healthy longevity Archives

Abiogenesis vs microRNA biogenesis (2)

April 20, 2018

by James Kohl with No Comment Adaptations Cytosis Diseases & Disorders Ecology RNA Directed

All serious scientists learned about Schrödinger’s claims in “What is Life?” (1944). All serious scientists have since linked the creation of the sun’s anti-entropic virucidal energy to “negentropy” and healthy longevity.

…paving the way for the definitive rejection of the non-recombination dogma for human mtDNA.

Recombination is quantized energy-dependent and biophysically constrained by the physiology of reproduction.

See the works of those who are scheduled to present during Schrödinger at 75 – The Future of Biology – September 2018

Duane Gish never published anything that is indexed on the PubMed database. If you claim that he or anyone else like him, including Henry M. Morris (1918–2006) is a bonafide scientist, please try to support your ridiculous claims in the context of the historical record of more than 72,000 published works that mention “microRNA.”

If you do not start with the creation of microRNAs (microRNA biogenesis), do not try to explain how natural selection for beneficial mutations links evolution to biodiversity. All serious scientists will make fun of you.

See:

Some will continue to use you as an example of human idiocy.

See why: Signatures of negative selection in the genetic architecture of human complex traits

Reported as: Natural selection still at work in humans

“In natural selection, or ‘survival of the fittest’, characteristics that improve survival are more likely to be passed on to the next generation,” Professor Yang said.

“The opposite also occurs, when DNA mutations with a detrimental effect on fitness are less likely to be passed on, by a process called negative selection.

Mutations link virus-driven energy theft to all pathology, not from negative selection to evolution.
Case report: detection of the identical virus in a patient presenting with severe fever with thrombocytopenia syndrome encephalopathy and the tick that bit her (April 17, 2018)

Phylogenetic analyses indicated that the SFTSV from the patient and the tick was identical. The patient gradually recovered with treatments of corticosteroids and immunoglobulin.

CONCLUSION:

These findings provide further evidence of SFTS viral transmission from H. longicornis to human.

Researchers in South Korea may already know how to protect human populations from the transmission of viruses, which has been linked from the transgenerational epigenetic inheritance of pathology to the viral hecatomb in the deep sea.
See also: virus south korea
After the USA fought two land-wars in Asia, the uselessness of vaccine in South Korea and the senseless loss of life has been linked from the “creationist capital of the world” to denuclearization via seemingly futile cycles of protein biosynthesis and the virus-driven driven degradation of messenger RNA.
The facts about energy-dependent RNA-mediated DNA repair extend across species in the context of hearing loss and all other pathology via the cell biology game “Cytosis” for ages 10+

Players compete to build enzymes, hormones and receptors and fend off attacking Viruses!

Science, state, and spirituality: Stories of four creationists in South Korea

Supposedly, Duane Gish and Henry M. Morris (1918–2006) were responsible for making South Korea the “creationist capital of the world.”

Hashem Al-Ghaili pits all creationsts claims against his pseudoscientific nonsense in Memories can pass between generations through DNA (video)

If you wish to pit the claims about evolved instincts against my claims about microRNA biogenesis and biophysically constrained viral latency against the the claims of serious scientists from South Korea, start by explaining how Duane Gish linked the creation of the sun’s anti-entropic virucidal energy to all biodiversity.

…paving the way for the definitive rejection of the non-recombination dogma for human mtDNA.

Recombination is quantized energy-dependent and biophysically constrained by the physiology of reproduction.

See the works of those who are scheduled to present during Schrödinger at 75 – The Future of Biology – September 2018

See:

Some will continue to use you as an example of human idiocy.

See why: Signatures of negative selection in the genetic architecture of human complex traits

Reported as: Natural selection still at work in humans

“In natural selection, or ‘survival of the fittest’, characteristics that improve survival are more likely to be passed on to the next generation,” Professor Yang said.

“The opposite also occurs, when DNA mutations with a detrimental effect on fitness are less likely to be passed on, by a process called negative selection.

Phylogenetic analyses indicated that the SFTSV from the patient and the tick was identical. The patient gradually recovered with treatments of corticosteroids and immunoglobulin.

CONCLUSION:

These findings provide further evidence of SFTS viral transmission from H. longicornis to human.

Players compete to build enzymes, hormones and receptors and fend off attacking Viruses!

Indeed, the role of quantized energy as information in information-dependent naturally occurring RNA interference may soon be linked to denuclearization in North Korea (and everywhere else) by the factual representations of researchers from the Republic of South Korea.

See: A Single Amino Acid at the Polymerase Acidic Protein Determines the Pathogenicity of Influenza B Viruses (2018)
The looming threat of the next viral apocolypse is far greater than the nuclear threat, and researchers in South Korea are probably prepared to defend their population of modern humans.
Bill Gates, for comparison, is still touting the use of relatively useless vaccines.
See: Emergence of Human G2P[4] Rotaviruses in the Post-vaccination Era in South Korea: Footprints of Multiple Interspecies Re-assortment Events (April 16, 2018)

Compared to the G2 RotaTeq vaccine strain, 17-24 amino acid changes, specifically A87T, D96N, S213D, and S242N substitutions in G2 epitopes, were observed. These results suggest that multiple interspecies re-assortment events might have contributed to the emergence of G2P[4] rotaviruses in the post-vaccination era in South Korea.

If researchers in the so-called “creationist capital of the world” decide to genetically engineer a virus and wipe out the less-well ecologically adapted population of modern humans in North Korea, there would be virtually no loss of physical resources. The population of Seoul would benefit most by expanding into more rural areas.
Although this could lead to the futility of another land-war in Asia, it has become clear that everything ends badly. If that was not true, nothing would end. The current threat to anything that might otherwise be considered eternally significant was predicted in the science fiction novel “Quantico” by Greg Bear. It’s not funny any more, but see: Jon Stewart interviews Greg Bear
See also: Substitutions Near the Receptor Binding Site Determine Major Antigenic Change During Influenza Virus Evolution (2013) This author’s comment was recently removed:

The major antigenic changes of the influenza virus are primarily caused by a single amino acid near the receptor binding site.

But see the editor’s summary: Koel et al. (p. 976) show that major antigenic change can be caused by single amino acid substitutions.
The energy-dependent fixation of single amino acid substitutions in viruses has since been linked to all pathology in all living genera via the failure of virus-infected cell types to repair their damaged supercoiled DNA. The late Timothy J. Cunningham knew that as well as anyone. Sadly, he vanished without a trace and was found dead a river near his home several weeks later.

Since then, I was asked to comment on the eternal significance of the Vietnam Memorial Wall. I did not yet mention that thermal cycles have been linked to cracks in the Vietnam Memorial Wall because the article was about the American Veterans Traveling Tribute’s Wall.

I wrote:

The Vietnam Veterans Memorial wall (The Wall) was built with private contributions from the American people. It stands as a symbol of America’s honor, and to recognize the men and women who served and sacrificed their lives in the Vietnam War. The Wall was designed by the daughter of Chinese intellectuals who fled their homeland before the 1949 Communist takeover. She lives in Athens, Ohio.

The Wall is made up of two panels 246 feet 9 inches long. At it’s highest point the wall is over 10 feet tall. The names of more than 58,000 men and women who gave their lives or remain missing are inscribed on the black granite walls. Names are added when more remains are found.

The Vietnam Veterans Memorial wall stirs emotion. It can even be somewhat overwhelming to visit. When people looks into the polished volcanic rock of the wall, it reportedly “looks back:” It envelops its visitors in the names of those who lost their lives in a war which lasted nearly two decades.

For the hundreds of thousands of Vietnam veterans who are still alive, it is a place of eternal significance.

The Traveling Vietnam Veterans wall is a 80% sized replica of the Vietnam Veterans Memorial Wall in Washington, D.C.

Whether or not you have visited The Wall in Washington, D.C. and/or visited other places of ‘eternal significance,’ you may want to take advantage of the opportunity to see the American Veterans Traveling Tribute’s Traveling Vietnam Wall from May 16-20, 2018 at the Lions Club Fairgrounds 1729 S. Main Street, Ellijay, Georgia 30540.

American Legion Post 82 and the Ellijay Lions Club are the sponsors. American Legion Post 82 will have guides, counselors, and security 24 hrs a day and a computer list to locate where the veterans names are inscribed.

There is no cost to see The Traveling Vietnam Veterans wall. Pencil rubbing of the names can be made just as it can be with the Wall in D.C.

Donations to the American Legion Post 82 Ellijay will be used to help our Veterans and our community.

Biologically uninformed theorists do not understand how researchers in the “creationist capital of the world” have linked the Laws of Thermodynamics to biophysically constrained viral latency. Virus-driven constraint-breaking mutations or nuclear war will almost undoubtedly lead to the death of us all.

Who do you think might save you in a “worst case” scenario? If not for the American Legion, you probably would not have been warned.

Part 2: Light-controlled cell biology (revisited)

March 23, 2018

by James Kohl with No Comment Adaptations Alternative Splicings Autophagy biophotonics Diseases & Disorders Ecology RNA Directed

Greg Bear took the lead with this approach in his novel Quantico (2006). A genetically engineered virus was used to erase the memory of a specifically targeted human population to reduce inter-ethnic conflict.

[Greg Bear] …served as a consultant for NASA, the U.S. Army, the State Department, the International Food Protection Association, and Homeland Security on matters ranging from privatizing space to food safety, the frontiers of microbiology and genetics, and biological security.

Greg Bear is a likely candidate for work with Robert Redfield, who is currently the director of the CDC. Predictably, Timothy J. Cunningham will reappear as second in command at the CDC — when the Trump administration is ready to finish draining the academic swamp.

Until then, see: Three dimensional two-photon imaging of neuronal activity in freely moving mice using a miniature fiber coupled microscope with active axial-scanning

The ability to link two-photon imaging from the proton motive force to social behavior in the mouse model can be linked from food energy-dependent pheromone-controlled feedback loops to all vertebrate behavior via changes in the potential of hydrogen (pH) and RNA-mediated cell type differentiation.

This was reported in this video — with the mention of this published work. High performance plasma amyloid-β biomarkers for Alzheimer’s disease

There is no mention of microRNAs in the published work. See for comparison: MicroRNA+ Alzheimer’s+amyloid-β biomarkers

The role of the microRNA/messenger RNA balance (Breen, Kemena, Vlasov, Notredame, & Kondrashov, 2012; Duvarci, Nader, & LeDoux, 2008; Griggs et al., 2013; Monahan & Lomvardas, 2012) in adaptive evolution will certainly be discussed in published works that will follow.

Biologically uninformed theorists have realized that there is no such thing as Mutation-Driven Evolution (2013). That fact forces them to attempt to drown accurate information about top-down energy-dependent causation in the raw sewage they have continued to dump into their swamp — in their efforts to protect their ridiculous theories from scrutiny.
See also: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
Measurement of changes in the microRNA/messenger RNA balance are used to monitor autophagy, which protects all organized genomes from the virus-driven degradation of messenger RNA in the context of what is known to all serious scientists about supercoiled DNA and food energy-dependent biophysically constrained RNA-mediated healthy longevity.

Polymaths and paradigm shifts: from Asimov to Bear (1)

March 14, 2018

by James Kohl with One Comment Adaptations biophotonics Diseases & Disorders Ecology Light Energy Model Organisms Physics RNA Directed RNA–Mediated Epigenetic Heredity Subatomic Variations

Summary: In the context of what is known about how top-down causation must be linked to all biodiversity on Earth, the anti-entropic virucidal energy of sunlight links differences in the energy of two photons from the proton motive force to the creation of microRNAs. The link from the proton motive force to the creation of microRNAs is endogenous RNA interference (RNAi). Endogenous RNAi is manifested as energy-dependent differences in biophysically constrained viral latency.
Biophysically constrained viral latency has been linked to healthy longevity in all living genera from what appears to be the “dawn of creation.”
See: Conceptual Insights, Energy Transformations in Oxidative Phosphorylation (2002)

View this media module for an animated, interactive summary of how electron transfer potential is converted into proton-motive force and, finally, phosphoryl transfer potential in oxidative phosphorylation.

See: Section 18.4A Proton Gradient Powers the Synthesis of ATP
Place what is known to all serious scientists about the proton motive force into the context of energy-dependent electron transfer potential.
See also: Chemiosmosis

…the term proton-motive force (PMF)… can be described as the measure of the potential energy stored as a combination of proton and voltage (electrical potential) gradients across a membrane. The electrical gradient is a consequence of the charge separation across the membrane (when the protons H⁺ move without a counterion, such as chloride Cl⁻).

See: Search results for proton motive force
On February 2, 2018 and on February 26, 2018 I linked the claim that Permeability transition in human mitochondria persists in the absence of peripheral stalk subunits of ATP synthase (2017) to findings on RNA-RNA interactions in The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14 (1993) This link opens the to free pdf

Two small lin-4 transcripts of approximately 22 and 61 nt were identified in C. elegans and found to contain sequences complementary to a repeated sequence element in the 3′ untranslated region (UTR) of lin-14 mRNA, suggesting that lin-4 regulates lin-14 translation via an antisense RNA-RNA interaction.

The small lin-4 transcripts of approximately 22 and 61 nt were subsequently referred to as pre-mRNAs before the term pre-mRNA became microRNA as the number of nucleotides (nt) was reduced to 22 in the context of more than 70,000 published works on microRNAs. See: microRNA
In the context of what is known about how top-down causation must be linked to all biodiversity on Earth, the anti-entropic virucidal energy of sunlight links differences in the energy of two photons from the proton motive force to the creation of microRNAs. The link from the proton motive force to the creation of microRNAs is endogenous RNA interference (RNAi). Endogenous RNAi is manifested as energy-dependent differences in biophysically constrained viral latency. Biophysically constrained viral latency has been linked to healthy longevity in all living genera from what appears to be the “dawn of creation.”
For instance see: Recent Explosive Human Population Growth Has Resulted in an Excess of Rare Genetic Variants (2012) and Evolution and Functional Impact of Rare Coding Variation from Deep Sequencing of Human Exomes (2012)
Reported May 17, 2012 as: Humans riddled with rare genetic variants
See also: Analysis of 6,515 exomes reveals the recent origin of most human protein-coding variants (2013)
Reported November 28, 2012 Past 5,000 years prolific for changes to human genome
See also: The splicing code (Feb 2018)

…except for very few and marginal variations, it is the same from bacteria to man, the RNA stretch: 5′ GUGUUC 3′ reads as the dipeptide: Val-Phe in bacteria, in yeast, in Arabidopsis, in zebra fish, in mouse and in human. A degree of ambiguity is possible if mutations are introduced in the tRNAs in a way that the anticodon reads one amino acid but the aminoacyl-transferase attaches a different one onto the tRNA.

See also: Creatures’ Adaptability Begins with Their Sensors
Sensory input must be linked to energy-dependent RNA-mediated biophysically constrained viral latency.
See: OLYMPUS experiment sheds light on structure of protons

…most of the time, only one of the photons has high energy, while the other must carry very little energy indeed…

In 2013 Isaac Asimov Memorial Debate:The Existence of Nothing, Neil deGrasse Tyson made this spurious claim:

Isaac Asimov, “…perhaps, the last polymath of our civilization.”

A polymath should be required to link quantum physics from quantum chemistry to biophysically constrained viral latency and all biodiversity. Wide-ranging knowledge should include what is known about the conserved molecular mechanisms that link the food energy-dependent physiology of reproduction to ecological adaptations in species from microbes to humans.
Eshel Ben-Jacob and Greg Bear are polymaths. Isaac Asimov was not.
Eshel Ben-Jacob presciently linked Learning from Bacteria about Natural Information Processing (2009) to the biophysically constrained viral latency Greg Bear placed into the context of the creation of a new human species in two books reviewed in Nature:
Evolution rising from the grave (2000)
Living with the Neanderthals (2003)
See also: Dependence of RNA synthesis in isolated thymus nuclei on glycolysis, oxidative carbohydrate catabolism and a type of “oxidative phosphorylation” (1964)
Polymaths should be able to recognize patterns that link photophosphorylation and oxidative phosphorylation from the creation of enzymes to biophysically constrained RNA-mediated DNA repair, which links ecological variation from phytoremediation to ecological adaptations in all living genera. Anyone who fails to do that in the context of the weekend resurrection of the bacterial flagellum in P. fluorescens should be called a biologically uninformed theorist or a science journalist who has no excuse for reporting pseudoscientific nonsense.
The only way to resurrect the bacterial flagellum over-the-weekend involves what is known as the proton motive force. Fro example: A twitter search for “proton motive force” led me to this claim, thanks to Nigel Ten Fleming

Enzyme-bound ATP forms readily in the absence of a proton-motive force.

In the context of Energy Transformations in Oxidative Phosphorylation (2002), that claim was followed by this claim:

…the role of the proton gradient is not to form ATP but to release it from the synthase.

How to biophysically constrain the flu virus (1)

February 14, 2018

by James Kohl with No Comment Adaptations Alternative Splicings biophotonics Cytosis Diseases & Disorders Ecology Light Energy Model Organisms Physics RNA Directed RNA interference Subatomic

Excerpt: John E Walker (Factor-dependent archaeal transcription termination) will probably explain the molecular mechanism of how ATP is made, which may be important to know for those who have learned how important ATP is by playing “Cytosis.” The creation of ATP can be linked to the creation of RNA and the prevention of messenger RNA degradation in the context of the Virus-mediated archaeal hecatomb in the deep seafloor.
What the flu does to your body, and why it makes you feel awful

…when you have an influenza infection, you can rest assured that it is because your body is fighting hard. It’s combating the spread of the virus in your lungs and killing infected cells.

Why suffer needlessly or die prematurely. See: Cytosis: A Cell Biology Board Game

A board game taking place inside a human cell! Players compete to build enzymes, hormones and receptors and fend off attacking Viruses! (2 to 5 Players, Ages 10 & up, Plays in 50 to 75 mins)

Download the “Science Behind the Game” to learn how food energy-dependent alternative splicings of pre-mRNA protect all cell types, or see Alternative splicing and the evolution of phenotypic novelty.
Link the alternative splicings to species-specific behaviors via the physiology of reproduction in From Fertilization to Adult Sexual Behavior and anything else I have published or presented during the past two decades.
All behavior is energy-dependent. The energy comes from sunlight. Quantized energy as information from sunlight is linked to healthy longevity via its anti-entropic virucidal effect.
For example: Special UV light safely kills airborne flu virus, finds study

Scientists have known for decades that broad-spectrum UVC light, which has a wavelength of between 200 to 400 nanometers, or nm), is highly effective at killing bacteria and viruses by destroying the molecular bonds that hold their DNA together.

For comparison to vaccinations:
Far-UVC light: A new tool to control the spread of airborne-mediated microbial diseases

A key advantage of the UVC based approach, which is in clear contrast to vaccination approaches, is that UVC light is likely to be effective against all airborne microbes. For example, while there will almost certainly be variations in UVC inactivation efficiency as different influenza strains appear, they are unlikely to be large7,10. Likewise, as multi-drug-resistant variants of bacteria emerge, their UVC inactivation efficiencies are also unlikely to change greatly9.

In the context of vaccinations:
Substitutions Near the Receptor Binding Site Determine Major Antigenic Change During Influenza Virus Evolution

The major antigenic changes of the influenza virus are primarily caused by a single amino acid near the receptor binding site.

Clearly, vaccinations may not protect you and prevention via use of UV light is desirable.
When you learn how UV light protects you at the level of particle physics, you will understand the horrors of neo-Darwinian theory and big bang cosmology .
See Subatomic
The link from quantum physics to quantum chemistry was reported last month. Modern diversification of the amino acid repertoire driven by oxygen.
Schrödinger at 75, The Future of Biology is scheduled for September 2018
John E Walker (Factor-dependent archaeal transcription termination) will probably explain the molecular mechanism of how ATP is made, which may be important to know for those who have learned how important ATP is by playing “Cytosis.” The creation of ATP can be linked to the creation of RNA and the prevention of messenger RNA degradation in the context of the Virus-mediated archaeal hecatomb in the deep seafloor.
People who have played “Cytosis” can predict what will happen at the Schrödinger at 75 conference. They will jump ahead of most academics if they play “Subatomic” and link particle physics to all biophysically constrained biodiversity.
The fun factor is important to most people. They don’t care about supercoiled DNA or the virus-driven degradation of messenger RNA. But other scientists are having fun watching the creator of the genious games teach facts to theorists. We are especially pleased about his help in teaching the facts about energy-dependent cell biology to anyone who wants to have fun, prevent or survive the flu, or to become a serious scientist.
Alternatively, play the Mutation-driven evolution game (available only as an outdated 2013 textbook).
But remember: Nobody wants to belong to the party of losers. One of the best strategies in such a case is evidently an interpretation of the change as a gradual accumulation of knowledge while their work has always been at the cutting edge. — Kalevi Kull
Simply put, you could be dead by the time pseudoscientists start to tell the truth. For example, this is the truth:

“There had been years of biophysical experiments and biochemical experiments, and it was always assumed that there was just one dynein molecule,” Lander adds.

Lander just admitted that their assumptions may have made many serious scientists wrong about every aspect of energy-dependent life on Earth.
See also: Real Heroes Have the Guts to Admit They’re Wrong

…one reason we can’t admit we have the facts wrong is that it’s too painful to our self-conception as smart, right-thinking people—or to our political tribal identity.

In the past year alone, mathematicians have pulled papers when they’ve learned their proofs don’t hold and economists have retracted work after finding they’d misclassified their data. The Harvard stem-cell biologist Douglas Melton had a hit 2013 paper that got cited hundreds of times—but when colleagues couldn’t replicate the finding, he yanked it.

They discount the fact that any claims that have been placed into the context of neo-Darwinian theories have been invalidated first by Schrödinger in “What is Life? (1944) and since then by all serious scientists who have linked the sun’s anti-entropic virucidal energy from the physiology of reproduction to biophysically constrained viral latency and all biodiversity.
See also: Windowed Granger causal inference strategy improves discovery of gene regulatory networks

Significance

Discovery of gene regulatory networks (GRNs) is crucial for gaining insights into biological processes involved in development or disease. Although time-resolved, high-throughput data are increasingly available, many algorithms do not account for temporal delays underlying regulatory systems—such as protein synthesis and posttranslational modifications—leading to inaccurate network inference. To overcome this challenge, we introduce Sliding Window Inference for Network Generation (SWING), which uniquely accounts for temporal information. We validate SWING in both in silico and in vitro experimental systems, highlighting improved performance in identifying time-delayed edges and illuminating network structure. SWING performance is robust to user-defined parameters, enabling identification of regulatory mechanisms from time-series gene expression data.

Reported as: New machine learning algorithm uncovers time-delayed interactions in cells

SWING puts together a more complete picture of the cause-and-effect interactions happening among genes by incorporating time delays and sliding windows. Rather than only looking at the individual perturbations and responses, SWING uses time-resolved, high-throughput data to integrate the time it takes for those responses to occur.

Researchers will continue to scramble in attempts to put their findings into the context of what has already been presented in: Olfaction Warps Visual Time Perception
and in:

Diet-driven RNA interference and mental health (3)

February 6, 2018

by James Kohl with No Comment Adaptations Alternative Splicings Autophagy base editing biophotonics Cytosis Diseases & Disorders Ecology Light Energy microRNA editing Model Organisms Neuronal Plasticity Nutrigenomics Physics RNA Directed RNA editing RNA interference RNA-directed DNA methylation RNA-mediated epigenetic regulation of gene expression RNA-mediated gene silencing RNA–Mediated Epigenetic Heredity Variations

Discover’s “My Science Shop” now advertises the games that led to development of the cell biology game: “Cystosis,” which is a neo-Darwinian evolutionary theory-killer. Cytosis links the creation of anti-entropic viruidal light to all biodiversity on Earth via the physiology of reproduction and biophysically constrained viral latency.

See the dumbed-down version of that fact: Missing Mutations Suggest a Reason for Sex

Summary: A good model with a good model organism predicts. The mouse-to-human model of biophysically constrained viral latency predicts that one base pair and one fixed RNA-mediated amino acid substitution link the pheromone-controlled physiology of reproduction to all vertebrate biodiversity via food odors. Predictably, in the axolotyl (aka the “walking fish”), an iodine isotope and cryo-EM technology will soon be used to establish the facts about how the creation of sunlight must be linked from the creation of ATP and the creation of RNA to DNA repair and all biodiversity via the physiology of reproduction and healthy longevity in all living genera.

See for example: A Conserved MicroRNA Regulatory Circuit Is Differentially Controlled during Limb/Appendage Regeneration

…we employ next-generation sequencing to identify shared, differentially regulated mRNAs and noncoding RNAs in three different, highly regenerative animal systems: zebrafish caudal fins, bichir pectoral fins and axolotl forelimbs.

See for comparison: Mutation, Not Natural Selection, Drives Evolution also reported as: We are all mutants (March 2014)

In 1972, he devised a now widely used formula, Nei’s standard genetic distance, which compares key genes of different populations to estimate how long ago the groups diverged. In the early ’90s, Nei was a co-developer of free software that creates evolutionary trees based on genetic data. Two decades later, Molecular Evolutionary Genetics Analysis, or MEGA, remains one of the most widely used and cited computer programs in biology.

But it’s his natural selection-busting theory, which Nei developed in the ’80s and expanded on in the 2013 book Mutation-Driven Evolution, that the researcher wants to see embraced, cited and taught in schools.

That’s not going to happen except in the context of teaching students the difference between a ridiculous theory and facts about ecology!
See: Israeli Middle Schools School to Include Theory of Evolution

…learning about evolution is not the primary function of the decision, but rather to use it as a building block for students to learn more about their ecology.

…we conclude from our current data that the phototropic response in Arabidopsis roots is induced by an unknown mechanism…

No intelligent person on Earth is going to teach students that any phototropic response is induced by an unknown mechanism.
See for comparison: Overexpression of microRNA408 enhances photosynthesis, growth, and seed yield in diverse plants and Transposon-derived small RNAs triggered by miR845 mediate genome dosage response in Arabidopsis
Instead, students who are 10 years old or older will learn cell biology in the context of accurate representations of how what organisms eat biophysically constrains viral latency in the context of the physiology of reproduction. Students who learn to play the games that led to the development of the game “Cytosis” can start with the creation of microRNAs in plants and link the creation of sunlight to all biodiversity via the physiology of reproduction in plants and animals.
They will learn that embracing a ridiculous theory of mutation-driven evolution led to acceptance of evolutionary trees based on mathematical models of genetic data. They will learn how biophysically constrained top-down causation links RNA-mediated fixation of amino acid substitutions to all cell type differentiation in all living genera via what is known to serious scientists about sensing and signaling in the context of quantitative proteomics.
Ras/ERK-signalling promotes tRNA synthesis and growth via the RNA polymerase III repressor Maf1 in Drosophila

These findings suggest that stimulation of tRNA synthesis may be one way that Ras promotes mRNA translation to drive cell and tissue growth.

The light induced stimulation of tRNA synthesis links sensing and signaling from energy-dependent protein biosynthesis and degradation in the context of microRNA-mediated switches that are “flipped” by the availabilty of nutrients, water, and oxygen. Oxidative phosphorylation is required to link the switches to the energy-dependent stability of supercoiled DNA, which protects all organized genomes from the virus-driven degradation of messenger RNA.

See: Quantitative proteomics identifies redox switches for global translation modulation by mitochondrially produced reactive oxygen species (open access)

Reported as: Nano-switches in the cell: A team with researchers has discovered a new mechanism for the regulation of protein synthesis.

..increased levels of reactive oxygen species inhibit protein synthesis. Using biochemical and cell biological methods, she showed that damaged mitochondria can signal their metabolic state to the protein synthesis machinery via reactive oxygen species and, thereby, slow down cellular protein synthesis. It is assumed that the temporary reduction of the protein synthesis rate under oxidative stress has a positive effect on the survival of the cells as it is believed to help to restore cellular homeostasis. This also prevents the cell from synthesizing proteins that cannot be taken up by damaged mitochondria, which, as a consequence, accumulate in the cytoplasm and thus need to be degraded.

Anyone who knows anything about energy-dependent microRNA-mediated autophagy will recognize the ridiculous representation and claim about the discovery of a new mechanism for the regulation of protein synthesis. The creation of the sun’s anti-entropic virucidal energy links the creation of ATP to the creation of enzymes and microRNAs. The microRNAs regulate protein biosynthesis and degradation. There is nothing new about that. Yoshinora Ohsumi won the 2016 Nobel Prize in Physiology and Medicine for details about autophagy in the context of a published work from 1998.
He was the senior author of A protein conjugation system essential for autophagy

This conjugation can be reconstituted in vitro and depends on ATP. To our knowledge, this is the first report of a protein unrelated to ubiquitin that uses a ubiquitination-like conjugation system. Furthermore, Apg5 and Apg12 have mammalian homologues, suggesting that this new modification system is conserved from yeast to mammalian cells.

The modification system is ATP-dependent and microRNA-mediated.
See: The tipping point (revisited): 68,000 publications
See also: The tipping point (revisited): 69,000 publications
For updates, see: MicroRNA at PubMed
Moving forward, it is time to link the creation of microRNAs from fixation of RNA-mediated amino acid substitutions to mental health.
See: Diet-driven RNA interference and mental health (4)

GPX4-Cys bypasses the requirement of selenoproteins for cell viability

Diet-driven RNA interference and cancer prevention (2)

January 14, 2018

by James Kohl with No Comment Adaptations Cytosis Diseases & Disorders Ecology RNA Directed

See first: Diet-driven RNA interference and cancer prevention
A RNA-Sequencing approach for the identification of novel long non-coding RNA biomarkers in colorectal cancer

Our data highlight the capability of RNA-seq to discover novel lncRNAs involved in human carcinogenesis, which may serve as alternative biomarkers and/or molecular treatment targets.

Like all other data, their data refutes the pseudoscientific nonsense touted by neo-Darwinian theorists and “Big Bang” cosmologists. The energy-dependent creation of the novel biomarkers is the link from quantized energy as information to healthy longevity via the physiology of pheromone-controlled reproduction in all living genera.
Conclusion:

Functional relevance of CRCAL-3 and CRCAL-4 related to cell cycle was suggested by in vitro experiments as well as by GO term enrichment analysis in the TCGA dataset. Our data highlight the capability of RNA-seq technology to discover novel lncRNAs involved in human carcinogenesis, which may serve as alternative biomarkers and/or molecular treatment targets for human cancers.

The functional relevance of anything that has consistently been linked from energy-dependent RNA-mediated cycles of protein biosynthesis and degradation is that all the evidence links supercoiled DNA to protection of organized genomes from the virus-driven degradation of messenger RNA that links mutations to all pathology.
No matter how many attempts are made in the future to claim that the facts have not been known to all serious scientists, the obfuscations will fail.
See: Cytosis

A board game taking place inside a human cell! Players compete to build and fend off attacking Viruses!

Serious scientists know that enzymes, hormones and receptors do not automagically create themselves and that the virus-driven degradation of messenger RNA prevents the creation of the enzymes, hormones and receptors that serious scientists have linked to healthy longevity and interethnic similarities and differences in all human populations.

Tai Chi vs PTSD and cancer

December 20, 2017

by James Kohl with No Comment Autophagy biophotonics Diseases & Disorders Ecology Human Brain Light Energy microRNA editing Nutrigenomics RNA interference

The link from energy medicine to Precision medicine is clear to all serious scientists
Tai Chi Proves Beneficial for Veterans with PTSD

Anything that is relatively simple and inexpensive to implement in at-risk populations is not likely to be accepted by most politicians.

It would not be rejected by the CDC — if funding documentation excluded the words that the current director reportedly recently recommended be excluded.

See: BANNED: CDC Gets List Of ‘Forbidden Words’ From The Trump Administration

Instead of comparing Trump to Hitler, use of Tai Chi would be examined in the context of protection from the virus-driven degradation of messenger RNA that causes all pathology. The cure for PTSD and suicide prevention would then more readily be linked from the sun’s anti-entropic virucidal energy to all healthy longevity via the energy-dependent de novo creation of food energy-dependent microRNAs that protect us all from activation of the death gene in the context of autophagy.

Optimized food energy-dependent autophagy, which is the most likely cure for brain cancer and all other cancers, would be an added benefit — especially for veterans who return from military service overseas.

See: Reduced expression of brain-enriched microRNAs in glioblastomas permits targeted regulation of a cell death gene

See also: Energy as information and constrained endogenous RNA interference (6.37 minute-long video)

A rendering of how changes in an electron's motion (bottom view) alter the scattering of light (top view), as measured in a new experiment that scattered more than 500 photons of light from a single electron. Previous experiments had managed to scatter no more than a few photons at a time. Credit: Extreme Light Laboratory|University of Nebraska-Lincoln

Elsevier fails to support the concept of autophagy

December 15, 2017

by James Kohl with No Comment Alternative Splicings Autophagy Diseases & Disorders Ecology Light Energy microRNA editing Nutrigenomics RNA interference RNA-mediated gene silencing Variations What's in the News

Summary: Who lets biologically uninformed theorists make presumptions about evolution after all serious scientists have linked light-harvesting from energy-dependent changes in electrons to ecosystems in all living genera via natural selection for food energy-dependent codon optimality. Who lets them pretend not to know that the pheromone-controlled physiology of reproduction links autophagy to the transgenerational epigenetic inheritance of healthy longevity? Who is causing the unnecessary suffering and premature death of your loved ones?
Elsevier publishing supports the pseudoscientific nonsense touted by theorists by who publish articles like this:
Neurotransmitter Funneling Optimizes Glutamate Receptor Kinetics (open access) Published Online: December 14, 2017 (with my emphasis)

These studies suggest that neurotransmitter binding is a directed process for which kinetics have been optimized (presumably by evolution)…

Our experiments reveal a strikingly elaborate management of ligand transport by AMPA receptors, whereby flexible positive charges ensure that glutamate binding reactions are fast. The existence of these pathways is surprising, and the fact that they alter the kinetics of receptor activity indicates that the molecular mechanisms that determine the action of neurotransmitters at receptors are more complex than previously thought. R660 is conserved between AMPA and NMDA receptors; in kainate receptors, R660 and R661 are replaced by lysine residues (Figure S8). It is possible that these helix F interactions also coordinate ligand binding in kainate and NMDA receptors. Given that electrostatic interactions are also important for coordination in other neurotransmitter binding sites (McCammon, 2009), these principles of ligand funneling may be general.

They linked the lysine residues (i.e., amino acid substitutions) from electrostatic interactions to RNA-mediated cell type differentiation in all living genera. Their studies do not link any experimental evidence from electrostatic interactions or optimized kinetics to evolution. Evolution cannot optimize any aspect of energy-dependent kinetics. Evolution cannot optimize any aspect of energy-dependent RNA-mediated cell type differentiation, which is biophysically constrained by the physiology of pheromone-controlled reproduction.
The nonsense about evolution was reported as: Scientists chart how brain signals connect to neurons (with my emphasis)

Scientists at Johns Hopkins have used supercomputers to create an atomic scale map that tracks how the signaling chemical glutamate binds to a neuron in the brain. The findings, say the scientists, shed light on the dynamic physics of the chemical’s pathway, as well as the speed of nerve cell communications.

See: Life is physics and chemistry and communication
All experimental evidence of top-down causation links quantized energy from the speed of light on contact with water to energy as information-dependent changes in electrons and all ecosystems via the physiology of pheromone-controlled reproduction, which biophysically constrains viral latency. The use of supercomputers led the researchers to report findings that eliminate everything known to serious scientists about energy-dependent RNA-mediated cell type differentiation. It is common for theorists to eliminate energy as information-dependent changes and replace facts with mathematical models.
See for comparison: Codon identity regulates mRNA stability and translation efficiency during the maternal-to-zygotic transition (open access)

The bias between codons or amino acids, and mRNA expression levels has been previously recognized across species and is thought to result from selection for efficient, accurate translation, and folding of highly expressed genes (Ikemura, 1982; Akashi, 1994; Akashi & Gojobori, 2002; Drummond & Wilke, 2008; Kudla et al, 2009; Novoa & Ribas de Pouplana, 2012). The amino acid optimality code (Fig 6) provides an alternative perspective on sequence changes between paralogs in evolution and human disease.

This is not just an alternative perspective. It is a refutation of neo-Darwinian pseudoscientific nonsense that was reported as: Codon optimality at genome transition

Nucleotide triplets, or codons, designate specific amino acids for protein synthesis. However, that is not their only job. In yeast and bacteria, codons contribute to RNA stability, with “optimal” codons stabilizing RNAs and “suboptimal” codons destabilizing RNAs. This is possible because multiple codons can encode the same amino acid.

See also: Human GW182 Paralogs Are the Central Organizers for RNA-Mediated Control of Transcription Elsevier — Cell Reports (August 15, 2017)

Nuclear RNAi, regardless of whether it is controlling splicing, transcription, or some other nuclear process, would have distinct advantages as a mechanism for evolution, because it would expand sequence-specific control of gene expression by miRNAs.

No experimental evidence of biologically-based cause and effect suggests that microRNAs evolved to control sequence-specific gene expression. The authors linked TNRC6, MED14, NAT10, and WDR5 to RNA-mediated gene activation. They inadvertently linked the energy-dependent de novo creation of microRNAs to Trinucleotide Repeat Containing (TNRC) 6A expression. See: miR-26a-5p Regulates TNRC6A Expression and Facilitates Theca Cell Proliferation in Chicken Ovarian Follicles
The anti-entropic virucidal energy of sunlight links the creation of microRNAs and multiple codons to the creation of differences and similarities in the same amino acid. That fact has been ignored.
See also: MicroRNAs recruit eIF4E2 to repress translation of target mRNAs

There is increasing evidence indicating that translation initiation is a major target of miRNA repression…

…we provide evidence indicating that TNRC6A, the core component of RISC, can directly recruit eIF4E2 to target mRNA to repress translation.

They provided evidence that the energy-dependent de novo creation of microRNAs represses the expression of the mutations that cause all pathology.
See for example: Stem cell divisions, somatic mutations, cancer etiology, and cancer prevention
Reported as: New Study Finds That Most Cancer Mutations are Due to Random DNA Copying ‘Mistakes’

John Hopkins Kimmel Cancer Center scientists report data from a new study providing evidence that random DNA copying “mistakes” account for nearly two-thirds of the mutations that cause cancer. Their research is grounded on a novel mathematical model based on DNA sequencing and epidemiologic data from around the world.

This was reported in the context of the “bad luck” theory of cancer (video).
For comparison see: Why Is This Bacterium Hiding in Human Tumors?

“The whole idea of bacteria in tumors is fascinating and unexpected,” said Dr. Bert Vogelstein, a colon cancer researcher at Johns Hopkins.

See for comparison: QuEBS: Workshop on Quantum Effects in Biological Systems has established itself as an outstanding stage to present the research in the intersection of physics, chemistry and biology. This field has… established excitons in biology as the “must-talk-language” when describing the quantum effects in biological light-harvesting systems.
All serious scientists have linked the anti-entropic virucidal energy of sunlight from physics and chemistry to biophysically constrained viral latency via the de novo creation of microRNAs and the physiology of pheromone-controlled reproduction, which links autophagy to fixation of amino acid substitutions that stabilize the organized genome of all living genera in the context of autophagy.
Only biologically uniformed researchers, like Bert Vogelstein are surprised to find bacteria in tumors, because all serious scientists have link the viruses in bacteria from the degradation of messenger RNA in bacteria to the degradation of messenger RNA that causes all pathology in all living genera.

Nature vs Science and Autophagy.pro

December 15, 2017

by James Kohl with No Comment Adaptations Alternative Splicings Autophagy base editing biophotonics Diseases & Disorders Ecology Light Energy microRNA editing Model Organisms Nutrigenomics Physics RNA Directed RNA editing RNA interference RNA-mediated epigenetic regulation of gene expression RNA–Mediated Epigenetic Heredity Variations

Conclusion: The anti-entropic virucidal energy of sunlight links food energy directly from the innate immune system to all morphological and behavioral diversity. It all about energy. It’s all about the creation of enzymes. It’s all about the base pairs.

Until the day that I launched Autophagy.pro, I had only one or two Facebook posts that were marked as spam. Since December 11, 2017, I have had ~5 posts marked as spam.

See for example: This comment was marked as spam at Ciência Biomédica, when I responded to Synthetic protein packages its own genetic material and evolves

Packaging is energy-dependent and biophysically constrained. Nothing evolves. The concept is foolish. See: A universal trend of amino acid gain and loss in protein evolution

Excerpt: Amino acid composition of proteins varies substantially between taxa and, thus, can evolve.

WHY PULSE OXIMETERS DON’T NEED CALIBRATION

Laboratory co-oximeters determine the %HbO2 (%SaO2 ) by measuring the amount a specific frequency of light is absorbed as it passes through a known volume of blood. In contrast, pulse oximetry (SpO2) measures the change in light absorbed at systole and diastole. This allows the pulse oximeter to distinguish between the constant amount of light absorbed by the tissue, bone, venous blood, etc. from the arterial blood (the blood in the volume change due to the pulse).

The amount of light absorbed by the tissue, bone, venous blood etc., varies in the context of hydrogen-atom transfer in DNA base pairs in solution. Blood gas analysis in the medical laboratory links differences in hydrogen (H2) — as in H2O from quantized energy-dependent changes in the potential of hydrogen (pH) to all biophysically constrained biodiversity.

Stat Profile Prime CCS Blood Gas Analyzer from Nova Biomedical

Measuring pH links what is known about nutritional epigenetics from the innate immune system to healthy longevity via everything known about autophagy. The measurements can be compared in the context of what is known about virus-driven energy theft, which links stress from the replication of viruses to all pathology via critical care testing of other blood gas analytes such as pCO2, pO2, Sodium, Potassium, Chloride, Calcium, Glucose, Lactic Acid, and Hematocrit.

For example in a mammal, see: Epistasis Among Adaptive Mutations in Deer Mouse Hemoglobin (June 14, 2013)

See Fig. 2 Difference in the network of hydrogen bonds between high- and low-altitude Hb variants, HH-H and LL-L, respectively.

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My comment to the Science site (submitted 6/14/13 published 6/20/13):

In my model species-specific epistasis is nutrient-dependent and pheromone-controlled. An additional example of this showed up earlier this week in the context of the epigenetically-effected microRNA/messenger RNA balance: “miR-124 controls male reproductive success in Drosophila”

miR-14 acts in neurosecretory cells in the adult brain to control metabolism and miR-124 acts in the context of brain-directed neuroendocrine control of sexual differentiation and male pheromone production, which is controlled in mammals by gonadotropin-releasing hormone (GnRH) neurosecretory cells of the hypothalamus.

We can anticipate extension to mammals of the Drosophila model from the abstract of a forthcoming Science article: “MiR-200b and miR-429 Function in Mouse Ovulation and Are Essential for Female Fertility.” Given our earlier work in the context of molecular epigenetics and the concept of alternative splicings and sexual differentiation in Drosophila and C. elegans, I suspect we will see evidence for nutrient-dependent adaptive evolution of GnRH pulse frequency-controlled LH secretion and pheromone-controlled female fertility in mice.

If I’m correct, this evidence will link glucose and pheromones to feedback loops that control reproduction in invertebrates and vertebrates. (See Nutrient–dependent / pheromone–controlled adaptive evolution: a model). Model organisms exemplify these feedback loops in microbes, nematodes, insects, and other mammals. The mouse to human example that Kamberov et al., and Grossman et al., detailed is the most telling.

A single amino acid substitution appears to result in what seem to be nutrient-dependent changes in the thermodynamics of intracellular signaling, intranuclear interactions, stochastic gene expression, and selection for phenotype via organism-level thermoregulation in a human population that arose in what is now central China during the past ~30K years.

Using a model that integrates what is known about the common molecular mechanisms may help establish whether adaptive mutations lead to thermodynamic effects on organism-level thermoregulation and epistasis, or whether epigenetic effects of nutrients and their metabolism to species-specific pheromones that control reproduction via changes in the microRNA/messenger RNA balance are the driving force behind adaptive evolution in species from microbes to man.

See: Obligatory role of hypothalamic neuroestradiol during the estrogen-induced LH surge in female ovariectomized rhesus monkeys
Reported as: Estrogen discovery could shed new light on fertility problems December 12, 2017

Estradiol builds in the bloodstream until it reaches a concentration that causes a surge of the hypothalamic and pituitary hormones, including one called luteinizing hormone, which in turn trigger an ovary to release an egg.

“It’s a feedback loop…

The feedback loop is food energy-dependent and pheromone-controlled.
See: Feedback loops link odor and pheromone signaling with reproduction
Energy-dependent autophagy is the link from feedback loops to ecological adaptation. Science Magazine now has the opportunity to challenge the pseudoscientific nonsense of published works from the Nature Publishing Group. There is no need to consider mutations and evolution outside the context of virus-driven energy theft, which links the degradation of messenger RNA from mutations to all pathology.
See also: Combating Evolution to Fight Disease

Darwin probably anticipated the insemination of population genetics that led to the bastardization of his detailed observations in the “Modern Synthesis.” He politely insisted that ‘conditions of life’ be considered before natural selection.

There are two ‘conditions of life.’ It is nutrient-dependent and pheromone-controlled. Rosenberg and Queitsch now note the work with Dobzhansky’s rarely acknowledged claim: “I am a creationist and an evolutionist.” They also declare the need for “Deep understanding of the mechanisms that generate variation at the molecular level…”

Deep understanding of the ‘conditions of life’ does not come from theory.

Problems with the “modern synthesis” now lead us back to the facts about biologically-based cause and effect that Darwin and Dobzhansky approached with humility, which are the same biological facts that evolutionists approached with ignorance about behavioral affects and the arrogance that accompanies that ignorance. Rosenberg and Queitsch echo the sentiments of those who have been subjected to academic suppression.

Clearly, however, “nothing in evolution makes sense except in the light of biology” is not an exaggeration. It is a common sense statement about the biologically plausible genesis of functional cell types. Population genetics and evolutionary theories abandoned the biophysical constraints of ecological variation and the physiology of reproduction, which enable epigenetically-effected nutrient-dependent pheromone-controlled receptor-mediated ecological adaptations and species diversity via the complexities of protein folding and niche construction.

It’s time for biophysicists to tell theorists and pathologists how to differentiate between theories about the genesis of different cell types and the biological facts about the nutrient-dependent pheromone-controlled ecological adaptations that enable the genesis of different cell types in individuals of different species. Simply put, it’s time to stop trying to explain ecological adaptations in the context of mutations and evolution.

The retraction of Oligoarginine peptides slow strand annealing and assist non-enzymatic RNA replication attests to the amount of pseudoscientific nonsense published by the “Nature Publications Group” during the past few decades.
See: Retraction Watch

In retrospect, we were totally blinded by our belief [in our findings]…we were not as careful or rigorous as we should have been (and as Tivoli was) in interpreting these experiments.

How many others who published via the Nature Publishing Group were blinded by their belief in pseudoscientific nonsense that failed to link the food energy-dependent creation of enzymes and the creation of RNA from blood gas analyses to patient outcomes?
See for comparison: Dependence of RNA synthesis in isolated thymus nuclei on glycolysis, oxidative carbohydrate catabolism and a type of “oxidative phosphorylation” (1964)

The synthesis of RNA in isolated thymus nuclei is ATP dependent.

Who did not know that? How did non-enzymatic RNA replication become a non-energy-dependent consideration for anyone associated with the Nature Publishing Group?
See for comparison: Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40

Here we present the 3.0 ångström cryo-electron microscopy structure of mTORC1 and the 3.4 ångström structure of activated RHEB–mTORC1. RHEB binds to mTOR distally from the kinase active site, yet causes a global conformational change that allosterically realigns active-site residues, accelerating catalysis.

The global conformational change that allosterically realigns active-site residues (i.e., amino acids), accelerating catalysis, is an energy-dependent change.
Reported as: Scientists unlock structure of mTOR, a key cancer cell signaling protein

1) Like many proteins, mTOR is an enzyme, which binds to target molecules called substrates in a precise way to hasten chemical reactions. Specifically, it is a type of kinase, which removes phosphates (P) from ATP, the cell’s energy currency, and places them on other molecules.

The creation of the enzymatic activity of mTOR is quantized energy-dependent and it links the pheromone-controlled physiology of reproduction to biophysically constrained viral latency via autophagy. The retractions of Jack Szostak’s nonsense about the magical creation of enzymes after the energy of life emerged and organisms subsequently evolved in the context of differences in H2 to all biodiversity on Earth, can be placed into the context works by serious scientists.

2) …mTOR is an enzyme, which binds to target molecules called substrates in a precise way to hasten chemical reactions. Specifically, it is a type of kinase, which removes phosphates (P) from ATP, the cell’s energy currency, and places them on other molecules. From that 2013 study, which took more than five years to complete, the team learned some key things about the protein, such as what the ATP-binding site looks like…

The study that took more than 5 years to complete was published as: mTOR kinase structure, mechanism and regulation

The structures also reveal active-site residues and conformational changes that underlie inhibitor potency and specificity.

They had experimental evidence of energy-dependent changes in active-site residues (i.e., amino acids). They subsequently failed to link anything known to serious scientists about the energy-dependent changes from angstroms to ecosystems in all living genera via the physiology of pheromone-controlled reproduction. They seemingly ignored all claims about RNA-mediated amino acid substitutions in the context of autophagy, which links base pair changes from changes in the microRNA/messenger RNA balance to RNA editing.
How could the Nature Publishing Group not know what all serious scientists know?
See for example: All Nobel Laureates in Physiology or Medicine

The Nobel Prize in Physiology or Medicine 2017

Jeffrey C. Hall, Michael Rosbash and Michael W. Young

“for their discoveries of molecular mechanisms controlling the circadian rhythm”

The molecular mechanisms are energy-dependent.
Feedback of the Drosophila period gene product on circadian cycling of its messenger RNA levels (1990) Hardin, Hall and Michael Rosbash
Who, besides Jack Szostak, does not know that the creation of energy must be linked to RNA-mediated cell type differentiation via messenger RNA levels?

The Nobel Prize in Physiology or Medicine 2009

Elizabeth H. Blackburn, Carol W. Greider and Jack W. Szostak

“for the discovery of how chromosomes are protected by telomeres and the enzyme telomerase”

Where did the enzyme telomerase come from?
Face the facts, Jack (Szostak) and others. Cell type differentiation is food energy-dependent and biophysically constrained at every level of examination. Biophysical constraints on viral latency are required for ecological adaptation. The anti-entropic virucidal energy of sunlight links food energy directly from the innate immune system to all morphological and behavioral diversity. It’s all about energy. It’s all about the creation of enzymes. It’s all about the base pairs.
See: Structural diversity of supercoiled DNA

Denying Creation via RNA-directed DNA methylation

November 22, 2017

by James Kohl with No Comment Adaptations Diseases & Disorders Ecology Model Organisms RNA Directed RNA–Mediated Epigenetic Heredity Variations

Summary: Epigenetic mechanisms did not evolve. DNA methylation is food energy-dependent and RNA-directed. Phenotypes are not fixed by genetics. The food energy-dependent RNA-directed DNA methylation of all organized genomes is biophysically constrained by the metabolism of food to pheromones, which control the physiology of food-dependent reproduction.

On the day after he posted content on the refutation of Karl Popper’s nonsense and the pseudoscientific nonsense touted in every aspect of neo-Darwinian theory, antagonist Jay Feierman posted this to the Human Ethology group:

See: Chapter 27 – Evolution of Epigenetic Mechanisms in Animals and Their Role in Speciation

DNA methylation is involved in gene regulation, silencing of transposons, imprinting, polyphenism, and consolidation of speciation. It may even act as a driver of evolution via stochastic developmental and environmentally induced epigenotype diversification, transgenerational inheritance of epigenetic patterns with phenotypic effects, and differential selection and genetic fixation of these phenotypes.

Epigenetic mechanisms did not evolve. DNA methylation is food energy-dependent and RNA-directed. Phenotypes are not fixed by genetics. The food energy-dependent RNA-directed DNA methylation of all organized genomes is biophysically constrained by the metabolism of food to pheromones, which control the physiology of food-dependent reproduction. Food and pheromones typically biophysically constrain all virus-driven pathology. That allows ecological variation to be linked to ecological adaptation via transgenerational epigenetic inheritance in species from microbes to humans.
See: RNA-directed DNA methylation: an epigenetic pathway of increasing complexity
Simply put, increasing complexity does not automagically evolve. It is biophysically constrained by what organisms eat (i.e., food energy.)See also: RNA-mediated epigenetic regulation of gene expression

Jay Feierman‘s efforts to prevent the dissemination of accurate information about biophysically constrained biologically-based food energy-dependent RNA-mediated cause and effect have led to the unnecessary suffering and premature death of millions during the past 2 decades since I personally presented to him (at a conference) the model that has since been linked to all healthy longevity in all species. (His only question was “What about birds?”)

Rarely have I seen anyone display the lack of regard for biodiversity and for human life that Jay Feierman has included in his examples of “human idiocy.” His posts about the “Evolution of Epigenetic Mechanisms” and posts about the evolution of anything else should long ago have been the “last straw” for all serious scientists. And yet, it seems that no one can stop people like Jay Feierman.

For comparison, the late Charles Manson supposedly claimed: “I am the devil.” If true, in my opinion, another devil is alive and well and his name is Jay Feierman.

Search this domain for: RNA-directed DNA methylation or for RNA-mediated DNA methylation to find hundreds of blog posts that appear to attest to the devilish treachery of people like Jay R. Feierman. If you find one blog post that does not attest to his human idiocy and his treachery, please let me know. I may owe him an apology.

See also, this Google search: RNA mediated, which attests to the facts about why this is currently the top-ranked domain.

Feierman’s other posts to the Human Ethology Group on 11/20/17 include:

Formal Epistemology and Cartesian Skepticism: In Defense of Belief in the Natural World
Eleven Telomere, Epigenetic Clock, and Biomarker-Composite Quantifications of Biological Aging: Do They Measure the Same Thing?
Give one species the task to come up with a theory that spans them all: what good can come out of that?
A soft selective sweep during rapid evolution of gentle behaviour in an Africanized honeybee
Variability in Fitness Effects Can Preclude Selection of the Fittest
Does it always pay to defend one’s nest? A case study in African penguin

Throughout the animal kingdom, individual variation in reproductive success is commonly observed, even under similar environmental conditions. However, the mechanisms behind such differences remain unclear.

The mechanisms are energy-dependent and RNA-mediated. Feierman’s “bird-brained” nonsense takes us back to this example of food energy-dependent pheromone-controlled transgenerational epigenetic inheritance of morphology and behavior in a bird species, see: Estrogen receptor α polymorphism in a species with alternative behavioral phenotypes (2014)
For a direct attack on my accurate representations, see: One crank dies, another rises to take his place
In the context of A third of Americans don’t believe in evolution, I wrote:

Ecological adaptation occurs via the epigenetic effects of nutrients on alternative splicings of pre-mRNA which result in amino acid substitutions that differentiate all cell types of all individuals of all species. The control of the differences in cell types occurs via the metabolism of the nutrients to chemical signals that control the physiology of reproduction.
These facts do not refute evolution; they simply refute the ridiculous theory of mutation-initiated natural selection that most people here were taught to believe is the theory of evolution.
That theory is far too ridiculous to be anything but a joke in the context of biological-based increasing organismal complexity. But here, we have lots of jokers, don’t we? The proof of ecological variation that appears to refute the theory of evolution, which actually refutes itself, is that ecological adaptations occur too fast for mutations to compete with them as a source of anything but diseases and disorders.

For comparison, see the comment by Jay R. Feierman on my model:

7/25/13 Jay R. Feierman:

Variation is not nutrient availability and the something that is doing the selecting is not the individual organism. A feature of an educated person is to realize what they do not know. Sadly, you don’t know that you have an incorrect understanding [of] Darwinian biological evolution.

My model was published as a refutation of neo-Darwinian evolution. Nutrient-dependent/pheromone-controlled adaptive evolution: a model

No one has ever attempted to refute Darwinian evolution. Darwin reasserted the claim that others must start with his “conditions of life.” They are nutrient-dependent and pheromone-controlled. Anyone who has ever started with natural selection is as foolish as Darwin knew they would be.

In “Advancing Techniques Reveal the Brain’s Impressive Diversity,” Rusty Gage and two of his postdocs, Sara Linker and Tracy Bedrosian, describe nonvisual methods for delving ever deeper into neurons—analyzing not just what you see, but what you get by performing genome sequencing and transcriptional, posttranscriptional, posttranslational, and epigenetic analyses on single cells.

My comment:

The virus-driven degradation of messenger RNA has been linked to the destruction of all food energy-dependent pheromone-controlled biophysically constrained ecosystems in species from microbes to humans.
But Researchers reveal new details on aged brain, Alzheimer’s and dementia
only recently

…revealed a surprising relationship between dementia and decreased quality of RNA—a key player in gene expression—in the more aged brain.

Obviously, something has gone horribly wrong. Serious scientists can now simply recommend that everyone older than 10 play the game Cytosis.

A board game taking place inside a human cell! Players compete to build enzymes, hormones and receptors and fend off attacking Viruses!

Anyone older than 10 can then dismiss the claims of people like Rusty Gage about ecology and simply link what organisms eat from ecological variation to ecological adaptation via the physiology of pheromone-controlled reproduction, or link the virus-driven degradation of messenger RNA from mutations to all pathology.

Scent of Eros

Posts tagged: healthy longevity

Abiogenesis vs microRNA biogenesis (2)

CONCLUSION:

CONCLUSION:

Polymaths and paradigm shifts: from Asimov to Bear (1)

How to biophysically constrain the flu virus (1)

Diet-driven RNA interference and mental health (3)

Diet-driven RNA interference and cancer prevention (2)

Tai Chi vs PTSD and cancer

Elsevier fails to support the concept of autophagy

Nature vs Science and Autophagy.pro

Denying Creation via RNA-directed DNA methylation