Alternative splicing of pre-mRNA

Neurosteroids revisited two decades later

See also: Host-derived creation of all pathology (2 of 2)

These two statements are not being linked to the prevention of all disease.

1) “The synthesis of RNA in isolated thymus nuclei is ATP dependent.” (1964)

2) “Nucleosome remodelling (NR) regulates transcription in an ATP-dependent manner…” (2017)

See: Cell-targetable DNA nanocapsules for spatiotemporal release of caged bioactive small molecules
The link from olfaction to the space-time continuum via energy-dependent endogenous RNA interference was reported as:
Tiny nanopackages built out of DNA help scientists peek at how neurons work

“There are a host of research problems from cardiology to neurobiology that need a system like this to study very fast molecular phenomena, so it could be applied in a variety of ways.”

Cells talk to each other in chemical whispers that occur too fast for scientists to accurately study, Krishnan said. Her team aimed at one class of such chemical communications, known as neurosteroids.”

From Fertilization to Adult Sexual Behavior (1996) cited by 42

Though neurosteroids research is relatively new, certain findings already are important. For instance it is now known that (i) the enzymes that produce neurosteroids are transcribed from the same genes that produce gonadal and adrenal steroids (Compagnone, Bulfone, Rubenstein, and Mellon, 1995b; Mellon and Deschepper, 1993); (ii) transcription regulation for neurosteroidal enzymes is different from gonadal and adrenal regulatory processes (Zhang, Rodriguez, and Mellon, 1995); (iii) within discrete brain nuclei, some subareas differ with regard to utilization of neuro- and nonneurosteroids (Compagnone et al., 1995a; Roselli, 1995); and (iv) even early stages in the neurosteroid route from cholesterol to various end-product steroids affect sexual perceptions and behavior (Kavaliers and Kinsella, 1995).

Ramifications of such neurosteroid findings are diverse. For instance, they suggest nuances of reinterpretation may be in order regarding past data from gonadectomy and adrenalectomy experiments. Endogenous neurosteroid production may have contributed to results described in many experiments wherein gonadectomized animals who were subsequently administered powerful cross-hormone regimens nonetheless retained bisexual-like responses both to males and to females (e.g., Brand, Houtsmuller, and Slob, 1993; Vega-Matuszczyk, Fernandez-Guasti, and Larsson, 1988) or they may have effected the persistence of typical sexual activity seen after castration in some species (Young, 1961).

We linked energy-dependent endogenous RNA interference to neurosteroid production and differences in sexual behavior via the epigenetic effects of food odors and pheromones on RNA-mediated cell type differentiation. Food odors and pheromones are chemicals that clearly link the physiology of reproduction to biophysically constrained viral latency in all living genera.

It’s time to ask yourself why other scientists either ignored, or failed to learn about, our detailed interactions for more than 20 years. Could it be that they did not want you to learn that all life on Earth is energy-dependent and biophysically constrained by the physiology of reproduction? That means there is no such thing as mutation-driven evolution. Is that a problem for pseudoscientists?

Mutation-Driven Evolution

See for comparison: Nutrient-dependent/pheromone-controlled adaptive evolution: a model

…the epigenetic ‘tweaking’ of the immense gene networks that occurs via exposure to nutrient chemicals and pheromones can now be modeled in the context of the microRNA/messenger RNA balance, receptor-mediated intracellular signaling, and the stochastic gene expression required for nutrient-dependent pheromone-controlled adaptive evolution. The role of the microRNA/messenger RNA balance (Breen, Kemena, Vlasov, Notredame, & Kondrashov, ; Duvarci, Nader, & LeDoux, ; Griggs et al., ; Monahan & Lomvardas, ) in adaptive evolution will certainly be discussed in published works that will follow.

See also: Olfaction Warps Visual Time Perception and Time (and space) in the hippocampus

See also: microRNA neurosteroid Items: 1 to 20 of 681 and microRNA Items: 1 to 20 of 64001

With more than 64000 published works on microRNAs, another “tipping point” has been reached just prior to the release of the cell biology game “Cytosis.”