Adenosine triphosphate (ATP) is the most common high energy intermediate of living organisms. Cells utilize the energy derived from the breakdown of cellular fuels to synthesize ATP from ADP and inorganic phosphate. The free energy released from ATP hydrolysis is then used to sustain various cellular functions such as growth, movement, and response to the environment. Mammalian cells tightly regulate production and consumption of ATP – i.e. supply and demand are balanced to maintain intracellular ATP levels quite constant. Therefore, measuring the rate of ATP production enables a view into cellular function that is not provided by simply measuring the amount of ATP in the cell. The Agilent Seahorse XF Real-Time ATP Production Rate Assay quantifies ATP Production Rates from mitochondrial respiration and glycolysis in real time with live cells providing a unique insight into cellular phenotype and function.
…respiration and acidification changes upon addition of the thiazoldinediones were cell-type specific, with the rank order of mitochondrial impairment in whole cells being in accord with the known adverse effects of these drugs.
…this chapter also provides a detailed accounting of proton production during glucose oxidation in the context of plate-based assays.
Difference in proton production link differences in the energy of photons from the proton motive force and proton gradients to energy-dependent RNA-mediated cell type differentiation.
Pseudoscientists and other theorists complain about so-called predatory publishing and use their complaints to attack anyone who does not “toe the line” of dogmatic consensus. See for example: OMICS Publishing Group
See also: Prominent Cell Biologist Fired After Data Manipulation Investigation
The University of Tokyo confirmed last August that Yoshinori Watanabe tampered with research-related images, and dismissed him in late April.
Artificial restoration of the ICS network suppresses chromosome segregation errors in a wide range of CIN+ cells, including RB- and BRCA1-deficient cells. Thus, dysfunction of the ICS network might be a key mechanism underlying CIN in human tumorigenesis.
Food energy-dependent RNA-interference has since emerged as an effective treatment for all chromosomal instability, which appears to be caused by the virus-driven theft of quantized energy.
Additional details about energy-dependent healthy longevity will be found in the Science Behind the Game Subatomic which will link biophysically constrained viral latency from Cytosis to all biophysically constrained biodiversity via what organisms eat and the physiology of their pheromone-controlled reproduction.
See also: New EU-wide tests to tackle ‘food apartheid’
…recent comparisons of food samples showed that big Western brands use cheaper ingredients in products sold in former communist countries.
We’ve begun developing support materials for teachers and students to help them use ‘Darwin’s Demons’ to demonstrate and teach evolutionary concepts.
A National Science Foundation grant for evolution studies helped pay for the project.
Conclusion:
Adaptation, if anything, demonstrates intelligent design, not Darwinism. Of course they won’t tell you that at the University of Idaho, or most anywhere else. Instead they’ll stick you in front of a video game and tell you the stale, old fable.
Ecological models of food energy-dependent pheromone-controlled biophysically constrained adaptations have replaced evolutionary concepts except within the school system of the US and other backward countries. See: Israeli Middle Schools School to Include Theory of Evolution
…learning about evolution is not the primary function of the decision, but rather to use it as a building block for students to learn more about their ecology.
All serious scientist know the difference between evolution and adaptation.
See: Are Evolution and Adaptation the Same? (2018)
The energy-dependent de novo creation of the cell links ATP to RNA biosynthesis and the physiology of reproduction via food odors and pheromones in the context of this board game.
Cytosis is a worker placement game that takes place inside a Human Cell! Players utilize the organelles within a cell to collect cellular resources such as mRNA from the Nucleus, Lipids from the Smooth E.R., ATP from the Mitochondria, etc. and score points when they use these resources to complete Hormones, Receptors or Enzymes!
It refutes neo-Darwinian pseudoscientific nonsense by starting with Darwin’s energy-dependent “conditions of life.”
12/24/17 What are your insights into CRISPR and mTOR, for a young audience? I’m not mocking you…yet, Humpty Dumpty. What is the basis of your unifying principle? Vibration? Bohmian morphogenetic fields? Modified Darwin? God? –Nik Willmore @nikwillmore
God created the anti-entropic virucidal energy of sunlight and all energy-dependent biodiversity via the physiology of pheromone-controlled reproduction. I co-authored a book about that for a young audience in 1995/2002, and a 6-part series for http://RNA-mediated.com today.
Do you understand any aspect of how to model biophysically constrained biologically-based energy-dependent top-town causation and bottom-up effects on cell type differentiation via the physiology of reproduction and autophagy? The “walking fish” walks straight from quantum physics to quantum souls (2)
RNA interference (RNAi) is our indispensable antiphage defense mechanism. Viruses escape the defense system by the theft of quantized energy, which encodes RNAi suppressors that prevent elimination of viral RNAs. The suppressors ensure energy-dependent virus accumulation.
The significantly altered pathways mainly include the mitogen-activated protein kinase signaling pathway, cell adhesion molecules, chemokine signaling pathway, cytokine-cytokine receptor interaction, circadian rhythm-mammal, mineral absorption, protein processing in the endoplasmic reticulum, proximal tubule bicarbonate reclamation, vasopressin-regulated water reabsorption, and arachidonic acid metabolism. In conclusion, hcmv-miR-UL112 could serve as a potential biomarker, and the miRNA-mediated regulation of signaling pathways might play significant roles in the physiological effects of hcmv-associated diseases.
We conclude that miR-HA-3p is the first identified influenza virus-encoded microRNA-like functional RNA fragment and a novel virulence factor contributing to H5N1-induced ‘cytokine storm’ and mortality.
The major antigenic changes of the influenza virus are primarily caused by a single amino acid near the receptor binding site.
The serious scientists do not claim that viruses evolve. Scientists who make claims about evolution typically do not know how to link the creation of sunlight from ecological variation to food energy-dependent pheromone-controlled ecological adaptation via the physiology of biophysically constrained reproduction and biophysically constrained viral latency. Indeed, most pseudoscientists do not know the difference between a mutation and an RNA-mediated amino acid substitution.
See for comparison: Mechanisms of Recombination conference Start: Sunday, May 20, 9.00am Finish: Tuesday, May 22, 6.45pm
Description
Genetic recombination provides an important mechanism for the repair of chromosome breaks caused by DNA damage or replication fork demise. Defects in the recombination process have been linked to cancer predisposition, in particular breast cancers caused by mutations in BRCA1, BRCA2 and PALB2, and also acute leukemias associated with the rare genetic disease Fanconi anemia. Understanding precisely how recombination occurs is of interest to workers in the fields of meiosis, DNA repair, replication, chromosome architecture and interactions, and chromatin biology.
Douglas Bishop (University of Chicago, US)
A primary function of the ATPase activity of E. coli RecA is to prevent accumulation of a toxic form of the protein bound to undamaged chromosomal sites
Maria Jasin (Memorial Sloan Kettering Cancer Center, US)
Protecting the genome by homologous recombination
The energy-dependent microRNA-mediated creation of enyzmes protects all organized genomes from the virus-driven degradation of messenger RNA that links the theft of quantized energy from mutations to all pathology. Pseudoscientists who do not start with the creation of energy, have bastardized Darwin’s claims. His claims were based on placing “conditions of life” before natural selection. Conditions of life are energy-dependent and biophysically constrained by the mechanisms of pheromone-controlled recombination, which have been linked to autophagy by all serious scientists since 1925.
See also my RNA-mediated Facebook page and/or my RNA-mediated Facebook group and other tweets @jvkohl
The number of my tweet impressions since December 21, 2017 has climbed to more than 68,000 as the number of published works that mention “microRNA” has climbed to nearly 69,000. See for comparison: The tipping point (revisited): 68,000 publications, which was published to my other blog site on December 21, 2017.
See also: What Darwinists Fail to Consider (discussion attempt)
See also, this discussion attempt about the “spark of life.”
See also: Noncoding RNA Helps Cells Recover from DNA Damage
“The most logical, simple explanation is that the [noncoding RNA] counteracts the protein encoding form…”
The failure to integrate the Nobel Prize winning works of Ben Feringa (Chemisty 2016) and Yoshinori Ohsumi (Physiology or Medicine 2016) prevents theorists from linking what organisms eat to their pheromone-controlled physiology of reproduction in the context of Schrodinger’s claims in “What is Life?”(1944) and this claim by Roger Penrose in the reprint edition:
“How often do we still hear that quantum effects can have little relevance in the study of biology, or even that we eat food in order to gain energy?” (Roger Penrose 8 August 1991)
Small intranuclear proteins also participate in generating alternative splicing techniques of pre-mRNA and, by this mechanism, contribute to sexual differentiation in at least two species, Drosophila melanogaster and Caenorhabditis elegans…
The food energy that is linked from alternative splicing techniques of pre-mRNA to the chemistry of protein folding and the pheromone-controlled physiology of reproduction in all living genera seems to be largely ignored by those who are not Nobel Laureates.
Summary: I suspect that John Hewitt will soon publish an article on the energy-dependent creation of microRNAs and enzymes. He is most likely to link the virus-driven theft of quantized energy as information to all pathology without challenging pseudoscientists and other science journalists to revise their ridiculous claims about mutation-driven evolution. Digital medicine, on its way to being just plain medicine
There are already nearly 30,000 peer-reviewed English-language scientific journals, producing an estimated 2.5 million articles a year.
“Loss of EXD2 results in defective mitochondrial translation, impaired respiration, reduced ATP production…” and “…aberrant association of messenger RNAs with the mitochondrial ribosome.
Exonuclease 3′ –5′ domain-containing 2 (EXD2) is a mitochondrial ribonuclease. A ribonuclease is a type of nuclease that catalyzes the degradation of RNA into smaller components such as microRNAs. A nuclease is an enzyme capable of cleaving the phosphodiester bonds between monomers of nucleic acids. EXD2 is required for mitoribosome integrity and efficient mitochondrial translation.
See: The Excitable Mitochondria by John Hewitt, who brought the article on EXD2 to my attention in his tweets. The link from energy-dependent changes in EXD2 to homeostasis predicts the link from reduced ATP production to the virus-driven degradation of EXD2 to the aberrant associations that link mutations in messenger RNA to all pathology. I suspect that John Hewitt will soon publish an article on the energy-dependent creation of microRNAs and enzymes. He is most likely to link the virus-driven theft of quantized energy as information to all pathology without challenging pseudoscientists and other science journalists to revise their ridiculous claims about mutation-driven evolution. Challenging your peers leads to your elimination from consideration. Your peers cannot rise to the ocassion and meet the challenge, so they must ignore you.
As I finalize this series on enzyme-constrained interethnic diversity, I also offer information from my largely ignored FB posts on the anniversary dates indicated: January 10, 2017
“This is science at its best, with adventure, ideas, and lots of facts”. — Helen Fisher
“A treasure hunt through history, literature, and scientific data”. — Gina Ogden
On pages 160-162 of “The Scent of Eros” (1995/2002) we linked race and ethnicity to all biodiversity via the same model of biologically-based cause and effect. It is still the only valid model.
What exactly do people think was still being debated about the fact that all organisms must eat to reproduce, or that pheromones control the physiology of reproduction in all living genera?
How could race and ethnicity not be aspects of a valid model of biologically-based cause and effect unless pseudoscientists convinced you to believe in mutation-driven evolution?
January 10, 2016
This serves as a reminder to all sex researchers. Most of them understand nothing about how RNA-mediated sex differences in cell types are linked to sex differences in #behavior by nutrient-dependent amino acid substitutions.
They refused to accept the fact that the pheromone-controlled physiology of reproduction and chromosomal rearrangements link the molecularepigenetics of cell type differentiation in all cell types of all individuals of all species from microbes to humans.
Xistential crisis: Discovery shows there’s more to the story in silencing X chromosomes
Xist is widely believed to be both necessary and sufficient for X silencing,” … “We for the first time show that it’s not sufficient, that there have to be other factors, on the X-chromosome itself, that activate Xist and then cooperate with Xist RNA to silence the X-chromosome.
An example of how 20 years of ignorance about RNA-mediated cell type differentiation leads to “NEW” discoveries.
From Fertilization to Adult Sexual Behavior 1996
Genomic-imprinting is also manifest in specific parts of the X-inactivation region’s related XIST gene. Here male- and female-specific methyl-group patterns participate in X-inactivation in females and also in the preferential inactivation of the paternal X in human placentae of female concepti (Harrison, 1989; Monk, 1995). This process indicates that tissues of the early conceptus can sense and react differentially to epigenetic sexual dimorphisms on the female conceptus’ own two X chromosomes. Furthermore, variations of X-inactivation patterns often account for traits discordance in monozygotic twin females. In other words, they are often found to have nonidentical patterns of X-inactivation, yielding differing expression of noticeable X-linked traits (Machin, 1996). January 10, 2017
Professor PZ Myers hates Christianity. Nor is he a big fan of my good friend, Ken Ham.
In writing about his hatred, PZ unwittingly showed his hand when he said,
“I reject his notion of sin — the idea that there is some kind of divine law against which we can transgress — but humanists do not deny that we can do wrong and we can do harm. We think we should do better, not to appease some vengeful deity, but because it improves our lives and helps make those around us happier and better able to live up to their potential. We certainly do accept that death is inevitable, but not because we are wicked — the wicked often seem to flourish while the good may die young. Are we to measure the virtue of human beings by their longevity? Charles Manson is 82, and surely destined to join the saints in heaven, while every infant death must open a chute directly to hell for its wicked soul.”
His hatred is perfectly in line with the Bible:
“Because the carnal mind is enmity against God; for it is not subject to the law of God, nor indeed can be” (Romans 8:7).
PZ is unashamedly godless (a state the Bible refers to as “carnal”), and so his mind is at “enmity” against God. That means he is in a continual state of hostility towards his Creator. That certainly is true. Even though he doesn’t believe that He exists, but he contemptuously hates the very thought of “a god.”
But look at the pinpoint accuracy of the Scriptures:
“…for it [our carnal mind] is not subject to the law of God, nor indeed can be.”
His hatred is directed at the “law of God,”–the moral Law (the Ten Commandments).
PZ is like a criminal who hates the police, not because of who they are individually, but because of what they represent. They stand for the law–that which is right and good, and that is offensive to someone who loves and lives for crime.
PZ’s railings about his loved ones dying is tragic, but peripheral. They are not the main reason why he is angry.
His anger is primarily at God and His Law, because he doesn’t like being told what to do. Like you and I before we came to Christ, he loves his sin, and he who loves the darkness hates the light.
I’m not sure why PZ called Charles Manson “wicked,” when his atheistic worldview doesn’t allow for anyone to be “wicked.”
Or could it simply be that Manson transgressed the moral Law, which says “You shall not kill,” and PZ intuitively knows that, because of his God-given knowledge of right and wrong (see Romans 2:15).
It’s actually heartening to see him using his moral compass. If he would put down his weapons and study how God’s moral compass is infinitely higher, he may rethink his rejection of “The soul who sins, shall die.”
This is because every death is sobering evidence of the truth of that verse.
You can see PZ in action in our movie “Evolution vs God” (over 2 million views) at www.FullyFreeFilms.com
P.S. PZ hates the movie.
Now, a study shows that following the formation of DNA double-strand breaks, bidirectional transcription events adjacent to the break generate small RNAs that trigger the DNA damage response by local RNA:RNA interactions.
The RNA:RNA interactions are energy-dependent and they link the creation of microRNAs to the creation of enzymes, receptors, and hormones that protect organized genomes from virus-driven energy theft and all pathology. But they are not just RNA:RNA interactions. The interactions among microRNAs and messenger RNA link food energy and the pheromone-controlled physiology of reproduction to all biodiversity on Earth without the pseudoscientific nonsense touted by biologically uninformed theorists and science journalists such as Ed Yong and Carl Zimmer.
Anything that is relatively simple and inexpensive to implement in at-risk populations is not likely to be accepted by most politicians.
It would not be rejected by the CDC — if funding documentation excluded the words that the current director reportedly recently recommended be excluded.
Instead of comparing Trump to Hitler, use of Tai Chi would be examined in the context of protection from the virus-driven degradation of messenger RNA that causes all pathology. The cure for PTSD and suicide prevention would then more readily be linked from the sun’s anti-entropic virucidal energy to all healthy longevity via the energy-dependent de novo creation of food energy-dependent microRNAs that protect us all from activation of the death gene in the context of autophagy.
Optimized food energy-dependent autophagy, which is the most likely cure for brain cancer and all other cancers, would be an added benefit — especially for veterans who return from military service overseas.
The free-energy principle (FEP) is a formal model of neuronal processes that is widely recognised in neuroscience as a unifying theory of the brain and biobehaviour. More recently, however, it has been extended beyond the brain to explain the dynamics of living systems, and their unique capacity to avoid decay.
They don’t understand the question that Schrodinger answered. He linked the anti-entropic virucidal energy of sunlight to the physiology of pheromone-controlled reproduction via what organisms eat. What they eat protects them from the virus-driven degradation of their messenger RNA. What they eat links food energy-dependent changes in base pairs from microRNA editing to RNA editing and fixation of RNA-mediated amino acid substitutions in organized genomes of all individuals of all living genera.
The anti-entropic force of virucidal ultraviolet light links guanine–cytosine (G⋅C) Watson–Crick base pairing from hydrogen-atom transfer in DNA base pairs in solution to supercoiled DNA, which protects the organized genomes of all living genera from virus-driven entropy. For example, protection of DNA from permanent UV damage occurs in the context of photosynthesis and nutrient-dependent RNA-directed DNA methylation, which links RNA-mediated amino acid substitutions to DNA repair. In the context of thermodynamic cycles of protein biosynthesis and degradation, DNA repair enables the de novo creation of G protein coupled receptors (GPCRs). Olfactory receptor genes are GPCRs. The de novo creation of olfactory receptor genes links chemotaxis and phototaxis from foraging behavior to social behavior in species from microbes to humans. Foraging behavior links ecological variation to ecological adaptation in the context of this atoms to ecosystems model of biophysically constrained energy-dependent RNA-mediated protein folding chemistry. Protein folding chemistry links nutrient-dependent microRNAs from microRNA flanking sequences to energy transfer and cell type differentiation in the context of adhesion proteins, and supercoiled DNA that protects all organized genomes from virus-driven entropy.
Life that is not protected from the virus-driven degradation of messenger RNA links the reduced number of food energy-dependent microRNAs to activation of the death gene. See for example:
The natural contribution of food energy is linked to the endogenous level of microRNA expression seen in neuronal cells in the context of limited cell death compared control glioblastoma cells. That fact was linked to the treatment of brain cancers.
For a review of how food energy-dependent microRNAs protect the organized genomes of all living genera from the virus-driven degradation of messenger RNA that links mutations to all pathology, see:
One factor that is not always taken into account when studying gene expression in the aged brain is the quality of the genetic material itself,” says Miller. “This variable is not necessarily related to any specific pathology or disease, but these results highlight the importance of properly controlling for RNA quality when studying the aged brain and indicate that degradation of genetic material may be an underappreciated feature of neurodegeneration or dementia.
Re: degradation of genetic material may be an underappreciated feature of neurodegeneration or dementia.
Conclusion: Serious scientists can explain every aspect of energy-dependent biophysically constrained viral latency in the context of details about these pathways and everything that links changes from electrons to ecosystems in all living genera. Why are the serious scientists still challenged by “…the tendency of academia to reject any academic-like work from outside academia?” What aspect of the academic contribution that could lead to the cure for all pathology do biologically uninformed academics want to continue to reject and attack?
See: Creating genes and species
The “Cassandra syndrome” theme prevails throughout the history of all serious scientists. They are cursed with being able to predict the future because they are always disbelieved.
In a new opinion paper, published online Nov. 14 in the journal Trends in Cognitive Sciences, researchers proposed that this swelling and shrinking of the brain is a Darwinian process.
If you don’t understand the foundational level, then you can do brain imaging until you’re blue in the face, but you still will not understand the process at a deep causal level. — Dr. Jaak Panksepp, Author of Affective Neuroscience: The Foundations of Human and Animal Emotions
The foundational level is food energy-dependent. See RNA-mediated.com or the FB group RNA mediated.
See the missing foundational level extended from a Darwinian process of swelling and shrinking of the brain to claims about human evolution. From the Human Ethology Yahoo Group moderated by Jay Feierman. “Human evolution was uneven and punctuated, suggests new research
…this process was not a straightforward, smooth one – instead, it seems to have been punctuated, with different evolutionary patterns in different geographical regions.
More than 1300 hemoglobin variants attest to the obvious fact that evolutionary theorists cannot recognize any pattern that links food energy from what humans eat to the biophysically constrained pheromone-controlled physiology of reproduction. They ignore every aspect of food energy-dependent RNA-mediated amino acid substitutions, which protect all organized genomes from the virus-driven degradation of messenger RNA. The degradation of messenger RNA links mutations to all pathology.
See for examples of food energy-dependent pathology prevention: HbVar: A Database of Human Hemoglobin Variants and Thalassemias
To place food energy-dependent prevention of pathology into the perspective of difference in primates, see:
The Cassandra Effect describes the tendency of academia to reject any academic-like work from outside academia and that the more “academic” the contribution, the more strongly it is rejected and attacked.
This is the accurate representation of food energy-dependent pheromone-controlled learning and memory that has consistently been attacked or ignored since the time we published our 1996 Hormones and Behavior review. In our section on molecular epigenetics, we wrote:
Yet another kind of epigenetic imprinting occurs in species as diverse as yeast, Drosophila, mice, and humans and is based upon small DNA-binding proteins called “chromo domain” proteins, e.g., polycomb. These proteins affect chromatin structure, often in telomeric regions, and thereby affect transcription and silencing of various genes (Saunders, Chue, Goebl, Craig, Clark, Powers, Eissenberg, Elgin, Rothfield, and Earnshaw, 1993; Singh, Miller, Pearce, Kothary, Burton, Paro, James, and Gaunt, 1991; Trofatter, Long, Murrell, Stotler, Gusella, and Buckler, 1995). Small intranuclear proteins also participate in generating alternative splicing techniques of pre-mRNA and, by this mechanism, contribute to….
Alternative splicing techniques of pre-mRNA have since been linked to every aspect of cell type differentiation in all individuals of all species. The pre-mRNAs are called microRNAs and detailed examples of how food energy-dependent changes in the microRNA/messenger RNA balance can be linked to what has been known about RNA-mediated cell type differentiation to serious scientists. For example, serious scientists know that all changes in the microRNA/messenger RNA balance are energy-dependent. No changes are random. All changes are biophysically constrained. The changes constrain viral latency. That fact has been established in more than 67,000 indexed published works.
What do theorists do when they are repeatedly presented with overwhelming experimental evidence that links food energy-dependent microRNAs to refutation of all their ridiculous theories and all the pseudoscientific nonsense of neo-Darwinian evolution?
“Variation is not nutrient availability and the something that is doing the selecting is not the individual organism. A feature of an educated person is to realize what they do not know. Sadly, you don’t know that you have an incorrect understanding [of] Darwinian biological evolution.”
The microRNA gene targets, gene ontology, annotations and pathways were identified through various bioinformatics tools. Additionally, the pathways were mostly found common to “ubiquitin mediated proteolysis”, “cytokine signaling”, “maintenance of barrier function/cell junctions”, JAK/STAT pathway” “Toll-like receptor signaling”, “Wnt-signaling”, “adhesion molecules”, “apoptosis”, “endocytosis”, “vesicle mediated transport” etc.
Serious scientists can explain every aspect of energy-dependent biophysically constrained viral latency in the context of details about these pathways and everything that links changes from electrons to ecosystems in all living genera. Why are the serious scientists still challenged by “…the tendency of academia to reject any academic-like work from outside academia?” What aspect of the academic contribution that could lead to the cure for all pathology do biologically uninformed academics want to continue to reject and attack?
Summary: Food odors and pheromones biophysically constrain all pathology in species from microbes to humans. What kind of biologically uninformed science idiot leaves out everything known to serious scientists about the virus-driven degradation of messenger RNA and tells others they must falsify the neutral null theory that led to claims about a biophysically constrained beneficial “null mutation” in the Amish population of Berne, Indiana? Glutamylation Regulates Transport, Specializes Function, and Sculpts the Structure of Cilia
Reported as: How to Control Traffic on Cellular Highways
Reported in: How to control traffic on cellular highways http://neurosciencenews.com/enzyme-transportation-7915/
A gene variant that arose decades ago in an Amish group…
All gene variants are quantized energy-dependent and the pheromone-controlled physiology of reproduction protects all organized genomes from the virus-driven degradation of messenger RNA. The degradation of messenger RNA links mutations to all pathology. Any claim that “a gene variant arose” is a claim made by a biologically uninformed science idiot. Gene variants in humans are biophysically constrained by the availability of food energy. Other humans may not know that.
Watch and listen to Richard P. Feynman presciently claim that the “null mutation” theory of healthy longevity is an example of “human idiocy.”
“Using molecular modeling, the US-Canadian team of Travis Craddock, Stuart Hameroff and Jack Tuszynski had previously shown anesthetic binding in ‘quantum channels’, non-polar arrays of amino acid pi resonance clouds, winding through microtubules.”
The same kinds of amino acid substitutions that control the separations and interactions of side chains in fluorescent proteins also play an essential role in tuning the proposed mechanism for vibration detection—inelastic electron tunneling. Life literally runs on electron tunneling through the respiratory chain complexes in mitochondria.
For comparison, see the conclusion to: Quantized Energy Links Olfaction from Angstroms to Ecosystems Part 2
Beneficial “null mutations” can now be placed into the context of the creation of a universe that — with or without us — is always watching, like Santa Claus.
For a historical perspective on that pseudoscientific nonsense, see: Splendor and misery of adaptation, or the importance of neutral null for understanding evolution
To claim adaptation, the neutral null has to be falsified.
…specific, volatile, and zoosocial important chemosignals are a promising approach both to modeling posttraumatic stress disorders in humans [36] and to searching for mehods of their treatment.
Humans also have various pheromone-induced physiological effects, especially those associated with reproduction [46, 47]. This suggests that the human olfactory system is still an effective pathway for influencing environmental factors on the human nervous
system.
The assessment of genomes’ integrity plays the key role in the studies of mutagenicity in a polluted environment. We present a step-by-step recommendations for the analysis of the cytogenetic data and discuss the prospects of applying genetic tests for ecological monitoring, based on the example of analysis using crustacean species.
I suspect that the manufacturer of my human pheromone-enhanced fragrance products asked to speak with me next week due to the all-to-obvious link from human pheromones to biophysically constrained viral latency and the prevention of all pathology, which was detailed in the context of the creation of sunlight, which was subsequently linked from the creation of ATP to the creation of RNA. Pheromones and the luteinizing hormone for inducing proliferation of neural stem cells and neurogenesis
The last time I spoke with him, he asked how to monetize the facts. Bergdhal’s pathology may have prompted renewed interest. Attempts to discuss that fact with other veterans have failed. I think that some of them would rather see him crucified rather than link the energy-dependent weekend resurrection of the bacterial flagellum in P. fluorescens to the the energy-dependent Resurrection of Christ.
Bergdhal’s pathology can also be placed into the context of the problematic transitions from adolescence to adulthood that are altered by fixation of one energy-dependent RNA-mediated amino acid substitution.
See: Oppositional COMT Val158Met effects on resting state functional connectivity in adolescents and adults
The A or Met allele is associated with lower enzymatic activity and the polymorphism is associated with many different personality traits. The USAF is leading the way forward towards effective treatment of mental disorders in veterans, which is something the psychiatrists who evaluated Bergdhal know about. See for instance: US Air Force Studying Impact of Exome Sequencing in Routine Care
Summary: Not only does everything known to serious scientists about energy link RNA synthesis to life, everything McEwen and others have published links nutrient stress and/or social stress to the virus-driven degradation of messenger RNA and all pathology.
As moderator of the International Society for Human Ethology (ISHE), a not-for-profit scientific organization that consistently touts pseudoscientific nonsense in the context of neo-Darwinian evolution, Jay R. Feierman’s attacks on the works of serous scientists are increasing in frequency and in magnitude. Yesterday, he posted this link to a series of 25 lectures by Robert Sapolsky. You could spend ~25 hours to learn what Sapolsky was teaching to students until 2011, or ignore everything he has claimed because he has been teaching atheistic pseudoscientific nonsense in the context of neo-Darwinian theory.
Although all mutational types have worked in concert with evolutionary forces to generate the current human brain, in this review we will explore the impact of mobile elements…
Robert Sapolsky may be responsible for many of these ridiculous reports on the evolving primate brain. Sapolsky studied under Bruce McEwen, but Sapolsky failed to link energy as information from an endogenous substrate in all cell types to the light-activated creation of ATP and the creation of RNA in microbes like P. fluorescens.
With exposure to ultraviolet light, this species (P. fluorescens) fluoresces. The weekend resurrection of the bacterial flagellum was also reported in this species. The energy-dependent physiology of pheromone-controlled reproduction links the creation of the sun from the creation of ATP and the creation of RNA to the weekend resurrection of an irreducibly complex functional structure and all biophysically constrained biodiversity on Earth via McEwen et al., (1964). Dependence of RNA synthesis in isolated thymus nuclei on glycolysis, oxidative carbohydrate catabolism and a type of “oxidative phosphorylation”
Not only does everything known to serious scientists about energy link RNA synthesis to life, everything McEwen and others have published links nutrient stress and/or social stress to the virus-driven degradation of messenger RNA and all pathology.
Sapolsky is reported to be an atheist in a Wikipedia entry. That should not matter to anyone who is capable of linking quantized energy from the sense of smell in bacteria to our visual perception of mass and energy in the context of the space-time continuum. See: Olfaction Warps Visual Time Perception But, for those of us who have followed McEwen’s lead, and done that, Sapolsky’s lectures attest to his atheistic ignorance of biologically-based cause and effect.
His lectures can be viewed as examples of the human idiocy that Feynman mentioned in the context of the different measures used to make claims about energy as information. The origin of information still appears to come from the sun despite the fact that Feynman used the example of food energy. The history of publications on how the virus-driven energy theft of quantized energy has been linked from mutations to all pathology now includes information about how human endogenous retroviruses must be biophysically constrained.
The information is linked from energy as information to the physiology of pheromone-controlled reproduction in Bombyx mori to the control of cellular processing in mammals by everything I have published since 1995 and everything known about the creation of the innate immune system in bacteria (CRISPR). The works of those who claim that the emergence of energy and “evolution did it” can be compared to the works of serious scientists.
See for examples: Human pheromones and food odors: epigenetic influences on the socioaffective nature of evolved behaviors (2012) Transposable-element associated small RNAs in Bombyx mori genome (2012) Endogenous MOV10 inhibits the retrotransposition of endogenous retroelements but not the replication of exogenous retroviruses (2012) Control of mammalian retrotransposons by cellular RNA processing activities (2014) Protein-Coding Genes’ Retrocopies and Their Functions (2017) Identification and characterization of two putative microRNAs encoded by Bombyx mori cypovirus (2017)
This is the first report that an insect double stranded RNA virus may generate miRNAs and the results obtained will benefit the future study of the functions of BmCPV-encoded miRNAs on viral replication and virus-host interaction.
Independently of Butenandt & Hecker (14, 50), the fractionation of Bombyx extracts and purification of the pheromone was also reported on by Makino et at. (71).
Effects of Carnitine on Fatty-Acid Oxidation by Muscle (1959) by FRITZ, IRVING B. and MCEWEN, BRUCE
Since 1959, McEwen and many others have linked food energy and pheromones to the biophysically constrained viral latency that ensures the survival of all species. See also: Feedback loops link odor and pheromone signaling with reproduction
Since the time I met him in 1995, Jay R. Feierman has contributed to the unnecessary suffering and premature death of thousands via his misrepresentations of the facts about food energy-dependent pheromone-controlled RNA-mediated cell type differentiation.
See: Environment and Neurodegenerative Diseases: an Update on miRNA Role I’m beginning to think that the most obvious way to prevent the deaths by suicide of our veterans is not something that will be discussed in any scientific forum or on most forms of social media.
See for comparison: 7/25/13
Jay R. Feierman: Variation is not nutrient availability and the something that is doing the selecting is not the individual organism. A feature of an educated person is to realize what they do not know. Sadly, you don’t know that you have an incorrect understanding [of] Darwinian biological evolution. 7/26/13
Jay R. Feierman: I am absolutely certain that if you showed this statement to any professor of biology or genetics in any accredited university anywhere in the world that 100% of them would say that “Random mutations are the substrate upon which directional natural selection acts” is a correct and true statement.
Summary:
The creation of the enzyme is linked to the evolution of all biodiversity via the creation of the enzyme and mutations. See for comparison: Neuronal-expressed microRNA-targeted pseudogenes compete with coding genes in the human brain. Listen to this song about Santa Claus and note that he sees you when you’re sleeping and somehow unconsciously determines if you’ve been good or bad. Santa Claus may know that the sense of smell has repeatedly been linked to effects on hormones and unconscious affects on behavior.
The first major step of photosynthesis is triggered by an enzyme known as Rubisco. Previous research suggested that Rubisco is likely the most abundant protein on Earth
1) If physical theories were people, thermodynamics would be the village witch.
2) In the early twentieth century, information theory was constructed as the epitome of detachment from physics [7].
3) But as it turned out, not all information was created equal.
I’m reading a book by Matthew Cobb that fails to resolve that problem. In the first part of the book, he fails to link Schrodinger’s claims about sunlight and negative entropy from energy as information to all biophysically constrained biodiversity on Earth, and complains that Schrodinger gets not credit for the concept of energy as information because he never used the word information. See: Life’s Greatest Secret: The Race to Crack the Genetic Code and Genes Before DNA: How geneticists around the world struggled to bring the foundation of life’s building blocks to light “… there are no direct links between Schrödinger’s lectures and the experiments and theories that were part of the decades-long attempt to crack the genetic code…”
4) In the past twenty years, the field of non-equilibrium statistical mechanics has seen a rapid development in the treatment of driven classical and quantum systems beyond the linear response regime. This has culminated in the discovery of various fluctuation theorems which relate equilibrium thermodynamic quantities to non-equilibrium ones, and led to a revision on how we understand the thermodynamics of systems far from equilibrium [20–24].
5) Entanglement and phase transitions in condensed matter. Entanglement is frequently used as an indicator of quantum phase transitions in condensed matter systems. We do not cover this particular setting but the interested reader may find a comprehensive review in [36].
The authors of Constraining the timing of the Great Oxidation Event within the Rubisco phylogenetic tree ignore the fact that food energy as information must be linked to quantum entanglement via changes in base pairs in the context of the creation of amino acids and all protein-based biodiversity on Earth. Instead, they ignore biophysical constraints on energy-dependent base pairs that are linked to biophysically constrained viral latency via RNA-mediated fixation of amino acid substitutions in supercoiled DNA.
For instance, they start with the automagical creation of a protein. Then they link the automagical creation of the protein from the enzyme known as Rubisco to protein folding chemistry and to all biophysically constrained biodiversity on Earth. In the context below, anything is possible. All that theorists need to do is remove the energy and focus on the math, which they now must link to ecological adaptations.
Ribulose 1,5-bisphosphate (RuBP) carboxylase/oxygenase (RuBisCO, or Rubisco) catalyzes a key reaction by which inorganic carbon is converted into organic carbon in the metabolism of many aerobic and anaerobic organisms…
Therefore, it is possible that the mutational enrichment periods between the Form III and Form I common ancestral sequences correspond to the adaptation of key oxygen-sensitive components of Rubisco prior to, or coincident with, the Great Oxidation Event.
It is equally possible that mathematical models of energy-dependent biophysically constrained biologically-based cause and effect could be used in representations like this: Quantum common sense
We don’t need a conscious mind to measure or look. With or without us, the Universe is always looking
For comparison: Listen to this song about Santa Claus and note that he sees you when your sleeping and somehow unconsciously determines if you’ve been good or bad.
For comparison to the Rubisco phylogenetic tree see: The phylogenetic utility and functional constraint of microRNA flanking sequences
When pseudoscientists fail to link the quantized energy of sunlight as information from changes in base pairs to the creation of microRNAs and all biophysically constrained biodiversity, they typically proceed to tout ridiculous theories about mutations (e.g, mutational enrichment periods). They seem to not recognize the fact that the mutations are caused by the theft of quantized energy and the virus-driven degradation of messenger RNA.
The theft of quantized energy as information cannot lead to mutational enrichment periods outside the context of mathematical models. In this case, natural selection for energy-dependent codon optimality is no longer considered in the context of the Great Oxidation Event, which is placed into the context of a mathematical model. The creation of the enzyme is linked to the evolution of all biodiversity via the creation of the enzyme and mutations.
The term refers to a logical fallacy that because two events occurred in succession, the former event caused the latter event.
The logical fallacy is exemplified above. Rubisco links an enzyme to catalysis via a key reaction that corresponds to the adaptation of key oxygen-sensitive components of Rubisco prior to, or coincident with, the Great Oxidation Event.
The ease of obfuscation (the former event caused the latter) links other logical fallacies to claims about mutation-driven evolution. Those ridiculous claims can be compared to accurate representations of energy-dependent top-down causation in the context of the pheromone-controlled physiology of reproduction. Nutrient-dependent/pheromone-controlled adaptive evolution: a model.
Anyone who thinks they can continue to tout theories instead of facts about energy-dependent ecological adaptations should be cast out of academia. Minimally, they will continue to be told to stop linking their ridiculous theories about enzymes to all biodiversity on Earth without claims about how the enzymes were created. But first, they should be forced to admit that they do not know where the energy for the creation of the protein, Rubisco came from.
Rather than admit that their theories are examples of human idiocy (see Food energy), biologically uniformed science idiots continue to serve as examples of the idiocy (Richard P. Feynman’s term). The “food energy” snippet comes from one of his lectures in the series “The character of Physical Law.” He complains about all the different units that are used to measure the single concept of Energy.
His prescient perspective on human idiocy can now be viewed in the context of sunlight as the quantized energy of information. In the latest rendition of pseudoscientific nonsense, quantized energy as information has since been eliminated from the creation of an enzyme. Then, the protein, Rubisco is linked to ecological adaptation and all energy-dependent biodiversity on Earth (and perhaps even on other planets).
The altered human visual perception of mass and energy was placed into the context of the space time continuum via links to the food energy-dependent pheromone-controlled physiology of reproduction in bacteria.
…several studies report active target RNA-directed degradation of miRNAs, rather than passive ‘sponging’ activities.7 Together, this calls for re-inspection of the evolutionary, global in vivo impact, directionality and specificity of the competition between PSGs and protein-coding genes (PCGs) in the human brain.
Re-inspection of the evolutionary, global in vivo impact et al., in the context of the virus-driven degradation of messenger RNA will link the energy-dependent de novo creation of olfactory receptor genes to healthy longevity via biophysically constrained viral latency. The viral latency is manifested in pseudogenes. Humans have more pseudogenes than other mammals because more viruses were biophysically constrained. The biophysical constraints are food energy-dependent.
So far as I know, you cannot get to altered perception without the energy-dependent de novo creation of microRNAs and G protein-coupled receptors such as olfactory receptor genes. However, altered perception has been linked to social behavior via pheromones and de novo gene creation as well as the creation of pseudogenes that biophysically constrain human behavior in the context of neurogenesis and a potential cure for all neurodegenerative diseases.
The role of microRNA-based therapies (microRNA and disease) extends across the space time continuum to the formulation of the anti-suicidal nasal spray via the formulation of human pheromone-enhanced products. That fact is not being examined by anyone I know about.
The role that mutations and natural selection play in the automagical creation of all energy-dependent biodiversity has captured the attention of pseudoscientists and other biologically uninformed science idiots who have attacked me for more than 20 years. The question remains: When is enough, enough? Even friends are beginning to attack.
Darwin probably anticipated the insemination of population genetics that led to the bastardization of his detailed observations in the “Modern Synthesis.” He politely insisted that ‘conditions of life’ be considered before natural selection.
There are two ‘conditions of life.’ It is nutrient-dependent and pheromone-controlled. Rosenberg and Queitsch now note the work with Dobzhansky’s rarely acknowledged claim: “I am a creationist and an evolutionist.” They also declare the need for “Deep understanding of the mechanisms that generate variation at the molecular level…”
Deep understanding of the ‘conditions of life’ does not come from theory.
Problems with the “modern synthesis” now lead us back to the facts about biologically-based cause and effect that Darwin and Dobzhansky approached with humility, which are the same biological facts that evolutionists approached with ignorance about behavioral affects and the arrogance that accompanies that ignorance. Rosenberg and Queitsch echo the sentiments of those who have been subjected to academic suppression.
Clearly, however, “nothing in evolution makes sense except in the light of biology” is not an exaggeration. It is a common sense statement about the biologically plausible genesis of functional cell types. Population genetics and evolutionary theories abandoned the biophysical constraints of ecological variation and the physiology of reproduction, which enable epigenetically-effected nutrient-dependent pheromone-controlled receptor-mediated ecological adaptations and species diversity via the complexities of protein folding and niche construction.
It’s time for biophysicists to tell theorists and pathologists how to differentiate between theories about the genesis of different cell types and the biological facts about the nutrient-dependent pheromone-controlled ecological adaptations that enable the genesis of different cell types in individuals of different species. Simply put, it’s time to stop trying to explain ecological adaptations in the context of mutations and evolution.
The sequence of amino acids in a protein is sufficient to determine its three-dimensional structure.
Natural selection for energy-dependent codon optimality is the link from the physiology of reproduction to fixation of the amino acid substitutions that differentiate all cell types in all individuals of all living genera. That fact has now been placed, once again, into the context of this pseudoscientific nonsense.
See: Scientists Uncover That Humans Have A ‘Magnetic 6th Sense’ to Detect Something We Can’t Even See
Inspired by articles written by Collective-Evolution and Science Alert.
Kirschvink was able to discover in one of his experiments that when the magnetic field itself is rotated counterclockwise around a patient, their neutrons responded with generating a spike in electric activity.
See also: Joseph Kirschvink et al., “A Magnetotactic Origin for the Mitochondria (and Organelle-bearing Eukaryotes) at ∼2ga: In The Aftermath of the Cyanobacterial Radiation and the Great Oxygenation Event, Causing the End Of The Lomagundi-jatuli Carbon Isotope Excursion and Paving the Way for the Rest of Proterozoic Time” (paper presented at 34th International Geological Congress Unearthing our Past and Future—Resourcing Tomorrow, Brisbane, Australia, 5–10 August, 2012). — cited in “The Excitable Mitochondria” by John Hewitt
For attacks on my model by friends, see: MicroRNA: A novel target of curcumin in cancer therapy (Discussion attempt)
I do not think that any family members and/or most of my friends want the cure for cancer and all other pathology to be revealed — unless the cure cannot be linked to healthy longevity from my model of food energy-dependent pheromone-controlled RNA-mediated biodiversity. “A Magnetotactic Origin for the Mitochondria” divorces the origin of the mitochondria from the energy-dependent de novo creation of G protein-coupled receptors that link pH-taxis to chemotaxis and phototaxis. All energy-dependent taxis/movement is biophysically constrained by the anti-entropic virucidal energy of sunlight in the context of the physiology of pheromone-controlled reproduction. The claims that linked human pheromones to our “sixth sense” have nearly been removed from consideration during the past two decades. See for instance this review of See What I’m Saying: The Extraordinary Powers of Our Five Senses
The goals of the book are threefold: (1) to reveal that you have extraordinary perceptual skills of which you are largely unaware;(2) to show that by becoming aware of these skills and how they work, you can actually enhance how to use them; and (3) to convey that these skills illustrate some of the most important recent developments in perceptual science.
We show here for the first time the crucial role of viruses in controlling archaeal dynamics and therefore the functioning of deep-sea ecosystems, and suggest that virus-archaea interactions play a central role in global biogeochemical cycles.
…these events underlie a switch to expression of short mRNA isoforms and preferential use of alternative last exons in a number of genes, including ASCC3. Intriguingly, the switch between ASCC3 isoforms occurs on more than one level, in that the long mRNA isoform encodes a protein, functioning in the context of the ASCC complex and required for maintaining transcriptional suppression in the late stages of the DNA damage response, whereas the short isoform functions as a nuclear non-coding RNA that is required for transcription to recover. Intriguingly, the short and long isoforms constitute an autonomous regulatory module and functionally interrelate, so that the effect of deleting one can be at least partially compensated for by deleting the other (Figure 7H).
There is no such thing as an autonomous regulatory module. All RNA-mediated protein folding chemistry is energy dependent and functional interrelations link differences in the energy of photons from natural selection for energy-dependent codon optimality to all biodiversity on Earth via the physiology of reproduction.
Reported as: Noncoding RNA Helps Cells Recover from DNA Damage
“If the protein is made from the long pre-mRNA, then global transcription is repressed. But if the short RNA is made, it helps recover transcription hours after damage.” Uncovering mechanisms
How the short isoform aids repair remains unknown.
My comment to The Scientist: There is clear evidence that femtosecond blasts of UV light repair DNA in the context of energy-dependent changes in the microRNA/messenger RNA balance and autophagy, which protects all organized genomes from virus-driven energy theft and the degradation of messenger RNA.
The failure to integrate the Nobel Prize winning works of Ben Feringa (Chemisty 2016) and Yoshinori Ohsumi (Physiology or Medicine 2016) prevents theorists from linking what organisms eat to their pheromone-controlled physiology of reproduction in the context of Schrodinger’s claims in “What is Life?”(1944) and this claim by Roger Penrose in the reprint edition:
“How often do we still hear that quantum effects can have little relevance in the study of biology, or even that we eat food in order to gain energy?” (Roger Penrose 8 August 1991)
Small intranuclear proteins also participate in generating alternative splicing techniques of pre-mRNA and, by this mechanism, contribute to sexual differentiation in at least two species, Drosophila melanogaster and Caenorhabditis elegans…
The food energy that is linked from alternative splicing techniques of pre-mRNA to the chemistry of protein folding and the pheromone-controlled physiology of reproduction in all living genera seems to be largely ignored by those who are not Nobel Laureates.
