Cytosis can be used to teach everything from base editing to RNA editing to everyone over age 10. They will learn how to link the creation of energy to biophysically constrained viral latency via the physiology of pheromone-controlled reproduction.

The eternal significance of microRNAs (2)

Summary: What is known for sure, however, is that biological processes called “nature” are not simplistic. Neither is the entity called “the environment.” The two separate worlds overlap and intertwine so only a single interactive one exists. Yes, it may be simpler to look at each singly, but one does so at intellectual peril.
The Immune Landscape of Cancer (2018)

Multiple control modalities of the intracellular and extracellular networks (transcription, microRNAs, copy number, and epigenetic processes) were involved in tumor-immune cell interactions, both across and within immune subtypes.

More than 725 collaborators linked the anti-entropic virucidal energy of sunlight  from  the energy-dependent creation of microRNAs and biophysically constrained viral latency to cell type differentiation via autophagy.
See for comparison: From Fertilization to Adult Sexual Behavior (1996)

What is known for sure, however, is that biological processes called “nature” are not simplistic. Neither is the entity called “the environment.” The two separate worlds overlap and intertwine so only a single interactive one exists. Yes, it may be simpler to look at each singly, but one does so at intellectual peril.

Richard P. Feynman placed the intellectual peril into the context of food energy and human idiocy.
See:

See also: The Translation Machinery Is Immune from miRNA Perturbations: A Cell-Based Probabilistic Approach

Mature microRNAs (miRNAs) are non-coding RNA that regulate most human genes through base-pairing with their targets.

Base-pairing is energy-dependent and biophysically constrained. See: Structural diversity of supercoiled DNA and the parody: All About that Base (Meghan Trainor Parody) 12/10/14
Others now appear to be following on the heels of the late Eshel Ben-Jacob’s works, which showed that the “stochastic nature of miRNA action” is light energy-dependent and biophysically constrained by the physiology of pheromone-controlled reproduction in species from microbes to humans.
See: MicroRNA-based regulation of epithelial–hybrid–mesenchymal fate determination
MicroRNA-based regulation is obviously the key to biophysically constrained viral latency in the context of everything known about the eternal significance of microRNAs.
See also: microRNA 
The quantized energy-dependent differential expression of microRNAs has been linked to healthy longevity or from virus-driven energy theft to all pathology in more than 71,000 indexed published works.
Serious scientists now know that John McCain’s glioblastoma can probably be effectively treated with the microRNA-mediated immunotherapy that led to the remission of Jimmy Carter’s brain cancer.
See: John McCain’s brain cancer prognosis is ‘not very good,’ medical expert says
The reporters touch on the likely link from melanoma to brain cancer via microRNAs, and then dismiss it.
See for comparison: Reduced expression of brain-enriched microRNAs in glioblastomas permits targeted regulation of a cell death gene
Would you like to target the regulation of your cell death genes?
See: The Remarkable Cancer Treatment That Helped Jimmy Carter Combat Brain Tumor

…his doctors have said he no longer needs cancer treatment thanks in part to a groundbreaking new kind of medication that trains the immune system to fight cancer tumors.

Anyone who is interested in learning how to prevent all diseases of the body and the brain (e.g., suicide prevention) may want to select the following link. Broad Anti-tumor Activity of a Small Molecule that Selectively Targets the Warburg Effect and Lipogenesis.
The Warburg Effect links virus-driven energy theft to all pathology in the context of sympatric speciation, which is food energy-dependent and controlled by feedback loops that link the food energy to the pheromone-controlled physiology of reproduction.
Unfortunately, the Warburg effect is commonly used to explain mutation-driven evolution outside the context of the food energy that is required for sympatric speciation. Biologically uninformed theorists continue to display what Feynman referred to as human idiocy — as if no one on Earth can stop them.
But see: Cytosis. You could learn that the cure for all pathology is food energy-dependent and microRNA-mediated in the context of biophysically constrained viral latency.
See also: Substitutions Near the Receptor Binding Site Determine Major Antigenic Change During Influenza Virus Evolution
Anyone who makes claims about “viral evolution”  should be forced to explain why they have not learned how fixation of RNA-mediated amino acid substitutions have been linked to healthy longevity.

Editor’s summary: Five antigenic sites in the virus surface hemagglutinin protein, which together comprise 131 amino acid positions, are thought to determine the full scope of antigenic drift of influenza A virus. Koel et al. (p. 976) show that major antigenic change can be caused by single amino acid substitutions.

See also: Whole-transcriptome brain expression and exon-usage profiling in major depression and suicide: evidence for altered glial, endothelial and ATPase activity

Brain gene expression profiling studies of suicide and depression using oligonucleotide microarrays have often failed to distinguish these two phenotypes. Moreover, next generation sequencing approaches are more accurate in quantifying gene expression and can detect alternative splicing.

Who doesn’t want others to know that our 1996 Hormones and Behavior review of RNA-mediated cell type differentiation included a section on “molecular epigenetics” and alternative splicing? See: From Fertilization to Adult Sexual Behavior

Virus-mediated archaeal hecatomb in the deep seafloor

Carl Zimmer refutes theistic evolution (2)

Carl Zimmer refutes theistic evolution (1)
Carl Zimmer recognizes the need for a new definition of what heredity is. But he refuses to tell others what he knows about the role that viruses play in the transgenerational epigenetic inheritance of all pathology.
Examples of inherited pathology typically include his misrepresentations among others who fail to link ecological variation to ecological adaptation in the context of energy-dependent biophysically constrained viral latency.
See: Ancient Viruses Are Buried in Your DNA  by Carl Zimmer
His conclusion:

In other words, early embryos may have come to depend on the tricks viruses use to manipulate them. “We’re exploiting a property that has evolved for the virus’s benefit,” Dr. Katzourakis said.

No experimental evidence of biologically-based cause and effect suggests anything except virus-driven pathology has evolved.
See: Virus-mediated archaeal hecatomb in the deep seafloor

We show here for the first time the crucial role of viruses in controlling archaeal dynamics and therefore the functioning of deep-sea ecosystems, and suggest that virus-archaea interactions play a central role in global biogeochemical cycles.

We estimated that viral infections were responsible for the abatement of 1.0 to 2.2% day−1 (on average 1.6% day−1) of the bacterial abundance and 2.3 to 4.3% day−1 (on average 3.2% day−1) of the archaeal abundance in deep-sea sediments (Fig. 6).

The amount of virus-driven degradation of messenger RNA in archaea is clearly biophysically constrained via the energy-dependent physiology of the pheromone-controlled reproduction in bacteria. Neo-Darwinian theorists and so-called science journalists misrepresent the facts about how the virus-driven theft of quantized energy as information is biophysically constrained.
They trick people into believing that viruses and organisms evolve by failing to to mention that viral replication is not possible outside the context of energy theft from the host. Zimmer, for example, has consistently led others to believe in anything except how viral latency is biophysically constrained by what organisms eat and how metabolism is linked to reproduction.
Others like Zimmer are directly to blame for the level of ignorance reported in the context of this project.
The Global Virome Project

Our ability to mitigate disease emergence is undermined by our poor understanding of the diversity and ecology of viral threats, and of the drivers of their emergence.

The diversity and ecology of viral threats has always been linked to stress-induced changes in endogenous substrates. Light activation of endogenous substrates has been linked from the physiology of pheromone-controlled reproduction to biophysically constrained viral latency and healthy longevity in species from bacteria to humans.
Nutrient-stress and social stress have been linked from the degradation of messenger RNA in bacteria to the creation of archaea and L-forms, in which the membrane required for biophysically constrained viral latency is missing.
Zimmer and many other biologically uninformed journalists ignore this threat: Beware ‘Disease X’: the mystery killer keeping scientists awake at night 
The threat would not exist if de Vries 1902 definition of mutation had not been accepted by people with not enough common sense to know that food energy must be linked to heredity via biophysical constrained viral latency.
See: Polymaths and paradigm shifts: from Asimov to Bear (in prep)

An evolutionary theory killer

A reversible TCA cycle in a thermophile

Make no mistake, pseudoscientists have stolen the soul of science for more than 20 years, with their ridiculous claims about mutations and evolution.
For comparison, see:

“…considering that we have just 3 such round Nos ‘100’ ‘1000’ ‘10000’, its just three out of all realistic possibilities, no? Admit its looks cool just bec. we calc in Dec system. History books claims was invented by ancient societies; but I think its evolution: We have 10 fingers!”

My reply (SARCASM ALERT):

Thanks. The correlations are intriguing. Templeton funding might help you prove that the numbers game of evolution is true in the context of Cosmopsychism. With enough correlations, facts that link physics and chemistry to viral latency can be dismissed.

Thanks to the Ralser lab for bringing this to my attention with a claim about:
A reductive TCA cycle in a thermophile, which uses the same citrate synthase [enzyme] both for the oxidative and the reductive directionality.

“Every day it looks more likely that primoridial and modern metabolism look similar”

A link was provided to: A primordial and reversible TCA cycle in a facultatively chemolithoautotrophic thermophile

…raises the possibility of a facultatively chemolithomixotrophic origin of life.

Has anyone else considered that possibility?
I tried to look at it from the perspective of chemoorganoheterotrophic metabolism and electron-eating microbes that enzymatically (not automagically) create uranium isotopes, but I got side-tracked by the claims about mutations and evolution. I could not link those claims from the physiology of reproduction in microbes to claims that link the metabolism of food energy to pheromones that biophysically constrain viral latency in species from microbes to humans.

Now, the physiology of pheromone-controlled reproduction in electron-eating microbes that create uranium isotopes suggests the same thing that the Ralser lab suggested: SARCASM ALERT: “It’s turtles all the way down” (the infinite regress problem in cosmology).Unless, like the folks at the Ralser Lab,  you are a serious scientist.

The problem for pseudoscientists, theorists, and many so-called science journalists may be familiar to those at the Ralser lab. McEwen et al., (1964) reported “The synthesis of RNA in isolated thymus nuclei is ATP dependent.” All serious scientists know “ATP controls the crowd.

These findings suggest an additional way for cells to use ATP to maintain proteostasis in the crowded cytoplasm and also fine-tune the material properties of nonmembrane-bound organelles and the cell interior in general.

Obviously, there are now several groups of serious scientists that can make fun of all the pseudoscientists and so-called science journalists who have failed to link physics and chemistry to biophysically constrained viral latency via energy-dependent changes in base pairs in species from thermophiles to those that create uranium isotopes. But Kudos to the first group, or one of the first, to do that:

12/10/14 All about that base and Structural diversity of supercoiled DNA 10/12/15

Sarcasm Alert: I hope that claims about the emergence of energy and mutation-driven evolution did not confuse others as much as they confused so-called science journalists such as John Hewitt, Philip C. Ball, Carl Zimmer, and many others.
When you see the facts reported by an intelligent science journalist, please tell others about the claims that link the creation of energy from the game “Subatomic” to biophysically constrained viral latency in “Cytosis.” Comparisons will be made. It will become clearer that pseudoscientists, theorists and many others have lost their games.
See for example: Attacked from All Sides: RNA Decay in Antiviral Defense

…RNA decay machinery plays important roles in antiviral defense. This can involve either direct effects on vRNA stability or indirect regulation of the intracellular milieu. Furthermore, an emerging theme suggests that many RNA binding proteins can be repurposed from their endogenous roles in the nucleus to antiviral roles in the cytoplasm. Future studies are necessary to further elucidate how these RNA binding…

…proteins recognize foreign RNAs and how they interface with the RNA decay machinery to restrict vRNA replication.”

Alternatively, everyone can simply accept the fact that food energy typically restricts the virus-driven degradation of messenger RNA, and tell all the pseudoscientists and so-called science journalists where to put their pseudoscientific nonsense (e.g., where the sun don’t shine).
For example: Is the Universe a conscious mind?

Cosmopsychism might seem crazy, but it provides a robust explanatory model for how the Universe became fine-tuned for life

For comparison: A Big Bang in spliceosome structural biology and Alternative splicing and the evolution of phenotypic novelty
But remember to link the claims about the evolution of phenotypic novelty to the missing claims about behavior, and see the claims made by Bruce McEwen and Martin Picard in:
Psychological Stress and Mitochondria: A Conceptual Framework (Part 1)

Mitochondria, a subcellular organelle with its own genome, produce the energy required for life and generate signals that enable stress adaptation. An emerging concept proposes that mitochondria sense, integrate, and transduce psychosocial and behavioral factors into cellular and molecular modifications. Mitochondrial signaling might in turn contribute to the biological embedding of psychological states.

Reported as: Cellular ‘powerhouses’ may explain health effects of stress
in the same context as Psychological Stress and Mitochondria: A Systematic Review (Part 2)

Evidence from metabolomic, proteomic, and transcriptomic studies also suggest additional layers of regulation by which stressful experiences may alter mitochondrial components among rodents. Although these metabolites, protein composition, and gene expression outcomes do not reflect the functionality of mitochondria, when assessed in parallel with functional outcomes, they will help explain and refine our understanding of the mechanisms by which stress influences mitochondrial function and health. In addition, whereas functional changes should be regarded as primary indicators of MAL (21), stress-induced molecular changes within mitochondria may also reflect compensatory mechanisms or recalibrations that contribute to long-term changes in mitochondrial function and to the accumulation of MAL. [mitochondrial allostatic load (MAL)]

Review: Subatomic
See also: Self-evident: Contrary to recent opinion, there is such a thing as the self, and it is empirically amenable to scientific investigation 
It has been investigated at every level of investigation that links quantum physics from quantum chemistry to quantum souls in the context of what is known to all serious scientists about biophysically constrained energy-dependent protein folding chemistry that protects supercoiled DNA from the virus-driven degradation of messenger RNA, which links mutations to all pathology.
Conclusion (from self-evident):

The multitudinous self mediates scientific explanations of the complexity of real people with and without mental disorders. It also provides resources for enhancing the moral agency that permits people to flourish. For me, flourishing is simply the development of a person’s psychological and social skills in engagement with herself and with others, in the face of the challenges triggered by her physical, social and psychological environment. If we know the characteristics of the self, we might be able to improve the lives of those whose self-experiences are not conducive to flourishing. The self is not an idle concept, either scientifically or ethically; it organises human experience and proliferates moral possibilities. So, yes, know thyself. Every single part.

See: From Fertilization to Adult Sexual Behavior

Parenthetically it is interesting to note even the yeast Saccharomyces cerevisiae has a gene-based equivalent of sexual orientation (i.e., a-factor and alpha-factor physiologies). These differences arise from different epigenetic modifications of an otherwise identical MAT locus (Runge and Zakian, 1996; Wu and Haber, 1995).

Make no more mistakes, pseudoscientists have stolen the soul of science for more than 20 years, with their ridiculous claims about mutations and evolution.

This evolutionary tree shows the split between primate and rodent lineages about 90 million years ago, before the emergence of Alu elements in primates and B/ID elements in rodents. These short interspersed elements evolved independently in the two lineages to play the same role in gene regulation. Credit: Bronwyn Lucas

Read more at: https://phys.org/news/2018-01-convergent-evolution-gene-humans-mice.html#jCp

The MicroRNAome Strikes Back: A Sokalian hoax (1)

Summary: How can this not be a Sokalian hoax? The creation of sunlight is not linked to anti-entropic virucidal energy-dependent  cell-type-specific epigenetic modifications. The quantized energy-dependent epigenetic modifications include RNA-directed DNA methylation, histone modification, nucleosome remodeling and higher-order chromatin reorganization. Instead, the magic of non-cell autonomous DNA methylation in plants is placed into in the context of the cytosine residue in CG, CHG and CHH sequence contexts (where H represents A, T or C).
See for comparison: Analysis of 6,515 exomes reveals the recent origin of most human protein-coding variants January 2013
Reported as: Past 5,000 years prolific for changes to human genome

The findings confirm their earlier work suggesting that the majority of variants, including potentially harmful ones, were picked up during the past 5,000–10,000 years.

The variants are food energy-dependent and biophysically constrained by the physiology of pheromone-controlled reproduction in the context of the transgenerational epigenetic inheritance of all morphological and behavioral phenotypes.
See also: The palaeolithic diet and the unprovable links to our past November 2014

The picture is rapidly emerging that genetics play a pretty minor role in determining the specifics of our diet. Our physical and cultural environment mostly determines what we eat.

That fact can be placed into the context of how the physical environment of plant growth determines what cattle eat and how the food energy-dependent microRNAome prevents the virus-driven degradation of messenger RNA in the context of the transgenerational epigenetic inheritance of healthy longevity.
See for instance: The Bull Sperm MicroRNAome and the Effect of Fescue Toxicosis on Sperm MicroRNA Expression December 2014

In the last few decades, sperm have been reported to carry both RNA and microRNA to the fertilized zygote [17], [18]. MicroRNA (miRNA) are important regulators in translation, and their altered expression often leads to disease or cancer.

The anti-entropic virucidal efffect of sunlight (see: Schrodinger, 1944) on soil bacteria and plant growth is linked from the physiology of pheromone-controlled reproduction in soil bacteria to all biophysically constrained energy-dependent cell type differentiation in all living genera via changes in base pairs, microRNA editing, RNA editing and the hydrogen-atom transfer in DNA base pairs in solution, which is required for energy-dependent RNA-mediated DNA repair.
That fact led to another Sokalian-like hoax.  See for review The Sokal Hoax [quantum gravity]:The Sham That Shook the Academy

gravity, Sokal argued, was a fiction that society had agreed upon, and science needed to be liberated from its ideological blinders.

The original Sokal hoax about the obvious facts linked to gravity appears to have set the precedent for Nonomura’s monograph. In the context of word usage by Richard P. Feynman, this example of human idiocy can be used to show that nothing has changed in the world of biologically uninformed theorists. They still have not linked quantum physics to biophysically constrained life on Earth.
Nonomura indirectly argues that the quantized energy of virucidal light is not required to link sunlight from cell type differentiation in plants to all biophysically constrained biodiversity in animals.  He, like many others, provides details about the conserved molecular mechanisms of RNA-mediated cell type differentiation. But Nonomura, like Masatoshi Nei, in Mutation-driven evolution, starts with the pathways and asks that others ignore the facts about sunlight.
Sokal asked that others ignore the facts about gravity. Nonomura’s follow-up is brilliant!
Ignore sunlight! Ignore the link from sunlight to plant growth!  Ignore food energy! Display your level of human idiocy.

See how the hoaxes ridicule peer-review:  List of scholarly publishing hoaxes
The list of nonsense papers does not include cases of scientific misconduct. The intent

“…is typically to expose shortcomings in a journal’s peer review process or to criticize the standards of pay-to-publish journals.

See how it’s done: Small RNA pathways responsible for non-cell-autonomous regulation of plant reproduction

Especially in grass species, 21- and 24-nucleotide phasiRNAs are abundant in anthers during premeiosis and meiosis.

In the context of “non-autonomous regulation” microRNAs become small RNAs, which become small interfering RNAs (siRNAs) that become: trans-acting siRNA (tasiRNA) and phased secondary siRNA (phasiRNA) in the context of claims about the evolution of eukaryotic species to land plants. The land plants have somehow evolved a unique non-cell autonomous epigenetically-effected mode of reproduction that is not linked to the energy-dependent creation of the microRNAs.
The epigenetically-effected pathways of energy-dependent non-cell-autonomous regulation are placed into the context of automagical cell type differentiation via microRNA-mediated biophyiscally constrained viral latency until the time comes to claim that genetic and epigenetic regulation must differ between the germline and somatic companions. After that, the author tries to explain how the small RNAs (e.g., microRNAs, siRNAs, tasiRNA, phasiRNA) are linked from nutrient energy-dependent pheromone-controlled viral latency in my model. Every aspect of food energy-dependent RNA-mediated cell type differentiation in animals begins with the non-cell-autonomous regulation of somatic-to-reproductive cell communication in model plants.
What then, is non-cell autonomous regulation? Is it magic?

…sperm and egg cells develop as part of the multicellular gametophyte. Thus, the non-cell-autonomous regulation by somatic companions plays important roles in efficient reproduction, in addition to the cell-autonomous regulation. Epigenetic silencing of transposable elements is one of the central events by which the germline transmits the error-free genome to the next generation.

The transfer of the error-free genome to the next generation is food energy-dependent and the pheromone-controlled physiology of reproduction typically ensures transmission of the error-free genome to the next generation.
How can Nonomura’s most recent publication not be a Sokalian hoax? The creation of sunlight is not linked to anti-entropic virucidal energy-dependent cell-type-specific epigenetic modifications. The quantized energy-dependent epigenetic modifications include RNA-directed DNA methylation, histone modification, nucleosome remodeling and higher-order chromatin reorganization. Instead, the magic of non-cell autonomous DNA methylation in plants is placed into in the context of the cytosine residue in CG, CHG and CHH sequence contexts (where H represents A, T or C).
That magic extends to the magic of non-cell-autonomous cell type differentiation, which somehow defines all biophysically constrained cellular identities during the development of unicellular organisms or multicellular organisms.
But see for comparison from 1999 (First author is KI Nonomura): Organization of the 1.9-kb repeat unit RCE1 in the centromeric region of rice chromosomes.
The organization of chromosomes links everything known to serious scientists about the energy-dependent creation of supercoiled DNA to all biophysically constrained viral latency via the physiology of reproduction and energy-dependent microRNA-mediated mechanisms of recombination.
See: Mechanisms of Recombination conference 
See also: What should I do with my life? 
This is somewhat silly advice from the company that discovered how to epigeneticallly prevents activation of the death gene. Use the information from them to help drain the academic and to help drain the political swamp. Help yourself live a healthy life by helping the Trump administration make America great again. Limit the ability of others to make money from your unnecessary suffering and premature death,

"Evolution of Man. - Undoubtedly there once lived upon the earth races of men who were much lower in their mental organization than the present inhabitants.

Autophagy is the antiphage defense strategy (2)

2/15/17 Energy as information and constrained endogenous RNA interference (video)
The 6.46 minute-long technical presentation (above) from the Precision Medicine Virtual Conference is difficult to understand.Thus, 10 months later, Nik Willmore asked:

12/24/17 What are your insights into CRISPR and mTOR, for a young audience? I’m not mocking you…yet, Humpty Dumpty. What is the basis of your unifying principle? Vibration? Bohmian morphogenetic fields? Modified Darwin? God? –Nik Willmore 

12/25/17 Replying to

God created the anti-entropic virucidal energy of sunlight and all energy-dependent biodiversity via the physiology of pheromone-controlled reproduction. I co-authored a book about that for a young audience in 1995/2002, and a 6-part series for today.

1/1/18 Replying to

Do you understand any aspect of how to model biophysically constrained biologically-based energy-dependent top-town causation and bottom-up effects on cell type differentiation via the physiology of reproduction and autophagy? The “walking fish” walks straight from quantum physics to quantum souls (2)

1/9/18 Viral suppressors of RNAi employ a rapid screening mode to discriminate viral RNA from cellular small RNA

My paraphrased summary:

RNA interference (RNAi) is our indispensable antiphage defense mechanism. Viruses escape the defense system by the theft of quantized energy, which encodes RNAi suppressors that prevent elimination of viral RNAs. The suppressors ensure energy-dependent virus accumulation.

1/12/18 Human cytomegalovirus-encoded miR-UL112 contributes to HCMV-mediated vascular diseases by inducing vascular endothelial cell dysfunction

The significantly altered pathways mainly include the mitogen-activated protein kinase signaling pathway, cell adhesion molecules, chemokine signaling pathway, cytokine-cytokine receptor interaction, circadian rhythm-mammal, mineral absorption, protein processing in the endoplasmic reticulum, proximal tubule bicarbonate reclamation, vasopressin-regulated water reabsorption, and arachidonic acid metabolism. In conclusion, hcmv-miR-UL112 could serve as a potential biomarker, and the miRNA-mediated regulation of signaling pathways might play significant roles in the physiological effects of hcmv-associated diseases.

1/12/18 H5N1 influenza virus-specific miRNA-like small RNA increases cytokine production and mouse mortality via targeting poly(rC)-binding protein 2

We conclude that miR-HA-3p is the first identified influenza virus-encoded microRNA-like functional RNA fragment and a novel virulence factor contributing to H5N1-induced ‘cytokine storm’ and mortality.

Virus-encoded microRNA-like functional RNA fragments are not novel virulence factors. They link the virus-driven degradation of messenger RNA to all pathology in all living genera via the theft of quanitzed energy, which typically links the fixation of RNA-mediated amino acid substitutions to healthy longevity.
See: Viral MicroRNAs, Host MicroRNAs Regulating Viruses, and Bacterial MicroRNA-Like RNAs
All serious scientists know what goes wrong in the context of host microRNA-mediated regulation of viruses. They also know how it goes wrong. See Substitutions Near the Receptor Binding Site Determine Major Antigenic Change During Influenza Virus Evolution

The major antigenic changes of the influenza virus are primarily caused by a single amino acid near the receptor binding site.

The serious scientists do not claim that viruses evolve. Scientists who make claims about evolution  typically do not know how to link the creation of sunlight from ecological variation to food energy-dependent pheromone-controlled ecological adaptation via the physiology of biophysically constrained reproduction and biophysically constrained viral latency. Indeed, most pseudoscientists do not know the difference between a mutation and an RNA-mediated amino acid substitution.
See for comparison: Mechanisms of Recombination conference Start: Sunday, May 20, 9.00am Finish: Tuesday, May 22, 6.45pm

Description

Genetic recombination provides an important mechanism for the repair of chromosome breaks caused by DNA damage or replication fork demise. Defects in the recombination process have been linked to cancer predisposition, in particular breast cancers caused by mutations in BRCA1, BRCA2 and PALB2, and also acute leukemias associated with the rare genetic disease Fanconi anemia. Understanding precisely how recombination occurs is of interest to workers in the fields of meiosis, DNA repair, replication, chromosome architecture and interactions, and chromatin biology.

Download provisional conference program
Excerpts:

Douglas Bishop (University of Chicago, US)
A primary function of the ATPase activity of E. coli RecA is to prevent accumulation of a toxic form of the protein bound to undamaged chromosomal sites

Maria Jasin (Memorial Sloan Kettering Cancer Center, US)
Protecting the genome by homologous recombination

The energy-dependent microRNA-mediated creation of enyzmes protects all organized genomes from the virus-driven degradation of messenger RNA that links the theft of quantized energy from mutations to all pathology.  Pseudoscientists who do not start with the creation of energy, have bastardized Darwin’s claims. His claims were based on placing “conditions of life” before natural selection. Conditions of life are energy-dependent and biophysically constrained by the mechanisms of pheromone-controlled recombination, which have been linked to autophagy by all serious scientists since 1925.
See also my RNA-mediated Facebook page and/or my RNA-mediated Facebook group and other tweets @jvkohl
The number of my tweet impressions since December 21, 2017 has climbed to more than 68,000 as the number of published works that mention “microRNA” has climbed to nearly 69,000. See for comparison: The tipping point (revisited): 68,000 publications, which was published to my other blog site on December 21, 2017.
See also: What Darwinists Fail to Consider (discussion attempt)
See also, this discussion attempt about the “spark of life.”
See also: Noncoding RNA Helps Cells Recover from DNA Damage

“The most logical, simple explanation is that the [noncoding RNA] counteracts the protein encoding form…”

My comment to the Scientist:

There is clear evidence that femtosecond blasts of UV light repair DNA in the context of energy-dependent changes in the microRNA/messenger RNA balance and autophagy, which protects all organized genomes from virus-driven energy theft and the degradation of messenger RNA.

The failure to integrate the Nobel Prize winning works of Ben Feringa (Chemisty 2016) and Yoshinori Ohsumi (Physiology or Medicine 2016) prevents theorists from linking what organisms eat to their pheromone-controlled physiology of reproduction in the context of Schrodinger’s claims in “What is Life?”(1944) and this claim by Roger Penrose in the reprint edition:

“How often do we still hear that quantum effects can have little relevance in the study of biology, or even that we eat food in order to gain energy?” (Roger Penrose 8 August 1991)

See also: From Fertilization to Adult Sexual Behavior  In our section on molecular epigenetics, we wrote:

Small intranuclear proteins also participate in generating alternative splicing techniques of pre-mRNA and, by this mechanism, contribute to sexual differentiation in at least two species, Drosophila melanogaster and Caenorhabditis elegans…

The food energy that is linked from alternative splicing techniques of pre-mRNA to the chemistry of protein folding and the pheromone-controlled physiology of reproduction in all living genera seems to be largely ignored by those who are not Nobel Laureates.

See also: Search Results for “autophagy”

For God and Country

Enzyme-constrained interethnic diversity (8)

I am intrigued by the fact that I detailed the energy-dependent links to interethnic diversity in this blog post on the same day that the so-called science journalist Ed Yong placed everything known to serious scientists back into the context of neo-Darwinian evolution.
See for comparison to Ed Yong’s nonsense: “Players compete to build enzymes, hormones and receptors and fend off attacking Viruses!
Yong’s addendum:

*This article has been corrected to reflect the fact that Arc genes were co-opted by animals from a group of genes that also gave rise to retroviruses, and are not directly descended from retroviruses, as originally stated. We regret the error.

Retractions by Szostak reflect a similar theme.

In retrospect, we were totally blinded by our belief [in our findings]…we were not as careful or rigorous as we should have been (and as Tivoli was) in interpreting these experiments.

The food energy-dependent creation of Arc genes links the virus-driven theft of quantized energy to the creation of retroviruses, which are biophysically constrained by RNA-mediated amino acid substitutions in the context of the pheromone-controlled physiology of reproduction.
Something has gone horribly wrong in the context of respected scientist’s retractions and the addendums by science journalists who have failed to link ridiculous theories from top-down causation to biophysically constrained viral latency during the past two decades.
See for comparison:  The vibrational theory of olfaction for the win
John Hewitt will almost undoubtedly be the first science journalist to link the energy-dependent creation of enzymes from the sense of smell in bacteria to our visual perception of mass and energy.
Olfaction Warps Visual Time Perception will then be linked to “The Darwin Code: Intelligent Design without God” and interethnic biodiversity via food energy-dependent pheromone-controlled RNA-mediated amino acid substitutions.

A protein model is built into an electron density map, amino acid by amino acid. The result is a snapshot of the protein or protein complex at work. Image courtesy of Dr Sebastian Guettler.

The "walking fish" walks straight from quantum physics to quantum souls (2)

Summary: Cell fate conversion is food energy-dependent and pheromone-controlled in the context of the physiology of reproduction and autophagy, which links biophysically constrained viral latency to the differences in C. elegans and P. pacificus, a predatory nematode with teeth.

Application of RNAi and Heat-shock-induced Transcription Factor Expression to Reprogram Germ Cells to Neurons in C. elegans 1/01/2018

Summary

This protocol describes how to study cellular processes during cell fate conversion in Caenorhabditis elegans in vivo. Using transgenic animals,allowing heat-shock promoter-driven overexpression of the neuron fate-inducing transcription factorCHE-1 and RNAi-mediated depletion of the chromatin-regulating factor LIN-53germ cell to neuron reprogramming can be observed in vivo.

Cell fate conversion is food energy-dependent and pheromone-controlled in the context of the physiology of reproduction and autophagy, which links biophysically constrained viral latency to the differences in C. elegans and P. pacificus, a predatory nematode with teeth.
System-wide Rewiring Underlies Behavioral Differences in Predatory and Bacterial-Feeding Nematodes
Food energy arises only in the context of the creation of  The Immensity of the milky way…(video)

The facts that link sunlight on contact with water in this video from pheromone-controlled biophysically constrained viral latency to all biodiversity on Earth via the physiology of reproduction have been largely ignored since the time this article was published [in Russian] in 1994. [Pheromonal regulation of genetic processes: research on the house mouse (Mus musculus L.)] https://www.ncbi.nlm.nih.gov/pubmed/7995515

Non-human primates are the best example of how subatomic particles protect humans from all pathology in the context of food energy-dependent RNA-mediated cell type differentiation that links microRNAs to fixation of amino acid substitutions that differentiate all cell types in all individuals of all living genera.
See: Five reasons we’re excited by how structural biology is advancing cancer research Posted on 15 June, 2017

A protein model is built into an electron density map, amino acid by amino acid. The result is a snapshot of the protein or protein complex at work. Image courtesy of Dr Sebastian Guettler.

The major antigenic changes of the influenza virus are primarily caused by a single amino acid near the receptor binding site.
See also: One amino acid substitution differentiates humans and chimpanzees from gorillas.
See: Nothing in Biology Makes Any Sense Except in the Light of Evolution

For example, the so-called alpha chains of hemoglobin have identical sequences of amino acids in man and the chimpanzee, but they differ in a single amino acid (out of 141) in the gorilla (p. 127).

Humans And Chimps Differ At Level Of Gene Splicing (2007)
Comic relief for the biologically informed. Jon Stewart interviews Greg Bear
Comic relief for seniors.
For serious scientists: Single-residue insertion switches the quaternary structure and exciton states of cryptophyte light-harvesting proteins

Using X-ray crystallography, we show that cryptophyte PBPs adopt one of two quaternary structures, open or closed. The key feature of the closed form is the juxtaposition of two central chromophores resulting in excitonic coupling. The switch between forms is ascribed to the insertion of a single amino acid in the open-form proteins. Thus, PBP quaternary structure controls excitonic coupling and the mechanism of light harvesting. Comparing organisms with these two distinct proteins will reveal the role of quantum coherence in photosynthesis.

The fact that a single amino acid substitution links energy-dependent changes in base pairs from electrons to ecosystems via the physiology of reproduction in all living genera continues to be ignored by pseudoscientists and all theorists.
For comparison see: QuEBS 2018: Workshop on Quantum Effects in Biological Systems

…has established itself as an outstanding stage to present the research in the intersection of physics, chemistry and biology. This field has… established excitons in biology as the “must-talk-language” when describing the quantum effects in biological light-harvesting systems.

 
Cytosis can be used to teach everything from base editing to RNA editing to everyone over age 10. They will learn how to link the creation of energy to biophysically constrained viral latency via the physiology of pheromone-controlled reproduction.

A Mathematical Model Links Quantum Physics to Quantum Souls (1)

Historical facts: All energy-dependent cell type differentiation is biophysically constrained by the de novo creation of microRNAs and enzymes that metabolize food and drugs. All food energy-dependent metabolism occurs in the context of microRNA-mediated cause and effect and the physiology of pheromone-controlled reproduction. The food energy-dependent pheromone controlled physiology of reproduction in bacteria links what organisms eat to the transgenerational epigenetic inheritance of their morphological and behavioral phenotypes. The virus-driven degradation of messenger RNA has been linked to all pathology in the context of the National Microbiome Initiative, the Precision Medicine Initiative, Alpha Genomix profiling of pathways linked to the creation of CYP enzymes and test results that differentiate the most likely response to some medications based on fixation of  RNA-mediated amino acid substitutions in the organized genomes of different people and different populations of modern humans.
See: Nutrient-dependent pheromone-controlled ecological adaptations: from atoms to ecosystems (2014)
The ingestion of sago palm-like leaves linked increased endogenous vitamin C from the stability of the mouse genome to the stability of the organized genome in a modern human population via one base pair change and the fixation of one RNA-mediated amino acid substitution.
See also: Towards a systemic paradigm in carcinogenesis: linking epigenetics and genetics (2015)

The SMT’s [Somatic mutation theory’s] fundamental assumption is that there is no cancer without genetic or chromosomal harm.

See for comparison: Stem cell divisions, somatic mutations, cancer etiology, and cancer prevention
Watch as 2 of 3 co-authors of the article about can prevention tell the world that cancer is caused by “bad luck.”

Now see one of the 3 co-authors admit to his overwhelming ignorance in: Why Is This Bacterium Hiding in Human Tumors?

“The whole idea of bacteria in tumors is fascinating and unexpected,” said Dr. Bert Vogelstein, a colon cancer researcher at Johns Hopkins.

  1. The fundamental assumption that there is no cancer without genetic or chromosomal harm links the virus-driven degradation of messenger RNA in bacteria to the food energy-dependent pheromone-controlled physiology of reproduction in bacteria and healthy longevity via error-free DNA repair.
  2. The fundamental assumption that there is no cancer without genetic or chromosomal harm links virus-driven pathology to cell type-specific and species-specific pathology in all cell types of all individuals of all living genera via the failure of microRNA-mediated error-free DNA repair.

There is now a mathematical model of top-down causation that links the sun’s anti-entropic virucidal energy on contact with water to the physiology of pheromone-controlled reproduction and all biodiversity via RNA-mediated error-free DNA repair. The mathematical model refutes the pseudoscientific nonsense touted by neo-Darwinian theorists because it starts with the creation of the sun, which biophysically constrains viral latency. The importance of linking this mathematical model to all models of biologically-based cause and effect cannot be overstated.
See: Quantum Vacuum Dynamics, Coherence, Superluminal Photons and Hypercomputation in Brain Microtubules

After the Schrodinger’s intuition, expressed in his book “What is life?” [12], the first systematic approach to a quantum interpretation of biological process dated back to the model proposed by Frohlich [13] several years ago. He suggested the occurrence, in biological matter, of macroscopic quantum phenomena able to explain the energy transport without loss in the living organisms and signal transfer based on collective coherent oscillations associated to a branch of longitudinal
electric modes in the frequency range [ ] also known as Frohlich frequency. So in living systems, according to Frohlich’s model, energy could be stored in a thin two – dimensional layer placed beneath the cell membrane, that in this way would act as a biological superconducting medium, under dipolar propagating waves without thermal loss [13].

The ridiculous assumptions about thermal loss and evolution were placed into the context of other ridiculous assumptions that failed to start from the creation of the sun and link the anti-entropic virucidal energy of the sun from food energy to all biodiversity via the physiology of pheromone-controlled reproduction.
For comparison see: Reversing the thermodynamic arrow of time using quantum correlations

We observe a spontaneous heat flow from the cold to the hot system. This process is enabled by a trade off between correlations and entropy that we quantify with information-theoretical quantities.

Reported as: Experiment shows that arrow of time is a relative concept, not an absolute one

The second law of thermodynamics says that entropy, or disorder, tends to increase over time, which is why everything in the world around us appears to unfold forward in time. But it also explains why hot tea grows cold rather than hot. In this new effort, the researchers found an exception to this rule that works in a way that doesn’t violate the rules of physics as they have been defined.
The idea of entangled particles has been in the news a lot lately as researchers around the world attempt to use it for various purposes—but there is another lesser-known property of particles that is similar in nature, but slightly different. It is when particles become correlated, which means they become linked in ways that do not happen in the larger world. Like entanglement, correlated particles share information, though it is not as strong of a bond. In this new experiment, the researchers used this property to change the direction of the arrow of time.

Succinctly stated as:

This observation did not violate the second law of thermodynamics, the group explains, because the second law assumes there are no correlations between particles.

The ridiculous assumption that there are no correlations between subatomic particles led to assumptions that energy emerged and that all life evolved in the context of mutations and natural selection, which led to the “bad luck” theory of cancer.
Frohlich’s model was dismissed and so was the the fact that “…energy could be stored in a thin two – dimensional layer placed beneath the cell membrane, that in this way would act as a biological superconducting medium, under dipolar propagating waves without thermal loss [13].
[13.] Long-range coherence and energy storage in biological systems (1968)

Biological systems are expected to have a branch of longitudinal electric modes in a frequency region between 1011 and 1012 sec−1. They are based on the dipolar properties of cell membranes; of certain bonds recurring in giant molecules (such as H bonds) and possibly on pockets of non-localized electrons. In Section 2 it is shown quit generally that if energy is supplied above a certain mean rate to such a branch, then a steady state will be reached in which a single mode of this branch is very strongly excited. The supplied energy is thus not completely thermalized but stored in a highly ordered fashion. This order expresses itself in long-range phase correlations; the phenomenon has considerable similarity with the low-temperature condensation of a Bose gas. General consequences and proposals of experiments are discussed in section 3.

Four years earlier, McEwen et al., (1964) linked the creation of the sun’s anti-entropic virucidal energy to the creation of ATP and the creation of RNA.
See: Dependence of RNA synthesis in isolated thymus nuclei on glycolysis, oxidative carbohydrate catabolism and a type of “oxidative phosphorylation”

The synthesis of RNA in isolated thymus nuclei is ATP dependent.

That same year, Dobzhansky (1964) first asserted this claim:

The notion has gained some currency that the only worthwhile biology is molecular biology. All else is “bird watching” or “butterfly collecting.” Bird watching and butterfly collecting are occupations manifestly unworthy of serious scientists! I have heard a man whose official title happens to be Professor of Zoology declare to an assembly of his colleagues that “a good man cannot teach zoology. A good man can teach, of course, only molecular biology.

In 1973, Dobzhansky again mocked all the pseudoscientists whose mathematical model failed to link the creation of the sun’s anti-entropic energy from the physiology of pheromone-controlled reproduction to RNA-mediated fixation of amino acid substitutions that differentiate all cell types in all living genera.
See: Nothing in Biology Makes Any Sense Except in the Light of Evolution
He assumed that all serious scientists would recognize that the light of evolution linked Schrodinger’s claims about sunlight to all biodiversity via the food energy-dependent pheromone-controlled fixation of RNA-mediated amino acid substitutions.
He claimed

“…one can calculate the minimum numbers of single mutations needed to change the cytochrome C of one organism into that of another.”

He linked that calculation to this fact:

…the so-called alpha chains of hemoglobin have identical sequences of amino acids in man and the chimpanzee, but they differ in a single amino acid (out of 141) in the gorilla.

The levels of complexity that must be addressed by the calculations have since been addressed and reported in: Quantum Vacuum Dynamics, Coherence, Superluminal Photons and Hypercomputation in Brain Microtubules
Nothing has changed about the facts that all serious scientists have linked from biophysically constrained viral latency to all biodiversity via the physiology of pheromone-controlled reproduction.
For example, see: Substitutions Near the Receptor Binding Site Determine Major Antigenic Change During Influenza Virus Evolution

The major antigenic changes of the influenza virus are primarily caused by a single amino acid near the receptor binding site.

See also Cytosis:A board game taking place inside a human cell! Players compete to build enzymes, hormones and receptors and fend off attacking Viruses!

Alternative splicing of pre-mRNA

The overwhelming ignorance of sex researchers (2)

Conclusion: There is a clear link from Estrogen receptor α polymorphism in individuals and in species with differences in behavioral phenotypes. The differences are food energy-dependent and RNA-mediated. The differences link the sense of smell and the pheromone-controlled physiology of reproduction in soil bacteria from The Bull Sperm MicroRNAome and the Effect of Fescue Toxicosis on Sperm MicroRNA Expression to the report on the Obligatory role of hypothalamic neuroestradiol during the estrogen-induced LH surge in female ovariectomized rhesus monkeys

Reported on December 12, 2017 as: Estrogen discovery could shed new light on fertility problems

Estradiol builds in the bloodstream until it reaches a concentration that causes a surge of the hypothalamic and pituitary hormones, including one called luteinizing hormone, which in turn trigger an ovary to release an egg.

“It’s a feedback loop…

From our section on “Neurosteroids” in this December 1996 Hormones and Behavior review: From Fertilization to Adult Sexual Behavior

Perhaps significantly, neuron-specific transcription regulation of neurosteroidogenic enzymes and subsequent neurosteroids production suggest clues to mechanisms that allow some persons to develop in accord with typical gonadal male-pattern or female-pattern hormones and have appropriate male-typical or female-typical physiques nonetheless have parameters of their sexual behavior profile quite opposite to their physical phenotype. For instance, it might be possible for local neurosteroid action in CNS loci specific for sexual orientation to operate independently of other hormonal production and separately from gross body morphology in general. This could, for instance, account for different manifestations of transsexualism and homosexuality.

The “gay agenda” served its proponents well as they attempted to bury the facts that link feedback loops from odors and pheromones to biophysically constrained viral latency.

See: Feedback loops link odor and pheromone signaling with reproduction

Most sex researchers still live in fear that the biologically uninformed masses will learn that homosexual orientation is nothing more than another variation of what happens in the context of transgenerational epigenetic inheritance.

See: The overwhelming ignorance of sex researchers (December 8, 2016)

All serious scientists link food energy to the pheromone-controlled physiology of reproduction and autophagy, which protects all organized genomes from the virus-driven degradation of messenger RNA. The virus-driven degradation of messenger RNA links mutations to all pathology in species from microbes to humans.

If you try to make any aspect of pathology specific to any group of individuals in any human population, you challenge the totality of experimental evidence that links top-down causation to healthy longevity. You be forced to admit that you are not perfectly healthy, which means you are not qualified to judge the mental health or judge the physical health of others. The take home message is stop judging anyone based on your ignorance.

See also the author’s copy of this award-winning review: The Mind’s Eyes: Human pheromones, neuroscience, and male sexual preferences

Abstract:

The across-species genetic conservation of intercellular and extracellular chemical communication enables unicellular and multicellular organisms to functionally distinguish between self and non-self. Non-self olfactory/pheromonal input from the social environment elicits a vertebrate neuroendocrine response. The organization and activation of this neuroendocrine response modulates the concurrent maturation of the mammalian neuroendocrine system, the reproductive system, and the central nervous system during the development of sexual preferences that may be expressed in sexual behavior. Psychophysiological mechanisms for the development of these sexual preferences include focus on unconscious affects that are detailed in reciprocal cause and effect relationships. Olfactory/pheromonal conditioning elicits neuroendocrine effects accompanied by unconscious affects on the development of sexual preferences. Integrating these unconscious affects extends to humans a developmental model of behavior that includes the development of male sexual preferences for other males.

Conclusion:

ISSUES FOR FURTHER CONSIDERATION

    Rarely do sex researchers address the ongoing philosophical debate between canonical neo-Darwinism and Biblical creation.  Perhaps this is because any debate between scientific theory and religion arises from distinctly different domains of cognitive thought.  Does the acceptance of Darwin’s theory represent the glorification of Science pitted against religion, or is it a means by which Science and religion might be integrated?  Integration of Science and religion might be achieved by recognizing that the key components of this olfactory/pheromonal model appear to be as irreducibly complex as the basic tenets of evolution and the basic tenets of religion.

    From an evolutionary perspective, highly conserved GnRH peptide ligand/receptor signaling mechanisms are the molecular biochemical mechanisms for sexual reproduction in all organisms.  These signaling mechanisms also appear to play an integral role in the development of sexual preferences.  From a religious perspective, these signaling mechanisms dictate that the creation of life, which begets life, also allows for the creation of diversified life through the same mechanisms.  These mechanisms allow life to recognize the difference between self and non-self and to respond to this difference.

    Perhaps the creation of diversified human life gave us the ability to recognize differences between our sexual behavior and the sexual behavior of others.  Since all life does not beget diversified life, those who judge sexual preferences that do not seem to result in diversified life may be judging creation itself.

    It is easy to understand how someone could judge a particular sexual preference, without thought.  Unconscious affects that are manifest in the development of human sexual preferences are, by their nature, a part of diversified life that few people think about.  What we think about human sexual preferences becomes less meaningful when we realize that most of sexual behavior is not what we cognitively think it should be.  Indeed, the largest contributor to sexual preferences that are manifest in the sexual behavior of any species appears to be unconscious affect.  This also appears to be the basis for diversified life.

See this claim about diversified life for comparison: New Zealand discovery of fossilised ‘monster bird’ bones reveals a colossal, ancient penguin

Insights into penguin evolution

The other startling thing about the new colossal fossil is its ancient age. At 55 to 60 million years old, it is nearly as old as the earliest penguin ancestors ever found. It would have lived during a geological period known as the Paleocene, just after the mass extinction 66 million years ago that wiped out non-bird dinosaurs.

The most startling thing about this ridiculous claim is that it cannot be linked from anything known to serious scientists about biophysically constrained viral latency to all biodiversity on Earth via the pheromone-controlled physiology of reproduction and chromosomal rearrangements in birds.

See for comparison: Estrogen receptor α polymorphism in a species with alternative behavioral phenotypes 

Two fixed differences among 597 amino acids drive a Val73Ile and Ala552Thr (valine to alanine) polymorphism in ZAL2m that distinguish its morphological and behavioral phenotype from ZAL2.

See also: Autophagy.pro

There is a clear link from Estrogen receptor α polymorphism in individuals and in species with differences in behavioral phenotypes. The differences are food energy-dependent and RNA-mediated. The differences link the sense of smell and the pheromone-controlled physiology of reproduction in soil bacteria from The Bull Sperm MicroRNAome and the Effect of Fescue Toxicosis on Sperm MicroRNA Expression to the report on theObligatory role of hypothalamic neuroestradiol during the estrogen-induced LH surge in female ovariectomized rhesus monkeys

Cytosis can be used to teach everything from base editing to RNA editing to everyone over age 10. They will learn how to link the creation of energy to biophysically constrained viral latency via the physiology of pheromone-controlled reproduction.

Mouse morphs and primate diversity in 50 years

Excerpt:

Analysis of the crystal structure of deer mouse Hb at 1.8 Å resolution (24, 25) revealed that each of the eight rHb mutants is characterized by a unique constellation of hydrogen bonds within and between subunits (Table 2 and fig. S2). Additional hydrogen bonds between subunits of the same αβ dimer are formed in the presence of β128Ser (an L-type residue; fig. S2), which contributes to the observed epistasis between allelic α- and β-chain variants.

———————————
Energy-dependent RNA-mediated biophysically constrained viral latency (i.e., silencing of viral elements) protects all organized genomes from the degradation of messenger RNA that links mutations to all pathology. The mutations are caused by nutritional stress and/or social stress. That fact has been known to all serious scientists for at least 50 years. But see:
Silencing of viral elements: A cure for schizophrenia? ARTICLE Provisionally accepted

1. The problem.
Scientific evidence for various infectious agents as cause for psychosis in schizophrenia is not robust. Many pathogens that influence brain development might play a role in disease causation. It has been shown that influenza exposure before birth(Brown, 2012), exposure to herpes simplex during birth(Brown et al., 2011) or exposition to Toxoplasma gondii and other pathogens (Arias et al., 2012) increases risk for schizophrenia and/or compromises cognition. During psychosis viral and also ancient retroviral elements become may activated in the brain(Karlsson et al., 2001; Perron et al., 2012). The implication of this research for use in clinical practice is ambiguous, because a robust virus test is lacking.

Examples of human idiocy are the problem. See for comparison:

QuEBS workshop has established itself as an outstanding stage to present the research in the intersection of physics, chemistry and biology. This field has been developed in Lithuania for more than 20 years already. The beginnings could be associated with a series of “Light-harvesting Physics” international conferences, which were held in Lithuania (in Preila, 1992 and 1994, and in Birštonas, 1996). During these conferences, discussion of notable scientists and pioneers of Quantum Biology, such as Graham R. Fleming, Shaul Mukamel, Rienk van Grondelle, Richard Cogdell, Alfred Holzwarth and others, established excitons in biology as the “must-talk-language” when describing the quantum effects in biological light-harvesting systems.

Every aspect of biophysically constrained energy-dependent RNA-mediated life on Earth has refuted the pseudoscientific nonsense about emergence and evolution.

As climate warms, mice morph

Biologists document changes in teeth and skull structure in two species in southern Quebec over past 50 years

The ridiculous claim that the fixed amino acid substitutions were adaptive mutations proves how little the authors understand about biophysically constrained viral latency.

Excerpt 1)

“Biologists document changes in teeth and skull structure in two species in southern Quebec over past 50 years

Excerpt 2)

“These changes may be related to a dietary shift caused by climate change, combined with competition for food resources between the two species of mice, according to the researchers.”

All serious scientists know that food energy biophysically constrains the pheromone-controlled physiology of reproduction, which links the fixation of RNA-mediated amino acid substitutions to cell type differentiation in all living genera.
 
We have now arrived at the claims of biologically uninformed science idiots who tell us that two different species evolved in 50 years.
 

Excerpt 3)

“One question that remains to be settled is whether the changes are genetic, and will be passed on to future generations — actual evolution — or whether they represent “plasticity,” the capacity of some species to adjust to rapid environmental change.”

The facts about the transgenerational epigenetic inheritance of healthy longevity for comparison to virus-driven pathology have been exquisitely detailed. All serious scientists have dispensed with the nonsense that questions the capacity of some species to adjust to rapid environmental change. Ecological variation must be linked from the physiology of pheromone-controlled reproduction in all living genera via the conserved molecular mechanisms of RNA-mediated cell type differentiation that link fixation of amino acid substitutions to the morphological and behavioral phenotypes of all individuals and all species on Earth.

See for instance, on the same day that my 2013 refutation of Nei’s pseudoscientific nonsense about Mutation-driven evolution was published, this also was published: Epistasis Among Adaptive Mutations in Deer Mouse Hemoglobin

Epistasis is food energy-dependent. The energy must be biophysically constrained in the context of the physiology of pheromone-controlled transgenerational epigenetic inheritance. The creation of energy in a hydrogen atom was linked from the anti-entropic virucidal effect of sunlight to the stability of the organized genome of mice by hydrogen-atom transfer in DNA base pairs in solution and differences in the hemoglobin molecule of ecologically adapted species.

Analysis of the crystal structure of deer mouse Hb at 1.8 Å resolution (24, 25) revealed that each of the eight rHb mutants is characterized by a unique constellation of hydrogen bonds within and between subunits (Table 2 and fig. S2). Additional hydrogen bonds between subunits of the same αβ dimer are formed in the presence of β128Ser (an L-type residue; fig. S2), which contributes to the observed epistasis between allelic α- and β-chain variants.

See also:

…the so-called alpha chains of hemoglobin have identical sequences of amino acids in man and the chimpanzee, but they differ in a single amino acid (out of 141) in the gorilla.

The fact that every Angstrom is dynamic and the fact that energy-dependent changes in the microRNA/messenger RNA balance have been linked to biophysically constrained viral latency and all biodiversity was placed into the context of this parody:

 See also:


The Mechanical Properties of DNA are food energy-dependent and RNA-mediated

The elastic properties of the DNA molecule determine how it supercoils during replication, how it packs into confined biological structures and how it interacts with proteins during gene expression.

See: Nutrient-dependent pheromone-controlled ecological adaptations: from atoms to ecosystems
Pattern recognition

Nutrient-dependent atomic-level changes may determine the nucleotide changes in a specific base pair. The nucleotide changes appear to link nutrient-dependent single nucleotide polymorphisms (SNPs) from the availability of fruits and vegetables or fermented milk products to individual differences and to species differences in the need for certain vitamins. For example, cell type determination and differentiation are associated with the nutrient-dependent 3D distribution of amino acid substitutions as they accumulated during a history of ecological adaptations [32] in flies [9] and in humans [33]. Sex differences in behavior also appear to arise from the single-molecule and single cell levels in flies, which suggests that adaptive changes in behavior can be explained in the context of nutrient-dependent pheromone-controlled genome-environment interactions that alter circuit plasticity via amino acid substitutions [34].

Conclusion from: Nutrient-dependent pheromone-controlled ecological adaptations: from atoms to ecosystems

The companion papers [162-163] told a new short story of ecological adaptations. In the context of climate change and changes in diet, the story began with what probably was a nutrient-dependent base pair change and a variant epiallele that arose in a human population in what is now central China. Apparently, the effect of the epiallele was adaptive and it was manifested in the context of an effect on sweat, skin, hair, and teeth. In another mammal, such as the mouse, the effect on sweat, skin, hair, and teeth is probably due to a nutrient-dependent epigenetic effect on hormones responsible for the tweaking of immense gene networks that metabolize nutrients to pheromones. The pheromones appear to control the nutrient-dependent epigenetically-effected hormone-dependent organization and hormone-activation of reproductive sexual behavior in mammals such as mice and humans, but also in invertebrates and in microbes as previously indicated.

The ecological adaptations, which appear to be manifested in the human population are detailed in these two reports [162-163]. The ecological adaptations are likely to be nutrient-dependent and pheromone-controlled. If so, ecological variation probably leads to ecological, social, neurogenic, and socio-cognitive niche construction, which is manifested in increasing organismal complexity and species diversity. If not, there may be something as yet unknown about mutations and evolution that makes sense in the light of what is known about nutritional epigenetics and the molecular biology of species from microbes to man.

See for comparison: The evolution of H2
Biohydrogen production from hyperthermophilic anaerobic digestion of fruit and vegetable wastes in seawater: Simplification of the culture medium of Thermotoga maritima
Mechanism of Nitrogenase H2 Formation by Metal-Hydride Protonation Probed by Mediated Electrocatalysis and H/D Isotope Effects
The claims that energy emerged or that differences in hydrogen and differences in species evolved outside the context of the energy-dependent creation of enzymes are among the most ridiculous examples of human idiocy that any serious scientist has ever encountered.
Claims about the emergence of life were again retracted on November 23, 20-17 and reported on December 5, 2017.

”Definitely embarrassing:” Nobel Laureate retracts non-reproducible paper in Nature journal

See: Comment awaiting moderation.

James V. Kohl December 7, 2017 at 4:35 am
The Science Behind the Game “Cytosis,” pits the collaborative efforts of 20 serious scientists against the pseudoscientific nonsense touted by theorists. The serious scientists know how energy-dependent RNA-mediated cell type differentiation occurs.
Resources (e.g., mRNA, ATP) are used to build enzymes, hormones, and/or receptors. Health points accumulate to show why food energy must be linked from the physiology of pheromone-controlled reproduction to biophysically constrained viral latency.
For comparison, Szostak and other theorists have been stuck with their ridiculous misrepresentations of emergence and neo-Darwinian evolution, which failed to consider Darwin’s “conditions of life.”
“Conditions of life” are energy-dependent. The energy is Schrodinger’s anti-entropic virucidal energy. It comes from sunlight and is epigenetically “trapped” in food via the physiology of reproduction.
Board Game:
Cytosis: A Cell Biology Game
Title:
Cytosis – The Science Behind the Game https://boardgamegeek.com/filepage/155090/cytosis-science-behind-game
See also: Two retractions of human idiocy
See also: Routing gene therapy directly into the brain

Once the genetically-engineered HSCs are transplanted into the brain’s ventricles, the crucial enzyme they contain helps to metabolize the materials that were previously building up and causing tissue damage.

A new lineage of cells descended from the transplanted HSCs — a type of cell called a myeloid — begin to scavenge and consume the excess material that is responsible for neurodegeneration.

The pheromone-controlled differentiation of these cell types was predicted in the context of claims that pheromones biophysically constrain all pathology in the mouse to human model, which has been thoroughly detailed since 1994.
See: [Pheromonal regulation of genetic processes: research on the house mouse (Mus musculus L.)
See also: Pheromones and the luteinizing hormone for inducing proliferation of neural stem cells and neurogenesis

See also: Researchers Discover Key to Diseases in Mitochondrial DNA Mutations

Because the primary job of the mitochondrion is to produce energy, most of its genes are involved in pathways in the energy production process. Although it has a small genetic code, mtDNA contains the blueprints for building many of the enzymes and proteins that are needed to function in those pathways.
 
The virus-driven theft of quantized energy as information links the degradation of messenger RNA from mutations to all pathology in all living genera. The speed of light on contact with water has been linked to all energy-dependent RNA-mediated DNA repair in the context of the physiology of reproduction and the transgenerational epigenetic inheritance of healthy longevity.