For example, see: Hypothalamic stem cells control ageing speed partly through exosomal miRNAs
…these cells may have a role in regulating the neurons that release a hormone called GnRH, which is secreted by the hypothalamus and is associated with ageing. Imai would also like to know whether the microRNAs from the cells can pass into the bloodstream, which would carry them throughout the body.
I would like to know why Shin-ichiro Imai, who studies ageing at Washington University in St Louis, Missouri, claims to know nothing about food energy-dependent pheromone-controlled RNA-mediated biophysically constrained viral latency, which prevents the degradation of messenger RNA. I expect that anyone who studies aging to learn that the virus-driven degradation of messenger RNA links mutations to all pathology via effects on all cell types in all individuals of all living genera. Perhaps Shin-ichiro Imai, and others who have not learned anything about energy-dependent cell type differentiation can play the game “Cytosis” when it is released in September, 2017. Or, perhaps they all are neo-Darwinian theorists who prefer not to examine any of the experimental evidence that links energy-dependent microRNAs to healthy longevity and virus-driven energy theft to all pathology.
See for 63,127 examples: MicroRNA
See for comparison: The NAD World 2.0: the importance of the inter-tissue communication mediated by NAMPT/NAD+/SIRT1 in mammalian aging and longevity control by Shin-ichiro Imai
This is very technical, but begins to address the role of pheromones in anti-aging medicine, particularly with regard to neurodegenerative diseases. Pheromones are used to increase neurogenesis in the area of the brain that is responsible for learning and memory.
Jo Rockafellor Is this the stuff you created James?
James Kohl I have nothing to do with the patent, but am responsible for the concept and first linking pheromones, luteinizing hormone, and neurodegenerative disease associated with aging.
Coleen Powell Keep searching for a cure!
7/27/17 James Kohl The cure is treatment with food energy-dependent microRNAs. See:Hypothalamic stem cells control ageing speed partly through exosomal miRNAs. Liberals hate that fact because it refutes their ridiculous theories about the emergence of energy and the evolution of all biodiversity via mutations and natural selection. They would rather watch people like Dick suffer and die prematurely from cancer than admit that they are biologically uninformed science idiots. (idiot: someone with no professional expertise)
Without labeling them, Feynman claimed that liberals were examples of human idiocy. He failed to differentiate between the beliefs of conservatives and liberals, but those differences have become perfectly clear.
Even those who have learned nothing about “The character of Physical Law” understand that all organisms must eat. That is why Feynman complained about the different units that are used to measure the single concept of energy. The energy that sustains life and all biodiversity via the physiology of reproduction comes from food.
Reported by James Kohl on 7/27/14 Study shows epigenetic changes can drive cancer
“Potential applications of this novel mouse model include the testing of targeted epigenetic therapies for prevention and treatment of human cancer.” http://www.jci.org/articles/view/76507
“Our straightforward approach to epigenetic engineering should be useful in testing the causal role of other epigenetic alterations implicated in carcinogenesis, and broadly applicable toward elucidating epigenetic etiology in a wide range of diseases.”
Their straightforward approach confirms that cell type differentiation is nutrient-dependent and pheromone-controlled in species from microbes to man, which refutes any aspect of mutation-initiated natural selection in the context of the evolution of biodiversity.
7/27/15 Reported by James Kohl
New Technology Lets Scientists Easily Rewrite Living Organisms’ Genetic Code
[For scientists to rewrite the genetic code, they must know how it was created.] 7/22/15 Sexuality is fluid – it’s time to get past ‘born this way’ reported 7/27/15 by James Kohl
[For people to get past the ‘born this way’ pseudoscientific nonsense, they must learn how energy-dependent RNA-mediated cell type differentiation occurs in the context of the nutrient-dependent pheromone-controlled physiology of reproduction in species from microbes to humans.] Bacterial Hunger Games reported 7/27/15 by James Kohl
[Survivors find enough food to reproduce in the context of quorum sensing and the weekend resurrection of the bacterial flagellum, which was reported in P. fluorescens.] Go ahead, be sarcastic: Research uncovers creative benefits in using sarcasm when people trust each other reported 7/27/15 by James Kohl
[I’ve tried presenting facts; using examples of top-down causation, and discussing the facts and examples with biologically uninformed science idiots after sarcasm did not work.
Study identifies ‘major player’ in skin cancer genes reported 7/27/15 by James Kohl
[The virus-driven degradation of messenger RNA causes all pathology] Honeybees Show Evidence of Insecticides reported 7/27/15 by James Kohl
[I used the honeybee model organism as an example of nutrient-dependent pheromone-controlled RNA-mediated cell type differentiation in Nutrient-dependent/pheromone-controlled adaptive evolution: a model
An environmental drive evolved from that of nutrient ingestion in unicellular organisms to that of pheromone-controlled socialization in insects. In mammals, food odors and pheromones cause changes in hormones such as LH, which has developmental affects on pheromone-controlled sexual behavior in nutrient-dependent reproductively fit individuals across species of vertebrates.]
Addendum: Environmental drives are food energy-dependent and pheromone-controlled in the context of feedback loops linked from supercoiled DNA to chromosomal rearrangements and all biodiversity. I used the term evolved to get past the ignorance of any potential reviewers who would most likely be theorists. In “The Scent of Eros: Mysteries of Odor in Human Sexuality (1995/2002) we used the term mutation for the same reason. The editor at Continuum rightfully insisted.
The CRISPR craze: genome editing technologies poised to revolutionize medicine and industry reported 7/27/15 by James Kohl
[The CRISPR craze of using viruses to edit organized genomes is the example of more ignorance in medicine and industry than most people can comprehend.] See also: CRISPR–Cas systems exploit viral DNA injection to establish and maintain adaptive immunity
The acquisition of new spacer sequences from foreign DNA elements, also known as adaptation, is a hallmark of the CRISPR–Cas immune response1.
Any intelligent scientist would ask where the spacer sequences came from and learn that the spacers are food energy-dependent microRNAs that prevent the virus-driven degradation of messenger RNA and all pathology in all genera.
See Energy-dependent physical and biophysical constraints (9) (in prep) for examples of those who might otherwise seem to be intelligent scientists.