5th-6th Sept 2018 Dublin, Ireland

The eternal significance of microRNAs (7)

Sales of human pheromone-enhanced fragrance products have been virtually eliminated by the pseudoscientific nonsense touted by neo-Darwinian theorists and Big Bang cosmologists. I may revisit their ridiculous claims at ScentofEros.com and Pheromones.com, but prefer to continue moving forward via my other domains: RNA-mediated.com and Autophagy.pro.

Summary: 2018 Update: Sympatric speciation has been linked to species diversity as an example of an ecologically validated proof-of-concept in all living genera.

Theorists, other psedoscientists and nearly all so-called science journalists have failed to use common sense in their ridiculous representations.
See for example: Beating the Odds for Lucky Mutations: If DNA repair makes useful mutations more likely, it could accelerate cells’ adaptations to harsh environments (8/16/17) by Jordana Cepelewicz
See: 4/18/18 Nutrient-dependent Pheromone-Controlled Ecological Adaptations: From Angstroms to Ecosystems by James V. Kohl
My model of ecological adaptations was placed into the context of this article in Quanta Magazine by Jordana Cepelewicz — less than one year after she published her article on “lucky mutations” in Aeon.
5/10/18 A Thermodynamic Answer to Why Birds Migrate

…research makes a forceful argument that energy supply and demand is a driving ecological principle shaping the global structure of biodiversity.

See for comparison: 10/12/16 Virus-mediated archaeal hecatomb in the deep seafloor

We show here for the first time the crucial role of viruses in controlling archaeal dynamics and therefore the functioning of deep-sea ecosystems, and suggest that virus-archaea interactions play a central role in global biogeochemical cycles.

Evolutionary theorists and Big Bang cosmologists are forced to plagiarize the intellectual property of others like me and pretend that they are saying something new about the origin of all energy-dependent biophysically constrained biodiversity.
Jordana Cepelewicz is among the most serious offenders. I wonder why she thinks she can get away with directly contradicting the claims she made less than one year ago.
I have neglected some of the domains I established during the past 7 years because it became clear that pseudoscientists were not going to let people know that all aspects of sympatric speciation have been detailed in the context of food energy-dependent pheromone-controlled reproduction, which is required to biophysically constrain viral latency.
That fact was placed into the context of the cell biology game “Cytosis,” which was delivered to backers in October 2017.

A board game taking place inside a human cell! Players compete to build enzymes, hormones and receptors and fend off attacking Viruses!

See also: A transmissible RNA pathway in honey bees (2018)
The authors link my model of food energy-dependent pheromone-controlled biophysically constrained sympatric speciation from atoms to ecosystems in all living genera via my 2013 published review and my unpublished invited review of nutritional epigenetics.

Nutrient-dependent/pheromone-controlled adaptive evolution: a model (2013)

…the epigenetic ‘tweaking’ of the immense gene networks that occurs via exposure to nutrient chemicals and pheromones can now be modeled in the context of the microRNA/messenger RNA balance, receptor-mediated intracellular signaling, and the stochastic gene expression required for nutrient-dependent pheromone-controlled adaptive evolution. The role of the microRNA/messenger RNA balance (Breen, Kemena, Vlasov, Notredame, & Kondrashov, 2012; Duvarci, Nader, & LeDoux, 2008; Griggs et al., 2013; Monahan & Lomvardas, 2012) in adaptive evolution will certainly be discussed in published works that will follow.

For a historical perspective, see: Nutrient-dependent pheromone-controlled ecological adaptations: from atoms to ecosystems (2014 preprint)

Ideas from population genetics, which exclude ecological factors, are integrated with an experimental evidence-based approach that establishes what is currently known. This is known: Olfactory/pheromonal input links food odors and social odors from the epigenetic landscape to the physical landscape of DNA in the organized genomes of species from microbes to man during their development.

The facts about sympatric speciation for comparison to the neo-Darwinian pseudoscientific nonsense about mutation-driven evolution have been placed in to the context of 3 more recently published works.
A 360 degrees view of circular RNAs: From biogenesis to functions (2018)
Circular RNAs: Unexpected outputs of many protein-coding genes (2017)
The Output of Protein-Coding Genes Shifts to Circular RNAs When the Pre-mRNA Processing Machinery Is Limiting (2017)
It is no longer possible to successfully put the facts about sympatric speciation back into the context of ridiculous theories about the emergence of energy and evolution of all life on Earth. Anyone who returns to the links or to the published works I have posted here, will realize that pseudoscientists and most so-called science journalists know virtually nothing about food energy-dependent RNA-mediated cell type differentiation in any species.

Alternative splicing of pre-mRNA

Energy-dependent epigenetic translation to mRNA stability (5)

Energy-dependent epigenetic translation to mRNA stability (4)
From Fertilization to Adult Sexual Behavior

Small intranuclear proteins also participate in generating alternative splicing techniques of pre-mRNA and, by this mechanism, contribute to sexual differentiation in at least two species, Drosophila melanogaster and Caenorhabditis elegans….

See also: The Supraspliceosome – A Multi-Task Machine for Regulated Pre-mRNA Processing in the Cell Nucleus
Abstract conclusion:

…changes in these regulatory processing activities are associated with human disease and cancer. These findings emphasize the supraspliceosome as a multi-task master regulator of pre-mRNA processing in the cell nucleus.


…the initiator-tRNA species proposed to participate in SOS reside in the cell nucleus, are found associated with supraspliceosomes (Table 2c), and appear not to be charged with an amino acid [87].

Energy-dependent regulation of the supraspliceosome and RNA-mediated amino acid substitutions is charge-regulated and the change in the charge must be linked to fixation of the amino acid substitution in the organized genomes of all living genera before energy can be linked to biologically-based cause and effect via what is known to all serious scientists about how the physiology of reproduction must be linked to biodiversity.
The changes in the supraspiceosome must then be linked from chromosomal rearrangements to morphological and behavioral diversity.
See also: New study helps solve a great mystery in the organization of our DNA, which is a report on this peer-reviewed published work: Targeted Degradation of CTCF Decouples Local Insulation of Chromosome Domains from Genomic Compartmentalization

Beyond defining the functions of CTCF in chromosome folding, these results provide new fundamental insights into the rules governing mammalian genome organization.

My summary: The rules integrate what is known about energy-dependent adenosine to inosine RNA editing. See: Divergent prebiotic synthesis of pyrimidine and 8-oxo-purine ribonucleotides
Prebiotic synthesis starts with the sun’s anti-entropic virucidal energy.
See: Common origins of RNA, protein and lipid precursors in a cyanosulfidic protometabolism
RNA biosynthesis is energy-dependent and an endogenous substrate appears to be the link from sunlight to protometabolism. By starting from protometabolism, it is easy to link the energy from the innate immune system to polycombic ecological adaptations in all living genera via the physiology of reproduction.
See also: Polycomb Regulates Mesoderm Cell Fate-Specification in Embryonic Stem Cells through Activation and Repression Mechanisms

little is known about the mechanistic underpinnings of how differently composed Polycomb complexes instruct and maintain cell fate. Here we find that Mel18, also known as Pcgf2 and one of six Pcgf paralogs, uniquely regulates PRC1 to specify mesoderm cell fate in embryonic stem cells. Mechanistically, Mel18 functions as a classical Polycomb protein during early cardiac mesoderm differentiation by repressing pluripotency, lineage specification, late cardiac differentiation, and negative regulators of the BMP pathway. However, Mel18 also positively regulates expression of key mesoderm transcription factors, revealing an unexpected function of Mel18 in gene activation during cardiac differentiation. Taken together, our findings reveal that Mel18 is required to specify PRC1 function in both a context- and stage-specific manner.

The context- and stage-specific links from polycombic ecological adaptation are nutrient energy-dependent and the regulation of polycombic ecological adaptations is biophysically constrained by the pheromone-controlled physiology of reproduction in all living genera.
See: Polycombic ecological adaptation as a science, not a theory
See also: Polycombic ecological adaptation as a science, not a theory (2)
See also: Search Results for “Polycombic ecological adaptation
For contrast, see: Is inference the best way to explain the origin of consciousness?

This conversation is connected to: Consciousness is not a thing, but a process of inference

My comments:

  1. Excerpt: “On this view, a loss of consciousness occurs whenever our models lose their ‘thickness’ and become as ‘thin’ as a virus’s.”

Consciousness is energy dependent and biophysically constrained by the ability of organisms to find food and reproduce. Consciousness is manifested as increasing organismal complexity in the context of links from quantum consciousness to quantum souls.

The fact that it took only one journalist to expose all the others who have not asked the right questions about consciousness so that the questions could be answered in the context of what is known to all serious scientists about virus-driven energy theft and all pathology is revealed here, and in the first interview from the week before.

Superbugs, Bacteriophages and Phage Therapy: An Interview with James Kohl

2. I just placed the essay on “Consciousness” into the context of “snake centric” evolution after scanning two published works by the author [Friston, Karl J.]

1) Top-Down Control of Visual Responses to Fear by the Amygdala http://www.jneurosci.org/content/33/44/17435.abstract

2) Bayesian inferences about the self (and others): A review http://www.sciencedirect.com/science/article/pii/S1053810014000105

See also: “Isbell calls these findings “the first neuroscientific support” for her snake-centric evolutionary theory.” excerpted from http://news.sciencemag.org/evolution/2013/10/did-snakes-help-build-primate-brain

For comparison see:

“Science is the belief in the ignorance of experts” — Richard Feynman

Feynman supported the efforts of those who laugh at ‘experts,’ especially when the experts are not among the serious scientists who were forced to link ecological variation to energy-dependent ecological adaptation in the context of what is now known about how to link food energy-dependent changes from angstroms to ecosystems in all living genera via feedback loops and the pheromone-controlled physiology of reproduction.

In “The Pleasure of Finding Things Out,” (see pages 124 and 125 for a summary) Richard Feynman presciently predicted that the ability to see interactions at the level of atomic energy would link quantized energy from sunlight to photosynthesis and pattern recognition by biologists, who would then link quantum physics from chemistry to the growth and movement of all organisms on Earth.
See also:

This comment was posted to my FB group on April 17, 2017

1) The findings reveal similarities and differences with a recently published report on the IP3R using a completely different method called cryo-electron microscopy.

2) The team identified an amino acid sequence in the leaflet that is conserved in parasites, suggesting structural insights that may assist in drug discovery for these devastating conditions.

By identifying the amino acid sequence, they inadvertently linked natural selection for energy-dependent codon optimality to all biodiversity via the biophysically constrained physiology of reproduction in the context of hydrogen-atom transfer in DNA base pairs in solution.

See also Cryo-EM reveals a novel octameric integrase structure for betaretroviral intasome function as cited in:The Origin of Information: How to Solve It

Search Results for “hydrogen-atom transfer in DNA base pairs”

See also: Energy-dependent epigenetic translation to mRNA stability (5)