Cytosis can be used to teach everything from base editing to RNA editing to everyone over age 10. They will learn how to link the creation of energy to biophysically constrained viral latency via the physiology of pheromone-controlled reproduction.

The tipping point (revisited): 68,000 publications

MicroRNA  Items: 1 to 20 of 68011 (earlier today, on 12/21/17)

See for example: In Vitro Validation of miRNA-Mediated Gene Expression Linked to Drug Metabolism 12/20/17

The approaches described can be employed broadly for the validation of miRNA-mediated negative regulation of any gene. Determining miRNA-mediated regulation of enzymes and transporters affecting drug metabolism is a critical step in designing personalized therapy and for understanding the mechanisms responsible for variations in the responses to therapeutic agents.

The “…miRNA-mediated regulation of enzymes and transporters affecting drug metabolism…” links the National Microbiome Initiative to the Precision Medicine Initiative and to all healthy longevity or to all virus-driven pathology in all living genera via differences in energy as information.
For review, see: Energy as information and constrained endogenous RNA interference

Feedback loops link quantized energy as information to biophysically constrained RNA-mediated protein folding chemistry. Light induced energy-dependent changes link angstroms to ecosystems from classical physics to chemistry/chirality and to molecular epigenetics/autophagy. The National Microbiome Initiative links microbial quorum sensing to the physiology of reproduction via endogenous RNA interference and chromosomal rearrangements. The rearrangements link energy-dependent fixed amino acid substitutions to the Precision Medicine Initiative via genome wide inferences of natural selection. This detailed representation of energy-dependent natural selection for codon optimality links biologically- based cause and effect from G protein-coupled receptors to RNA-mediated amino acid substitutions and the functional structure of supercoiled DNA. Energy-dependent polycombic ecological adaptations are manifested in supercoiled DNA. Chromosomal inheritance links the adaptations from morphological phenotypes to healthy longevity via behavioral phenotypes. For contrast, virus-driven energy theft is the link from messenger RNA degradation to negative supercoiling, constraint breaking mutations, and hecatombic evolution. The viral hecatomb links transgenerational epigenetic inheritance from archaea to Zika virus-damaged DNA, which typically is repaired by endogenous RNA interference and fixation of RNA-mediated amino acid substitutions in organized genomes.

For a historical perspective on what is known about energy-dependent RNA-mediated (aka microRNA-mediated) cell type differentiation, see:
The quantum / classical RNA-mediated ‘tipping point’ 3/26/15
The tipping point? 50, 000 publications 5/16/16
The tipping point? 50, 000 publications (2) 5/16/16
The tipping point? 50,000 publications (3) 5/17/16
The tipping point? 50,000 publications (4) 5/26/16
The tipping point? 50,000 publications (5) 7/27/16
The tipping point (revisited): 60,000 4/20/17
By May 16, 2016, the innate antiphage defense strategy was linked from quantum physics to classical physics by 50,000 publications that mentioned microRNAs. Nineteen months later, every aspect of the microRNA-mediated gene expression that had already been linked to drug metabolism attests to the fact that not all scientists have followed the extant literature.
Many scientists are still among the pseudoscientists who who failed to notice the most obvious links from the antiphage defense strategy to healthy longevity. Perhaps they were also too busy to notice the most obvious links from the virus-driven degradation of messenger RNA to the need for drug therapies.
If so, that may explain why the drug therapies have been largely ineffective. The drug therapies may be like vaccinations. They appear to link the virus-driven degradation of messenger RNA to more mutations, which clearly link the virus-driven theft of quantized energy to all pathology.
With more than 18,000 published works in the past 19 months, (8,000 in the past 8 months) it is time to again address the tipping point between quantum physics and classical physics in the context of food energy-dependent pheromone-controlled microRNA-mediated cell type differentiation via what is known about autophagy.
In the context of drug metabolism, the energy-dependent microRNA-mediated creation of enzymes was linked from the metabolism of food to all biodiversity on Earth via pheromone-controlled physiology of reproduction.
See for example page 19 of the sample report from Alpha Genomix that you can download as a pdf here. The food energy-dependent creation of the CYP enzymes protects our organized genome by biophysically constraining viral latency.

See for comparison: Our Top 17 in ’17: The Year in Science at PLOSBLOGS 

…the far-reaching war on science being conducted by the Trump administration, an assault on facts which, as several of our bloggers have noted, constitutes a removal of scientific evidence from the formation and discussion of public policy and an evisceration of funding and communication of vital research in medical research and regulation, public health, climate, energy, agriculture and education.

The only war on science that I know about, is the one in which serious scientists are Combating Evolution to Fight Disease. To place that claim into the context of what has happened during 2017, see the retraction of this article.
Biomechanical Characteristics of Hand Coordination in Grasping Activities of Daily Living [retracted]
It was retracted because the authors mentioned the creator of the hand. The creation of the hand occurs only in the context of biophysically constrained viral latency.

See for comparison: Retraction Watch

In retrospect, we were totally blinded by our belief [in our findings]…we were not as careful or rigorous as we should have been (and as Tivoli was) in interpreting these experiments.

Where else besides PLOS have you seen a retraction for the mention of a creator? Where did PLOS report on the retraction for misrepresentations in “Nature Chemistry?” Who still believes that microRNA and messenger RNAs created each other so that they could automagically constrain viral latency?
Who else besides PLOS is waging a far-reaching war on science?
See: Nutrient-dependent pheromone-controlled ecological adaptations: from atoms to ecosystems 4/10/14

This atoms to ecosystems model of ecological adaptations links nutrient-dependent epigenetic effects on base pairs and amino acid substitutions to pheromone-controlled changes in the microRNA / messenger RNA balance and chromosomal rearrangements. The nutrient-dependent pheromone-controlled changes are required for the thermodynamic regulation of intracellular signaling, which enables biophysically constrained nutrient-dependent protein folding; experience-dependent receptor-mediated behaviors, and organism-level thermoregulation in ever-changing ecological niches and social niches. Nutrient-dependent pheromone-controlled ecological, social, neurogenic and socio-cognitive niche construction are manifested in increasing organismal complexity in species from microbes to man. Species diversity is a biologically-based nutrient-dependent morphological fact and species-specific pheromones control the physiology of reproduction. The reciprocal relationships of species-typical nutrient-dependent morphological and behavioral diversity are enabled by pheromone-controlled reproduction. Ecological variations and biophysically constrained natural selection of nutrients cause the behaviors that enable ecological adaptations. Species diversity is ecologically validated proof-of-concept. Ideas from population genetics, which exclude ecological factors, are integrated with an experimental evidence-based approach that establishes what is currently known. This is known: Olfactory/pheromonal input links food odors and social odors from the epigenetic landscape to the physical landscape of DNA in the organized genomes of species from microbes to man during their development.

Obama Advisers Urge Action Against CRISPR Bioterror Threat 11/17/16

Scientific advisers to President Obama warn that the U.S. urgently needs a new biodefense strategy and should regularly brief President-elect Donald Trump on the dangers posed by new technologies like CRISPR, gene therapy, and synthetic DNA, which they say could be coöpted by terrorists.

See for comparison:  2017 Global Infectious Diseases Threats to the United States 12/22/16

Flu.  Influenza remains one of the greatest threats to the US population killing on average 3,000-49,000 Americans annually.  People at the greatest risk of severe flu and death are pregnant women, residents of long-term care facilities, the very old (adults over the age of 65), the very young (children less than 2), Native American populations, and those with underlying chronic conditions such as asthma, COPD, heart disease, obesity, and other conditions.  Timely vaccination remains the most proven and effective way to avoid serious injury from influenza.

The new Trump Administration will face a formidable array of global and indigenous infectious disease threats in 2017.  A Global Health Security Agenda will help provide a framework for tackling some of these tough issues, but enhanced efforts will be needed to prevent new epidemics, especially from vector-borne and zoonotic neglected tropical diseases, measles, and the ever-constant threats from AMR and flu.

The biggest threat that the Trump administration has faced in the first year is the fake news. The most recent example accused him of censorship at the CDC for his director’s efforts to biophysically constrain energy-dependent viral latency. The CDC director’s efforts to help others with budget concerns were linked to censorship, and the President of the United States was compared to Hitler. Wake up and “Remember the Alamo.”
SARCASM ALERT: No, that was a different war. Wake up and remember the Manhattan Project, which also linked censorship about energy to the winning of a war.

Cytosis can be used to teach everything from base editing to RNA editing to everyone over age 10. They will learn how to link the creation of energy to biophysically constrained viral latency via the physiology of pheromone-controlled reproduction.

Vulgar Antagonists vs Quantum Effects

Exosome Cargo Could Be Drug Target For Neuropathic Pain

My discussion attempt was removed by Dfm Prime, who claims to be a patient advocate for those who are suffering from neurological insult.

See: Works at Neurosensory Neuroregenerative Research Foundation
Publication: Catechol-O-Methyl Transferase Inhibition Reduces Symptoms of Hallucinogen Persisting Perception Disorder
See for comparison: Oppositional COMT Val158Met effects on resting state functional connectivity in adolescents and adults
In my model, fluoroquinolone use to kill gut bacteria sometimes kills the bacteria that biophysically constrain the virus-driven degradation of messenger RNA, which links mutations to all pathology. The food energy-dependent pheromone-controlled physiology of reproduction links what is known about pathology in microbes to mental and physical pathology in humans via the conserved molecular mechanisms of energy-dependent RNA-mediated cell type differentiation. That is what we detailed in the molecular epigenetics section of this 1996 Hormones and Behavior review.
From Fertilization to Adult Sexual Behavior
Attempting to discuss anything that is known to serious scientists about epigenetically effected cell type differentiation is futile if, like Dfm Prime, they are not willing to examine the track record of publications during the past 20 years.
See: [Pheromonal regulation of genetic processes: research on the house mouse (Mus musculus L.)]

A study of the influence of pheromone stressor(s) on proliferating germ and somatic cells was performed on laboratory lines of house mouse in the context of the physiological hypothesis of mutation process, proposed by M.E. Lobashev in 1947. Data from experiments are presented, and results obtained during last 10-15 years are discussed. The adaptive role of cytogenetic and other observed pheromonal effects is considered. The possible existence of interorganism systems of genetic regulation is discussed, the search for and study of which may help in more complete understanding of the regularities of functioning of genetic material.

See also: (2017)
Noam Sobel and Luca Turin were speakers. Everything known to serious scientists about all the links from energy-dependent changes in electrons to ecosystems has since been linked from olfaction to quantum souls in the context of the space-time continuum and the food energy-dependent pheromone-controlled physiology of reproduction in species from microbes to humans.
See: Olfaction Warps Visual Time Perception
See also: Nutritional Deficiencies and Clinical Correlates in First-Episode Psychosis: A Systematic Review and Meta-analysis

…beneficial effects of other nutrient-based adjunctive treatments (such as NAC83 and Taurine84) are not due to restoring specific nutritional deficits, but instead attributed to these amino acids targeting pathological neurological processes.83,84 Therefore, even in the absence of clear deficiencies, certain nutrients may confer positive effects in FEP through the neurochemical properties of these compounds, regardless of deficiency status.

Reported as: “Nutrition may play a key role in early psychosis treatment” November 30, 2017

… this finding emphasises the importance of promoting a healthy diet for young people with psychosis, and potentially suggests adding targeted nutritional supplementation to standard treatment could improve recovery – although this theory has yet to be tested.

It’s not a theory and it does not need to be tested. See:

Nutrient-dependent pheromone-controlled ecological adaptations: from atoms to ecosystems

The plausibility and ecological validity of Kohl’s Laws in the context of Darwin’s ‘conditions of life’ can be compared to theories about biologically-based cause and effect in the context of species diversity. In mammals, for example, the explanatory power of a model of ecological variation and biophysically constrained nutrient-dependent pheromone-controlled ecological adaptations became clear with companion papers published in 2013. See for review [30].

The companion papers [162-163] told a new short story of ecological adaptations. In the context of climate change and changes in diet, the story began with what probably was a nutrient-dependent base pair change and a variant epiallele that arose in a human population in what is now central China. Apparently, the effect of the epiallele was adaptive and it was manifested in the context of an effect on sweat, skin, hair, and teeth. In another mammal, such as the mouse, the effect on sweat, skin, hair, and teeth is probably due to a nutrient-dependent epigenetic effect on hormones responsible for the tweaking of immense gene networks that metabolize nutrients to pheromones. The pheromones appear to control the nutrient-dependent epigenetically-effected hormone-dependent organization and hormone-activation of reproductive sexual behavior in mammals such as mice and humans, but also in invertebrates and in microbes as previously indicated.

The ecological adaptations, which appear to be manifested in the human population are detailed in these two reports [162-163]. The ecological adaptations are likely to be nutrient-dependent and pheromone-controlled. If so, ecological variation probably leads to ecological, social, neurogenic, and socio-cognitive niche construction, which is manifested in increasing organismal complexity and species diversity. If not, there may be something as yet unknown about mutations and evolution that makes sense in the light of what is known about nutritional epigenetics and the molecular biology of species from microbes to man.

Autophagy links the food energy-dependent pheromone-controlled physiology of reproduction to biophysically constrained viral latency and ecological adaptations. Nutrient stress and/or social stress link constraint-breaking mutations to all pathology via quantum effects in all biological systems.

QuEBS 2018: Workshop on Quantum Effects in Biological Systems July 10-13, 2018 in Vilnius, Lithuania
 
 
 

Alternative splicing of pre-mRNA

Light-activated error free DNA repair (2)

Summary: In the diagram and diatribes that accompany claims about de novo changes in electrons and the production of nucleotides, the amount of pseudoscientific nonsense becomes perfectly clear. Pseudoscientists start with energy-dependent changes but call the changes de novo changes in electrons. That allows the pseudoscientists to dismiss any facts about how the creation of energy must be linked to the creation of enzymes. The creation of enzymes does not automagically occur and the creation of all biodiversity must occur via the enzymatic metabolism of food to pheromones and the physiology of pheromone-controlled reproduction. Use of the phrase de novo changes is a clear indicator that pseudoscientists know nothing about biophysically constrained viral latency and nothing about cell type differentiation. All changes are energy-dependent and virus-driven energy theft links the degradation of messenger RNA from mutations to all pathology.
In Light-activated error free DNA repair, I wrote:

The creation of quantized energy in sunlight links energy as information from electrons to ecosystems via the physiology of reproduction in all living genera.

See also: Endogenous adenosine maintains cartilage homeostasis and exogenous adenosine inhibits osteoarthritis progression

We conclude that adenosine, acting at A2AR, is an important homeostatic regulator of chondrocytes and cartilage and adenosine repletion may represent a novel approach to treating OA (Fig. 6).

The link from exogenous adenosine to the endogenous adenosine that inhibits pathology is food energy-dependent and RNA-mediated.That is why adenosine repletion will almost undoubtedly be effective. Some friends have already found that supplements of curcumin and nicotinamide/niacinamide are helpful.
Science needs reason to be trusted to link the creation of visible light to the creation of the nicotinamide-dependent enzyme known as ketoreductase, which can be transformed from a carbonyl reductase into an initiator of radical species and a chiral source of hydrogen atoms.
If hydrogen-atom transfer in DNA base pairs in solution is not linked to healthy longevity, the virus-driven degradation of messenger RNA will not be linked from mutations to all pathology.
See: Accessing non-natural reactivity by irradiating nicotinamide-dependent enzymes with light
The link from the quantized energy of the sun has been placed into this context:

We demonstrate this new reactivity through a highly enantioselective radical dehalogenation of lactones-a challenging transformation for small-molecule catalysts. Mechanistic experiments support the theory that a radical species acts as an intermediate in this reaction, with NADH and NADPH (the reduced forms of nicotinamide adenine nucleotide and nicotinamide adenine dinucleotide phosphate, respectively) serving as both a photoreductant and the source of hydrogen atoms.

The photoreductant source of hydrogen atoms links the quantized energy of sunlight from quantum physics to quantum souls via error-free RNA-mediated DNA repair in the context of the physiology of pheromone-controlled reproduction and the creation of all morphological and behavioral diversity on Earth via what is known about the stability of the gonadotropin releasing hormone (GnRH) decapeptide. The creation of achiral glycine and its position at position 6 in the GnRH decapeptide is linked from food odors and pheromones to the stability of all vertebrate genomes.
See how easily the facts about the stability of supercoiled DNA in the organized genomes of all vertebrates was placed back into the context of evolution.
A quantum theory for the irreplaceable role of docosahexaenoic acid in neural cell signalling throughout evolution
Explanations from classical physics cannot be used to support the theory and nothing but that facts about chemistry links sunlight to the creation of enzymes that metabolize food and link the food energy to biophysically constrained life via the physiology of pheromone-controlled reproduction, which protects organized genomes from the virus-driven degradation of messenger RNA that links mutations to all pathology.

We suggest that DHA is one Darwin’s “Conditions of Existence” [conditions of life] which made DHA the master of DNA

How Popper killed Particle Physics

Even in his worst moments Popper never said a theory is scientific just because it’s falsifiable. That’s Popper upside-down and clearly nonsense. Unfortunately, upside-down Popper now drives theory-development, both in cosmology and in high energy physics.
It’s not hard to come up with theories that are falsifiable but not scientific. By scientific I mean the theory has a reasonable chance of accurately describing nature.

11/20/17
Jay R. Feierman:

Science is about predicting, not post hoc explaining except under the conditions stated above. I still find Popper’s methods useful for crafting theories in the bio-behavioral sciences. I’m not ready to declare his philosophy as dead.

7/25/13
Jay R. Feierman: Variation is not nutrient availability and the something that is doing the selecting is not the individual organism. A feature of an educated person is to realize what they do not know. Sadly, you don’t know that you have an incorrect understanding [of] Darwinian biological evolution.
Popper’s upside-down theory can be replaced in the context of the inside-out olfactory receptor, which links the epigenetic landscape to the physical landscape of DNA via two epigenetic traps
An Epigenetic Signature for Monoallelic Olfactory Receptor Expression
Nuclear Aggregation of Olfactory Receptor Genes Governs Their Monogenic Expression

We’ve got the evolution of complex cells inside-out

Almost everybody agrees that the complex eukaryotic cell evolved from a simple ancestor. The question is how.

All serious scientists know that the energy-dependent creation of ATP (epigenetic trap #1) must be linked from the creation of RNA (epigenetic trap #2) to all biodiversity on Earth via the physiology of pheromone-controlled reproduction in species from microbes to humans. For example, without the energy-dependent de novo creation of G protein-coupled receptors, there is no way to link any light-induced endogenous substrate to the creation of enzymes and the metabolism of food to the energy that sustains life in electron eating microbes and microbes that “eat” light.

 
“…Golden didn’t set out from school intent on pursuing a career in chronobiology. The field only barely existed when she did her graduate work in the 1980s. Her specialty was, and still is, studying bacteria that use light as a source of energy.

See also: Biogenic non-crystalline U(IV) revealed as major component in uranium ore deposits

The fact that bacteria eat electrons and produce uranium isotopes can now be linked from light-harvesting to all pheromone-controlled biophysically constrained biodiversity on Earth by what was known to Susan S. Golden in the 1980s.

Two Questions remain:

1) Where do the electrons come from?

2) Why doesn’t every serious scientist know how to link energy-dependent changes from electrons to ecosystems via the link from ultraviolet light to the vibrational theory of olfaction and RNA-mediated feedback loops that link food odors and pheromones to the physiology of reproduction in species from microbes to humans?

The vibrational theory of olfaction for the win by John Hewitt

On 11/21/17, John Hewitt alerted me to the fact that the information in this article might be linked from the de novo creation of olfactory receptor genes to all biodiversity on Earth via links from the physiology of pheromone-controlled reproduction in bacteria to human adult hippocampal neurogenesis. The monoallelic disease(s) known as Kallmann’s Syndrome clearly link the transgenerational epigenetic inheritance of virus-driven pathology to deficits in olfactory acuity and specificity. The olfactory deficites link interactions among all neuronal systems in the brain to healthy longevity via the substitution of the achiral amino acid glycine in position 6 of the GnRH decapeptide.

See: Long-Range GABAergic Inputs Regulate Neural Stem Cell Quiescence and Control Adult Hippocampal Neurogenesis

Taken together, these findings delineate a GABAergic network involving long-range GABAergic projection neurons and local PV interneurons that couples dynamic brain activity to the neurogenic niche in controlling NSC quiescence and hippocampal neurogenesis.

See for comparison: Guidelines for Genome-Scale Analysis of Biological Rhythms

1) Genome biology approaches have made enormous contributions to our understanding of biological rhythms, particularly in identifying outputs of the clock, including RNAs, proteins, and metabolites, whose abundance oscillates throughout the day.

2) …we discuss several unmet analytical needs, including applications to clinical medicine, and suggest productive avenues to address them.

This suggests they are going to try to make it appear that Schrodinger’s link from the anti-entropic virucidal effects of sunlight has only recently been discovered to be the key to the prevention of the virus-driven degradation of messenger RNA, which all serious scientists know is the link from mutations to all pathology.
SS Golden is the co-author and they propose 3 broadly applicable “golden rules” of light-activated biological rhythms. The “Golden Rules” do not link more than 66,000 published works on microRNAs to Kohl’s “Laws of Biology” in this 2014 invited review of nutritional epigenetics: Nutrient-dependent pheromone-controlled ecological adaptations: from atoms to ecosystems
The Law’s of Biology are Darwin’s “conditions of life.” Simply put, all organisms must eat and the physiology of pheromone-controlled reproduction must be linked to all morphological and behavioral biodiversity on Earth after the creation of light made life possible. Natural selection for anything that was selected after the creation of energy, should not be viewed in the context of explanations of anything else.
Nothing on Earth exists outside the context of biophysically constrained energy and viral latency. Nothing on Earth exists outside the context of energy-dependent natural selection for codon optimality in the context of fixation of RNA-mediated amino acid substitutions, the creation of enzymes and the interactions among complex systems in humans that link achiral glycine in position 6 of the GnRH decapeptide to all morphological and behavioral phenotypes.

See also: An epigenetics gold rush: new controls for gene expression

‘A-to-I editing’ can alter a protein’s coding sequence, and, in humans, is crucial for keeping the innate immune response in check.

See for comparison: Redox-sensitive alteration of replisome architecture safeguards genome integrity

DNA replication requires coordination between replication fork progression and deoxynucleotide triphosphate (dNTP)–generating metabolic pathways

The safeguards are energy-dependent and they have been linked from light-activated endogenous substrates in all cell types to changes in immune system function. That fact is ignored in the context of a “genome survellance mechanism.”

Studying this genome surveillance mechanism in cancer cells with elevated ROS levels and increased replication adaptability may provide opportunities to specifically target tumors.

Reported as: Redox sensing controls DNA replication!

Redox sensing controls DNA replication!

New DNA is generated in human cells from tiny building blocks called nucleotides produced by an enzyme called RNR (ribonucleotide reductase).

By starting with de novo changes in electrons, the diagram that accompanies the pseudoscientific nonsense of their claim makes the nonsense perfectly clear. They intend to leave out anything known to serious scientists who have linked the creation of energy to the creation of enzymes and to the creation of all biodiversity via the metabolism of food to pheromones and the physiology of pheromone-controlled reproduction.
For comparison, serious scientists have linked energy-dependent changes from atoms to ecosystems via the conserved molecular mechanisms of base editing, microRNA editing, and RNA editing as detailed in Light-activated error free DNA repair.
See for examples:
Nutrient-dependent pheromone-controlled ecological adaptations: from atoms to ecosystems
Reduced adenosine-to-inosine miR-455-5p editing promotes melanoma growth and metastasis

…adenosine-to-inosine (A-to-I) RNA editing occurs in microRNAs (miRNAs)…

Thanks to Dr. Phil Mills for bring this to my attention in the context of more than 40 skin cancer excisions I have had during the past few years. RNA editing by ADAR1 leads to context-dependent transcriptome-wide changes in RNA secondary structure

Our findings imply that the editing effect on RNA secondary structure is context dependent and underline the intricate regulatory role of ADAR1 on global RNA secondary structure.

See: Scientists demonstrate the importance of RNA editing in melanoma development

…a lack of RNA editing, a process by which information inside RNA molecules is transformed, leads to tumor growth and progression through manipulation of proteins.

See also: Study: Vitamin B3 might help against skin cancer

…people who took a specific type of vitamin B3 for a year had a 23 percent lower rate of new skin cancers compared to others…

The link from sun exposure to vitamin C production in plants and vitamin D production in human populations that might be protected from skin cancer by niacinamide, led me to become more focused on prevention. For example, a 23 percent lower rate of skin cancers translates to 10 less excision surgeries if I can achieve a better energy-dependent microRNA/messenger RNA balance.
Energy-dependent base editing has been linked to microRNA editing and linked from RNA editing to the fixation of RNA-mediated amino acid substitutions in the organized genomes of all living genera via the pheromone-controlled physiology of reproduction. Any presentation of data that fails to start with energy-dependent changes in the microRNA/messenger RNA balance implies a deliberate attempt to support the pseudoscientific nonsense of evolutionary theorists and/or big bang cosmologists.
It’s time for pseudoscientists to admit they’ve been wrong about mutation-driven evolution and move forward via consideration of experimental evidence.
See also: Systematic characterization of A-to-I RNA editing hotspots in microRNAs across human cancers
MicroRNA-mediated RNA editing links energy-dependent changes in base pairs from the creation of nucleotides to the stability of organized genome in all living genera via the physiology of pheromone-controlled reproduction in species from microbes to humans.  All serious scientists know that. However, the number of pseudoscientists is more than the serious scientists who will be presenting at this conference.
See: Mechanisms of Recombination conference
For comparison, the pseudoscientists have their own conferences. See for a possible example: Neuroimmunology and Neurological disorders
I’ve already asked the conference organizer “Who will be linking the molecular mechanisms of recombination to neuroimmunology via autophagy or help serious scientists to link the virus-driven degradation of messenger RNA to all pathology?” 
I no longer expect any answer to my questions from those who have not linked the creation of quantized energy to all biodiversity via the pheromone-controlled physiology of reproduction in species from microbes to humans.
See instead, more information on: A-to-I RNA editing

Redox sensing controls DNA replication!

Schrodinger's answer to Schrodinger's question

There is no such thing as de novo control of electrons or self-assembly.

Answering Schrödinger’s question: A free-energy formulation

The free-energy principle (FEP) is a formal model of neuronal processes that is widely recognised in neuroscience as a unifying theory of the brain and biobehaviour. More recently, however, it has been extended beyond the brain to explain the dynamics of living systems, and their unique capacity to avoid decay.

They don’t understand the question that Schrodinger answered. He linked the anti-entropic virucidal energy of sunlight to the physiology of pheromone-controlled reproduction via what organisms eat. What they eat protects them from the virus-driven degradation of their messenger RNA. What they eat links food energy-dependent changes in base pairs from microRNA editing to RNA editing and fixation of RNA-mediated amino acid substitutions in organized genomes of all individuals of all living genera.

Schrodinger answered this question: What is life when it is not protected from virus driven entropy? (video 6:37) Published on 30 Mar 2016

Abstract:

The anti-entropic force of virucidal ultraviolet light links guanine–cytosine (G⋅C) Watson–Crick base pairing from hydrogen-atom transfer in DNA base pairs in solution to supercoiled DNA, which protects the organized genomes of all living genera from virus-driven entropy. For example, protection of DNA from permanent UV damage occurs in the context of photosynthesis and nutrient-dependent RNA-directed DNA methylation, which links RNA-mediated amino acid substitutions to DNA repair. In the context of thermodynamic cycles of protein biosynthesis and degradation, DNA repair enables the de novo creation of G protein coupled receptors (GPCRs). Olfactory receptor genes are GPCRs. The de novo creation of olfactory receptor genes links chemotaxis and phototaxis from foraging behavior to social behavior in species from microbes to humans. Foraging behavior links ecological variation to ecological adaptation in the context of this atoms to ecosystems model of biophysically constrained energy-dependent RNA-mediated protein folding chemistry. Protein folding chemistry links nutrient-dependent microRNAs from microRNA flanking sequences to energy transfer and cell type differentiation in the context of adhesion proteins, and supercoiled DNA that protects all organized genomes from virus-driven entropy.

Life that is not protected from the virus-driven degradation of messenger RNA links the reduced number of food energy-dependent microRNAs to activation of the death gene. See for example:

Reduced expression of brain-enriched microRNAs in glioblastomas permits targeted regulation of a cell death gene 

The natural contribution of food energy is linked to the endogenous level of microRNA expression seen in neuronal cells in the context of limited cell death compared control glioblastoma cells. That fact was linked to the treatment of brain cancers.

For a review of how food energy-dependent microRNAs protect the organized genomes of all living genera from the virus-driven degradation of messenger RNA that links mutations to all pathology, see:

A Concise Review of MicroRNA Exploring the Insights of MicroRNA Regulations in Bacterial, Viral and Metabolic Diseases

For a example of how human idiocy has prevented the effective treatment of all pathology, see also:

Neuropathological and transcriptomic characteristics of the aged brain

Reported as: Researchers reveal new details on aged brain, Alzheimer’s and dementia

One factor that is not always taken into account when studying gene expression in the aged brain is the quality of the genetic material itself,” says Miller. “This variable is not necessarily related to any specific pathology or disease, but these results highlight the importance of properly controlling for RNA quality when studying the aged brain and indicate that degradation of genetic material may be an underappreciated feature of neurodegeneration or dementia.

 Re: degradation of genetic material may be an underappreciated feature of neurodegeneration or dementia.

See: Cytosis

A board game taking place inside a human cell! Players compete to build enzymes, hormones and receptors and fend off attacking Viruses!

Cytosis can be used to teach everything from base editing to RNA editing to everyone over age 10. They will learn how to link the creation of energy to biophysically constrained viral latency via the physiology of pheromone-controlled reproduction.

From base editing to RNA editing (3)

Summary: Claims about spontaneous deamination fail to link energy-dependent changes from base editing to RNA-mediated DNA repair of damage caused by the virus-driven degradation of messenger RNA.
Highly efficient RNA-guided base editing in mouse embryos 27 February 2017
They reported the use of RNA-programmable deaminases to make various animal models with single amino-acid substitutions.They linked the single amino acid substitutions from the correction of nonsense mutations in the future to the correction of genetic defects in human embryos.
Reported as: An Efficient Single-Nucleotide-Editing CRISPR

“We showed here for the first time that programmable deaminases efficiently induced base substitutions in animal embryos, producing mutant mice with disease phenotypes,” remarked senior study investigator Jin-Soo Kim, Ph.D., director of the Center for Genome Engineering at IBS. “This is a proof-of-principle experiment. The next goal is to correct a genetic defect in animals. Ultimately, this technique may allow gene correction in human embryos.”

Their technique linked base editing to naturally occurring energy-dependent gene editing in human embyos.  These researchers also inadvertently linked what is known about the pheromone-controlled physiology of reproduction from microbes to human populations outside the context of mutation-driven evolution.
They helped force other researchers to place their findings back into the context of “evolved” biodiversity after first linking evolution to the spontaneous deamination of cytosine. Claims about spontaneous deamination fail to link energy-dependent changes from base editing to RNA-mediated DNA repair of damage caused by the virus-driven degradation of messenger RNA.
Programmable base editing of A•T to G•C in genomic DNA without DNA cleavage

The spontaneous deamination of cytosine is a major source of C•G to T•A transitions, which account for half of known human pathogenic point mutations. The ability to efficiently convert target A•T base pairs to G•C could therefore advance the study and treatment of genetic diseases. While the deamination of adenine yields inosine, which is treated as guanine by polymerases, no enzymes are known to deaminate adenine in DNA. Here we report adenine base editors (ABEs) that mediate conversion of A•T to G•C in genomic DNA. We evolved a tRNA adenosine deaminase to operate on DNA when fused to a catalytically impaired CRISPR-Cas9. Extensive directed evolution and protein engineering resulted in seventh-generation ABEs (e.g., ABE7.10), that convert target A•T to G•C base pairs efficiently (~50% in human cells) with very high product purity (typically ≥ 99.9%) and very low rates of indels (typically ≤ 0.1%). ABEs introduce point mutations more efficiently and cleanly than a current Cas9 nuclease-based method, induce less off-target genome modification than Cas9, and can install disease-correcting or disease-suppressing mutations in human cells. Together with our previous base editors, ABEs advance genome editing by enabling the direct, programmable introduction of all four transition mutations without double-stranded DNA cleavage.

After a brief look at what they attribute to spontaneous deamination, please see: How flu shot manufacturing forces influenza to mutate

“Now we can explain — at an atomic level — why egg-based vaccine production is causing problems,” said TSRI Research Associate Nicholas Wu, Ph.D., first author of the study, published recently in the journal PLOS Pathogens.

In this 2014 invited review of nutritional epigenetics I linked energy-dependent changes from atoms to ecosystems in all living genera via food energy and the pheromone-controlled physiology of reproduction.

Nutrient-dependent pheromone-controlled ecological adaptations: from atoms to ecosystems

The plausibility and ecological validity of Kohl’s Laws [of Biology] in the context of Darwin’s ‘conditions of life’ can be compared to theories about biologically-based cause and effect in the context of species diversity. In mammals, for example, the explanatory power of a model of ecological variation and biophysically constrained nutrient-dependent pheromone-controlled ecological adaptations became clear with companion papers published in 2013. See for review [30].

The companion papers [162-163] told a new short story of ecological adaptations. In the context of climate change and changes in diet, the story began with what probably was a nutrient-dependent base pair change and a variant epiallele [amino acid substitution] that arose in a human population in what is now central China.

30) Kohl, J. V., Nutrient–dependent / pheromone–controlled adaptive evolution: a model. Socioaffective Neuroscience & Psychology 2013, 3. doi: 10.3402/snp.v3i0.20553
162) Kamberov, Yana G.; Wang, S.; Tan, J.; Gerbault, P.; Wark, A.; Tan, L.; Yang, Y.; Li, S.; Tang, K.; Chen, H., et al., Modeling Recent Human Evolution in Mice by Expression of a Selected EDAR Variant. Cell 2013, 152 (4), 691-702. doi: 10.1016/j.cell.2013.01.016
163) Grossman, Sharon R.; Andersen, Kristian G.; Shlyakhter, I.; Tabrizi, S.; Winnicki, S.; Yen, A.; Park, Daniel J.; Griesemer, D.; Karlsson, Elinor K.; Wong, Sunny H., et al., Identifying Recent Adaptations in Large-Scale Genomic Data. Cell 2013, 152 (4), 703-713. doi: 10.1016/j.cell.2013.01.035
See again: How flu shot manufacturing forces influenza to mutate

The researchers say further studies are needed to investigate replacing the egg-based system. “Other methods are now being used and explored for production of vaccines in mammalian cells using cell-based methods and recombinant HA protein vaccines,” said Wilson.

“There’s a huge need for flu vaccine research,” added Wu.

There is a huge need for biologically uninformed theorists to address the fact that the flu virus does not mutate and evolve.
See: Substitutions Near the Receptor Binding Site Determine Major Antigenic Change During Influenza Virus Evolution

The major antigenic changes of the influenza virus are primarily caused by a single amino acid near the receptor binding site.

The energy-dependent physiology of pheromone-controlled reproduction in species from microbes to humans prevents the virus-driven degradation of messenger RNA that links mutations to all pathology. Only RNA-mediated amino acid substitutions have been linked from ecological variation to ecological adaptations. Claims that anything mutates and evolved are not based on the facts about cell type differentiation that are known to all serious scientists.
Those facts are included in the rules of this game: Cytosis: A Cell Biology Board Game

A board game taking place inside a human cell! Players compete to build enzymes, hormones and receptors and fend off attacking Viruses!

 

Cytosis

From base editing to RNA editing (2)

Summary: The link from the creation of the sun’s anti-entropic virucidal energy and the physiology of pheromone-controlled reproduction to fixation of RNA-mediated amino acid substitutions in the organized genomes of all living genera is all that is required to claim adaptation for comparison to Koonin’s moronic assertion that the amino acid composition of proteins varies because the composition evolved.
Digital reconstruction of the Ceprano calvarium (Italy), and implications for its interpretation

A “fresh” (i.e., not yet “fossil”) bone can be plastically deformed before it breaks because it is still rich in collagen and because the calcium crystals that constitute large part of the bony matrix are not yet substituted by other minerals, as happens during the process of mineralization34. Such a diagenetic process may occur in environments that are rich in water, like a riverbed or a perilacustrine paleosol; the latter was probably the case in the Ceprano area5.

The virus-driven degradation of messenger RNA links the diagenetic process in living tissue links to the fossil record via changes that appear to have occurred during the past 5-10,000 years.
See for instance: MicroRNA-32 promotes calcification in vascular smooth muscle cells: Implications as a novel marker for coronary artery calcification
The increased level of calcification in smooth muscle cells, which is associated with increased rates of coronary artery calcification is a clear indicator that the proliferation of viruses in organized genomes causes the negative supercoiling of DNA, which serious scientists have linked to all pathology.
See also: A Post Mortem Case Study: Diffuse Pulmonary Ossification and Sudden Death
Case studies have no explanatory power outside the context of models that link electrons to ecosystems in all living genera. In this case study, it is clear that the pulmonary ossification and sudden death can be placed into the context of my model of nutritional epigenetics.
See: Nutrient-dependent pheromone-controlled ecological adaptations: from atoms to ecosystems

This atoms to ecosystems model of ecological adaptations links nutrient-dependent epigenetic effects on base pairs and amino acid substitutions to pheromone-controlled changes in the microRNA / messenger RNA balance and chromosomal rearrangements. The nutrient-dependent pheromone-controlled changes are required for the thermodynamic regulation of intracellular signaling, which enables biophysically constrained nutrient-dependent protein folding; experience-dependent receptor-mediated behaviors, and organism-level thermoregulation in ever-changing ecological niches and social niches. Nutrient-dependent pheromone-controlled ecological, social, neurogenic and socio-cognitive niche construction are manifested in increasing organismal complexity in species from microbes to man. Species diversity is a biologically-based nutrient-dependent morphological fact and species-specific pheromones control the physiology of reproduction. The reciprocal relationships of species-typical nutrient-dependent morphological and behavioral diversity are enabled by pheromone-controlled reproduction. Ecological variations and biophysically constrained natural selection of nutrients cause the behaviors that enable ecological adaptations. Species diversity is ecologically validated proof-of-concept. Ideas from population genetics, which exclude ecological factors, are integrated with an experimental evidence-based approach that establishes what is currently known. This is known: Olfactory/pheromonal input links food odors and social odors from the epigenetic landscape to the physical landscape of DNA in the organized genomes of species from microbes to man during their development.

Attempts to support theories about random mutations and evolution have failed miserably and have largely been replaced with facts about energy-dependent RNA-mediated cell type differentiation.
See: RNA Editing Possible with CRISPR-Cas13

The tool itself could be further developed, adds computational biologist Eugene Koonin of the National Center for Biotechnology Information who also was not involved in the study. “This paper is not the end of the road,” he says. It’s possible that Cas13b could be fused to a variety of editing enzymes that would allow a range of different sequence changes. The possibilities are numerous, Koonin says, and “the best is still to come.”

This paper is the end of the road for pseudoscientists and biologically uninformed theorists, like Eugene Koonin, who made this ridiculous claim in 2005:
Amino acid composition of proteins varies substantially between taxa and, thus, can evolve. –Jordan et al., (2005) A universal trend of amino acid gain and loss in protein evolution
See for comparison: The entire evolution of the microbial world and the virus world, and the interaction between microbes and viruses and other life forms have been left out of the Modern Synthesis… (2015) — Eugene Koonin
See also Koonin’s attack on all models of ecological adaptation: Splendor and misery of adaptation, or the importance of neutral null for understanding evolution (2016)

…population genetic theory, combined with the data of comparative genomics, clearly indicates that such a “pan-adaptationist” approach is a fallacy. The proper question is: how has this sequence evolved? And the proper null hypothesis posits that it is a result of neutral evolution: that is, it survives by sheer chance provided that it is not deleterious enough to be efficiently purged by purifying selection. To claim adaptation, the neutral null has to be falsified.

The link from the creation of the sun’s anti-entropic virucidal energy and the physiology of pheromone-controlled reproduction to fixation of RNA-mediated amino acid substitutions in the organized genomes of all living genera is all that is required to claim adaptation for comparison to Koonin’s moronic assertion that the amino acid composition of proteins varies because the composition evolved.
Each time a new claim attests to the facts about energy-dependent RNA-mediated biophysically constrained cause and effect, remember how long those facts have been placed on hold by people like Eugene Koonin and Jay R. Fiereman, who is the moderator of the International Society for Human Ethology’s Yahoo Group.
See this attempt to discuss mysterious DNA changes with Jay R. Feierman who on 7/25/13 wrote:

Variation is not nutrient availability and the something that is doing the selecting is not the individual organism. A feature of an educated person is to realize what they do not know. Sadly, you don’t know that you have an incorrect understanding [of] Darwinian biological evolution.

All DNA modifications are energy-dependent and RNA-mediated. Publications in Science and Nature attest to the foolishness of those who have tried to link base editing and RNA editing to human cell type differentiation without starting with the fact that RNA-mediated amino acid substitutions are food energy-dependent.
Clearly there are no mysterious stress-linked DNA modifications. Nutrient stress and/or social stress cause the proliferation of viruses. Typically the proliferation of viruses is biophysically constrained by food energy and the pheromone-controlled physiology of reproduction in species from microbes to humans.
See “Cytosis” for the game-ending details that placed the nonsense about neutral null falsification back into the historical perspective of the “Dark Ages.”
See also: Tempo and mode of genome evolution in a 50,000-generation experiment (with my emphasis)

Evidence for beneficial mutations

We sought to understand what proportion of the genomic changes in the non-mutator populations was adaptive, and how that proportion changed over time. One line of evidence derives from the expectation that synonymous substitutions—point mutations in protein-coding genes that do not affect the amino-acid sequence—are neutral and should therefore accumulate at a rate equal to the underlying mutation rate20,35. This expectation is not strictly true owing to selection on codon usage, RNA folding, and other effects, but it is generally thought that such selection is extremely weak, affects only a small fraction of sites at risk for synonymous mutations, or both 36,37.

RNA-mediated protein folding chemistry is biophysically constrained. It is nutrient energy-dependent and biodiversity is controlled by the energy-dependent physiology of reproduction. In 2015, Lenski’s group admitted to their lie about the beneficial mutations, with the claim “This expectation is not strictly true owing to selection on codon usage…”
No beneficial mutations have been found by serious scientists. But Lenski’s group clearly indicated they would continue to lie about all aspects of energy-dependent biodiversity. They hoped to make it appear that all energy-dependent biodiversity emerged and then automagically evolved. If they could do that, they knew that their idiot minions were not likely to examine selection for energy-dependent codon usage. But then,
See for comparison: The dynamics of molecular evolution over 60,000 generations
After 10,000 more generations, Lenski’s group reported that standard models of mutation-driven evolution has not been supported by their experimental evidence. Instead, they placed their results into the context of natural selection for energy-dependent codon usage and long-term adaptation, which obviously occurred outside the context of mutation–selection balance and neutral mutation accumulation.
They clearly indicated that the complexity of ecological variation and energy-dependent ecological adaptation must be considered before reporting anything in the context of natural genetic variation. Simply put, they refuted all the pseudoscientific nonsense their past claims caused to be touted by other biologically uninformed theorists. They reported that ecological adaptation occurs outside the context of the mutations and evolution.
But see: Molecular evolution: No escape from the tangled bank

Ecological interactions emerge spontaneously in an experimental study of bacterial populations cultured for 60,000 generations, and sustain rapid evolution by natural selection.

The claim that there is no escape from the tangled bank is true. Joshua B. Plotkin took Lenki’s group’s refutation of mutation-driven evolution and placed it back into the context of the spontaneous emergence of energy-dependent ecological interactions. And then, he again touted the nonsense about evolution by natural selection.
See also: Rapid and Inexpensive Evaluation of Nonstandard Amino Acid Incorporation in Escherichia coli (2017)

…we developed a toolkit for characterizing any Escherichia coli OTS that reassigns the amber stop codon (TAG). It assesses OTS performance by comparing how the fluorescence of strains carrying plasmids encoding a fused RFP-GFP reading frame, either with or without an intervening TAG codon, depends on the presence of the nsAA. We used this kit to (1) examine nsAA incorporation by seven different OTSs, (2) optimize nsAA concentration in growth media, (3) define the polyspecificity of an OTS, and (4) characterize evolved variants of amberless E. coli with improved growth rates.

Even with the tools available, which have refuted all ridiculous theories of mutation-driven evolution, the claims that variants “evolved” continues to plague all serious scientists. It seems that placing the claims that variants evolved into the context of natural selection for energy-dependent codon optimality and the physiology of pheromone-controlled reproduction in all living genera serves no purpose. However, even if biologically uninformed science idiots are not willing to admit that top-down causation requires first consideration for the energy source, there is hope for the future. Most people intuitively understand that the food energy from what organisms eat must be linked to the metabolism of food and the metabolism of food to species-specific pheromones is the only known link from the physiology of reproduction to all biophysically constrained biodiversity in the context of viral latency.
Epigenetic effects must be linked to affects on behavior and the difference between an effect on hormones and an affect of hormones on behavior must be considered in the context of how food odors and pheromones are linked to the physiology of human reproduction by serious scientists.
For example, see: Feedback loops link odor and pheromone signaling with reproduction
 
 

Lethal virus kills 5 billion people?

Until death: Virus-driven failure of multisensory integration (2)

Summary: The virus-driven degradation of messenger RNA is clearly linked to frontotemporal dementia (FTD) by altered language, personality, behavior, cognition and motor function. What causes FTD? If the virus-driven degradation of messenger RNA causes all pathology, I would expect to find a link from microRNAs to the pathology and to the effective treatment.

The social and economic burden of frontotemporal degeneration

Reported as: Study reveals staggering economic burden of dementia in younger people

Frontotemporal degeneration (FTD) accounts for 20 to 50 percent of dementia cases in people under the age of 65. FTD ravages an individual’s quality of life by dramatically altering their language, personality, behavior, cognition and motor function.

FTD alters language, personality, behavior, cognition and motor function. What causes FTD? If the virus-driven degradation of messenger RNA causes all pathology, I would expect to find a link from microRNAs to the pathology and to the effective treatment.
See for instance: Tumour necrosis factor-α (TNF-α) and miRNA expression in frontal and temporal neocortex in Alzheimer’s disease and the effect of TNF-α on miRNA expression in vitro
See also: miR-106b inhibits tau phosphorylation at Tyr18 by targeting Fyn in a model of Alzheimer’s disease
The facts that link the virus-driven degradation of messenger RNA to all pathology have also been placed into the context of this report: Global Sensory Impairment Predicts Morbidity and Mortality in Older U.S. Adults
I mentioned before that this was reported in the news as: Problems with senses may predict older adults’ overall health, ability to function

Researchers have mainly focused on what happens after people lose one or two of their senses. However, we know that losing more than two senses occurs frequently for older adults. Until now, no studies have examined how losing multiple senses affects older adults.

I also mentioned that the virus-driven loss of G protein-coupled receptors has been linked to the loss of multiple senses in all organisms at all ages.
See: Olfaction Warps Visual Time Perception
For comparison, pseudoscientists reported Brain wiring affects how people perform specific tasks

“Individuals organize themselves into densely interconnected communities, like the dormitories and sports teams, though individuals within these groups also have connections with people outside of those groups. Brains are the same way: Brain regions are organized into communities with lots of connections between regions in the community and fewer connections to regions outside of the community. But people’s brains are different. Some people have brains that are better described as having rigid community structure—or higher modularity—while other people have brains without such rigid community structure—or lower modularity.”

The individuals of all species must find food to reproduce. That’s how the individuals become part of a species. Their pheromone-controlled physiology of reproduction has been linked to all biodiversity in all genera. The claim “Individuals organize themselves…” is foolish. Claims about higher or lower modularity could be linked to the pseudoscientific nonsense touted in reports like this: The fusiform face area and occipital face area show sensitivity to spatial relations in faces
See also: The Blur of Pleasure: Appetitively Appealing Stimuli Decrease Subjective Temporal Perceptual Acuity
Reported as:  Appetizing imagery puts visual perception on fast forward

“Our research shows that emotionally-charged stimuli, specifically positive and negative images, may influence the speed, or the temporal resolution, of visual perception…”

See for comparison: Supercool Protein Imaging Gets the Nobel Prize

See also: Nutrient-dependent pheromone-controlled ecological adaptations: from atoms to ecosystems

See for comparison: How childhood trauma affects the brain

The researchers’ conclusion is that experiencing abuse in early life “may lastingly disrupt” the connectivity between the areas of the brain that are key in cognitive and emotional processes.

Receptor mediated epigenetic effects on hormones are the link to affects on behavior via energy-dependent RNA-mediated cell type differentiation in the context of the creation of enzymes and the physiology of pheromone-controlled reproduction. See anything ever published by Bruce McEwen for examples of how a single amino acid substitution predicts differences in behavioral development.
 
Keep in mind that “Bump stock” is not a person. It’s an invention that can be examined in the context of cryo-EM to explain why someone would use reports on the “bump stock” technology to obfuscate the facts about the cryo-EM technology. The facts about cryo-EM and supercoiled DNA can be used to eradicate all virus-driven pathology.
 
For example, the ability to examine virus-driven changes in the transfer of energy in DNA base pairs can be linked to what is known about food energy-dependent RNA-mediated amino acid substitutions in organized genomes. The substitutions typically stabilize the organized genomes of people like Stephen Paddock.
 

See also: Irreversibility and the Arrow of Time in a Quenched Quantum System

Reported as: Physicists confirm thermodynamic irreversibility in a quantum system

“Our experiment shows the irreversible nature of quantum dynamics, but does not pinpoint, experimentally, what causes it at the microscopic level, what determines the onset of the arrow of time,” coauthor Mauro Paternostro at Queen’s University in Belfast, UK, told Phys.org. “Addressing it would clarify the ultimate reason for its emergence.”

For comparison, see: Charles Darwin’s 150-year-old theory of how life on earth emerged gets thumbs-up from scientists

Their ridiculous theories can be placed into the context of Lewis Carrol’s attribution of this thought process to “Humpty Dumpty.”

 

“Emergence” and “evolution” are meaningless terms outside the context of ridiculous theories and pseudoscientific nonsense touted by researchers who are biologically uninformed science idiots. They seem to think that they can put the pieces of biophysically constrained life on Earth back into their theories as if “Humpty Dumpty” exemplified a creature with an evolved shell.

Cryo-EM has helped to pinpoint why the nature of quantum dynamics is irreversible. At the microscopic level of hydrogen-atom transfer in DNA base pairs in solution, the creation of energy as information has been linked to healthy longevity in all living genera. Virus-driven energy theft has been linked from the degradation of messenger RNA to all pathology.

See also: Neuropathology of suicide: recent findings and future directions

“…the unravelling of the unique epigenetic processes that occur in the brain has opened promising avenues in suicide research.”

Reported without citation in the context of: How childhood trauma affects the brain

What led my former FB friends to claim that my life’s works and efforts toward suicide prevention were “bullspit” or that “nobody cared?” The Nobel Prize in Chemistry just validated my model in the context of what is known about cryo-EM.
 

What led researchers who are biologically uninformed science idiots to criticize my model? Criticisms of the nutrient-dependent pheromone-controlled evolutionary model

Who will be the first to apologize for the role they played in the suicide death of Stephen Paddock and the unnecessary suffering and death of his victims?

Moving forward, what role will “apologetics” play in consoling the victims of virus-driven energy theft and all pathology?

See: Celebrate Your Inner Virus 

…we seek to highlight the strengths of what makes a virus on this Virus Appreciation Day.

Answers in Genesis is an apologetics ministry, dedicated to helping Christians defend their faith and proclaim the gospel of Jesus Christ.

Virus appreciation is interesting in the context of claims this group made since 1999.

See: Did God Make Pathogenic Viruses? (1999)

Without viruses, the genetic revolution we are now experiencing would be impossible. They also serve numerous beneficial functions that we are just beginning to research and understand.

Viral Genome Junk Is Bunk (2015)

…mammalian viruses may not have existed at all before the Curse, but after mankind’s sin may have been allowed to develop from DNA sequence already present in the now-fallen people and animals of the earth. Again, cutting-edge genome research confirms the Genesis account of origins.

I agree, but the Genesis account of origins puts the Curse before the creation of viruses, which have been linked from the virus-driven degradation of messenger RNA to mutations and all pathology during the past 5-10,000 years.

See: Analysis of 6,515 exomes reveals the recent origin of most human protein-coding variants

Reported as: Past 5,000 years prolific for changes to human genome

Of 1.15 million single-nucleotide variants found among more than 15,000 protein-encoding genes, 73% in arose the past 5,000 years, the researchers report. 164,688 of the variants — roughly 14% — were potentially harmful, and of those, 86% arose in the past 5,000 years. More broadly, the results suggest that humans are carrying around larger numbers of deleterious mutations than they did a few thousand years ago. But this doesn’t mean that humans now are more susceptible to disease, says Akey. Rather, it suggests that most diseases are caused by more than one variant, and that diseases could operate through different genetic pathways and mechanisms in different people.

Stress has different effects on different people.

See for comparison: Epigenetic Regulation of the Kappa Opioid Receptor by Child Abuse

…this receptor may be epigenetically regulated by stressful experiences, in particular as a function of early social life.

See also: Cell stress response sheds light on treating inflammation-related cancer, aging

A Traumatic Experience Can Reshape Your Microbiome

The stress-linked reshaping of  your microbiome has repeatedly been linked from the virus-driven failure of multisensory integration to suicide.

Alternative splicing of pre-mRNA

Caught in an epigenetic trap: flag waving consequences

Egypt concert-goers arrested for raising rainbow flag
This is an example of “flag waving” consequences from another part of the world.

They are accused of “public indecency” and “inciting immorality among young people”, the sources said following Monday’s arrests.

Why? These protesters were probably caught in an epigenetic trap. See: Search Results for “epigenetic trap”
The colors of the rainbow link the anti-entropic virucidal energy of sunlight to epigenetically trapped water in supercoiled DNA and all biophysically constrained biodiversity via the physiology of pheromone-controlled reproduction in species from microbes to humans.
The “rainbow” flag may be merely another example of human idiocy. Those who raise it typically know nothing about how water and the colors of the rainbow are linked from the energy-dependent RNA-mediated sexual differentiation of cell types in species from yeasts to humans. Yet, they tend to rally round their flag, not the flag of any country.
For example, “gay” liberals in the United States of America have rights that cost the lives of our veterans. They can raise their “rainbow” flag without being arrested.
Who do they thank for that privilege, and when did they begin to thank them?
If they don’t thank a veteran, do they ever thank serious scientists?
See also:
Sensing atoms caught in ripples of light
Amount of water in stem cells can determine its fate as fat or bone
Isolating water’s impact on vibrations within DNA

An epigenetic trap stabilizes singular olfactory receptor expression

Structural diversity of supercoiled DNA
Cytogenetic approaches for determining ecological stress in aquatic and terrestrial biosystems
 

Alternative splicing of pre-mRNA

Sexual communication signals: New Insights!

Nobody wants to belong to the party of losers. One of the best strategies in such a case is evidently an interpretation of the change as a gradual accumulation of knowledge while their work has always been at the cutting edge.Kalevi Kull

New insights in the evolution of sexual communication signals

Abstract excerpt:

Our research focuses on identifying a) the genes underlying sexual signals and responses in both sexes2-4, and b) ecological factors that may cause divergence in sexual communication. Factors that we found to affect sexual communication are closely related species with similar mating signals5, low nutritional quality, (toxic) secondary plant metabolites and pathogens6.

Elizabeth Pennisi reported on this 2017 conference presentation and claimed:

The results “demonstrate the importance of the social environment,” Halfwerk says. “One form does not attract males on its own, only in close proximity of the other form.” That result also parallels what’s been found in humans: that an attractive woman in a crowd of less attractive women also seems to attract more attention. But pinning down exactly why this happens should be much easier in moths than people, she notes. “That’s the nice thing about insects.”

See: Sexy females help ‘Plain Jane’ moths snag their mates

No experimental evidence of biologically-based sexual communication suggests that sex signals evolved. The fine-tuned systems of communication among individuals and species pose an evolutionary dilemma because they are food energy-dependent. Ecological variation must be linked from food energy to biophysically constrained ecological adaptations by the pheromone-controlled physiology of reproduction in all living genera. Also, everything known to serious scientists about energy-dependent top-down creation links the anti-entropic virucidal energy of sunlight from the creation of ATP to the creation of messenger RNA. That fact does not appear to be coincidental.

See: Dependence of RNA synthesis in isolated thymus nuclei on glycolysis, oxidative carbohydrate catabolism and a type of “oxidative phosphorylation”

The synthesis of RNA in isolated thymus nuclei is ATP dependent.

Detailed experimental evidence also links the virus-driven degradation of messenger RNA from mutations to all pathology. That fact leaves neo-Darwinian theorists and “Big Bang” cosmologists without any acceptable theory of anything or any theory of everything.

See for comparison: A New Physics Theory of Life and Jeremy England’s idea that “You start with a random clump of atoms, and if you shine light on it for long enough, it should not be so surprising that you get a plant.” 

Theorists and philosophers cannot link energy as information or “big bang” cosmology to biodiversity without the creation of energy. Most of them ignore the fact that they do not know where the energy in a hydrogen atom came from.

Without the de novo creation of energy, they cannot link hydrogen-atom transfer in DNA base pairs in solution from microRNA flanking sequences to SNPs, and they cannot link food energy as information to fixation of RNA-mediated amino acid substitutions in organized genomes. For comparison, all serious scientists have linked what is known about the food energy-dependent fixation of amino acid substitutions to the structure and function of supercoiled DNA, and all serious scientists have linked energy-dependent RNA-mediated cause and effect to all biodiversity via the physiology of pheromone-controlled reproduction.

That fact helps to explain why Richard Feynman referred to some theoretical physicists as examples of human idiocy.

See: Food energy

That suggests Elizabeth Pennisi is a biologically uninformed. She reported: “That’s the nice thing about insects.” If she was not a biologically uninformed science idiot, she would have linked food energy to the physiology of reproduction in all invertebrates and vertebrates. That is how the pheromone-controlled physiology of reproduction is linked from ecological variation to all biodiversity via what is known to all serious scientists about ecological adaptation.
See: Feedback loops link odor and pheromone signaling with reproduction and Olfaction Warps Visual Time Perception

For comparison to the science reporting by Elizabeth Pennisi,  J.A. Parker is the only person besides me, who has reported on this 2017 conference presentation:

See also: All in the (bigger) family by Elizabeth Pennisi with my comment:

The 2015 Society for Integrative and Comparative Biology (SICB) presenters may not recognize how much progress has been made since the 2013 ecological epigenetics symposium. For example, since then authors claimed “…ctenophore neural systems, and possibly muscle specification, evolved independently from those in other animals.” http://dx.doi.org/10.1038/nature13400

Six months later, other authors traced signaling factors found in vertebrates to the origin of nerve cell centralization via the diffuse nerve net of animals like the sea anemone. http://dx.doi.org/10.1038/ncomms6536 That fact suggests ecological variation is linked to ecological adaptations in morphological and behavioral phenotypes via signaling protein concentrations that differentiate various cell types in body axes and the central nervous system.

Links across species from the epigenetic landscape to the physical landscape of DNA in organized genomes appear to have their origins in the conserved molecular mechanisms of RNA-directed DNA methylation and RNA-mediated protein folding. Two weeks after the publication that refuted ideas about independently evolved neural systems or muscle specification — and perhaps refuted the independent evolution of anything else, SICB presenters linked crustaceans to insects.

Apparently, they’ve learned that the same set of microRNAs controls expression of the genes for rate-limiting enzymes that control the hormone production of different hormones in insects and crustaceans.

Why were they left with any questions about how crustaceans and insects could all be part of one big family? They linked RNA-mediated cell type differentiation to what we described in our section on molecular epigenetics in our 1996 Hormones and Behavior review. From Fertilization to Adult Sexual Behavior http://www.hawaii.edu/PCSS/biblio/articles/1961to1999/1996-from-fertilization.html

See also: Sex differences in microRNA-mRNA networks: examination of novel epigenetic programming mechanisms in the sexually dimorphic neonatal hypothalamus

Integrating miRNAs and their broad actions on gene function into our conceptualization of the factors directing sexual differentiation of the brain could be a highly informative next step in efforts to understand the complexities behind these processes.

They linked sex differences in microRNAs to the sexual differentiation of all cell types in all living genera that sexually reproduce via microRNA-mRNA networks.
See also: The phylogenetic utility and functional constraint of microRNA flanking sequences

…miRNAs can be employed as both qualitative [9] and quantitative markers, with the latter demonstrated clearly here. Our investigation demonstrates the utility of miRNA sequences as classical phylogenetic markers, and shows this usage is robust to different algorithms of phylogenetic analysis and the analysis of fast-evolving lineages. Such a method provides novel characters for assessing phylogenetic relationships that will be of use in a range of contexts for resolving branches across the tree of life.

See also: Role of olfaction in Octopus vulgaris reproduction

Future work on O. vulgaris olfaction must also consider how animals acquire the odours detected by the olfactory organ and what kind of odour the olfactory organ perceives. The OL acting as control centre may be target organ for metabolic hormones such as leptin like and insulin like peptides, and olfactory organ could exert regulatory action on the OL via epigenetic effects of nutrients and pheromones on gene expression (Kohl, 2013; Elekonich and Robinson, 2000).

Kohl (2013) is: Nutrient-dependent/pheromone-controlled adaptive evolution: a model (June 14, 2013)

…the epigenetic ‘tweaking’ of the immense gene networks that occurs via exposure to nutrient chemicals and pheromones can now be modeled in the context of the microRNA/messenger RNA balance, receptor-mediated intracellular signaling, and the stochastic gene expression required for nutrient-dependent pheromone-controlled adaptive evolution. The role of the microRNA/messenger RNA balance (Breen, Kemena, Vlasov, Notredame, & Kondrashov, ; Duvarci, Nader, & LeDoux, ; Griggs et al., ; Monahan & Lomvardas, ) in adaptive evolution will certainly be discussed in published works that will follow.

Elekonich and Robinson (2000) cited:  From Fertilization to Adult Sexual Behavior (1996)
At the time of our 1996 Hormones and Behavior review, microRNAs were called pre-mRNAs. See our section on molecular epigenetics:

Yet another kind of epigenetic imprinting occurs in species as diverse as yeast, Drosophila, mice, and humans and is based upon small DNA-binding proteins called “chromo domain” proteins, e.g., polycomb. These proteins affect chromatin structure, often in telomeric regions, and thereby affect transcription and silencing of various genes (Saunders, Chue, Goebl, Craig, Clark, Powers, Eissenberg, Elgin, Rothfield, and Earnshaw, 1993; Singh, Miller, Pearce, Kothary, Burton, Paro, James, and Gaunt, 1991; Trofatter, Long, Murrell, Stotler, Gusella, and Buckler, 1995). Small intranuclear proteins also participate in generating alternative splicing techniques of pre-mRNA and, by this mechanism, contribute to sexual differentiation in at least two species, Drosophila melanogaster and Caenorhabditis elegans (Adler and Hajduk, 1994; de Bono, Zarkower, and Hodgkin, 1995; Ge, Zuo, and Manley, 1991; Green, 1991; Parkhurst and Meneely, 1994; Wilkins, 1995; Wolfner, 1988). That similar proteins perform functions in humans suggests the possibility that some human sex differences may arise from alternative splicings of otherwise identical genes.

Social odors are still called pheromones and we linked the food energy-dependent pheromone-controlled physiology of reproduction to all biophysically constrained biodiversity on Earth via sex differences in microRNAs (pre-mRNAs).
The sex differences in microRNAs will soon be linked to sex differences in healthy longevity and to sex differences in diseases in the context of the cell biology game: “Cytosis.” Next, the game “Subatomic” will teach others how to build an atom.
The fact that this invited review linked energy-dependent changes in atoms to ecosystems may still go unnoticed, since the invited review was returned without review.
See: Nutrient-dependent pheromone-controlled ecological adaptations: from atoms to ecosystems
But, for God’s sake, see for comparison: 7/25/13
Jay R. Feierman:

“Variation is not nutrient availability and the something that is doing the selecting is not the individual organism. A feature of an educated person is to realize what they do not know. Sadly, you don’t know that you have an incorrect understanding [of] Darwinian biological evolution.”

Do not ignore the fact that Jay R. Feierman has no understanding of how ecological variation must be linked to energy-dependent ecological adaptation via the pheromone-controlled physiology of reproduction.
See also: December 5, 2016

[MODERATOR NOTE: I’m not going to post more from Kohl until he answers the very direct and simple question posed to him by anon, which is whether he (Kohl) believes that RNA splicing can change DNA.]

What I believe about RNA splicing is irrelevant unless someone else links the creation of energy to ATP and the creation of RNA outside the context of energy-dependent alternative splicings of pre-mRNA and the link from energy to the creation of the pre-mRNAs and to energy-dependent biophysical constraints on supercoiled DNA in all living genera.

As Heyn points out, “we still do not fully understand the mechanisms that drive epigenetic variation in populations.”

Natural selection for energy-dependent codon optimality links RNA-directed DNA methylation to all biophysically constrained biodiversity via the pheromone-controlled physiology of reproduction. That fact seems to be missing from this representation of a failed paradigm (neo-Darwinian evolution).
Claims that facts about natural selection and epigenetic variation in populations are not fully understood can be viewed in the context of reports by those who understand the facts about Darwin’s “conditions of life.” They are energy-dependent and RNA-mediated
See for example: Codon identity regulates mRNA stability and translation efficiency during the maternal-to-zygotic transition and Olfaction Warps Visual Time Perception
It has become obvious to all serious scientists that the sense of smell in bacteria must be linked from mRNA stability to our visual perception of mass and energy in the context of natural selection across the time-space continuum via the pheromone-controlled physiology of reproduction. The complexity of that fact may not be understood by biologically uninformed theorists, but no theorist should claim that the mechanisms of food energy-dependent pheromone-controlled biophysically constrained cell type differentiation are not understood by all serious scientists.
Re: …a strong link between population-specific DNA methylation, mRNA levels, and genotypes.
See also: Methylation Variation Documented Between Human Populations

“Our analysis of five worldwide populations revealed a strong correspondence between population-specific DNA methylation, [messenger RNA] levels, and genotypes,” the authors wrote. “The correlation with genetic divergence was stronger for DNA methylation, and, consistent with this, our results suggest stronger local genetic control of population-specific DNA methylation levels than of mRNA expression levels.”

The strong link and/or strong correspondence between food energy-dependent DNA methylation, messenger RNA levels and genotypes is biophysically constained by the pheromone-controlled physiology of reproduction in all livng genera. See for example: Dependence of RNA synthesis in isolated thymus nuclei on glycolysis, oxidative carbohydrate catabolism and a type of “oxidative phosphorylation”

The synthesis of RNA in isolated thymus nuclei is ATP dependent.

Glycolysis and the citric acid cycle appear to provide the free energy for nuclear ATP synthesis and the food-energy-depenent biosynthesis of messenger RNA. If so, all pathology is caused by the virus-driven degradation of messenger RNA, which links mutations but not from ecological variation to ecological adaptations.
See also: Back to Basics: Next-generation sequencing methods and applications (with my emphasis)

…another common NGS application (although one currently more of a research application than a front-line clinical tool) is to examine the transcriptome of a sample—that is, the identity and relative abundance of mRNA transcripts present. Sometimes referred to as “exome sequencing,” this approach is efficient in that it applies resources only to that small portion of the genome which is functionally expressed. Of course, not all significant genetic aberrations occur within coding regions; but by observing levels (or even presence/absence) of transcripts in comparison to reference “normal” conditions, important mutations in non-coding regions such as gene promoters or splice site regulators can be inferred. When such findings are plausibly related to a disease condition, more directed studies to confirm the root cause can then be undertaken as or if needed.

See also: microRNA “exome sequencing Items: 1 to 20 of 55 There is no need to infer that splice site regulators are not food energy-dependent and yet that is what biologically uninformed neo-Darwinian theorists have consistently done with their claims about Mutation-driven evolution. For comparison, all serious scientists are Combating Evolution to Fight Disease.
See also: Global Epigenomic Reconfiguration During Mammalian Brain Development July 4, 2013

DNA methylation is implicated in mammalian brain development and plasticity underlying learning and memory. We report the genome-wide composition, patterning, cell specificity, and dynamics of DNA methylation at single-base resolution in human and mouse frontal cortex throughout their lifespan. Widespread methylome reconfiguration occurs during fetal to young adult development, coincident with synaptogenesis. During this period, highly conserved non-CG methylation (mCH) accumulates in neurons, but not glia, to become the dominant form of methylation in the human neuronal genome. Moreover, we found an mCH signature that identifies genes escaping X-chromosome inactivation. Finally, whole-genome single-base resolution 5-hydroxymethylcytosine (hmC) maps revealed that hmC marks fetal brain cell genomes at putative regulatory regions that are CG-demethylated and activated in the adult brain, and that CG demethylation at these hmC-poised loci depends on Tet2 activity.

See also: Inherited chromosomally integrated human herpesvirus 6 genomes are ancient, intact and potentially able to reactivate from telomeres, which was reported as: “Study of inherited herpes virus finds links to ancient humans” August 30, 2017

We used molecular dating methods to compare, for example, the inherited HHV-6B genomes in five individuals from Sardinia, Orkney and England, and estimated that the most recent common ancestor with the inherited HHV-6B existed 24,500 ±10,600 years ago.

The molecular dating methods are evaluated outside the context of what is known about energy-dependent pheromone-controlled feedback loops, which have been linked from the sense of smell in bacteria to our visual perception of mass and energy in the context of the space-time continuum. But, rather than repeat myself, I will simple support my claims with a link to: Analysis of 6,515 exomes reveals the recent origin of most human protein-coding variants, which was reported in January, 2013, as: Past 5,000 years prolific for changes to human genome. The changes can be place into the context of exome sequencing, but not mutation-driven evolution.
The recent origin of most human protein-coding variants can be linked from food energy-dependent changes in exomes that are biophysically constrained by the pheromone-controlled physiology of reproduction in all living genera. The recent origin of the variant can also be linked from the virus-driven degradation of messenger RNA to all pathology.

Of 1.15 million single-nucleotide variants found among more than 15,000 protein-encoding genes, 73% in arose the past 5,000 years, the researchers report. 164,688 of the variants — roughly 14% — were potentially harmful, and of those, 86% arose in the past 5,000 years.

See also: Whole-Exome Sequencing Reveals a Rapid Change in the Frequency of Rare Functional Variants in a Founding Population of Humans (2013)
I repeat:

Nobody wants to belong to the party of losers. One of the best strategies in such a case is evidently an interpretation of the change as a gradual accumulation of knowledge while their work has always been at the cutting edge.Kalevi Kull
Cytosis

Your indifference is killing you and others (4)

Summary:
I suspect that Subatomic, like Cytosis, will help link atoms to ecosystems via my model of nutritional epigenetics and the pheromone-controlled visual perception of mass and energy, which has been linked from the sense of smell in bacteria across the space time continuum via olfaction.
From 7 years ago.
Published 7 years ago on 15 Aug 2010 by James V. Kohl of Pheromones.com, RNA-mediated.com, and Autophagy.pro
Kohl is the co-author of “The Scent of Eros” and he is the creator of: The Scent of Eros and The Mind’s Eyes human pheromone-enhanced products. This is an excerpt from his presentation at the 2010 Annual Gathering of Mensa (i.e., the “high IQ” society).

Pheromones have since been linked from suicide prevention to the prevention of all neurodegenerative diseases and the prevention of all other pathology, which includes cancer prevention.

See for examples:

 
 
 

Everything known to serious scientists about biophysically constrained energy-dependent RNA-mediated cell type differentiation and viral latency in the context of quantum physics and the space time continuum will soon be known to everyone older than 10 who plays the game “Cytosis” and the game “Subatomic.”

In less than 3 hours of play-time, it will become clear that the virus-driven theft of quantized energy causes the degradation of messenger RNA, which links mutations to all pathology.

Suzan Mazur: What is your definition of life?

Eviatar Nevo: Our understanding of origin of life is very slim. . . . [First] life didn’t fossilize. The best we can know about origin of life may be from viruses we are looking at. They could have been at the origin of life before they parasitized it, or became symbionts in prokaryotes and eukaryotes. . . .

Young earth creationist / scientists put the virus-driven parasitism of life into the perspective of perfect creation in: Viral Genome Junk Is Bunk

“The most parsimonious answer is: the RNA viruses got their genes from their hosts.”6

The fact that viruses got their genes from their hosts became clear in the context of what is known about natural selection for energy-dependent codon optimality.

The extent of codon usage bias in human RNA viruses and its evolutionary origin (2003)

Revealing the determinants of codon usage bias is central to the understanding of factors governing viral evolution. Herein, we report the results of a survey of codon usage bias in a wide range of genetically and ecologically diverse human RNA viruses. This analysis showed that the overall extent of codon usage bias in RNA viruses is low and that there is little variation in bias between genes. Furthermore, the strong correlation between base and dinucleotide composition and codon usage bias suggested that mutation pressure rather than natural (translational) selection is the most important determinant of the codon bias observed. However, we also detected correlations between codon usage bias and some characteristics of viral genome structure and ecology, with increased bias in segmented and aerosol-transmitted viruses and decreased bias in vector-borne viruses. This suggests that translational selection may also have some influence in shaping codon usage bias.

Codon identity regulates mRNA stability and translation efficiency during the maternal-to-zygotic transition

Synopsis

Embedded Image

In addition to spelling out protein sequence, mRNA codon triplets contain translation‐dependent regulatory information that influences transcript stability and contributes to controlled turnover of maternal mRNAs in frogs, mice, and flies.

  • Codon optimality forms a regulatory code within the genetic code that controls mRNA stability and translation efficiency.

  • Codon composition shapes maternal mRNA clearance during the maternal‐to‐zygotic transition in zebrafish, frog, mouse, and fly in a translation‐dependent manner.

  • Amino acid composition also influences mRNA stability in vertebrates.

  • Codon optimality correlates with codon bias, suggesting that codon optimality shapes steady‐state mRNA levels in homeostasis.

Excerpt:

The amino acid optimality code (Fig 6) provides an alternative perspective on sequence changes between paralogs in evolution and human disease.

Reported as: A code within a code: how codons influence mRNA stability

The sequence changes in the amino acid optimality code link energy-dependent changes in base pairs to fixation of amino acid substitutions in supercoiled DNA via the physiology of reproduction. The substitutions protect all organized genome from the virus driven degradation of messenger RNA that links mutations to all pathology.

See also: Kinetic Rain | Art + Com

The level of creativity required to link physics to chemistry and the conserved molecular mechanisms that link kinetic energy and food energy to RNA-mediated cell type differentiation via quantum mechanics and amino acid substitutions is exemplified in this moving sculpture and ignored by theorists who might unknowingly attribute all the interactions to mutations and evolution.

See also: The  Critical Thinking Cafe

The group has been archived. No more comments will be added by those who lack the critical thinking skills required to link what organisms eat to the physiology of pheromone-controlled reproduction and all biodiversity.

It should be even clearer that two games “Cytosis” and “Subatomic” will put an end to any theoretical nonsense about mutations and evolution.

I suspect that Subatomic, like Cytosis, will help link atoms to ecosystems via my model of nutritional epigenetics and the pheromone-controlled visual perception of mass and energy, which has been linked from the sense of smell in bacteria across the space time continuum via olfaction.
Nutrient-dependent pheromone-controlled ecological adaptations: from atoms to ecosystems