See also: Unravelling the genetic mystery behind mitochondrial disease
Mitochondrial disease is an illness that robs its sufferers of energy, and damages muscles and major organs like the brain and heart. About one in 5000 babies – or one Australian baby born each week – are born with a severe form of the disease, which can often lead to an early death.
My comment: Virus-driven energy theft of quantised energy is the cause of all pathology. That fact is not a genetic mystery. It is fact known to all serious scientists who understand why Church et al., (2015) applied for this patent RNA-Guided Human Genome Engineering.
Viruses steal the energy that all cell types require for cell-type differentiation, which links ecological variation to ecological adaptation and healthy longevity in the absence of excess nutrient-stress and/or excess social stress. Stress-linked pathology is manifested when changes in hydrogen-atom transfer in DNA base pairs in solution facilitate codon usage in codon usage that enables their proliferation and prevent cell type differentiation.
The energy stolen by viruses is quantised energy:
See: A quantum theory for the irreplaceable role of docosahexaenoic acid in neural cell signalling throughout evolution
My comment: This is not a quantum theory of neural cell signalling throughout evolution. It exemplifies what is know to serious scientists about the obvious links from ecological variation to ecological adaptation, which is nutrient-energy-dependent and pheromone-controlled in species from microbes to humans.
See also: Two fatty acyl reductases involved in moth pheromone biosynthesis 7/18/16
Studies over the last two decades have pinpointed that the epigenetic effect of pheromone-driven adaptive evolution is one of the major factors driving the successful diversification of Lepidopteran insects10. In moths, a few substitutions in critical amino acids in the key pheromone biosynthetic enzymes are sufficient to create a novel pheromone component11,12.
See also: Role of olfaction in Octopus vulgaris reproduction 1/1/15
Future work on O. vulgaris olfaction must also consider how animals acquire the odours detected by the olfactory organ and what kind of odour the olfactory organ perceives. The OL acting as control centre may be target organ for metabolic hormones such as leptin like and insulin like peptides, and olfactory organ could exert regulatory action on the OL via epigenetic effects of nutrients and pheromones on gene expression (Kohl, 2013; Elekonich and Robinson, 2000).
Kohl (2013) Nutrient-dependent/pheromone-controlled adaptive evolution: a model is also cited in Two fatty acyl reductases involved in moth pheromone biosynthesis.
In my 2013 review, I concluded:
the model represented here is consistent with what is known about the epigenetic effects of ecologically important nutrients and pheromones on the adaptively evolved behavior of species from microbes to man. Minimally, this model can be compared to any other factual representations of epigenesis and epistasis for determination of the best scientific ‘fit’.
The criticisms of my 2013 review may be of interest in the criticisms of Elaine Morgan’s works, since there is still no other model that links ecological variation to ecological adaptation.
In his Criticisms of the nutrient-dependent pheromone-controlled evolutionary model, Andrew Jones wrote:
James Kohl presents an unsupported challenge to modern evolutionary theory and misrepresentations of established scientific terms and others’ research. It was a mistake to let such a sloppy review through to be published.
Andrew Jones did not offer any other model for comparison. He seemed to think that he could support his criticisms via his claim in his thesis:
Despite their challenges, ribozymes have made an interesting niche for themselves in the field of abiogenesis. The evolution of a successful RNA polymerase ribozyme is a lofty goal. While its discovery would not be the be-all and end-all of abiogenesis research, it would represent an important stepping stone between prebiotic chemistry and life. The encapsulation of such a ribozyme is also an important step, as it would enable a system of heredity and evolution through natural selection. Based on progress in current research, it is only a matter of time before that ribozyme is discovered.
The current state of college education in the United States of American and perhaps elsewhere is reflected in the thesis by Andrew Jones as a continuation of the pseudoscientific nonsense that is used to support hypothesis-free science with claims that a system of heredity and evolution through natural selection may exist outside the context of any model that links energy-dependent changes from angstroms to ecosystems in all living genera.
See this invited review of nutritional epigenetics, for example: Nutrient-dependent pheromone-controlled ecological adaptations: from atoms to ecosystems 4/10/14
This atoms to ecosystems model of ecological adaptations links nutrient-dependent epigenetic effects on base pairs and amino acid substitutions to pheromone-controlled changes in the microRNA / messenger RNA balance and chromosomal rearrangements. The nutrient-dependent pheromone-controlled changes are required for the thermodynamic regulation of intracellular signaling, which enables biophysically constrained nutrient-dependent protein folding; experience-dependent receptor-mediated behaviors, and organism-level thermoregulation in ever-changing ecological niches and social niches. Nutrient-dependent pheromone-controlled ecological, social, neurogenic and socio-cognitive niche construction are manifested in increasing organismal complexity in species from microbes to man. Species diversity is a biologically-based nutrient-dependent morphological fact and species-specific pheromones control the physiology of reproduction. The reciprocal relationships of species-typical nutrient-dependent morphological and behavioral diversity are enabled by pheromone-controlled reproduction. Ecological variations and biophysically constrained natural selection of nutrients cause the behaviors that enable ecological adaptations. Species diversity is ecologically validated proof-of-concept. Ideas from population genetics, which exclude ecological factors, are integrated with an experimental evidence-based approach that establishes what is currently known. This is known: Olfactory/pheromonal input links food odors and social odors from the epigenetic landscape to the physical landscape of DNA in the organized genomes of species from microbes to man during their development.
In 2004, Elaine Morgan suggested it might be another 10 years before her concept of ecological adaptation gained more acceptance. If not for students like Andrew Jones, acceptance of historical works that link angstroms to ecosystems in all living genera via experimental evidence of biologically-based cause and effect would already be accepted. Until the experimental evidence is accepted and the theories are declared by all serious scientists to be ridiculous, you and your loved ones will suffer and die from virus-driven pathology. Why aren’t you already as sick of that as I am after 40 years experience as a medical laboratory scientist?