…the reversible and dynamic m6A RNA methylation, the most prevalent internal modification in mRNA, plays broad and key roles in diverse biological processes. Through the functional interactions with m6A methyltransferases, demethylases, and m6A-binding proteins, this epigenetic modification affects various aspects of RNA metabolism, including mRNA transcription, splicing, nuclear export, localization, translation and stability, and post-transcriptional regulate gene expression at the RNA level.
Indeed, breakthrough discoveries on biological functions of m6A are constantly emerging in the last few years, and we are still at the very beginning of this novel and fundamental research. The mechanism of m6A post-transcriptional regulation should be further investigated.
Researchers seem to be stuck on the fact that there is no defined boundary between epigenetics and genetics. They may also be unwilling to acknowledge and accept the facts about energy-dependent biophysically constrained RNA-mediated protein folding chemistry and virus-driven energy theft, which causes all pathology.