (5)

Summary: The quantized energy linked to RNA synthesis (1964) is biophysically constrained (1968) in the context of RNA-directed DNA methylation and the physiology of reproduction that links food energy-dependent fixation of amino acid substitutions to cel ...

Caption: Contemporary analyses of cell metabolism have called out three metabolites: ATP, NADH, and acetyl-CoA, as sentinel molecules whose accumulation represent much of the purpose of the catabolic arms of metabolism and then drive many anabolic pathways. Such analyses largely leave out how and why ATP, NADH, and acetyl-CoA (Figure 1) at the molecular level play such central roles. Yet, without those insights into why cells accumulate them and how the enabling properties of these key metabolites power much of cell metabolism, the underlying molecular logic remains mysterious. Four other metabolites, S-adenosylmethionine, carbamoyl phosphate, UDP-glucose, and Δ2-isopentenyl-PP play similar roles in using group transfer chemistry to drive otherwise unfavorable biosynthetic equilibria. This review provides the underlying chemical logic to remind how these seven key molecules function as mobile packets of cellular currencies for phosphoryl transfers (ATP), acyl transfers (acetyl-CoA, carbamoyl-P), methyl transfers (SAM), prenyl transfers (IPP), glucosyl transfers (UDP-glucose), and electron and ADP-ribosyl transfers (NAD(P)H/NAD(P)+) to drive metabolic transformations in and across most primary pathways. The eighth key metabolite is molecular oxygen (O2), thermodynamically activated for reduction by one electron path, leaving it kinetically stable to the vast majority of organic cellular metabolites

MicroRNA-mediated denuclearization (4)

Summary: Christ's lab showed that in vivo formation of I-motif structures is pH dependent and helped to put the "fear of God" into atheistic communists. I-motif DNA structures are formed in the nuclei of human cells (4/23/18) Reported as: In human cells, ...

MicroRNA-mediated denuclearization (2)

Summary: The virus-driven theft of quantized energy creates a cellular environment that promotes the survival and self-proliferation of viruses by encoding viral miRNAs or miRNA-like molecules. The viral miRNAs or miRNA-like molecules target different ...

MicroRNA-mediated denuclearization

Kim Says North Korea Is Stopping Nuclear and Missile Tests Early today, he said the country was stopping nuclear and missile tests and shuttering its atomic test site, which has “done its job.” Those concessions were long demanded by the U.S., lifting hop ...

High-throughput sequencing and analysis of microbial community cDNA (#metatranscriptomics) are providing valuable insight into in situ microbial activity and metabolism in the oceans.

The eternal significance of microRNAs (4)

Conclusion: Conserved energy biophysically constrains viral latency. Metatranscriptomics High-throughput sequencing and analysis of microbial community cDNA are providing valuable insight into in situ microbial activity and metabolism in the oceans. Wh ...

Abiogenesis vs microRNA biogenesis (3)

Reappraising the human mitochondrial DNA recombination dogma My comment to BioRxiv (Hold on, this is waiting to be approved by BioRxiv) Thank you for helping to show what has been missing from neo-Darwinian theories and other claims that were base ...

Abiogenesis vs microRNA biogenesis (2)

All serious scientists learned about Schrödinger's claims in "What is Life?" (1944). All serious scientists have since linked the creation of the sun's anti-entropic virucidal energy to "negentropy" and healthy longevity. See also: Reappraising the human ...

Abiogenesis vs microRNA biogenesis

Summary: The pseudoscientific nonsense about abiogenesis that has been touted by Karo Michaelian and others like him has caused the unnecessary suffering and premature death of millions to billions of people by placing the pathogenic consequences of dereg ...