Excerpt: “It’s not conventional gene therapy and it’s not gene correction, but it’s editing how the genome is folded,” Blobel explains.
My comment: Protein biosynthesis and degradation are nutrient-dependent and they are controlled by the physiology of RNA-mediated metabolic and genetic networks in all genera.
See: RNA-mediated gene activation
Given that many of the reports discussed in this review are very recent, it appears that we have barely begun to appreciate the tremendous diversity of ncRNAs, and how they may impact gene expression. The sheer number of potentially functional transcripts, from small 20 nt RNAs to 10 kb lincRNAs, will likely be reflected in their equally diverse mechanisms of action. Cytoplasmic ncRNAs can modulate gene expression through binding to complementary mRNAs, whereas in the nucleus, they may interact with chromosomal DNA, as well as the myriad of coding and non-coding transcripts. The complexity of RNA-mediated gene regulatory networks that will undoubtedly be unveiled in the near future is difficult to imagine. Perhaps terms such as “RNA-mediated gene regulation” will no longer be used, as it will have an even broader meaning than “protein-mediated gene regulation.”
My comment: No matter what terms are used in accurate representations of biologically-based RNA-mediated cause and effect, terms like mutations and evolution will not be among them.
Those terms will only be used by theorists who do not understand the requirement to link physics to chemistry and the conserved molecular mechanisms of cell type differentiation in all genera.