IMG_3010

Enzyme-constrained interethnic diversity (7)

Summary:  I suspect that John Hewitt will soon publish an article on the energy-dependent creation of microRNAs and enzymes. He is most likely to link the virus-driven theft of quantized energy as information to all pathology without challenging pseudoscientists and other science journalists to revise their ridiculous claims about mutation-driven evolution.
Digital medicine, on its way to being just plain medicine

There are already nearly 30,000 peer-reviewed English-language scientific journals, producing an estimated 2.5 million articles a year.

Until recently, no published works linked the creation of the sun’s anti-entropic virucidal energy from ATP to the creation of RNA and biophysically constrained viral latency.
But see: EXD2 governs germ stem cell homeostasis and lifespan by promoting mitoribosome integrity and translation January 15, 2018

“Loss of EXD2 results in defective mitochondrial translation, impaired respiration, reduced ATP production…” and “…aberrant association of messenger RNAs with the mitochondrial ribosome.

Exonuclease 3′ –5′ domain-containing 2 (EXD2) is a mitochondrial ribonuclease. A ribonuclease is a type of nuclease that catalyzes the degradation of RNA into smaller components such as microRNAs. A nuclease is an enzyme capable of cleaving the phosphodiester bonds between monomers of nucleic acids. EXD2 is required for mitoribosome integrity and efficient mitochondrial translation.
See: The Excitable Mitochondria by John Hewitt, who brought the article on EXD2 to my attention in his tweets. The link from energy-dependent changes in EXD2 to homeostasis predicts the link from reduced ATP production to the virus-driven degradation of EXD2 to the aberrant associations that link mutations in messenger RNA to all pathology. I suspect that John Hewitt will soon publish an article on the energy-dependent creation of microRNAs and enzymes. He is most likely to link the virus-driven theft of quantized energy as information to all pathology without challenging pseudoscientists and other science journalists to revise their ridiculous claims about mutation-driven evolution. Challenging your peers leads to your elimination from consideration. Your peers cannot rise to the ocassion and meet the challenge, so they must ignore you.
As I finalize this series on enzyme-constrained interethnic diversity, I also offer information from my largely ignored FB posts on the anniversary dates indicated:
January 10, 2017

The scent of eros: mysteries of odor in human sexuality

“This is science at its best, with adventure, ideas, and lots of facts”. — Helen Fisher

“A treasure hunt through history, literature, and scientific data”. — Gina Ogden

On pages 160-162 of “The Scent of Eros” (1995/2002) we linked race and ethnicity to all biodiversity via the same model of biologically-based cause and effect. It is still the only valid model.

What exactly do people think was still being debated about the fact that all organisms must eat to reproduce, or that pheromones control the physiology of reproduction in all living genera?

How could race and ethnicity not be aspects of a valid model of biologically-based cause and effect unless pseudoscientists convinced you to believe in mutation-driven evolution?

January 10, 2016

This serves as a reminder to all sex researchers. Most of them understand nothing about how RNA-mediated sex differences in cell types are linked to sex differences in #behavior by nutrient-dependent amino acid substitutions.
They refused to accept the fact that the pheromone-controlled physiology of reproduction and chromosomal rearrangements link the molecular epigenetics of cell type differentiation in all cell types of all individuals of all species from microbes to humans.

Xistential crisis: Discovery shows there’s more to the story in silencing X chromosomes
Xist is widely believed to be both necessary and sufficient for X silencing,” … “We for the first time show that it’s not sufficient, that there have to be other factors, on the X-chromosome itself, that activate Xist and then cooperate with Xist RNA to silence the X-chromosome.
An example of how 20 years of ignorance about RNA-mediated cell type differentiation leads to “NEW” discoveries.
From Fertilization to Adult Sexual Behavior 1996
Genomic-imprinting is also manifest in specific parts of the X-inactivation region’s related XIST gene. Here male- and female-specific methyl-group patterns participate in X-inactivation in females and also in the preferential inactivation of the paternal X in human placentae of female concepti (Harrison, 1989; Monk, 1995). This process indicates that tissues of the early conceptus can sense and react differentially to epigenetic sexual dimorphisms on the female conceptus’ own two X chromosomes. Furthermore, variations of X-inactivation patterns often account for traits discordance in monozygotic twin females. In other words, they are often found to have nonidentical patterns of X-inactivation, yielding differing expression of noticeable X-linked traits (Machin, 1996).
January 10, 2017

The anniversary of an attack on science.

Odious Christianity
Ray Comfort

Professor PZ Myers hates Christianity. Nor is he a big fan of my good friend, Ken Ham.
In writing about his hatred, PZ unwittingly showed his hand when he said,

“I reject his notion of sin — the idea that there is some kind of divine law against which we can transgress — but humanists do not deny that we can do wrong and we can do harm. We think we should do better, not to appease some vengeful deity, but because it improves our lives and helps make those around us happier and better able to live up to their potential. We certainly do accept that death is inevitable, but not because we are wicked — the wicked often seem to flourish while the good may die young. Are we to measure the virtue of human beings by their longevity? Charles Manson is 82, and surely destined to join the saints in heaven, while every infant death must open a chute directly to hell for its wicked soul.”
His hatred is perfectly in line with the Bible:
“Because the carnal mind is enmity against God; for it is not subject to the law of God, nor indeed can be” (Romans 8:7).
PZ is unashamedly godless (a state the Bible refers to as “carnal”), and so his mind is at “enmity” against God. That means he is in a continual state of hostility towards his Creator. That certainly is true. Even though he doesn’t believe that He exists, but he contemptuously hates the very thought of “a god.”
But look at the pinpoint accuracy of the Scriptures:
“…for it [our carnal mind] is not subject to the law of God, nor indeed can be.”
His hatred is directed at the “law of God,”–the moral Law (the Ten Commandments).
PZ is like a criminal who hates the police, not because of who they are individually, but because of what they represent. They stand for the law–that which is right and good, and that is offensive to someone who loves and lives for crime.
PZ’s railings about his loved ones dying is tragic, but peripheral. They are not the main reason why he is angry.
His anger is primarily at God and His Law, because he doesn’t like being told what to do. Like you and I before we came to Christ, he loves his sin, and he who loves the darkness hates the light.
I’m not sure why PZ called Charles Manson “wicked,” when his atheistic worldview doesn’t allow for anyone to be “wicked.”
Or could it simply be that Manson transgressed the moral Law, which says “You shall not kill,” and PZ intuitively knows that, because of his God-given knowledge of right and wrong (see Romans 2:15).
It’s actually heartening to see him using his moral compass. If he would put down his weapons and study how God’s moral compass is infinitely higher, he may rethink his rejection of “The soul who sins, shall die.”
This is because every death is sobering evidence of the truth of that verse.
You can see PZ in action in our movie “Evolution vs God” (over 2 million views) at www.FullyFreeFilms.com
P.S. PZ hates the movie.

January 10, 2017

How Your Toxic Boss Is Hurting Your Mental Health

Get out before the DNA damage is irreparable.


I do not have a boss. But the stress of attempting to interest others in what is known about how biologically-based cause and effect must be linked to interethnic similarities and differences may prevent some further attempts to explain how DNA damage is biophysically constrained in the context of naturally occurring RNA interference and viral latency.
November 27, 2017 See: Damage-induced lncRNAs control the DNA damage response through interaction with DDRNAs at individual double-strand breaks
Reported on November 29, 2017 as: RNA takes over control of DNA break repair

Now, a study shows that following the formation of DNA double-strand breaks, bidirectional transcription events adjacent to the break generate small RNAs that trigger the DNA damage response by local RNA:RNA interactions.

The RNA:RNA interactions are energy-dependent and they link the creation of microRNAs to the creation of enzymes, receptors, and hormones that protect organized genomes from virus-driven energy theft and all pathology.  But they are not just RNA:RNA interactions. The interactions among microRNAs and messenger RNA link food energy and the pheromone-controlled physiology of reproduction to all biodiversity on Earth without the pseudoscientific nonsense touted by biologically uninformed theorists and science journalists such as Ed Yong and Carl Zimmer.

 
Alternative splicing of pre-mRNA

Trashing the 2nd Law

Summary: Autophagy is the antiphage defense strategy. (December 8, 2016) Other definitions no longer apply.
See: Experiment shows that arrow of time is a relative concept, not an absolute one
Everything that theorists were taught to believe about entropy was probably based on the ridiculous assumption that “…there are no correlations between particles.”
Everything known to serious scientists about energy-dependent autophagy shows that the creation of energy must be linked from the biophysically constrained physiology of pheromone-controlled reproduction via feedback loops that protect life from the virus-driven degradation of messenger RNA, which links mutations to all pathology.
See:
1) Olfaction Warps Visual Time Perception
2) Molecular recognition in olfaction
3) QuEBS 2018: Workshop on Quantum Effects in Biological Systems
Research in the intersection of physics, chemistry and biology has been developed for more than 20 years based on what is known about the creation of quantized energy as information and details of the quantum effects in biological light-harvesting systems, which have been linked from the sense of smell in bacteria to our visual perception of energy and mass in the context of the space-time continuum.
See for comparison: Bamboo Specialists from Two Mammalian Orders (Primates, Carnivora) Share a High Number of Low-Abundance Gut Microbes
Reported on December 6, 2017 as: Separated Since the Dinosaurs, Bamboo-Eating Lemurs, Pandas Share Common Gut Microbes

“This really underscores the role that diet plays in determining what lives in our guts – and, in turn, how these microbial ecosystems can shape the way animals live,” McKenney says.

Microbial ecosystems are food energy-dependent and the pheromone-controlled physiology of reproduction biophysically constrains viral latency. Without the pheromone-controlled physiology of food energy-dependent reproduction, bacteriophages and the virus-driven theft of quantized energy would link mutations to loss of functional structures that protect organized genomes from the degradation of messenger RNA. Everything known about cell type differentiation in all living genera has been placed into the context of links from physics and chemistry to molecular epigenetics via what is known about supercoiled DNA.
For comparison, see this claim:

“The bamboo lemur’s evolutionary tree diverged from that of both panda species 83 million years ago – that’s 18 million years before dinosaurs went extinct,” says Erin McKenney, a postdoctoral researcher at North Carolina State University and lead author of a paper on the study. “These species are also separated by thousands of miles and the Indian Ocean. Red pandas and giant pandas aren’t closely related either, with their most recent ancestor coming 47.5 million years ago. Lemurs are primates, red pandas are related to raccoons, and pandas are related to bears.

“Yet all three species share these 48 gut microbes – more than 12 percent of the microbial types found in each species’ gut,” McKenney says. “The only common feature is their diet: all three species live almost exclusively on bamboo.”

The common feature was presented in this 2013 review: Nutrient-dependent/pheromone-controlled adaptive evolution: a model, which is a refutation of all neo-Darwinian pseudoscientific nonsense, and also a refutation of the ridiculous misrepresentations of “Big Bang” cosmologists. Those misereqpresentations led to two retractions of works published by Jack Szostak’s group in which false claims were made about non-enzymatic RNA replication.
See for comparison to what is known about the links from food energy to the pheromone-controlled physioloy of reproduction in species from microbes to humans: Altered responses to social chemosignals in autism spectrum disorder
reported as: Study: Autism Linked with Different Reactions to Chemical Signals
Conclusion:

“we speculate that social dysosmia may underlie part of the impaired reading of emotional cues in ASD.”

See for comparison: Global Sensory Impairment Predicts Morbidity and Mortality in Older U.S. Adults
Reported as: Problems with senses may predict older adults’ overall health, ability to function

Until now, no studies have examined how losing multiple senses affects older adults. To learn more, a team of researchers from the University of Chicago [including Martha McClintock] designed a study to focus on just that. Their study was published in the Journal of the American Geriatrics Society.

Problems with the senses are tractable to differences in the energy-dependent changes in base pairs that link changes in the microRNA/messenger RNA balance from RNA editing to the pheromone-controlled fixation of amino acid substitutions that stabilize the organized genomes of all living genera by protecting the organized genomes from the virus-driven degradation of messenger RNA.
See: Structural diversity of supercoiled DNA
The complexity of the interactions was again recently placed into the context of quantum correlations — with new insights.

Reversing the thermodynamic arrow of time using quantum correlations 

…standard thermodynamics presupposes the absence of initial correlations between interacting systems. We here experimentally demonstrate the reversal of the arrow of time for two initially quantum correlated spins-1/2, prepared in local thermal states at different temperatures, employing a Nuclear Magnetic Resonance setup. We observe a spontaneous heat flow from the cold to the hot system. This process is enabled by a trade off between correlations and entropy that we quantify with information-theoretical quantities.

They linked the creation of the sun’s anti-entropic virucidal energy from the physiology of food energy-dependent pheromone-controlled reproduction to biophysically constrained viral latency in all living genera. Constrained viral latency exemplifies the constrained entropy that Schrodinger placed into the context of What is Life? (1944). The updated version of his work was reported as: Experiment shows that arrow of time is a relative concept, not an absolute one

The idea of entangled particles has been in the news a lot lately as researchers around the world attempt to use it for various purposes—but there is another lesser-known property of particles that is similar in nature, but slightly different. It is when particles become correlated, which means they become linked in ways that do not happen in the larger world. Like entanglement, correlated particles share information, though it is not as strong of a bond. In this new experiment, the researchers used this property to change the direction of the arrow of time.

Everything known to serious scientists about biophysically constrained energy-dependent RNA-mediated pheromone-controlled entropy (aka the “arrow of time”) is now referred to in the context of autophagy, which links the food energy-dependent fixation of amino acid substitutions to healthy longevity during species-specific developmental staging in species from microbes to humans.

See:Micro RNAs mir-184 and let-7 alter Drosophila metabolism and longevity

… adult-specific overexpression of let-7 in female nervous tissue increased median fly lifespan by ~22%. We provide evidence that this lifespan extension is not due to alterations in nutrient intake or to decreased insulin signaling.

That fact about biophysically constrained entropy (autophagy/the “arrow of time”)  replaces all theories about the emergence of life and evolution of biodiversity. Ridiculous theories were based on the 2nd Law of Thermodynamics, which assumes there are no correlations between subatomic particles. Darwin’s “conditions of life” and “Kohl’s Laws of Biology” show that the correlations are manifested at every level of examination.

See: Feedback of the Drosophila period gene product on circadian cycling of its messenger RNA levels

The feedback controls energy-dependent differences in H2, which consists of two different hydrogens. Control begins at the level of subatomic particles. The controlled differences link the speed of light on contact with water (H20) to all biodiversity via the physiology of pheromone-controlled reproduction. That fact is exemplified in Drosophila and in the Amish population of Berne, Indiana. That modern human population manifests a nutrient energy-dependent pheromone-controlled 10-year increase in their  RNA-mediated lifespan.

The claim that “A null mutation in SERPINE1 protects against biological aging in humans” can be viewed in the context of what Richard Feynman claimed about human idiocy. Mathematical models of energy-dependent biophysically constrained entropy link autophagy to healthy longevity. They link the virus-driven degradation of messenger RNA from mutations to all pathology. Only biologically uninformed science idiots publish research that supports ideas about mutation-driven evolution.


Few intelligent people would argue against the fact that life is food energy-dependent. But see: 7/25/13
Jay R. Feierman:

Variation is not nutrient availability and the something that is doing the selecting is not the individual organism. A feature of an educated person is to realize what they do not know. Sadly, you don’t know that you have an incorrect understanding [of] Darwinian biological evolution.

My understanding is based on an understanding shared by many scientists and non-scientists, but no pseudoscientists.
Whether or not non-scientists know the facts about RNA-mediated cell type differentiation, they are not likely to believe that the selection of what to eat by the organisms that eat it is the most critical factor in species survival. That helps to explain why: A third of Americans don’t believe in evolution
My comment:

Ecological adaptation occurs via the epigenetic effects of nutrients on alternative splicings of pre-mRNA which result in amino acid substitutions that differentiate all cell types of all individuals of all species. The control of the differences in cell types occurs via the metabolism of the nutrients to chemical signals that control the physiology of reproduction.

These facts do not refute evolution; they simply refute the ridiculous theory of mutation-initiated natural selection that most people here were taught to believe is the theory of evolution.

That theory is far too ridiculous to be anything but a joke in the context of biological-based increasing organismal complexity. But here, we have lots of jokers, don’t we? The proof of ecological variation that appears to refute the theory of evolution, which actually refutes itself, is that ecological adaptations occur too fast for mutations to compete with them as a source of anything but diseases and disorders.

See also the attack on my scientific credibility by PZ Myers and his idiot minions: One crank dies, another rises to take his place (2014)

Is alternative splicing the only mechanism to create variants in cells? No, of course not. External signals cause changes in the phosphorylation state of proteins in the cytoplasm, for example, that can affect metabolic activity; no alternative splicing involved. Signals can also switch on and switch off specific genes, again, no alternative splicing needed.

Most of the serious scientists I know laugh at people like PZ Myers. Some of them use sarcasm to address the ignorance of pseudoscientists. For example, see: A not entirely serious future history of neuroscience (2017)
Sarcasm alert. Thanks to Luca Turin for calling attention to this.
Excerpt 1)

Author’s note: resting for a moment in a dark corner of the Society for Neuroscience conference’s poster hall, on the quiet solitude of the Wednesday afternoon in the History of Neuroscience aisle, a shambling figure, bent with age, appeared with a speed that belied his years. Suddenly lunging for me, he shoved a sheaf of papers into my hand, hissing in my ear “it gets worse — so much worse”. Startled, I glanced at the front page, and the date written at the top: 6th October 2106. “What is…” I began, but he’d already whirled away — “A warning!” he spat back over his shoulder. Then he stopped, growled “I hate this bit”, squeezed his conference badge — and vanished.
What follows is the text I have been able to reconstruct from those crumpled, torn, faded pages.

Excerpt 2)

2037: Janelia Farm announces its Drosophila model of schizophrenia. HHMI instructs it to diversify its range of species.

My addendum: Electron spin changes during general anesthesia in Drosophila (2014)

Back to the future: The insect-to-elephant model of pheromone-controlled biophysically constrained viral latency is abandoned, again. Insect pheromone in elephants

The insect-to-elephant model of the food energy-dependent pheromone-controlled physiology of reproduction links alternative splicing of pre-mRNA, which now are called microRNAs by all serious scientists, to survival of all individuals in all species. The virus-driven degradation of messenger RNA links mutations to all pathology.

When should you unfriend someone on Facebook?

What we need to remember is that the devil is in the details.

Feedback of the Drosophila period gene product on circadian cycling of its messenger RNA levels (1990)
See for comparison: An Evolving Approach: The Public Response to Darwinism at Abilene Christian University, 1935-1989 (Stone-Campbell Journal 20:2, 2017)
Only by ignoring everything that has been learned about energy-dependent RNA-mediated biophysically constrained viral latency can historians and other pseudoscientists  continue to tout their ridiculous theories.
 

Difference in the network of hydrogen bonds between high- and low-altitude Hb variants, HH-H and LL-L, respectively

The α1 and β1 subunits of HH-H (light blue) and LL-L (light red) are superimposed, and van der Waals radii are shown for α-chain residues that are in atomic contact with β-chain residues of the opposing α2β2 dimer.

The overwhelming ignorance of sex researchers

Summary: J. Michael Bailey, and others like him, pretend to not know how non-coding variants are epigenetically linked from differences in hydrogen bonds to all energy-dependent biophysically constrained morphological and behavioral phenotypes.

Genome-Wide Association Study of Male Sexual Orientation [Energy-dependent changes in biophysically constrained viral latency]

We identified several [energy-dependent changes in] SNPs with p < 10−5, including regions of multiple supporting SNPs on chromosomes 13 (minimum p = 7.5 × 10−7) and 14 (p = 4.7 × 10−7). The genes nearest to these peaks have functions plausibly relevant to [biophysically constrained viral latency and] the development of  sexual orientation.

Reported as: Gene variants identified that may influence sexual orientation in men and boys

The findings by the team do not settle the argument of whether homosexuality in people is biology-based, but instead offers more evidence that suggests it is likely the case. Prior studies that looked at family histories have also offered some evidence of biology playing a role while other studies have found some differences in chromosomes. In this study, the number of samples tested was too small to offer conclusive evidence—larger studies will have to be undertaken to solidify the evidence.

I was not surprised to see J. Michael Bailey listed as a co-author. He is a biologically uninformed pseudoscientist and a passive/aggressive antagonist.

It’s been more than 4 years since food energy-dependent changes in hydrogen-atom transfer in DNA base pairs in solution were linked to biophysically constrained viral latency and all biodiversity via the pheromone-controlled physiology of reproduction in all living genera.

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Sex researchers like J. Michael Bailey, are still among the majority of those who have paid no attention to the extant literature since the time we published this 1996 review in Hormones and Behavior (with a section on molecular epigenetics.)

From Fertilization to Adult Sexual Behavior

Parenthetically it is interesting to note even the yeast Saccharomyces cerevisiae has a gene-based equivalent of sexual orientation (i.e., a-factor and alpha-factor physiologies). These differences arise from different epigenetic modifications of an otherwise identical MAT locus (Runge and Zakian, 1996; Wu and Haber, 1995).

All serious scientists know that everyone else must also start with differences in the quantized energy of hydrogen to get from epigenetic modifications to differences in morphological and behavioral phenotypes. Serious scientists also know that social science is pseudoscience and that pseudoscientific nonsense is the cause of all preventable unnecessary suffering and premature death.

See for instance:

1) Epistasis Among Adaptive Mutations in Deer Mouse Hemoglobin
2) Mutation-Driven Evolution
and my refutation of neo-Darwinian pseudoscientific nonsense. All three were published on June 14, 2013.
3) Nutrient-dependent/pheromone-controlled adaptive evolution: a model
Please join the other serious scientists who have been quietly ridiculing people like J. Michael Bailey for more than 20 years.

QuEBS workshop has established itself as an outstanding stage to present the research in the intersection of physics, chemistry and biology. This field has been developed in Lithuania for more than 20 years already. The beginnings could be associated with a series of “Light-harvesting Physics” international conferences, which were held in Lithuania (in Preila, 1992 and 1994, and in Birštonas, 1996). During these conferences, discussion of notable scientists and pioneers of Quantum Biology, such as Graham R. Fleming, Shaul Mukamel, Rienk van Grondelle, Richard Cogdell, Alfred Holzwarth and others, established excitons in biology as the “must-talk-language” when describing the quantum effects in biological light-harvesting systems.

Light harvesting is the source of energy-dependent changes in hydrogen that link physics, chemistry, and molecular epigenetics to accurate representations of RNA-mediated cell type differentiation. All aspects of energy-dependent RNA-mediated cell type differentiation have been virtually ignored by J. Michael Bailey, who is the proud owner of the Sexnet listserver. It has been a consistent source of misinformation for all participants during the past two decades.
See for comparison my comments on: Evolution of a Vertebrate Social Decision-Making Network
1)

Re: Cause and effect. How could it not be the adaptive evolution from yeasts of the ligand-receptor binding exemplified across species by the conservaton of gonadotropin releasing hormone (GnRH) and diversification of its receptor? Model organisms like the threespine stickleback make clear the involvement of ecological niche construction. The honeybee invertebrate model organism makes clear the involvement of the nutrient dependent ecological niche in construction of the pheromone-dependent social niche. Invertebrate and vertebrate models collectively attest to the common molecular biology of adaptively evolved social decision-making networks. In mammals, the hypothalamic neurogenenic niche (probably located in the MPOA) responds to nutrients to enable fertility and responds to pheromones to enable sexual reproduction that has adaptively evolved from its origins in brewer’s yeast. Never before has there been such a clear reprentation of cause and effect across species from microbes to man, where nutrient chemicals calibrate the intracellular signaling and their metabolism to pheromones standardizes and controls the stochastic gene expression required for reproduction. Gene expression enables adaptive evolution of the brain and ensures that our ability to acquire nutrient chemicals is the first priority for reproduction via appropriate social behaviors, as it is in every species. For example, microbes eat the DNA of heterospecifics but not conspecifics, which indicate more social sense than what some people today are capable of recognizing in the design of biology (the evolved gene, cell, tissue, organ, organ system pathway that directly links sensory input to the mammalian neuroendocrine system and the hormones responsible for our behavior, which activates the same ‘organized’ pathway).

2)
Re: The Intersection of Neurotoxicology and Endocrine Disruption. NeuroToxicology, Bernard Weiss

Abstract excerpts: …hormones help steer the process of brain development.

…sex differences in behavior are primarily the outcomes of differences in how the brain is sexually differentiated during early development by gonadal hormones (the Organizational Hypothesis).

… environmental chemicals are capable of altering these underlying events and processes. Among those chemicals, the group labeled as endocrine disrupting chemicals (EDCs) offers the clearest evidence of such selectivity… —————– I have terminally argued to conclusion that the clearest evidence of chemicals that alter the underlying events and processes of brain development and its sexual differentiation are the nutrient chemicals and pheromones responsible for the adaptive evolution of species from microbes to man.

Focus on endocrine disruption establishes what happens when toxic chemicals alter the same events and processes of brain development and its sexual differentiation via epigenetic effects on gonadotropin releasing hormone (GnRH) pulsatility, luteinizing hormone, olfactory bulb neurogenesis, hippocampal neurogenesis, learning, and memory in vertebrates.

For contrast, I’ve modeled the epigenetic effects of food odors and pheromones on homeostasis and species diversification, and for many years, my friend Teresa Binstock and co-author (e.g., with Milton Diamond)stressed the importance of endocrine disruption (specifically due to bisphenol A and phthalates) on J. Michael Bailey’s “Sexnet”. Now that the basic principles of biology and levels of biological organization, which link sensory input from the environment directly to behavior via intracellular signaling and stochastic gene expression, have been clarified by work with model organisms, I look forward to learning if there are any reasons to avoid the incorporation of current information on endocrine disruption into existing studies of the homeostatic development of human sexual behavior.

Comparing typical and atypical epigenetic effects that appear to extend to those that are transgenerational seems even more important now than in 1996.

Kohl, J.V. (2012) Human pheromones and food odors: epigenetic influences on the socioaffective nature of evolved behaviors. Socioaffective Neuroscience & Psychology, 2: 17338

See also: Open Chromatin Profiling in hiPSC-Derived Neurons Prioritizes Functional Noncoding Psychiatric Risk Variants and Highlights Neurodevelopmental Loci

Our study shows that noncoding disease variants in OCRs can affect neurodevelopment, and that analysis of open chromatin regions can help prioritize functionally relevant noncoding variants identified by GWAS.

After Alan R. Sanders and others published this, the claims in Genome-Wide Association Study of Male Sexual Orientation can be viewed in the context of two decades of false claims and pleas for more funding.

Conclusion:

In this study, the number of samples tested was too small to offer conclusive evidence—larger studies will have to be undertaken to solidify the evidence.

Cytosis can be used to teach everything from base editing to RNA editing to everyone over age 10. They will learn how to link the creation of energy to biophysically constrained viral latency via the physiology of pheromone-controlled reproduction.

Mouse morphs and primate diversity in 50 years

Excerpt:

Analysis of the crystal structure of deer mouse Hb at 1.8 Å resolution (24, 25) revealed that each of the eight rHb mutants is characterized by a unique constellation of hydrogen bonds within and between subunits (Table 2 and fig. S2). Additional hydrogen bonds between subunits of the same αβ dimer are formed in the presence of β128Ser (an L-type residue; fig. S2), which contributes to the observed epistasis between allelic α- and β-chain variants.

———————————
Energy-dependent RNA-mediated biophysically constrained viral latency (i.e., silencing of viral elements) protects all organized genomes from the degradation of messenger RNA that links mutations to all pathology. The mutations are caused by nutritional stress and/or social stress. That fact has been known to all serious scientists for at least 50 years. But see:
Silencing of viral elements: A cure for schizophrenia? ARTICLE Provisionally accepted

1. The problem.
Scientific evidence for various infectious agents as cause for psychosis in schizophrenia is not robust. Many pathogens that influence brain development might play a role in disease causation. It has been shown that influenza exposure before birth(Brown, 2012), exposure to herpes simplex during birth(Brown et al., 2011) or exposition to Toxoplasma gondii and other pathogens (Arias et al., 2012) increases risk for schizophrenia and/or compromises cognition. During psychosis viral and also ancient retroviral elements become may activated in the brain(Karlsson et al., 2001; Perron et al., 2012). The implication of this research for use in clinical practice is ambiguous, because a robust virus test is lacking.

Examples of human idiocy are the problem. See for comparison:

QuEBS workshop has established itself as an outstanding stage to present the research in the intersection of physics, chemistry and biology. This field has been developed in Lithuania for more than 20 years already. The beginnings could be associated with a series of “Light-harvesting Physics” international conferences, which were held in Lithuania (in Preila, 1992 and 1994, and in Birštonas, 1996). During these conferences, discussion of notable scientists and pioneers of Quantum Biology, such as Graham R. Fleming, Shaul Mukamel, Rienk van Grondelle, Richard Cogdell, Alfred Holzwarth and others, established excitons in biology as the “must-talk-language” when describing the quantum effects in biological light-harvesting systems.

Every aspect of biophysically constrained energy-dependent RNA-mediated life on Earth has refuted the pseudoscientific nonsense about emergence and evolution.

As climate warms, mice morph

Biologists document changes in teeth and skull structure in two species in southern Quebec over past 50 years

The ridiculous claim that the fixed amino acid substitutions were adaptive mutations proves how little the authors understand about biophysically constrained viral latency.

Excerpt 1)

“Biologists document changes in teeth and skull structure in two species in southern Quebec over past 50 years

Excerpt 2)

“These changes may be related to a dietary shift caused by climate change, combined with competition for food resources between the two species of mice, according to the researchers.”

All serious scientists know that food energy biophysically constrains the pheromone-controlled physiology of reproduction, which links the fixation of RNA-mediated amino acid substitutions to cell type differentiation in all living genera.
 
We have now arrived at the claims of biologically uninformed science idiots who tell us that two different species evolved in 50 years.
 

Excerpt 3)

“One question that remains to be settled is whether the changes are genetic, and will be passed on to future generations — actual evolution — or whether they represent “plasticity,” the capacity of some species to adjust to rapid environmental change.”

The facts about the transgenerational epigenetic inheritance of healthy longevity for comparison to virus-driven pathology have been exquisitely detailed. All serious scientists have dispensed with the nonsense that questions the capacity of some species to adjust to rapid environmental change. Ecological variation must be linked from the physiology of pheromone-controlled reproduction in all living genera via the conserved molecular mechanisms of RNA-mediated cell type differentiation that link fixation of amino acid substitutions to the morphological and behavioral phenotypes of all individuals and all species on Earth.

See for instance, on the same day that my 2013 refutation of Nei’s pseudoscientific nonsense about Mutation-driven evolution was published, this also was published: Epistasis Among Adaptive Mutations in Deer Mouse Hemoglobin

Epistasis is food energy-dependent. The energy must be biophysically constrained in the context of the physiology of pheromone-controlled transgenerational epigenetic inheritance. The creation of energy in a hydrogen atom was linked from the anti-entropic virucidal effect of sunlight to the stability of the organized genome of mice by hydrogen-atom transfer in DNA base pairs in solution and differences in the hemoglobin molecule of ecologically adapted species.

Analysis of the crystal structure of deer mouse Hb at 1.8 Å resolution (24, 25) revealed that each of the eight rHb mutants is characterized by a unique constellation of hydrogen bonds within and between subunits (Table 2 and fig. S2). Additional hydrogen bonds between subunits of the same αβ dimer are formed in the presence of β128Ser (an L-type residue; fig. S2), which contributes to the observed epistasis between allelic α- and β-chain variants.

See also:

…the so-called alpha chains of hemoglobin have identical sequences of amino acids in man and the chimpanzee, but they differ in a single amino acid (out of 141) in the gorilla.

The fact that every Angstrom is dynamic and the fact that energy-dependent changes in the microRNA/messenger RNA balance have been linked to biophysically constrained viral latency and all biodiversity was placed into the context of this parody:

 See also:


The Mechanical Properties of DNA are food energy-dependent and RNA-mediated

The elastic properties of the DNA molecule determine how it supercoils during replication, how it packs into confined biological structures and how it interacts with proteins during gene expression.

See: Nutrient-dependent pheromone-controlled ecological adaptations: from atoms to ecosystems
Pattern recognition

Nutrient-dependent atomic-level changes may determine the nucleotide changes in a specific base pair. The nucleotide changes appear to link nutrient-dependent single nucleotide polymorphisms (SNPs) from the availability of fruits and vegetables or fermented milk products to individual differences and to species differences in the need for certain vitamins. For example, cell type determination and differentiation are associated with the nutrient-dependent 3D distribution of amino acid substitutions as they accumulated during a history of ecological adaptations [32] in flies [9] and in humans [33]. Sex differences in behavior also appear to arise from the single-molecule and single cell levels in flies, which suggests that adaptive changes in behavior can be explained in the context of nutrient-dependent pheromone-controlled genome-environment interactions that alter circuit plasticity via amino acid substitutions [34].

Conclusion from: Nutrient-dependent pheromone-controlled ecological adaptations: from atoms to ecosystems

The companion papers [162-163] told a new short story of ecological adaptations. In the context of climate change and changes in diet, the story began with what probably was a nutrient-dependent base pair change and a variant epiallele that arose in a human population in what is now central China. Apparently, the effect of the epiallele was adaptive and it was manifested in the context of an effect on sweat, skin, hair, and teeth. In another mammal, such as the mouse, the effect on sweat, skin, hair, and teeth is probably due to a nutrient-dependent epigenetic effect on hormones responsible for the tweaking of immense gene networks that metabolize nutrients to pheromones. The pheromones appear to control the nutrient-dependent epigenetically-effected hormone-dependent organization and hormone-activation of reproductive sexual behavior in mammals such as mice and humans, but also in invertebrates and in microbes as previously indicated.

The ecological adaptations, which appear to be manifested in the human population are detailed in these two reports [162-163]. The ecological adaptations are likely to be nutrient-dependent and pheromone-controlled. If so, ecological variation probably leads to ecological, social, neurogenic, and socio-cognitive niche construction, which is manifested in increasing organismal complexity and species diversity. If not, there may be something as yet unknown about mutations and evolution that makes sense in the light of what is known about nutritional epigenetics and the molecular biology of species from microbes to man.

See for comparison: The evolution of H2
Biohydrogen production from hyperthermophilic anaerobic digestion of fruit and vegetable wastes in seawater: Simplification of the culture medium of Thermotoga maritima
Mechanism of Nitrogenase H2 Formation by Metal-Hydride Protonation Probed by Mediated Electrocatalysis and H/D Isotope Effects
The claims that energy emerged or that differences in hydrogen and differences in species evolved outside the context of the energy-dependent creation of enzymes are among the most ridiculous examples of human idiocy that any serious scientist has ever encountered.
Claims about the emergence of life were again retracted on November 23, 20-17 and reported on December 5, 2017.

”Definitely embarrassing:” Nobel Laureate retracts non-reproducible paper in Nature journal

See: Comment awaiting moderation.

James V. Kohl December 7, 2017 at 4:35 am
The Science Behind the Game “Cytosis,” pits the collaborative efforts of 20 serious scientists against the pseudoscientific nonsense touted by theorists. The serious scientists know how energy-dependent RNA-mediated cell type differentiation occurs.
Resources (e.g., mRNA, ATP) are used to build enzymes, hormones, and/or receptors. Health points accumulate to show why food energy must be linked from the physiology of pheromone-controlled reproduction to biophysically constrained viral latency.
For comparison, Szostak and other theorists have been stuck with their ridiculous misrepresentations of emergence and neo-Darwinian evolution, which failed to consider Darwin’s “conditions of life.”
“Conditions of life” are energy-dependent. The energy is Schrodinger’s anti-entropic virucidal energy. It comes from sunlight and is epigenetically “trapped” in food via the physiology of reproduction.
Board Game:
Cytosis: A Cell Biology Game
Title:
Cytosis – The Science Behind the Game https://boardgamegeek.com/filepage/155090/cytosis-science-behind-game
See also: Two retractions of human idiocy
See also: Routing gene therapy directly into the brain

Once the genetically-engineered HSCs are transplanted into the brain’s ventricles, the crucial enzyme they contain helps to metabolize the materials that were previously building up and causing tissue damage.

A new lineage of cells descended from the transplanted HSCs — a type of cell called a myeloid — begin to scavenge and consume the excess material that is responsible for neurodegeneration.

The pheromone-controlled differentiation of these cell types was predicted in the context of claims that pheromones biophysically constrain all pathology in the mouse to human model, which has been thoroughly detailed since 1994.
See: [Pheromonal regulation of genetic processes: research on the house mouse (Mus musculus L.)
See also: Pheromones and the luteinizing hormone for inducing proliferation of neural stem cells and neurogenesis

See also: Researchers Discover Key to Diseases in Mitochondrial DNA Mutations

Because the primary job of the mitochondrion is to produce energy, most of its genes are involved in pathways in the energy production process. Although it has a small genetic code, mtDNA contains the blueprints for building many of the enzymes and proteins that are needed to function in those pathways.
 
The virus-driven theft of quantized energy as information links the degradation of messenger RNA from mutations to all pathology in all living genera. The speed of light on contact with water has been linked to all energy-dependent RNA-mediated DNA repair in the context of the physiology of reproduction and the transgenerational epigenetic inheritance of healthy longevity.
Cytosis can be used to teach everything from base editing to RNA editing to everyone over age 10. They will learn how to link the creation of energy to biophysically constrained viral latency via the physiology of pheromone-controlled reproduction.

Two retractions of human idiocy

Excerpt: …she was interested in the PNAS research because it identified a potential inhibitor of the hepatitis C virus…

”Definitely embarrassing:” Nobel Laureate retracts non-reproducible paper in Nature journal

1)

This retraction marks the second in six months for Nature Chemistry after having none for eight years.

2)

In 2009, Szostak also retracted a 2008 paper in Proceedings of the National Academy of Sciences after an outside researcher could not replicate the results. The retraction notice credited Katherine Berry, then a doctoral student at the University of California, Berkeley, for bringing the issues to their attention. (Full disclosure: RW’s Victoria Stern and Berry were roommates freshman year of college).

Berry, who’s now an assistant professor of biochemistry at Mount Holyoke in South Hadley, Mass., told us that she was interested in the PNAS research because it identified a potential inhibitor of the hepatitis C virus…

Comment awaiting moderation

James V. Kohl December 7, 2017 at 4:35 am

The Science Behind the Game “Cytosis,” pits the collaborative efforts of 20 serious scientists against the pseudoscientific nonsense touted by theorists. The serious scientists know how energy-dependent RNA-mediated cell type differentiation occurs.

Resources (e.g., mRNA, ATP) are used to build enzymes, hormones, and/or receptors. Health points accumulate to show why food energy must be linked from the physiology of pheromone-controlled reproduction to biophysically constrained viral latency.

For comparison, Szostak and other theorists have been stuck with their ridiculous misrepresentations of emergence and neo-Darwinian evolution, which failed to consider Darwin’s “conditions of life.”

“Conditions of life” are energy-dependent. The energy is Schrodinger’s anti-entropic virucidal energy. It comes from sunlight and is epigenetically “trapped” in food via the physiology of reproduction.

Board Game:
Cytosis: A Cell Biology Game
Title:
Cytosis – The Science Behind the Game https://boardgamegeek.com/filepage/155090/cytosis-science-behind-game

Addendum: Naturally occurring base editing, microRNA editing, and RNA editing link the energy-dependent creation of microRNAs from natural selection for energy-dependent codon optimality to the physiology of pheromone-controlled reproduction, which biophysically constrains viral latency. Constraint breaking mutations have been linked to all pathology. The misrepresentations of Szostak and others like him have contributed to a history of unnecessary suffering and premature death. Richard Feynman helped to place their claims into this perspective:

 

 

Lethal virus kills 5 billion people?

Reporting new scientific truths is not allowed in the USA

Summary: If we keep training serious scientists in the United States but force them to return to their homeland to report new scientific truths, our Homeland Security will suffer from the ignorance of pseudoscientists who are still touting ridiculous claims about mutations and evolution.

A new scientific truth does not triumph by convincing its opponents and making them see the light, but rather because its opponents eventually die, and a new generation grows up that is familiar with it.

Every great scientific truth goes through three stages. First, people say it conflicts with the Bible. Next they say it has been discovered before. Lastly they say they always believed it.

Sugar industry withheld evidence of sucrose’s health effects nearly 50 years ago

The results suggest that the current debate on the relative effects of sugar vs. starch may be rooted in more than 60 years of industry manipulation of science. Last year, the Sugar Association criticized a mouse study suggesting a link between sugar and increased tumor growth and metastasis, saying that “no credible link between ingested sugars and cancer has been established.”
 

First question: Why would they lie about a thing like that?

Second question: Who taught you to believe in them?

See also: Psychiatric Fallout From Toxic Exposure October 21, 2016 Posted to the Psychiatry Research Yahoo Group on November 25, 2017

Face-saving attempts will continue to be made by everyone who taught anyone else to believe in the pseudoscientific nonsense about random mutations and evolution. Clearly, psychiatrists decided it was good for business to ensure a decline in mental health that should have been attributed to the effects of sugar.
 

I recognized the obvious link from glucose levels to triglycerides before the nonsense about cholesterol and heart disease became a means to support the medical practices of pill prescribing physicians. Only diabetics had levels of triglycerides that left a chalky-white to pink color in their plasma or serum. Ultracentrifugation was sometimes required or chemical “clearing” with mathematical corrections in order to report accurate results.

Study: Autism Linked with Different Reactions to Chemical Signals (senior author Noam Sobel, Israel).

Responses to compounds in human sweat may help explain why people with autism spectrum disorder tend to struggle with social cues.

See also: Olfaction Warps Visual Time Perception (senior author Wen Zhou, China)
If we keep training serious scientists in the United States but force them to return to their homeland to report new scientific truths, our Homeland Security will suffer from the ignorance of pseudoscientists who are still touting ridiculous claims about mutations and evolution.
http://www.cc.com/video-clips/sz2odd/the-daily-show-with-jon-stewart-greg-bear
Sci-fi author Greg Bear tells Jon about the not-so-distant future of technology and helping Homeland Security.
This is not funny anymore:
See also: The vibrational theory of olfaction for the win
Compare the facts to this ridiculous representation of the virus-driven evolution of human heterosexual love: VIRUS EVOLUTION ( AMAZING DOCUMENTARY)
In his science fiction novels from 1999 and 2003, Greg Bear linked what was known about biophysically constrained food energy-dependent pheromone-controlled ecological adaptations to the creation of a new more intelligent human subspecies that communicated with pheromones. They adapted to the virus-driven degradation of their messenger RNA, which has been linked from mutations to all pathology in species from archaea to non-human primates. Everything known to all serious scientists about biophysically constrained viral latency has since been placed into the context of refutations of neo-Darwinian pseudoscientific nonsense.
For a historical approach to the overwhelming ignorance of biologically uninformed theorists, see:

“The Darwin Code: Intelligent Design without God”

Perhaps the most intriguing method of gene swapping in bacteria is the bacteriophage, or bacterial virus. Bacteriophages–phages for short–can either kill large numbers of host bacteria, reproducing rapidly, or lie dormant in the bacterial chromosome until the time is right for expression and release. Lytic phages almost invariably kill their hosts. But these latter types–known as lysogenic phages–can actually transport useful genes between hosts, and not just randomly, but in a targeted fashion.

But remember that the quality of RNA begins with its energy-dependent creation and researchers recently made the claim that they had …revealed a surprising relationship between dementia and decreased quality of RNA—a key player in gene expression—in the more aged brain.
The decreased quality of the RNA has also been linked to the creation of the death gene via what is known about glioblastoma. A Harvard and MIT trained physicist reported that fact to me, and I could hardly believe how easy it was to confirm it that Abcam researchers knew about it ~20 years ago.
See: Reduced expression of brain-enriched microRNAs in glioblastomas permits targeted regulation of a cell death gene
See also: A Concise Review of MicroRNA Exploring the Insights of MicroRNA Regulations in Bacterial, Viral and Metabolic Diseases

I look forward to the day when serious scientists in the United States can report their refutations of neo-Darwinian pseudoscientific nonsense without being ostracized by claims that serious scientists exist on the fringes of what is known to all other serious scientists in the world. The virus-driven degradation of messenger RNA links mutations to all pathology, not to the evolution of one species from another.

Cytosis can be used to teach everything from base editing to RNA editing to everyone over age 10. They will learn how to link the creation of energy to biophysically constrained viral latency via the physiology of pheromone-controlled reproduction.

Achromobacter and killer theories

A pan-genomic approach to understand the basis of host adaptation in Achromobacter 

Ecological variation is linked to food energy-dependent biophysically constrained viral latency by the pheromone-controlled physiology of reproduction in species from microbes to humans.

For comparison, these authors claim:

This study provides strong phylogenetic and pan-genomic bases to motivate further research on Achromobacter, and contributes to the understanding of opportunistic pathogen evolution.

Their claim exemplifies how teaching neo-Darwinian theory causes unnecessary suffering and how it may cause the premature death of our loved ones. Physicians who do not know the difference between the human idiocy of claims about pathogen evolution and the facts about pathogen adaptation to a host are not likely to ever link the conserved molecular mechanisms of energy-dependent RNA-mediated cell type differentiation to healthy longevity.

That means they are not likely to link the virus-driven degradation of messenger RNA from mutations to all pathology. They will never look for the results of a search like this:

bacteriophage achromobacter For example: (1974) Bacteriophages and cryptic lysogeny in Achromobacter

See this explanation of energy-dependent viral latency: Viral replication: lytic vs lysogenic (video 5:10) Instead of accurately representing the anti-entropic virucidal effect of UV light, as explained here: Energy as information and constrained endogenous RNA interference (video 6:46)

How much longer will it be until everyone realizes that teaching students to believe in mutation-driven evolution leads them to become professors who are the biologically uninformed science idiots? The professors teach medical professionals to believe in the “bad luck” theories of pathology. See for comparison to the “Bad Luck” theory of random mutations.

In the world of serious scientists, bacteria become archaea and humans become non-human primates in the context of the viral hecatomb (i.e., the virus-driven degradation of messenger RNA). In the world of pseudoscientists who teach physicians to believe in “bad luck” theories, the only hope that most people have is the fact that energy-dependent polycombic ecological adaptations typically biophysically constrain viral latency.

Clearly, bacteriophages (viruses in bacteria) can steal quantized energy to proliferate and kill. Evolutionary theorists are willing to let that continue to happen. Are you?

If not, see: Cytosis

See also: To save a young woman besieged by superbugs, scientists hunt a killer virus

Part of the issue is that phages [viruses] are alive, and continue evolving inside the body.

Viruses are not “alive” and nothing alive evolves inside or outside the body. Organisms adapt to the virus-driven degradation of messenger RNA, or species become extinct.

See also: Episode 10: A giant Petri dish chock-full of superbugs shows evolution as it happens  by Carl Zimmer

…you can observe the evolution of antibiotic resistance in a series of bursting waves. It’s so eminently viewable, in fact, that the MEGA plate video has been watched almost 25 million times since it was posted online in September.

The pseudoscientific nonsense touted by journalists like Carl Zimmer will continue to cause unnecessary suffering and premature deaths. The pathology will be attributed to antibiotic resistance, instead of the failure to teach intelligent students about food energy-dependent pheromone-controlled ecological adaptations.

Amino acid modification FA_Epigenetics_Table1

Eutrophication and phosphorylated biodiversity

In Chinese philosophy, yin and yang (also yinyang or yin yang, 陰陽 yīnyáng “dark–bright”) describe how seemingly opposite or contrary forces may actually be complementary, interconnected, and interdependent in the natural world, and how they may give rise to each other as they interrelate to one another.

Last night I dreamed that someone added color to this symbol and represented it as a spinning disk (in a publication from the Nature publishing group).  The specifics of the dream helped me to complete this accurate representation of biophysically constrained viral latency.
See for comparison: Phosphorylation, oligomerization and self-assembly in water under potential prebiotic conditions
Reported as: Scientists find potential ‘missing link’ in chemistry that led to life on Earth

“It reminds me of the Fairy Godmother in Cinderella, who waves a wand and ‘poof,’ ‘poof,’ ‘poof,’ everything simple is transformed into something more complex and interesting,” Krishnamurthy said.

In the context of energy-dependent Biblical Creation or Chinese philosophy, the speed of light on contact with water links the Common origins of RNA, protein and lipid precursors in a cyanosulfidic protometabolism to a cleansing Flood of Biblical proportions. After-the-Flood, eutrophication probably stimulated the growth of aquatic plant life.
That speculation helps to explain the rapid re-population of the Earth via the “the process by which a body of water becomes enriched in dissolved nutrients (such as phosphates)…
For comparison, Krishnamurthy’s ‘poof,’ ‘poof,’ ‘poof’ theory of how increasing complexity initially arose twice — before and after the extinction of many different species, will always be placed into the context of a “Fairy Tales.”  Serious scientists can use what is known about biophysically constrained viral latency to link eutrophication from phosphorylation and oligomerization to what has been referred to as the Cambrian Explosion — the rapid diversification of most major living animal body plans (phyla) in the fossil record.
However, serious scientists can also link the facts about eutrophication, phosphorylation and oligomerization to all food energy-dependent pheromone-controlled biodiversity on Earth via the weekend resurrection of the bacterial flagellum.
See: Evolutionary resurrection of flagellar motility via rewiring of the nitrogen regulation system
See also: A communal catalogue reveals Earth’s multiscale microbial diversity reported as: Mapping the Microbiome of…Everything
The funding includes money from the John Templeton Foundation, which in the past seems to have ensured that all results would be reported in the context of randomness and evolution. But, even with millions of dollars spent trying to support that dogma, efforts are doomed to fail.
Eugene Koonin said it best: The entire evolution of the microbial world and the virus world, and the interaction between microbes and viruses and other life forms have been left out of the Modern Synthesis…
That fact is readily linked to the ‘poof,’ ‘poof,’ ‘poof’ theory of how increasing complexity arose, because the theory does not include any information on how the virus-driven degradation of messenger RNA has since been linked to all pathology.
Indeed, the fossil record may be the best example of how the viral hecatomb links the virus-driven degradation of messenger RNA to calcification of tissues and to ossification of the tissue that neo-Darwinian theorists claim is evidence that our ancestors evolved into us. Their ridiculous claims have not been supported by any experimental evidence of biophysically constrained biologically-based top-down causation.
If serious scientists allow the ‘poof,’ ‘poof,’ ‘poof’ theory, the pseudoscientists may continue to prevail against all odds. In the world of science, their theories would never be considered. Instead, it seems that biologically uninformed science idiots can suggest anything.When they continue to repeat their suggestions, the uninformed masses may believe them — rather than attempt to learn anything about eutrophication, phosphorylation, or food energy-dependent pheromone-controlled feedback loops, ecological adaptations, and biodiversity.
For instance, in the context of energy-dependent top-down causation, physics and chemistry can be linked from molecular epigenetics to supercoiled DNA in organized genomes via Histone methylation and amino acid substitutions.​​

Lysine methylation of H3 and H4 is implicated in both transcriptional activation and repression depending on the methylation site, while arginine methylation promotes transcriptional activation1.

Methylation is food energy-dependent and RNA-mediated in species from microbes to humans. That fact and all facts about supercoiled DNA, which prevents the virus-driven degradation of messenger RNA, can be placed into the following two representations of cause and effect — or represented as a spinning yin-yang symbol.
The major antigenic changes of the influenza virus are primarily caused by a single amino acid near the receptor binding site.
…the so-called alpha chains of hemoglobin have identical sequences of amino acids in man and the chimpanzee, but they differ in a single amino acid (out of 141) in the gorilla.
See this black and white representation of energy-dependent biodiversity.
See for comparison, this 3-D imagery:

My comment on Inching toward the 3D genome has not been removed.

Re: “…the nucleome structure changes as cells age, differentiate, and divide, and researchers want to understand how and why.”
Cell type differentiation is nutrient-dependent. RNA-directed DNA methylation links RNA-mediated amino acid substitutions to cell type differentiation via protein folding during life history transitions. Amino acid substitutions stabilize protein folding; mutations perturb it, during nutrient-dependent theromodynamic cycles of protein biosynthesis and degradation.
Life is physics and chemistry and communication — http://dx.doi.org/10.1111/nyas.12570
The metabolism of nutrients links metabolic networks to genetic networks via species-specific pheromones that control the physiology of reproduction. Simply put, pheromones link nutrient-dependent life via physics, chemistry, and the conserved molecular mechanisms of communication in species from microbes to man.
Until nutrient-dependent protein folding is linked via the conserved molecular mechanisms of amino acid substitutions and pheromone-controlled DNA stability in organized genomes, which links the epigenetic landscape to the physical landscape of DNA, researchers must take a piece-meal approach to integrating the requirements for life and successful life history transitions — despite the fact that life history transitions have been detailed in the context of the honeybee model organism. See: Honey bees as a model for understanding mechanisms of life history transitions http://www.ncbi.nlm.nih.gov/pubmed/15925525

Gene Robinson is the senior author of this report on phosphorylation in the honeybee model organism. See: Socially responsive effects of brain oxidative metabolism on aggression

Despite ongoing high energetic demands, brains do not always use glucose and oxygen in a ratio that produces maximal ATP through oxidative phosphorylation. In some cases glucose consumption exceeds oxygen use despite adequate oxygen availability, a phenomenon known as aerobic glycolysis. Although metabolic plasticity seems essential for normal cognition, studying its functional significance has been challenging because few experimental systems link brain metabolic patterns to distinct behavioral states. Our recent transcriptomic analysis established a correlation between aggression and decreased whole-brain oxidative phosphorylation activity in the honey bee (Apis mellifera), suggesting that brain metabolic plasticity may modulate this naturally occurring behavior.

Elekonich and Robinson (2000) cited our 1996 Hormones and Behavior review:

The development of species-typical and sex-specific adult behaviors in vertebrate animals is influenced by gonadal steroid hormones, non-gonadal hormones, and non-hormonal factors working on the underlying neural circuitry (reviewed in Diamond et al., 1996; Kawata, 1995; Schlinger, 1998).

The facts that link the creation of sunlight from the creation of ATP to the creation of RNA have been known since 1964.
See: Dependence of RNA synthesis in isolated thymus nuclei on glycolysis, oxidative carbohydrate catabolism and a type of “oxidative phosphorylation”

The synthesis of RNA in isolated thymus nuclei is ATP dependent.

The facts about Honey bees as a model for understanding mechanisms of life history transitions have been ignored.
See also: Feedback loops link odor and pheromone signaling with reproduction
What can be said about the amount of willful ignorance that has been displayed by theorists, since “What is Life?” was published in 1944?

Indeed, in the case of higher animals we know the kind of orderliness they feed upon well enough, viz. the extremely well-ordered state of matter in more or less complicated organic compounds, which serve them as foodstuffs. After utilizing it they return it in a very much degraded form -not entirely degraded, however, for plants can still make use of it. (These, of course, have their most power supply of ‘negative entropy’ the sunlight.) (pp. 73 and 74)

In the reprint edition, Roger Penrose (8 August 1991) wrote:

How often do we still hear that quantum effects can have little relevance in the study of biology, or even that we eat food in order to gain energy?

See also my comments on: Methyldynamics behind virtually all pathologies?

Vast Complexity of Chromatin 3D Shapes
http://jonlieffmd.com/blog/vast-complexity-of-chromatin-3d-shapes
N6-methyladenosine marks primary microRNAs for processing http://dx.doi.org/10.1038/nature14281
Our 1996 Hormones and Behavior review linked pre-mRNAs (microRNAs) to RNA-mediated cell type differentiation in species from yeasts to mammals via what was known about the conserved molecular mechanisms of nutrient-dependent RNA-mediated protein folding and the pheromone-controlled physiology of reproduction.
From Fertilization to Adult Sexual Behavior http://www.hawaii.edu/PCSS/biblio/articles/1961to1999/1996-from-fertilization.html
See also:
Unraveling the secrets of RNA-mediated events http://rna-mediated.com/unraveling-the-secrets-of-rna-mediated-events/

It is difficult for me, as a medical laboratory scientist, to understand how others who are involved in diagnostic medicine seem to have accepted ridiculous theories that cannot be linked to results reported from testing in the medical laboratory.
See: Feedback of the Drosophila period gene product on circadian cycling of its messenger RNA levels

Mutations in the period (per) gene of Drosophila melanogaster affect both circadian and ultradian rhythms. Levels of per gene product undergo circadian oscillation, and it is now shown that there is an underlying oscillation in the level of per RNA. The observations indicate that the cycling of per-encoded protein could result from per RNA cycling, and that there is a feedback loop through which the activity of per-encoded protein causes cycling of its own RNA.

What have other medical laboratory scientists and medical professionals been taught to believe about the underlying oscillation that have since been linked from cryo-EM to all energy-dependent biophysically constrained viral latency? Is there any model of biologically-based cause and effect that links anything except food energy-dependent feedback loops from the physiology of pheromone-controlled reproduction to all biodiversity? If not, help stop the nonsense.
Play the cell biology game: Cytosis: A Cell Biology Board Game

A board game taking place inside a human cell! Players compete to build enzymes, hormones and receptors and fend off attacking Viruses!

Stop playing the games of theorists.

Cytosis

Long-term adaptation replaces evolution (2)

The food energy-dependent “doubling up” on ‘junk DNA’ is biophysically constrained by the physiology of pheromone-controlled reproduction. The metabolism of food to species-specific pheromones links the conserved molecular mechanisms of RNA-mediated cell type differentiation in all individuals of all living genera to healthy longevity via what is known about amino acid substitutions in supercoiled DNA, which link energy-dependent changes in chirality to autophagy.

See: It’s all about that base

The virus-driven degradation of messenger RNA in bacteria links top-down causation to what happens to archaea and L-forms in the context of the viral hecatomb, which links the destruction of G protein-coupled receptors to all pathology because the de novo creation of G protein-coupled receptors links the creation of the sense of smell to all biodiversity.

Our ability to detect differences in amino acid substitutions in the blood has been linked to the ability of flies to find food and to reproduce via the physiology of food-energy-dependent pheromone-controlled reproduction.

See: A mammalian blood odor component serves as an approach-avoidance cue across phylum border – from flies to humans
See also:

Adaptive evolution by spontaneous domain fusion and protein relocalization

Phenotypic heterogeneity promotes adaptive evolution

My 2013 model of energy-dependent ecological adaptations: Nutrient-dependent/pheromone-controlled adaptive evolution: a model refuted neo-Darwinian pseudoscientific nonsense. That that model is being revisited each day that another publication is added to those that link the energy-dependent de novo creation of microRNAs to all biodiversity via hydrogen-atom transfer in DNA base pairs in solution. See: microRNA

For example:Recent advances in signal amplification strategy based on oligonucleotide and nanomaterials for microRNA detection-a review.

See also:

Overview of microRNA biology. Mohr AM et al. Semin Liver Dis. (2015)

MicroRNA Therapeutics: the Next Magic Bullet? Simonson B et al. Mini Rev Med Chem. (2015)

MicroRNAs in cancer: biomarkers, functions and therapy. Hayes J et al. Trends Mol Med. (2014)

A rendering of how changes in an electron's motion (bottom view) alter the scattering of light (top view), as measured in a new experiment that scattered more than 500 photons of light from a single electron. Previous experiments had managed to scatter no more than a few photons at a time. Credit: Extreme Light Laboratory|University of Nebraska-Lincoln

Losers: rediscovering an epigenetic key

Epigenetic mechanisms modulate differences in Drosophila foraging behavior

Little is known about how genetic variation and epigenetic marks interact to shape differences in behavior.

Reported as: An epigenetic key to unlock behavior change October 16, 2017

“One of the big questions in the Child & Brain Development program over the years has been how experience gets embedded in our biology and the mechanisms for that,” says Sokolowski.

See for comparison: See Brain on stress: How the social environment gets under the skin (2012)

Brain circuits are plastic and remodeled by stress to change the balance between anxiety, mood control, memory, and decision making. Such changes may have adaptive value in particular contexts, but their persistence and lack of reversibility can be maladaptive.

Adaptations are energy-dependent and biophysically constrained by the pheromone-controlled physiology of reproduction in all living genera.
Food energy links epigenetic effects on hormones to the affect of hormones on behavior.
See: The authors note that on page 17184, right column, first paragraph, line 4, “effect” should instead appear as “affect.”
See for comparison:

Nobody wants to belong to the party of losers. One of the best strategies in such a case is evidently an interpretation of the change as a gradual accumulation of knowledge while their work has always been at the cutting edge. — Kalevi Kull

Sokolowski’s group is a group of losers. They failed to link food energy to biophysically constrained viral latency via the pheromone-controlled physiology of reproduction.
See: Dependence of RNA synthesis in isolated thymus nuclei on glycolysis, oxidative carbohydrate catabolism and a type of “oxidative phosphorylation” (1964)

The synthesis of RNA in isolated thymus nuclei is ATP dependent.

See for comparison: From Fertilization to Adult Sexual Behavior

Molecular epigenetics. It is now understood that certain genes undergo a process called “genomic or parental imprinting.” Early in embryonic development attached methyl groups become removed from most genes. Several days later, methyl groups are reattached in appropriate sites. Fascinatingly, some such genes reestablish methylation patterns based upon whether the chromosomal segment carrying the gene came from maternal or paternal chromosomes. These sexually dimorphic patterns are labeled genomic or parental imprinting, and these imprintings are inheritable but non-genetic modifications of specific genes (Razin and Shemer, 1995; Reik, 1989; Surani, 1991; Zuccotti and Monk, 1995).

Imprinting is food energy-dependent and biophysically constrained by RNA-directed DNA methylation in the context of the pheromone-controlled physiology of reproduction.
See also: Species of Drosophila (1972)

Because species have distinct food and microhabitat preferences, conspecific individuals meet more often than individuals of different species. More widespread and more potent than this ecological isolation is ethological (behavioral, sexual) isolation.