Summary: Genetic mutations do not drive evolution. Energy-dependent RNA-mediated fixation of amino acid substitutions links the physiology of reproduction to biophysically constrained viral latency.
With minimal effort, you can peruse the science news each day to see how many pseudoscientists report their findings outside the context of food energy-dependent pheromone-controlled biophysically constrained RNA-mediated cell type differentiation.
See for example:
Type 2 diabetes has hepatic origins
The researchers are now working on identifying the endogenous ligand produced by the body, or on developing molecules that could mimic its function.
Clearly, they are aware of the fact that they must link food energy to the endogenous substrate without claiming that gene activation and the creation of the protein automagically occur.
Diabetes, obesity behind 800,000 cancers worldwide: study
“Our study shows that diabetes—either on its own or combined with being overweight—is responsible for hundreds of thousands of cancer cases each year across the world.”
Who did not know that?
New study finds mycobacteria can sense presence of proteins that cause disease
The transcription factor regulates the levels of the protein cargo transported by the machinery. When the bacteria sense the machinery is absent, the levels of the protein substrates are reduced.
“We hypothesized that there are gender-based differences in body composition and ectopic fat depots and that these could be associated with gender-specific risk profiles for diseases like diabetes, heart disease and stroke,” said lead author Miriam A. Bredella, M.D., radiologist at Massachusetts General Hospital and associate professor of radiology at Harvard Medical School in Boston.
Sex-differences in cell types link the food energy-dependent pheromone-controlled physiology of reproduction to RNA-mediated cell type stability in all living genera.
Women may be more vulnerable to concussions because of ‘leaner’ nerve fibers
The paper shows us that there is a fundamental, anatomical difference between male and female axons,” Smith said. “In the male axon, there are a great number of microtubules, which make the entire structure stronger, whereas in female axons, it’s more of a leaner type of architecture, so it’s not as strong.
This representation of energy-dependent RNA-mediated cell type differentiation is sexist. If researchers claimed there were racial differences in biophysically constrained cell type differentiation, the claim would be racist.
That’s the problem that all pseudoscientists have with cryo-EM. It makes everything that will be reported in the context of energy-dependent links from electrons to ecosystems appear to be racist in the context of A Civic Biology: Presented in Problems (New York, 1914)
Exploratory whole-exome analysis revealed higher expression of humanin-like 8 (MTRNR2L8, or HN8) in both suicide and depression (Figure 1, Supplementary Table 2). MTRNR2L8 is an isoform of the humanin gene (HN) (43), a newly discovered mitochondrial-derived 24 amino acid peptide (44), which is coded by nuclear DNA.
These effects appear to be driven primarily by depression, with the exception of genes involved in ‘DNA-dependent ATPase activity’, which appear to be greater in suicide but not depression. Results suggest cortical gene expression related to microglial, endothelial and glial cell functions may contribute toward or be altered in MDD and suicide, and identify the putative genes and pathways which may play a functional role in these disorders.
Thermotogae are strict anaerobes and gram negative. Their peptidoglycan is unique in having as much D-lysine as the usual L-lysine. And, no LPS (or, at least, no LPS-making enzymes), despite being gram-negative.
The stability of all organized genomes is energy-dependent and biophysically constrained by the fixation of amino acid substitutions in organized genomes. The amount of D-lysine compared to the amount of L-lysine links the dynamic control of chirality to the quantized energy-dependent creation of supercoiled DNA, which protects all organized genomes from the virus-driven degradation of messenger RNA that links mutations to all pathology.
The fact that hydrogen-atom transfer in DNA base pairs in solution links quantized energy as information from the creation of sunlight to the quality of RNA, which must be linked to energy-dependent DNA repair, seems to have escaped the attention of theorists.
Chemists reveal one mechanism of dihydrogen production by nitrogenase (with my emphasis)
Can anyone help to link the calculations to the evolution of the two types of hydrogens in the context of Feynman’s claims about food energy and human idiocy?
A correspondent wrote:
Interesting chirality issues, however I know of no biological system where light directly changes polymer helicity, and this paper is not a biological system. Vines can change their macroscopic helicity, incredibly, just by single amino acid substitutions in different cytoskeltal monomer proteins.