GPX4-Cys bypasses the requirement of selenoproteins for cell viability

Quantized energy-dependent viral trophism

…mutations cause activation of your death gene.
Conclusion: You may be able to stop the ongoing activation of your death gene by a change in diet.
See: Reduced expression of brain-enriched microRNAs in glioblastomas permits targeted regulation of a cell death gene
See also: A Concise Review of MicroRNA Exploring the Insights of MicroRNA Regulations in Bacterial, Viral and Metabolic Diseases
——————————————–
Daniel L.Hurdiss (@DanielHurdiss) announced publication of this refutation of neo-Darwinian pseudoscientific nonsense in his twitter feed before the start of the new year with no indication that it refutes all theories of emergence and evolution.
Role of enhanced receptor engagement in the evolution of a pandemic acute hemorrhagic conjunctivitis virus

…receptors are important determinants of viral tropism…

The quantized energy-dependent creation of the receptors biophysical constrains viral latency via feedback loops that link the de novo creation of enzymes from microRNA-mediated metabolism to the species-specific pheromones that biophysically constrain autophagy.
That fact has become clearer since the 1994 publication of  Pheromonal Regulation of Genetic Processes: Research on the House Mouse (Mus musculus L.)
The exquisite clarity led to this:

Previously, , Ariane Briegel @BriegelAriane blocked me from following her tweets (one of which led me to the tweet by Daniel Hurdiss).
In 2014, (with others) she published Structure of bacterial cytoplasmic chemoreceptor arrays and implications for chemotactic signaling [Two of the authors are not based in the United States and Ariane Briegel now has her own lab in Leiden — in the Dutch province of South Holland.]

Most motile bacteria sense and respond to their environment through a transmembrane chemoreceptor array whose structure and function have been well-studied, but many species also contain an additional cluster of chemoreceptors in their cytoplasm.

Phototaxis must first be linked to energy-dependent pH-taxis and chemotaxis, which is why I commented on her publication of The dark side of the new popularity of cryo-electron microscopy.  It appeared to be yet another attempt to keep people in the dark about what is already known to serious scientists about light-activated endogenous substrates and cell type differentiation.
[Researchers based outside the United States are probably less likely to support the Trump administration’s efforts to drain the academic swamp.] See for comparison: Nutrient-dependent pheromone-controlled ecological adaptations: from atoms to ecosystems
My invited review of nutritional epigenetics was returned without review and Briegel has since decided it is a good idea for reviewers to be fair. I will add that blocking specific people from seeing your tweets is not an effective strategy. Simply put, it is not fair. If it was, the President of the United States of America would probably have used a tweet blocking strategy by now.
Instead, he was falsely accused of censorship when the director of the CDC suggested that certain key words, such as “transgender” should not be used in funding attempts. What about Briegel’s censorship?
I suspect that President Trump will keep tweeting away in his attempts to drain the academic swamp. In any case, that’s what I will keep doing. Watch what happens to those who hide their claims each time a serious scientist asks them to explain why they failed to link their results from quantum physics to quantum souls — in the context of words that might otherwise be used in future funding attempts. For example, words like food and energy could be used in funding attempts that would clearly show that food energy biophysically constrains viral latency.
See for example: Selenium Utilization by GPX4 Is Required to Prevent Hydroperoxide-Induced Ferroptosis

… a variety of dietary compounds such as… selenium… [target] a sequence of cellular and molecular pathways.

In the context of dietary microRNAs and exosomes, a change in the diet is an attractive option for the prevention/treatment of pathology.
That fact was placed into the context of Cytosis, a successful non-government funded cell biology board game.

A board game taking place inside a human cell! Players compete to build enzymes, hormones and receptors and fend off attacking Viruses!

The cell biology game links the creation of the sun’s anti-entropic virucidal energy from quantum physics to quantum souls via the creation of ATP, and the light-induced creation of messenger RNA.
The first time that experimental evidence of that fact was published may have been in 1964. See: Dependence of RNA synthesis in isolated thymus nuclei on glycolysis, oxidative carbohydrate catabolism and a type of “oxidative phosphorylation”
See also: Effects of Carnitine on Fatty-Acid Oxidation by Muscle (1959), which was published in “Science Magazine.” McEwen and his co-author, Irving B. Fritz claimed:

…it is relevant to ask by what means serum fatty acids are transported from blood vessels through the interstitial space to the active sites for fatty-acid oxidation in muscle cells.

See also: Pheromones: a new term for a class of biologically active substances (1959) Was published in “Nature.”
It made it equally relevant to ask how fatty-acid oxidation in muscle cells was biophysically constrained in the context of the food energy-dependent pheromone-controlled physiology of reproduction.
It should be obvious that the dumbing down of “Science” has not effectively eliminated the intelligent approach that the Trump administration must take to Make America Great Again, by draining the academic swamp. However, for an example of what he is fighting against, see:
pH-Taxis of Biohybrid Microsystems (published in one of the Nature Publishing Group’s journals)

The motion analysis of microrobots also sheds light on the propulsion dynamics of the flagellated bacteria as bioactuators. It is expected that similar driving mechanisms are shared among pH-taxis, chemotaxis, and thermotaxis. By identifying the mechanism that drives the tactic behavior of bacteria-propelled microsystems, this study opens up an avenue towards improving the control of biohybrid microsystems.

The identified mechanism was place into the context of the weekend resurrection of the bacterial flagellum (in Science Magazine, 2015). The mechanism is food energy-dependent and controlled by the physiology of reproduction in species from microbes to humans via food energy-dependent fixation of RNA-mediated amino acid substitutions, which were reported to be mutations.The mutations cause activation of your death gene.
Conclusion: You may be able to stop the ongoing activation of your death gene by a change in diet.
See: Reduced expression of brain-enriched microRNAs in glioblastomas permits targeted regulation of a cell death gene
See also: A Concise Review of MicroRNA Exploring the Insights of MicroRNA Regulations in Bacterial, Viral and Metabolic Diseases
See also: Autophagy.pro

Cytosis can be used to teach everything from base editing to RNA editing to everyone over age 10. They will learn how to link the creation of energy to biophysically constrained viral latency via the physiology of pheromone-controlled reproduction.

Who created your virus-driven death gene? (3)

Summary: Students in the United States can learn how pseudoscientists bastardized Darwin’s theory by playing the game “Cytosis.” It links the creation of virucidal light to the creation of ATP and the creation of RNA, which biophysically constrains all energy-dependent biodiversity in the context of the physiology of pheromone-controlled reproduction.

See for comparison: Male Flies Find a Mate With Wedding Gifts Made of Vomit and Weird Dancing

When researchers artificially activated the fruitless circuitry with light, the flies were compelled to perform their mating rituals, but still in ways that were species-specific.

Please help to stop others who are reporting this nonsense without placing it into the context of what neuroscientists should already know about light-activated energy-dependent species-specific unconscious affect. The advance report links to a study published in the Journal of Neuroscience.

Optogenetic activation of the fruitless-labeled circuitry in Drosophila subobscura males induces mating motor acts

The news bastardized the findings before serious scientists could report the truth about the study results in the proper context, which is not vomit and weird dancing. A light-activated endogenous substrate was linked from the creation of enzymes, hormones, and receptors to the pheromone-controlled physiology of reproduction in all living genera.

See for example our award-winning 2001 review: Human Pheromones: “Integrating Neuroendocrinology and Ethology

The ‘affective primacy hypothesis’ [5] asserts that positive and negative affective reactions can be evoked with minimal stimulus input and virtually no cognitive processing. Olfactory signals seem to induce emotional reactions whether or not a chemical stimulus is consciously perceived. We theorize that the importance of human non-verbal signals is based upon information processing, which occurs in the limbic system, and without any cognitive (cortical) assessment. Affect thus does not require conscious interpretation of signal content. Underlying this fact is that affect dominates social interaction and it is the major currency in social interactions [6]. Affective reactions can occur without extensive perceptual and cognitive encoding. They are made with greater confidence than cognitive judgments, and can be made sooner [5, 7]. Olfactory input from the social environment is well adapted to fit such assertions. For example, chemical cues allow humans to select for, and to mate for, traits of reproductive fitness that cannot be assessed simply from visual cues.

We the Muslims don’t need religious slogans or politically expedient responses to scientific and socio-political realities. Let us find genuine and true answers. Turkish students can learn about evolution in general and guided evolution in particular in the Muslim Times.

See for comparison:

Students in the United States can learn how pseudoscientists bastardized Darwin’s theory by playing the game “Cytosis.” It links the creation of virucidal light to the creation of ATP and the creation of RNA, which biophysically constrains all energy-dependent biodiversity in the context of the physiology of pheromone-controlled reproduction.

Restaurant won’t remove controversial Caitlyn-Bruce bathroom signs

“…the pre- and post-transition photos were “merely a lighthearted gesture to push back against the political correctness that seems to have a stranglehold on this country right now.”
“…name calling and words like transphobic, deviant, racist, homophobic, bigot, etc. serve nothing but to continue to divide us…”

Have the Rothschild Banks contributed to the teaching of neo-Darwinian evolution in the United States?

Where would we be without the “political correctness?”
For example, ask your doctor about microRNAs and the “death gene.” Cite this as an introduction to the conversation that few transphobics, deviants, racists, homophobics, or bigots want to have.
A Concise Review of MicroRNA Exploring the Insights of MicroRNA Regulations in Bacterial, Viral and Metabolic Diseases
MicroRNAs are endogenous noncoding RNAs that control gene expression. They are NONRANDOMLY distributed in our organized genomes.
Food energy-dependent microRNAs prevent the virus-driven activation of death genes. See for example: Reduced expression of brain-enriched microRNAs in glioblastomas permits targeted regulation of a cell death gene
Endogenous microRNAs link energy-dependent ecological adaptations to chromosomal rearrangements in our sex chromosomes. Quantized energy as information links biophysically constrained viral latency to all biodiversity on Earth via the physiology of pheromone-controlled reproduction.
Ask your doctor if you smell like a girl or smell like a boy. Then open the door to your mind before you go to the bathroom.

Alternative splicing of pre-mRNA

Agilent technology and energy-dependent autophagy

The first step towards understanding the link from the creation of energy to metabolism-related cellular function is called energy phenotyping. It requires the  technology to measure energy-dependent changes in RNA-mediated metabolic switches via the RNA interference (RNAi) screening strategy. Endogenous RNAi must then be linked  to the prevention of the virus-driven degradation of messenger RNA that causes all pathology.
Scientists discover possible master switch for programming cancer immunotherapy

…they employed an RNA interference screening strategy which can test the actual function of thousands of factors simultaneously.

See also: Energy as information and constrained endogenous RNA interference (video 6:46 minutes)
Abstract:

Feedback loops link quantized energy as information to biophysically constrained RNA-mediated protein folding chemistry. Light induced energy-dependent changes link angstroms to ecosystems from classical physics to chemistry/chirality and to molecular epigenetics/autophagy. The National Microbiome Initiative links microbial quorum sensing to the physiology of reproduction via endogenous RNA interference and chromosomal rearrangements. The rearrangements link energy-dependent fixed amino acid substitutions to the Precision Medicine Initiative via genome wide inferences of natural selection. This detailed representation of energy-dependent natural selection for codon optimality links biologically- based cause and effect from G protein-coupled receptors to RNA-mediated amino acid substitutions and the functional structure of supercoiled DNA. Energy-dependent polycombic ecological adaptations are manifested in supercoiled DNA. Chromosomal inheritance links the adaptations from morphological phenotypes to healthy longevity via behavioral phenotypes. For contrast, virus-driven energy theft is the link from messenger RNA degradation to negative supercoiling, constraint breaking mutations, and hecatombic evolution. The viral hecatomb links transgenerational epigenetic inheritance from archaea to Zika virus-damaged DNA, which typically is repaired by endogenous RNA interference and fixation of RNA-mediated amino acid substitutions in organized genomes.

See also: Measuring the Metabolic Switch in Cancer Cells – Agilent (pdf)

Yoshida used TRAP1-null cells and transient TRAP1 mutants on an Agilent Seahorse XF96 Analyzer to show that TRAP1 regulates a metabolic switch between oxidative phosphorylation and aerobic glycolysis in immortalized mouse fibroblasts and in human tumor cells. TRAP1 deficiency promotes increased mitochondrial respiration, fatty acid oxidation, accumulation of TCA intermediates, ATP, and ROS, while suppressing glucose metabolism.

The virus-driven degradation of messenger RNA is the only perfectly obvious reason for changes in oxidative phosphorylation and aerobic glycolysis that prevent the metabolism of glucose. Natural selection for energy-dependent codon optimality links the creation of energy to the metabolism of glucose via the creation of enzymes that metabolize food energy. Energy-dependent RNA-mediated error-free DNA repair and fixation of amino acid substitutions is required to link the creation of enzymes and the species-specific production of pheromones from the physiology of reproduction to biophysically constrained viral latency and all morphological and behavioral phenotypes in all living genera.
In that context, energy-dependent natural selection for codon optimality links biologically-based cause and effect from hydrogen-atom transfer in DNA base pairs in solution to the transgenerational epigenetic inheritance of healthy longevity. For contrast, the virus-driven theft of quantized energy links changes in non-coding RNAs to all pathology.
For example, see: Reduced expression of brain-enriched microRNAs in glioblastomas permits targeted regulation of a cell death gene
See also: A Concise Review of MicroRNA Exploring the Insights of MicroRNA Regulations in Bacterial, Viral and Metabolic Diseases
The link from the virus-driven theft of quantized energy to glioblastoma may be the best example of how viruses are readily linked to the cell death gene in all cell types of all individuals of all living genera. That fact is more obvious with further examination of details provided for free in book chapters from Codon Publishing.
See: Noncoding RNAs in Glioblastoma  Free book chapter from Codon Publishing

The vast majority of the human genome is transcribed into noncoding RNAs. Among these, microRNAs (miRNA) and long noncoding RNAs (lncRNA) are frequently deregulated in cancer, where they regulate a wide variety of functions.

See also: Epigenetic Mechanisms of Glioblastoma Free book chapter from Codon Publishing

Aberrant DNA methylation is a common event in the genesis and progression of tumors. The application of next-generation sequencing enables the identification and mapping of DNA methylation and its derivatives, 5fC and 5hmC, to base-pair resolution. This chapter describes nine novel hypermethylation genes and six hypomethylation genes, identified by constructing a DNA methylation profile, in glioblastoma. Abnormal promoter methylation and histone modifications were associated with differential expression of miRNAs in glioblastoma: miR-185 reversed global DNA methylation and the methylation level of the hypermethylation genes by targeting DNMT; and miR-101 regulated histone methylation of hypomethylation genes by targeting EED, EZH2, and DNMT3A. The long noncoding RNA CASC2c directly bound to miR-101 via microRNA response elements, and there was a reciprocal repression between CASC2c and miR-101. Despite being competitors they both led to the overexpression of their target hypomethylation genes CPEB1, PRDM16, and LMO3. Taken together, glioblastoma is a complicated pathological process with deregulated methylation and histone modifications. Focal differentially methylated region and differentially methylated site studies will be helpful for the identification of regulatory elements of transcription. Studies of intragenic and distant intergenic alterations in DNA methylation will help elucidate the nature of epigenetic deregulation in glioblastoma.

The Seahorse XF Cell Energy Phenotype Test kit is a simple assay kit that simultaneously measures the two major energy producing pathways in live cells – mitochondrial respiration and glycolysis, allowing rapid determination of energy phenotypes of cells and investigation of metabolic switching.
The simultaneous measurement of two major energy-producing pathways in live cells allows serious scientists to report their findings in the context of what is known about mitochondrial respiration and glycolysis. Glycolysis is epigenetically effected and RNA-mediated. No magic of evolution or nonsense about natural selection for anything except food and reproduction is required to explain how rapid metabolic switching determines whether or not viral latency is biophysically constrained across the time-space continuum.
See: From Fertilization to Adult Sexual Behavior (1996)

Yet another kind of epigenetic imprinting occurs in species as diverse as yeast, Drosophila, mice, and humans and is based upon small DNA-binding proteins called “chromo domain” proteins, e.g., polycomb. These proteins affect chromatin structure, often in telomeric regions, and thereby affect transcription and silencing of various genes (Saunders, Chue, Goebl, Craig, Clark, Powers, Eissenberg, Elgin, Rothfield, and Earnshaw, 1993; Singh, Miller, Pearce, Kothary, Burton, Paro, James, and Gaunt, 1991; Trofatter, Long, Murrell, Stotler, Gusella, and Buckler, 1995). Small intranuclear proteins also participate in generating alternative splicing techniques of pre-mRNA and, by this mechanism, contribute to sexual differentiation in at least two species, Drosophila melanogaster and Caenorhabditis elegans (Adler and Hajduk, 1994; de Bono, Zarkower, and Hodgkin, 1995; Ge, Zuo, and Manley, 1991; Green, 1991; Parkhurst and Meneely, 1994; Wilkins, 1995; Wolfner, 1988). That similar proteins perform functions in humans suggests the possibility that some human sex differences may arise from alternative splicings of otherwise identical genes.

See: Epigenetic modifications poster (Abcam)
Also from Abcam: Mechanisms of Recombination conference
The bottom line is The secret to safe DNA repair  (2015)

…if you don’t have this enzyme, then this error-free repair is stopped. You can’t do it. If you can’t do the error-free repair, among other things that happen is that you expect these cells to be cancer prone.

Clearly, the creation of the enzyme is energy-dependent and biophysically constrained by the pheromone-controlled physiology of reproduction. Pseudoscientists seem to know nothing about that, and most serious scientists are not telling you the facts that link the virus-driven degradation of messenger RNA to the “death gene” via the mechanisms that fail during recombination.
But see: microRNA autophagy  and also see: See:  Agilent Seahorse XF Publications Alert for December 2017
Selected publications
Autophagy maintains the metabolism and function of young and old stem cells
Ho, T. T., Warr, M. R., Adelman, E. R., Lansinger, O. M., Flach, J., Verovskaya, E. V., Figueroa, M. E. and Passegue, E.
Nature. 2017 Mar 9, 543 (7644):205-210.
Involvement of autophagy in the outcome of mitotic catastrophe
Sorokina, I. V., Denisenko, T. V., Imreh, G., Tyurin-Kuzmin, P. A., Kaminskyy, V. O., Gogvadze, V. and Zhivotovsky, B.
Sci Rep. 2017 Nov 6, 7 (1):14571.
Sugar or Fat?-Metabolic Requirements for Immunity to Viral Infections
Shehata, H. M., Murphy, A. J., Lee, M. K. S., Gardiner, C. M., Crowe, S. M., Sanjabi, S., Finlay, D. K. and Palmer, C. S.
Front Immunol. 2017 Oct 16, 8:1311.
System-wide Benefits of Intermeal Fasting by Autophagy
Martinez-Lopez, N., Tarabra, E., Toledo, M., Garcia-Macia, M., Sahu, S., Coletto, L., Batista-Gonzalez, A., Barzilai, N., Pessin, J. E., Schwartz, G. J., Kersten, S. and Singh, R.
Cell Metab. 2017 Dec 5, 26 (6):856-871 e5.
Late-onset Alzheimer’s disease is associated with inherent changes in bioenergetics profiles
Sonntag, K. C., Ryu, W. I., Amirault, K. M., Healy, R. A., Siegel, A. J., McPhie, D. L., Forester, B. and Cohen, B. M.
Sci Rep. 2017 Oct 25, 7 (1):14038.

BAG3 directly stabilizes Hexokinase 2 mRNA and promotes aerobic glycolysis in pancreatic cancer cells
An, M. X., Li, S., Yao, H. B., Li, C., Wang, J. M., Sun, J., Li, X. Y., Meng, X. N. and Wang, H. Q.
J Cell Biol. 2017 Dec 4, 216 (12):4091-4105.
Drug resistance induces the upregulation of H2S-producing enzymes in HCT116 colon cancer cells
Untereiner, A. A., Pavlidou, A., Druzhyna, N., Papapetropoulos, A., Hellmich, M. R. and Szabo, C.
Biochem Pharmacol. 2017 Oct 20, [epub ahead of print]
ISG15 governs mitochondrial function in macrophages following vaccinia virus infection
Baldanta, S., Fernandez-Escobar, M., Acin-Perez, R., Albert, M., Camafeita, E., Jorge, I., Vazquez, J., Enriquez, J. A. and Guerra, S.
PLoS Pathog. 2017 Oct 27, 13 (10):e1006651.
High throughput measurement of metabolism in planarians reveals activation of glycolysis during regeneration
Osuma, E. A., Riggs, D. W., Gibb, A. A. and Hill, B. G.
Regeneration. 2017 Nov 02, [epub ahead of print]
Current technical approaches to brain energy metabolism
Barros, L. F., Bolanos, J. P., Bonvento, G., Bouzier-Sore, A. K., Brown, A., Hirrlinger, J., Kasparov, S., Kirchhoff, F., Murphy, A. N., Pellerin, L., Robinson, M. B. and Weber, B.
Glia. 2017 Nov 7, [epub ahead of print]
Glucose-regulated protein 75 determines ER–mitochondrial coupling and sensitivity to oxidative stress in neuronal cells
Honrath, B., Metz, I., Bendridi, N., Rieusset, J., Culmsee, C. and Dolga, A. M.
Cell Death Discovery. 2017 Nov 06, [epub ahead of print]

Associations Between Microbiota, Mitochondrial Function, and Cognition in Chronic Marijuana Users
Panee, J., Gerschenson, M. and Chang, L.
J Neuroimmune Pharmacol. 2017 Nov 4, [epub ahead of print]
RNA cytosine methyltransferase Nsun3 regulates embryonic stem cell differentiation by promoting mitochondrial activity
Trixl, L., Amort, T., Wille, A., Zinni, M., Ebner, S., Hechenberger, C., Eichin, F., Gabriel, H., Schoberleitner, I., Huang, A., Piatti, P., Nat, R., Troppmair, J. and Lusser, A.
Cell Mol Life Sci. 2017 Nov 4, [epub ahead of print]
Deep transcriptome annotation enables the discovery and functional characterization of cryptic small proteins
Samandi, S., Roy, A. V., Delcourt, V., Lucier, J. F., Gagnon, J., Beaudoin, M. C., Vanderperre, B., Breton, M. A., Motard, J., Jacques, J. F., Brunelle, M., Gagnon-Arsenault, I., Fournier, I., Ouangraoua, A., Hunting, D. J., Cohen, A. A., Landry, C. R., Scott, M. S. and Roucou, X.
Elife. 2017 Oct 30, 6.
The Human Knockout Gene CLYBL Connects Itaconate to Vitamin B12
Shen, H., Campanello, G. C., Flicker, D., Grabarek, Z., Hu, J., Luo, C., Banerjee, R. and Mootha, V. K.
Cell. 2017 Nov 2, 171 (4):771-782 e11.

See also: Research areas for this month include:

See for comparison: Autophagy

Autophagy is a process by which cellular material is degraded by lysosomes or vacuoles and recycled. Several autophagy pathways operate within a cell, including macroautophagy, microautophagy and chaperone-mediated autophagy.

Latest Research and Reviews

For example:

Dual role of autophagy in hallmarks of cancer

Quantitative assessment of cell fate decision between autophagy and apoptosis

The Nature Publications Group has fallen far behind the data and technical expertise of all the serious scientists in the world. It seems likely that they will attempt to portray autophagy as something besides the innate phage defense system and fail miserably.

Autophagy is the antiphage defense strategy December 8, 2016

What would you do if your publisher arrived at the “Autophagy Party” more than a year late and you had to introduce them as a supporter of neo-Darwinian nonsense and “Big Bang” cosmology?
Nobody wants to belong to the party of losers. One of the best strategies in such a case is evidently an interpretation of the change as a gradual accumulation of knowledge while their work has always been at the cutting edge. — Kalevi Kull
 

Lethal virus kills 5 billion people?

Reporting new scientific truths is not allowed in the USA

Summary: If we keep training serious scientists in the United States but force them to return to their homeland to report new scientific truths, our Homeland Security will suffer from the ignorance of pseudoscientists who are still touting ridiculous claims about mutations and evolution.

A new scientific truth does not triumph by convincing its opponents and making them see the light, but rather because its opponents eventually die, and a new generation grows up that is familiar with it.

Every great scientific truth goes through three stages. First, people say it conflicts with the Bible. Next they say it has been discovered before. Lastly they say they always believed it.

Sugar industry withheld evidence of sucrose’s health effects nearly 50 years ago

The results suggest that the current debate on the relative effects of sugar vs. starch may be rooted in more than 60 years of industry manipulation of science. Last year, the Sugar Association criticized a mouse study suggesting a link between sugar and increased tumor growth and metastasis, saying that “no credible link between ingested sugars and cancer has been established.”
 

First question: Why would they lie about a thing like that?

Second question: Who taught you to believe in them?

See also: Psychiatric Fallout From Toxic Exposure October 21, 2016 Posted to the Psychiatry Research Yahoo Group on November 25, 2017

Face-saving attempts will continue to be made by everyone who taught anyone else to believe in the pseudoscientific nonsense about random mutations and evolution. Clearly, psychiatrists decided it was good for business to ensure a decline in mental health that should have been attributed to the effects of sugar.
 

I recognized the obvious link from glucose levels to triglycerides before the nonsense about cholesterol and heart disease became a means to support the medical practices of pill prescribing physicians. Only diabetics had levels of triglycerides that left a chalky-white to pink color in their plasma or serum. Ultracentrifugation was sometimes required or chemical “clearing” with mathematical corrections in order to report accurate results.

Study: Autism Linked with Different Reactions to Chemical Signals (senior author Noam Sobel, Israel).

Responses to compounds in human sweat may help explain why people with autism spectrum disorder tend to struggle with social cues.

See also: Olfaction Warps Visual Time Perception (senior author Wen Zhou, China)
If we keep training serious scientists in the United States but force them to return to their homeland to report new scientific truths, our Homeland Security will suffer from the ignorance of pseudoscientists who are still touting ridiculous claims about mutations and evolution.
http://www.cc.com/video-clips/sz2odd/the-daily-show-with-jon-stewart-greg-bear
Sci-fi author Greg Bear tells Jon about the not-so-distant future of technology and helping Homeland Security.
This is not funny anymore:
See also: The vibrational theory of olfaction for the win
Compare the facts to this ridiculous representation of the virus-driven evolution of human heterosexual love: VIRUS EVOLUTION ( AMAZING DOCUMENTARY)
In his science fiction novels from 1999 and 2003, Greg Bear linked what was known about biophysically constrained food energy-dependent pheromone-controlled ecological adaptations to the creation of a new more intelligent human subspecies that communicated with pheromones. They adapted to the virus-driven degradation of their messenger RNA, which has been linked from mutations to all pathology in species from archaea to non-human primates. Everything known to all serious scientists about biophysically constrained viral latency has since been placed into the context of refutations of neo-Darwinian pseudoscientific nonsense.
For a historical approach to the overwhelming ignorance of biologically uninformed theorists, see:

“The Darwin Code: Intelligent Design without God”

Perhaps the most intriguing method of gene swapping in bacteria is the bacteriophage, or bacterial virus. Bacteriophages–phages for short–can either kill large numbers of host bacteria, reproducing rapidly, or lie dormant in the bacterial chromosome until the time is right for expression and release. Lytic phages almost invariably kill their hosts. But these latter types–known as lysogenic phages–can actually transport useful genes between hosts, and not just randomly, but in a targeted fashion.

But remember that the quality of RNA begins with its energy-dependent creation and researchers recently made the claim that they had …revealed a surprising relationship between dementia and decreased quality of RNA—a key player in gene expression—in the more aged brain.
The decreased quality of the RNA has also been linked to the creation of the death gene via what is known about glioblastoma. A Harvard and MIT trained physicist reported that fact to me, and I could hardly believe how easy it was to confirm it that Abcam researchers knew about it ~20 years ago.
See: Reduced expression of brain-enriched microRNAs in glioblastomas permits targeted regulation of a cell death gene
See also: A Concise Review of MicroRNA Exploring the Insights of MicroRNA Regulations in Bacterial, Viral and Metabolic Diseases

I look forward to the day when serious scientists in the United States can report their refutations of neo-Darwinian pseudoscientific nonsense without being ostracized by claims that serious scientists exist on the fringes of what is known to all other serious scientists in the world. The virus-driven degradation of messenger RNA links mutations to all pathology, not to the evolution of one species from another.

Redox sensing controls DNA replication!

Schrodinger's answer to Schrodinger's question

There is no such thing as de novo control of electrons or self-assembly.

Answering Schrödinger’s question: A free-energy formulation

The free-energy principle (FEP) is a formal model of neuronal processes that is widely recognised in neuroscience as a unifying theory of the brain and biobehaviour. More recently, however, it has been extended beyond the brain to explain the dynamics of living systems, and their unique capacity to avoid decay.

They don’t understand the question that Schrodinger answered. He linked the anti-entropic virucidal energy of sunlight to the physiology of pheromone-controlled reproduction via what organisms eat. What they eat protects them from the virus-driven degradation of their messenger RNA. What they eat links food energy-dependent changes in base pairs from microRNA editing to RNA editing and fixation of RNA-mediated amino acid substitutions in organized genomes of all individuals of all living genera.

Schrodinger answered this question: What is life when it is not protected from virus driven entropy? (video 6:37) Published on 30 Mar 2016

Abstract:

The anti-entropic force of virucidal ultraviolet light links guanine–cytosine (G⋅C) Watson–Crick base pairing from hydrogen-atom transfer in DNA base pairs in solution to supercoiled DNA, which protects the organized genomes of all living genera from virus-driven entropy. For example, protection of DNA from permanent UV damage occurs in the context of photosynthesis and nutrient-dependent RNA-directed DNA methylation, which links RNA-mediated amino acid substitutions to DNA repair. In the context of thermodynamic cycles of protein biosynthesis and degradation, DNA repair enables the de novo creation of G protein coupled receptors (GPCRs). Olfactory receptor genes are GPCRs. The de novo creation of olfactory receptor genes links chemotaxis and phototaxis from foraging behavior to social behavior in species from microbes to humans. Foraging behavior links ecological variation to ecological adaptation in the context of this atoms to ecosystems model of biophysically constrained energy-dependent RNA-mediated protein folding chemistry. Protein folding chemistry links nutrient-dependent microRNAs from microRNA flanking sequences to energy transfer and cell type differentiation in the context of adhesion proteins, and supercoiled DNA that protects all organized genomes from virus-driven entropy.

Life that is not protected from the virus-driven degradation of messenger RNA links the reduced number of food energy-dependent microRNAs to activation of the death gene. See for example:

Reduced expression of brain-enriched microRNAs in glioblastomas permits targeted regulation of a cell death gene 

The natural contribution of food energy is linked to the endogenous level of microRNA expression seen in neuronal cells in the context of limited cell death compared control glioblastoma cells. That fact was linked to the treatment of brain cancers.

For a review of how food energy-dependent microRNAs protect the organized genomes of all living genera from the virus-driven degradation of messenger RNA that links mutations to all pathology, see:

A Concise Review of MicroRNA Exploring the Insights of MicroRNA Regulations in Bacterial, Viral and Metabolic Diseases

For a example of how human idiocy has prevented the effective treatment of all pathology, see also:

Neuropathological and transcriptomic characteristics of the aged brain

Reported as: Researchers reveal new details on aged brain, Alzheimer’s and dementia

One factor that is not always taken into account when studying gene expression in the aged brain is the quality of the genetic material itself,” says Miller. “This variable is not necessarily related to any specific pathology or disease, but these results highlight the importance of properly controlling for RNA quality when studying the aged brain and indicate that degradation of genetic material may be an underappreciated feature of neurodegeneration or dementia.

 Re: degradation of genetic material may be an underappreciated feature of neurodegeneration or dementia.

See: Cytosis

A board game taking place inside a human cell! Players compete to build enzymes, hormones and receptors and fend off attacking Viruses!