RNA-mediated development

The Arthur M. Sackler Colloquia are sources for up-to-date information about biologically based cause and effect, which links epigenetic effects on hormones to the affects of hormones on behavior. The difference between effect and affect was place into the context here: Correction for McEwen, Brain on stress: How the social environment gets under the skin

The authors note that on page 17184, right column, first paragraph, line 4, “effect” should instead appear as “affect.”

In the early 1990’s, Bruce McEwen offered me the best advice that I have ever received. Start with gene activation or your model cannot be validated. His advice led me to detail how the epigenetic landscape becomes the physical landscape of DNA in the organized genomes of species from microbes to humans. Now see:

Notes on the role of dynamic DNA methylation in mammalian development

This paper results from the Arthur M. Sackler Colloquium of the National Academy of Sciences, “Epigenetic Changes in the Developing Brain: Effects on Behavior,” held March 28–29, 2014, at the National Academy of Sciences in Washington, DC. The complete program and video recordings of most presentations are available on the NAS website at

It is suggested that mammalian genomic methylation patterns represent an evolutionary adaptation of a genome defense system that endows genomes with the ability to inactivate specific genomic regions in a self-perpetuating manner which is essentially irreversible over the lifespan of the organism (38), whereas dynamic gene activation and repression during development are controlled by conserved protein- and RNA-based pathways that are largely common to both methylating and nonmethylating organisms.

My comment: The conclusion is expressed as if it were merely a suggestion of how ecological variation leads to RNA-mediated ecological adaptations in all genera. That helps to not offend evolutionary theorists who understand nothing about how cell type differentiation occurs and nothing about how mutations perturb cell type differentiation and lead to pathology. The conclusion allows evolutionary theorists to continuing believing in ridiculous theories about beneficial mutations. Theorists start with genes, not with gene activation. That’s why their ridiculous theories have no explanatory power in the context of biologically-based cause and effect.
For contrast, starting with RNA enables serious scientists to link ecological variation to ecological adaptations without the pseudoscientific nonsense about beneficial mutations and the evolution of increasing organismal complexity.
See for comparison: RNA interference (RNAi): by Nature Video

See also:

2 Responses

Add a Comment

Your email address will not be published. Required fields are marked *