Watering Young Plant - Vintage Effect

The eternal significance of microRNAs (1)

Common Allele Linked to Sugar Consumption Leads to Lower Body Fat, Higher Blood Pressure
One energy-dependent change in a base pair is linked from the FGF21 rs838133 variant to microRNA-mediated changes in morphology and behavior. The quantized energy as information link from microRNAs to morphology and behavior is common to my mouse-to-human model of sympatric speciation.

By linking the common allele to sugar consumption, the authors attest to the fact that sympatric speciation is quantized energy-dependent. Energy as information biophysically constrains viral latency in the context of the game Cytosis for ages 10+.
See also: Nutrient-dependent pheromone-controlled ecological adaptations: from atoms to ecosystems
Theorists have been reluctant to comment on this invited review of nutritional epigenetics, which I posted to Figshare.com on 4/10/14. As of today, the model of food energy-dependent pheromone-controlled ecological adaptations / sympatric speciation has been available for 4 years.
In my mouse-to-human model, the variant is rs3827760, aka 1540T/C, 370A or Val370Ala. It is a SNP in the ectodysplasin A receptor EDAR gene on chromosome 2.
Summary: The energy-dependent creation of ATP synthase, ATP, microRNAs, messenger RNA, and supercoiled DNA biophysically constrains viral latency in the context of the “Levels of Biological Organization” I included in this presentation from 2010: Human Pheromones: Linking Neuroendocrinology and Ethology (revisited) See slide # 6.
See also, our award-winning 2001 review: Human pheromones: integrating neuroendocrinology and ethology

5th-6th Sept 2018 Dublin, Ireland

Polymaths and paradigm shifts: from Asimov to Bear (4)

Saying Goodbye to the RNA World Theory

RNA has a limited ability for catalysis compared to peptides, and would have struggled to maintain its catalytic activity under the changing temperature conditions of early Earth. Carter and Wills also argued that if an RNA world existed, it would have been unlikely for it to incorporate peptides later on.

See for comparison: Dependence of RNA synthesis in isolated thymus nuclei on glycolysis, oxidative carbohydrate catabolism and a type of “oxidative phosphorylation” (1964)

Isolated thymus nuclei transport amino acids into an intranuclear pool by a process which seems to depend on energy from nuclear ATP synthesis (20).

The energy-dependent creation of ATP synthase has since been linked to this claim from McEwen et al., (1964):

The synthesis of RNA in isolated thymus nuclei is ATP dependent.

By starting with the energy-dependent de novo creation of enzymes, others have linked Schrödinger’s claims from “What is Life” (1944)  to all biophysically constrained biodiversity.
Say Hello again to Schrödinger at 75 – The Future of Biology
Let Timothy J. Cunningham, who disappeared from the CDC last month, reintroduce you. See his publications on:
1)”Racial Disparities in Age-Specific Mortality”
2) “Sex-specific relationships between adverse childhood experiences”
3) “Associations between antioxidants and all-cause mortality”
4) “Health and Safety Issues for Travelers”
Serious scientists know that all racial/ethnic disparities are food energy-dependent, RNA-mediated, and pheromone-controlled  in the context of enymes, metabolism, and amino acid substitutions. Fixation of the RNA-mediated amino acid substitutions differentiates all cell types in all living genera — including sex differences in cell types.
See for examples our section on molecular epigenetics from this 1996 Hormones and Behavior review of RNA-mediated cell type differentiation. From Fertilization to Adult Sexual Behavior

Small intranuclear proteins also participate in generating alternative splicing techniques of pre-mRNA and, by this mechanism, contribute to sexual differentiation in at least two species, Drosophila melanogaster and Caenorhabditis elegans…

Parenthetically it is interesting to note even the yeast Saccharomyces cerevisiae has a gene-based equivalent of sexual orientation (i.e., a-factor and alpha-factor physiologies). These differences arise from different epigenetic modifications of an otherwise identical MAT locus…

See for comparison, this nonsense: Caenorhabditis elegans glia modulate neuronal activity and behavior

Introduction: a brief on evolution of neuroglia

“Nothing in biology makes sense except in the light of evolution”. — Theodosius Dobzhansky (1900–1975)

Evolution of the nervous system proceeded through an increase in number and complexity of the nervous elements and through their specialization into electrically excitable neurons connected through defined synaptic contacts and electrically non-excitable neuroglia forming networks through intercellular gap junctions. Intercellular chemical neurotransmission is, however, characteristic for both forms of the neural cells that express appropriate receptors and are capable of secreting neurotransmitters. The evolution of the nervous system was not a straight journey from less complex and accomplished networks to the more refined ones; at the turning point between invertebrates and vertebrates, a fundamental metamorphosis occurred that changed the overall structure of the central nervous system (CNS).

The difference in the energy of two photons has since been linked from the proton motive force to the creation of enzymes and metabolism of food. The pheromone-controlled physiology of reproduction in species from bacteria to humans has linked DNA methylation from the creation and fixation of RNA-mediated amino acid substitutions to viral latency and all biodiversity. Timothy J. Cunningham placed that fact into the context of his history of published works.
For comparison, see: On the Difference between Physics and Biology: Logical Branching and Biomolecules (2018) and The Large Scale Structure of Space-Time(1975) George FR Ellis was a coauthor of both published works.
He, and others like him, failed to link Physics and Chemistry from molecular epigenetics to what is known about energy-dependent RNA-mediated biophysically constrained cell type differentiation to all biodiversity on Earth. Framing what is known to all serious scientists about cell type differentiation in the context of what Ellis might think is a logical representation of biomolecules attests to his lack of logic across the time-space continuum of his life.
See for comparison: Olfaction Warps Visual Time Perception (2017).
See also Odor-induced mood state modulates language comprehension by affecting processing strategies (2016)
The 2016 citation to The impact of natural odors on affective states in humans can now be linked to the accurate representations of top-down biophysical constraints on food energy-dependent pheromone-controlled feedback loops. The feedback loops are required to biophysically constrain viral latency.
See: What is life when it is not protected from virus driven entropy (video)

The anti-entropic force of virucidal ultraviolet light links guanine–cytosine (G⋅C) Watson–Crick base pairing from hydrogen-atom transfer in DNA base pairs in solution to supercoiled DNA, which protects the organized genomes of all living genera from virus-driven entropy. For example, protection of DNA from permanent UV damage occurs in the context of photosynthesis and nutrient-dependent RNA-directed DNA methylation, which links RNA-mediated amino acid substitutions to DNA repair. In the context of thermodynamic cycles of protein biosynthesis and degradation, DNA repair enables the de novo creation of G protein coupled receptors (GPCRs). Olfactory receptor genes are GPCRs. The de novo creation of olfactory receptor genes links chemotaxis and phototaxis from foraging behavior to social behavior in species from microbes to humans. Foraging behavior links ecological variation to ecological adaptation in the context of this atoms to ecosystems model of biophysically constrained energy-dependent RNA-mediated protein folding chemistry. Protein folding chemistry links nutrient-dependent microRNAs from microRNA flanking sequences to energy transfer and cell type differentiation in the context of adhesion proteins, and supercoiled DNA that protects all organized genomes from virus-driven entropy.

See for comparison: Gay, Straight, and the Reason Why: The Science of Sexual Orientation (2011)

Still, even in fruit flies, other sensory input besides pheromones — acoustic, tactile, and visual stimuli — play a role in sexual attraction, and sex specific responses to these stimuli appear to be innate rather than learned by association [36.]. We simply don’t know where the boundary between prespecified attraction and learned association lie in our own species, nor do we have compelling evidence for the primacy of one sense over another. (pp. 210- 211)

See also: Gay, Straight, and the Reason Why: The Science of Sexual Orientation, 2nd edition (2016)
From the second edition of LeVay’s book:

… chemosignal enthusiasts point to a variety of studies in which sniffing body secretions or substances purified from secretions appears to have some psychological effect… (p. 115)

LeVay cites Kohl et al., (2001) Human pheromones: integrating neuroendocrinology and ethology.
He has never mentioned the fact that the effects of virus-driven entropy on cell type differentiation were linked human sexual orientation in The Scent of Eros: Mysteries of Odor in Human Sexuality (1995/2002) and in the book chapter he cited in the first edition of Gay, Straight, and the Reason Why: The Science of Sexual Orientation.
See for comparison: Always follow your nose: the functional significance of social chemosignals in human reproduction and survival (2015) This article is part of a Special Issue “Chemosignals and Reproduction”
John Cacioppo, a Founder of Social Neuroscience, Dies

The University of Chicago psychology professor made fundamental contributions to understanding the neural mechanisms of social experiences.

My comment to The Scientist:

See also: Evolution of neuroarchitecture, multi-level analyses and calibrative reductionism (2012)

I hope John Cacioppo is remembered for this refutation of neo-Darwinian pseudoscientific nonsense:

Although peptide chemistry has been with us since amino acids first formed, the social role of oxytocin did not exist prior to the evolutionary sculpting of the vertebrate brain.

He may have been one of the first social scientists to recognize the fatal flaw that others continue to include in their works. All other serious scientists, like him, start with the energy-dependent creation of enzymes and amino acids. Only pseudoscientists still start with the evolution of the vertebrate brain.

I remember when he and his wife turned towards me and smiled — after I asked the speaker from Argentina about the role of oxytocin in a rodent model. No studies were being done for the obvious reason that few people knew where oxytocin came from.

I invited the speaker to lunch and we laughed a lot about the works that tried to link oxytocin to differences in behavior without linking the differences to altered  RNA-mediated non-mendelian inheritance of an epigenetic change in the mouse

RIP John Cacioppo

See also: Multilevel integrative analyses of human behavior: social neuroscience and the complementing nature of social and biological approaches (2000)
Nothing published during that 12-year period and nothing published before or since then suggests the the neuroarchitecture of intelligent creatures somehow evolved.
For comparison, see: Human pheromones and nutrient chemicals: epigenetic effects on ecological, social, and neurogenic niches that affect behavior (2012) Presented at the Society for Social Neuroscience Annual Meeting 2012
See also: Neuroglia in C. elegans (2018)

The nematode C. elegans is one of the most important model organisms for understanding neurobiology. Its completely mapped neural connectome of 302 neurons and fully characterized and stereotyped development have made it a prototype for understanding nervous system structure, development, and function. Fifty-six out of C. elegans‘ total of 959 somatic cells are classified as neuroglia. Although research on worm glia has lagged behind studies focused on neurons, there has been a steep upswing in interest during the past decade. Information arising from the recent burst of research on worm glia supports the idea that C. elegans will continue to be an important animal model for understanding glial cell biology. Since the developmental lineage of all cells was mapped, each glial cell in C. elegans is known by a specific name and has research associated with it. We list and describe the glia of the hermaphrodite form of C. elegans and summarize research findings relating to each glial cell. We hope this lecture provides an informative overview of worm glia to accompany the excellent and freely available online resources available to the worm research community.

The worm research community seems to be largely unaware of this fact: System-wide Rewiring Underlies Behavioral Differences in Predatory and Bacterial-Feeding Nematodes
The have failed to link food odors from the pheromone-controlled physiology of reproduction to ecological adaptatation manifested in morphological and in behavioral diversity.

5th-6th Sept 2018 Dublin, Ireland

From photons to the proton motive force (1)

Conclusion: If you would like to learn how to link quantized energy-dependent changes in atoms to ecosystems in all living genera via the physiology of reproduction, join others age 10+ who will be playing this game in September 2018.
Fly’s Blood-Brain Barrier Has Circadian Rhythms

“the anatomic characteristics of insect and vertebrate BBB structures are quite distinct.”

The molecular mechanisms are conserved.
My comment to The Scientist:

Feedback of the Drosophila period gene product on circadian cycling of its messenger RNA levels (1990)

The levels of complexity have since been placed into the context of how energy-dependent changes in the microRNA/messenger RNA balance link atoms to ecosystems in all living genera via feedback loops.

For instance, see: Feedback loops link odor and pheromone signaling with reproduction

When theorists fail to start with energy-dependent changes they are forced to use de Vries 1902 definition of mutation in attempts to link the virus-driven theft of quantized energy to evolution. Two forthcoming conferences will place that pseudoscientific nonsense into its proper perspective.

Evolution – Genetic Novelty/Genomic Variations by RNA Networks and Viruses

Schrödinger at 75 – The Future of Biology – September 2018

See also:  Here Comes Single-Cell Optogenetics

.. two-photon excitation with computer-generated holography (a way to precisely sculpt light in 3D) allow light to be focused tightly enough  to hit one cell.

OLYMPUS experiment sheds light on structure of protons

…most of the time, only one of the photons has high energy….

Permeability transition in human mitochondria persists in the absence of peripheral stalk subunits of ATP synthase

Production of ATP depends on the oxidation of energy-rich compounds to produce a chemical potential difference for hydrogen ions, the proton motive force (pmf), across the inner mitochondrial membrane (IMM).

Researchers who have not linked differences in the energy of photons to the proton motive force are not likely to be among those who are presenting in September: Schrödinger at 75 – The Future of Biology
See for comparison: Subatomic

Subatomic is a deck building game where players are competing to build a number of available Elements, which score them points. Each player starts with the same small deck of cards that consist of Proton, Neutron, and Electron Cards. They use these cards to build upon their current Atom (by playing these cards face-up as Subatomic Particles) in an attempt to construct one of the available Element Cards. Or players may use their hand of cards to purchase more powerful cards for later use (by playing them in combinations of face-down as energy and face-up as Subatomic Particles!) Subatomic introduces a unique variation on deck building with a highly accurate chemistry theme, with the ultimate goal of building Elements to score points, but allowing many varying types of strategies.

If you would like to learn how to link quantized energy-dependent changes in atoms to ecosystems in all living genera via the physiology of reproduction, join others age 10+ who will be playing this game in September 2018.

5th-6th Sept 2018 Dublin, Ireland

Anti-entropic sunlight: Schrödinger’s Creationist Secret? (5)

Anti-entropic sunlight: Schrödinger’s Creationist Secret? (3)

The list of those scheduled to present has changed. Michael Rosbash has been added. John E. Walker is not scheduled, which suggests that everyone else already knows that the creation of the sun’s anti-entropic virucidal energy is the link from the creation of ATP to the creation of RNA and all biophysically constrained viral latency via feedback loops and the physiology of reproduction.
Rosbash, as all serious scientists know,  started with energy-dependent changes in cycles of RNA biosynthesis. Feedback of the Drosophila period gene product on circadian cycling of its messenger RNA levels (1990). Pseudoscientists failed to link the energy from feedback to biophysically constrained viral latency.
But see: Permeability transition in human mitochondria persists in the absence of peripheral stalk subunits of ATP synthase

Production of ATP depends on the oxidation of energy-rich compounds to produce a chemical potential difference for hydrogen ions, the proton motive force (pmf), across the inner mitochondrial membrane (IMM).

Other serious scientists have consistently linked photophosphorylation from oxidative phosphorylation to all biodiversity via the physiology of pheromone-controlled reproduction in species from soil bacteria to humans
Speakers (new copy-protected list)
Speakers (old list)
See also: Viral Resistance Project
The differences in innate immunity and ecological adaptation are obviously nutrient energy-dependent and transgenerationally inherited in the context of the epigenetically-effected physiology of pheromone-controlled reproduction and the affects of hormones on behavior. For instance, pheromones biophysically constrain viral latency via the fixation of amino acid substitutions.
See for comparison: Evolution – Genetic Novelty/Genomic Variations by RNA Networks and Viruses
There are several neo-Darwinian theorists who are scheduled to present, which means they may be ready to accept the ridicule from serious scientists.
See for example: A universal trend of amino acid gain and loss in protein evolution

Amino acid composition of proteins varies substantially between taxa and, thus, can evolve.

See also: Why I got rid of my friends
Some of my former friends kept dumping their garbage about evolution on others in the same way that I. King Jordan and Eugene Koonin did it with their comment about the evolution of the amino acid composition of proteins. See for comparison: All About that Base (Meghan Trainor Parody) 12/10/14 and Energy as information and constrained endogenous RNA interference 2/15/17
Help others who are Combating Evolution to Fight Disease

5th-6th Sept 2018 Dublin, Ireland

The MicroRNAome Strikes Back: A Sokalian hoax (10)

Linda Buck, Ben Feringa, Michael Gazzaniga, Christof Koch, Nick Lane and Svante Paabo are among the presenters who will almost undoubtedly discuss some or all of my claims.
Prepare to ask questions or intelligently discuss accurate representations of top-down causation by watching this:

The energy-dependent creation of the microRNAome protects the organized genomes of all living genera from the virus-driven degradation of messenger RNA that links mutations to all pathology.
See: The Bull Sperm MicroRNAome and the Effect of Fescue Toxicosis on Sperm MicroRNA Expression

MicroRNA present in mature sperm appears to not only be left over from spermatogenic processes, but may actually serve important regulatory roles in fertilization and early developmental processes. Further, our results indicate the possibility that environmental changes may impact the expression of specific miRNA.

See also: Dynamic control of chirality and self-assembly of double-stranded helicates with light
See for comparison: A Bioenergetic Basis for Membrane Divergence in Archaea and Bacteria (2014)

We conclude that the enzymes involved took these alternatives by chance in independent populations that had already evolved distinct ion pumps. Our model offers a quantitatively robust explanation for why membrane bioenergetics are universal, yet ion pumps and phospholipid membranes arose later and independently in separate populations. Our findings elucidate the paradox that archaea and bacteria share DNA transcription, ribosomal translation, and ATP synthase, yet differ in equally fundamental traits that depend on the membrane, including DNA replication.

The microRNA-mediated creation of enzymes is quantized energy-dependent and biophysically constrained by phosphorylation in the context of food energy and the transgenerational epigenetic inheritance of all morphological and behavioral phenotypes in species from bacteria to primates. Membrane divergence in archaea occurs via the virus-driven degradation of messenger RNA, which links the loss of quantized energy from mutations to all pathology. The degradation of the cell membrane links archaea to L-forms, the last remnant of the life of a cell. See: The Inner Life of the Cell (video)
See also: Virus-mediated archaeal hecatomb in the deep seafloor (2016)

We show here for the first time the crucial role of viruses in controlling archaeal dynamics and therefore the functioning of deep-sea ecosystems, and suggest that virus-archaea interactions play a central role in global biogeochemical cycles.

So far as I know, none of the people who are presenting at “The Future of Biology” meeting have linked Schroedinger’s claims from the past to what is known about the conserved molecular mechanisms of energy-dependent biophysically constrained RNA-mediated cell type differentiation in species from microbes to humans. Even if they are not evolutionary theorists, most have not linked the energy-dependent fixation of RNA-mediated amino acid substitutions to increasing organismal complexity and some have even reversed what is known about top-down causation. For example, Nick Lane, like Gunter P. Wagner have used mathematical models of correlations.
See: Pervasive correlated evolution in gene expression shapes cell and tissue type transcriptomes
They start with this admission”

A major challenge for interpreting this data is that cell type transcriptomes may not evolve independently…

They seem to think they can use statistics and interpretations to address the challenge of facts about increasing organismal complexity.

Our study provides a statistical method to measure and account for correlated gene expression evolution when interpreting comparative transcriptome data.

See for comparison: From Fertilization to Adult Sexual Behavior and Nutrient-dependent/pheromone-controlled adaptive evolution: a model
The fact that what organisms eat has been linked from the food energy-dependent creation of enzymes, receptors, and hormones to the affect of hormones on behavior in all invertebrates and vertebrates was placed into the context of the cell biology game, Cytosis.

A board game taking place inside a human cell! Players compete to build enzymes, hormones and receptors and fend off attacking Viruses!

During the month of January (2018), 2831 people learned from my twitter profile about the domains RNA-mediated.com and Autophagy.pro and some of them learned from more than 100,000 impressions how energy must be linked to RNA-mediated biophysically constrained viral latency by autophagy.
Jan 2018 Summary
Tweet impressions
Profile visits
New followers

Why do I have only 29 new followers? Are theorists really that scared? If so, how will they help to prevent the next viral apocalypse, if it has not already started before September, 2018?

See also:

If my claims about biophysically constrained energy-dependent RNA-mediated cell type differentiation are not discussed by Linda Buck, Ben Feringa, Michael Gazzaniga, Christof Koch, Nick Lane, and Svante Paabo others will have another example of what happens after a paradigm shift.

 In the past nothing happened because serious scientists failed to acknowledge this fact: Feedback loops link odor and pheromone signaling with reproduction. The article was co-authored by LInda Buck. There is no mention of mutations or evolution and Linda Buck is scheduled to present what can best be described as a refutation of neo-Darwinian evolution.


Science journalists or paid propagandists? (3)

See: Science journalists or paid propagandists? (2)
See also from the first blog post in this series: Science journalists or paid propagandists?
Differential Expression of Putative Pheromone-detecting Cells and Receptors in the Olfactory Epithelium of an African Cichlid Fish
The link from sunlight and chirality to nutrient energy-dependent reproduction is not addressed in the presentationss from SICB 2017
There is nothing in a search for chirality
At the 2016 meeting, Epigenetic regulation of Toll-like Receptor 4 expression as a facilitator of invasiveness in Kenyan house sparrows (Passer domesticus) seemed to suggest that epigenetic regulation automagically occurred.
There is one abstract fron 2017 that links sunlight to chirality without reporting on chirality, but at least they report on autophagy.
Disease Resistant Corals Activate Autophagy over Apoptosis after an Immune Challenge 

…disease resistant corals upregulated pathways involved in autophagy, indicating attempts at adapting to changing conditions. These data show how cell survival pathways contribute to the immune response and subsequent patterns of disease resistance on coral reefs. Understanding these mechanisms will help inform trajectories of reefs under continuous climate and disease pressure.

There is one 2017 abstract that links chirality and autophagy to energy-dependent RNA-mediated amino acid substitutions.
ATP Production Increases with Addition of Varying Concentrations of Vespa Amino Acid Mixture (VAAM)

…our previous work suggests VAAM affects the electron transport chain and ATP synthase activity. While increased exercise capacity shortly after VAAM exposure has been observed in multiple species, the relationship between VAAM and ATP production has been assumed without supporting data, until now.

They haven’t decided whether or not RNA-mediated DNA repair is a good thing.
See also: Molecular organization of Octopus brains: Insight into unique memory center signaling

We identified 16,194 transcripts in the VL and found ~25.5% appear to be cephalopod-specific. Next we used targeted and unbiased computational predictions and manual annotation to identify putative signaling molecules form the VL transcriptomes. We have cloned and localized 11 neuropeptides (NP) to components of the VL circuit. NPX3 is abundantly expressed in the cell bodies of the SFL, where the VL circuit originates and NPX1 & 2 localize to the AM cell bodies of each VL gyrus. Among the 7 NPs that localize to the VL LE neurons, 2 unique cephalopod NPs, NPX4 & 5, are abundant in Octopus, but absent in the ancestrally branching Nautilus (which lacks a VL). This expansion of signaling molecules in the VL circuit may be a key feature of unique memory systems of cephalopods, implying extensive parallel evolution of cephalopod brains and memory circuits.

The expansion of the signaling molecules is nutrient energy-dependent and the increasing organismal complexity is pheromone-controlled via the physiology of reproduction in species from microbes to humans.
Conservation, convergence, and novelty in Octopus bimaculoides embryogenesis

To shed light on the gene networks important in this highly derived developmental program, we sequenced and analyzed transcriptomes from five stages spanning embryogenesis in the California two-spot octopus, Octopus bimaculoides. Genome analysis has shown that the core developmental gene repertoire of the octopus is broadly similar to that found in typical invertebrate bilaterians (Albertin et al. 2015). We detect transcripts for these developmental transcription factors and signaling ligands primarily during the middle stages that coincide with the emergence of the body plan, but not before. Bioinformatics-based differential expression analysis identified suites of genes that show dynamic changes, including stage-specific expression profiles. Notably, many of the differentially expressed genes in the early transcriptomes are not found in the genomes of other sequenced animals. These results indicate that the fish-like early stages of cephalopod development deploy cephalopod-specific genes, and suggest a major role for taxonomically restricted genes in the evolution of cephalopod developmental mechanisms.

They fail to link the sun’s anti-entropic virucidal energy to the light they try to shed on gene networks that automagically “…coincide with the emergence of the body plan, but not before.” The coincidental emergence fails to link Dobzhansky’s (1973) “light of evolution” to deferentially expressed genes that are not found in the early transcriptomes or organized genomes of other sequenced animals.
Behavioral Dynamics of Niche Partitioning between Two Octopus Species in a Shallow Coastal Environment

O. vulgaris uses parachute attack and spends more time foraging on rock and rubble, mostly nocturnally. This study identifies ecological and behavioral components that facilitate coexistence of sympatric species, provides insight into cephalopod ecology and baseline conservation requirements for unique sand-dwelling organisms.

They link nutrient energy-dependent changes in niche construction from ecological variation to ecological adaptation and the coexistence of sympatric species via foraging behaviors, foraging times and diet, but fail to link the foraging and diet to the pheromone-controlled physiology of reproduction and transgenerational epigenetic inheritance of morphological and behavioral phenotypes in all living genera via conserved molecular mechanisms of biologically-based cause and effect..
Feeding on the Unseen: Ingestion and Assimilation of Bacteriophages by Brachionus plicatilis (Rotifera)

… bacteriophages (< 0.05 μm) are abundant in seawater (to 108/mL) and represent a potential food source for rotifers and other planktonic invertebrates.

They linked the ingestion of viruses from metabolic networks to genetic networks via dichlorotriazinylamino fluorescein (DTAF)-labeled bacteriophages and found that the fluorescence of rotifers was greater in the DTAF-bacteriophage treatments, which led to the hypothesis that viuses in seawater may be a food source for planktonic invertebrates and their larvae.
See for comparison: Viral and cellular messenger RNA targets of viral microRNAs appear to link the nutrient energy-dependent physiology of pheromone-controlled reproduction to protection from virus-driven energy theft and genomic entropy via virally encoded microRNAs. The virus-driven energy theft benefits the viruses. Nutrient energy-dependent metabolic and genetic networks link hydrogen-atom transfer in DNA base pairs in solution form energy-dependent microRNA flanking sequences to viral latency (prevention of viral replication cycles) in the context of energy-dependent autophagy.
Abstract excerpt:

Emerging data suggest that viral miRNAs may be particularly important for regulating the transition from latent to lytic replication and for attenuating potentially inhibitory host antiviral immune responses.

It is time to link the emerging data to energy-dependent healthy longevity and virus-driven energy theft to all pathology, instead of playing word games. See for example: Epigenetics and Genetics of Viral Latency

… viral latency is responsible for life-long pathogenesis and mortality risk…

See also: Virus-mediated archaeal hecatomb in the deep seafloor

We show here for the first time the crucial role of viruses in controlling archaeal dynamics and therefore the functioning of deep-sea ecosystems, and suggest that virus-archaea interactions play a central role in global biogeochemical cycles.

They insult the intelligence of any serious scientist who has ever linked energy-dependent changes from angstroms to ecosystems and all healthy longevity and all serious scientists who have linked virus-driven energy theft to all pathology via the transgenerational epigenetic inhertance that links the virus-mediated archaeal hecatomb to Zika virus-damaged DNA in human infants.
See also from the 2017 SICB annual meeting
Pheromone-mediated Communication in a Bird Ectoparasite

Pheromone-mediated communication governs many aspects of insect behavior, population dynamics, and community ecology.

We are currently working to determine the structures of volatile compounds produced by lice and to identify their use in pheromonal communication.

Someone is paying them to do that.
Evolutionary Mechanisms that Inhibit Interspecies Mating in Drosophila

Given that the sensory pathway for inhibiting inter-species mating is conserved, we are using modern genetic tools to understand how the neural circuits underlying mate choice have evolved in disparate fly species. We generated novel transgenic lines in D. melanogaster and other fly species to determine whether Gr32a functions in an analogous manner across species. These studies involve examining the control of Gr32a expression and its function in different species. Taken together, my studies will lead to a better understanding of how behavioral reproductive isolation has evolved.

Reproductive isolation did not evolve. Thomas Hunt Morgan won the 1933 Nobel Prize in Physiology or Medicine for his works on chromosomal inheritance and Schrodinger/Dirac won the Prize
Flight Stability and Olfactory Navigation is Supported by Multisensory Antennal Inputs in the Moth Manduca sexta 

To characterize the effects of different environments on plume tracking, we challenged males with only one odor-detecting antenna to track a plume in an either turbulent or laminar air flow.

Be ready to compare the reports from science journalists to what was known about moth pheromones in 1959 and energy-dependent RNA synthesis in 1964.
Pheromones: a new term for a class of biologically active substances
Then, prepare to die from virus-driven energy theft if you allow theorists to continue touting their pseudoscientific nonsense or allow science journalist to continue reporting it.
Obama Advisers Urge Action Against CRISPR Bioterror Threat

For the past two decades, the government has focused its biodefense efforts on a list of known pathogens—such as anthrax, smallpox, and Ebola—declared by the Department of Health and Human Services and Department of Agriculture to have the “potential to pose a severe threat to public health and safety.” Government-funded research on these pathogens receives special scrutiny, and the National Institutes of Health limits researchers from conducting experiments that could make certain germs, like influenza, more dangerous.

See also: CRYPTOCHROME mediates behavioral executive choice in response to UV light

Opsin-based light sensing is clearly critical for behavioral light responses… CRY is a major modulator of a wide range of fly behavioral responses to UV light.

This may be your last chance.

1) Admit that the de novo creation of G protein-coupled receptors links the anti-entropic virucidal effects of UV light to the innate immune system and supercoiled DNA.
2) Admit that supercoiled DNA links chemotaxis and phototaxis to the pheromone-controlled weekend resurrection of the bacterial flagellum.
3) Admit that the weekend resurrection of the bacterial flagellum attests to what is known to all serious scientists about biophysically constrained RNA-mediated protein folding chemistry.
Alternatively, wait for serious scientists to demand that you and all other theorists be ousted from your positions in academia if you do not stop touting pseudoscientific nonsense about beneficial mutations and evolution. Energy is information and virus-driven energy theft links mutations to all pathology. If you do not agree, try to invent another theory on your way out the door of your ivory tower.