In order to survive, the organism needs to engage in natural genetic modification in real time, an exquisitely precise molecular dance of life with RNA and DNA responding to and participating in “downstream” biological functions.
My comment：RNA-mediated gene duplications and fixation of RNA-mediated amino acid substitutions link the honeybee model organism of nutrient-dependent pheromone-controlled morphological and behavioral phenotypes to cell type differentiation and biodiversity of all vertebrates. That is why all serious scientists are willing to follow Mae Won Ho’s lead. They are eliminating the boundaries that neo-Darwinian theorists placed between RNA-mediated gene duplication and epigeneticaly-effected RNA-mediated cell type differentiation.
For example, Donna Maney’s group has continued to focus on Darwin’s ‘conditions of life,” which we now know link metabolic networks to genetic networks in the context of life history transitions, morphology, and differences in hormone-organized and hormone-activated behavior. She also appears to be teaching her students to put the role of RNA-mediated chromosomal rearrangements before the role of mutations, which many neo-Darwinian theorists seem to think somehow lead to the evolution of biodiversity.
See for example:
See for comparison: Estrogen Receptor Alpha as a Mediator of Life-History Trade-offs
Disruptive selection that drives incompatible traits into alternative phenotypes is most likely to act on genes with multiple functions. Such genes include those that encode the action or regulation of hormones。。。
My comment：If you think experimental evidence of biologically-based cause and effect links mutations to the evolution of biodiversity, please tell serious scientists how a constraint-breaking mutation could simultaneously lead to changes in morphology and to changes in hormone-organized and hormone-activated behavior that are attributed to chromosomal rearrangements in white-throated sparrow morphs.