Summary: Koonin thinks that serious scientists who have linked the creation of energy to all biodiversity via the physiology of pheromone-controlled reproduction in species from microbes to humans must prove that everything the serious scientists know did not occur randomly after the sun’s anti-entropic virucidal energy emerged from nothing.
Other pseudoscientists have taken a step towards refuting Koonin’s moronic claim with publication of:
A mammalian blood odor component serves as an approach-avoidance cue across phylum border – from flies to humans
Taken together, our results strongly suggest that E2D is a blood signature substance that serves as an approach-avoidance cue across phylum borders; it elicits approach responses in blood-feeding invertebrates as well as in mammalian predators, while eliciting avoidance behavior in mammalian prey species. These results demonstrate the existence of a cross-species food- and alarm cue that affects behavior in both human and non-human animals alike.
The omnipresent adaptation to E2D indicates that the selection pressure for this chemical cue is preserved through evolution. This can shed light on human evolution, our formation as a species. “Our finding in humans fits in with the paleontological data showing that early primates were small-bodied insectivores. There is no question that humans are opportunistic predators, but we probably evolved from a prey species and some aspects of this trait lingers on,” says principal investigator Johan Lundström, associate professor at the Karolinska Institutet in Sweden.
Ecological variations are linked to ecological adaptations via what is known to serious scientists about quantum physics, which recently were placed into the context of observations that link electrons to ecosystems in all living genera via the 2017 Nobel Prize-winning cryo-EM technology. With the help of many others and also via my monographs and my presentations during the past 25 years this fact has become perfectly clear. The human ability to detect DNA differences in tissue type via the sense of smell is the link to biophysically constrained viral latency and all biodiversity.
There is no question that the passive-aggressive behavior of researchers like Johan Lundström is displayed as their failure to cite any of my published works.
See also: Smelling DNA with Joseph Orkin
Our ability to smell DNA arises only after the quantized energy-dependent creation of G protein-coupled receptors.
See also, from 1985: THE QUANTAL NATURE OF CONTROLLING STIMULUS-RESPONSE RELATIONS AS MEASURED IN TESTS OF STIMULUS GENERALIZATION
…the quantal interpretation, proposes that a stimulus-response relation functions as a unit that may or may not occur. From the latter viewpoint, the continuity typically obtained during generalization tests is deemed to be artifactual and to result from averaging across multiple controlling stimulus-response relations.
The “omnipresent adaptation to E2D” links multiple controlling stimulus-response relations from the energy-dependent de novo creation of G protein-coupled receptors to the foraging behavior of bacteria and to the physiology of pheromone-controlled human reproduction. Without the ability to sense differences in the fixation of amino acid substitutions in organized genomes DNA, biologically uninformed science idiots have no way to explain omnipresent pathology. Simply put, they have failed to link our choices to all pathology.
Clearly, serious scientists have linked the physiology of pheromone-controlled human reproduction from food energy to the ability to reproduce in all living genera. That is how the omnipresent pathology links the virus-driven degradation of messenger RNA from bacteria to the creation of archaea and L-forms. The L-forms are the last representation of what happens to all life forms that cannot find enough food energy to biophysically constrain viral latency.
See: Virus-mediated archaeal hecatomb in the deep seafloor
We show here for the first time the crucial role of viruses in controlling archaeal dynamics and therefore the functioning of deep-sea ecosystems, and suggest that virus-archaea interactions play a central role in global biogeochemical cycles.
For comparison, see: A universal trend of amino acid gain and loss in protein evolution
Amino acid composition of proteins varies substantially between taxa and, thus, can evolve.
Eugene Koonin knows that: “The entire evolution of the microbial world and the virus world, and the interaction between microbes and viruses and other life forms have been left out of the Modern Synthesis…”
That fact forces him to fight against the claims of adaptationists who have refuted his pseudoscientific nonsense about mutations and evolution.
See: Splendor and misery of adaptation, or the importance of neutral null for understanding evolution
Koonin thinks that serious scientists who have linked the creation of energy to all biodiversity via the physiology of pheromone-controlled reproduction in species from microbes to humans must prove that everything the serious scientists know did not occur randomly after the sun’s anti-entropic virucidal energy emerged from nothing.
No one I know expects you to understand the overwhelming complexity of the links from quantum physics to chemistry and molecular epigenetics to quantum souls. Many people I know expect you to be able to understand the claims about “Light Unshackled.”
In this study, across 60 melanoma cell lines, we find bimodal expression patterns of MHC-II, while MHC-I expression was ubiquitous. A unique subset of melanomas are capable of expressing MHC-II under basal or IFNγ-stimulated conditions. Using pathway analysis, we show that MHC-II(+) cell lines demonstrate signatures of ‘PD-1 signalling’, ‘allograft rejection’ and ‘T-cell receptor signalling’, among others.
UV light induced changes in the microRNA/messenger RNA balance have been linked to healthy longevity via the food energy-dependent RNA-mediated fixation of pheromone-controlled amino acid substitutions in organized genomes. Differences in the amino acid substitutions have been found in the organized genomes of all species.
The virus-driven theft of quantized energy such as UV light has been linked from the degradation of messenger RNA to all pathology.
See also: Medical Breakthroughs: Cancer
During clinical trials, the medication was famously used to treat former President Jimmy Carter, who two years ago announced he had cancer in his brain and liver and said his fate was “in the hands of God, whom I worship.” Four months later, his cancer was gone.
Was it God who caused the cancer, or did God cause its demise? From my perspective on light energy as information and energy-dependent RNA-mediated DNA repair, it is clear that melanoma-specific MHC-II expression represents a link from the virus-driven degradation of messenger RNA to a predicatable response from the innate immune system. That response has been made somewhat more predictable in the context of the phenotype that predicts the response to anti-PD-1/PD-L1 therapy.
See also: New Dancing Couple: PD-L1 and MicroRNA
MicroRNAs are regulatory molecules (~20 nt in length) with the ability to regulate the expression of genes. The recently described PD-1 and PD-L1 molecules have great importance for potential use in immunotherapy of many cancers. These molecules are associated with immune checkpoints and provide an opportunity for the treatment of advanced NSCLC patients with synthetic monoclonal antibodies. PD-L1 expression is strictly associated with microRNA function in lung cancer cells. The group of microRNAs related to PD-L1 includes, among others, miR-200, miR-197 or miRNA-34. Expression of these molecules may be useful in lung cancer diagnosis, qualification to anti-PD-1 or anti-PD-L1 antibody therapy and could be a potential therapeutic target. However, studies on PD-L1-related microRNAs are necessary to develop advanced targeted molecular therapies.
Studies of studies on PD-L1-related microRNAs and other microRNAs link the changes in electrons to ecosystems in all living genera. Focus on prevention and effective treatments of all pathology has been delayed by the focus on the CRISPR/Cas 9 gene editing technology. That focus is much more closely linked to the pseudoscientific nonsense touted by neo-Darwinian theorists who failed to link the virus-driven degradation of messenger RNA to all pathology.