An evolutionary theory killer

How to create biologically uninformed theorists

Summary: On March 2, 2018, Philip C. Ball and Nick Lane started making claims about proton gradients. Their claims are based on my model of quantized energy as information. This post includes added support for what is known to all serious scientists about the light-activated endogenous substrates that link molecular epigenetics to RNA-mediated autophagy.
See first: Energy as information and constrained endogenous RNA interference (audio/visual aid 2017)

Feedback loops link quantized energy as information to biophysically constrained RNA-mediated protein folding chemistry. Light induced energy-dependent changes link angstroms to ecosystems from classical physics to chemistry/chirality and to molecular epigenetics/autophagy.

The National Microbiome Initiative links microbial quorum sensing to the physiology of reproduction via endogenous RNA interference and chromosomal rearrangements. The rearrangements link energy-dependent fixed amino acid substitutions to the Precision Medicine Initiative via genome wide inferences of natural selection.

This detailed representation of energy-dependent natural selection for codon optimality links biologically- based cause and effect from G protein-coupled receptors to RNA-mediated amino acid substitutions and the functional structure of supercoiled DNA. Energy-dependent polycombic ecological adaptations are manifested in supercoiled DNA. Chromosomal inheritance links the adaptations from morphological phenotypes to healthy longevity via behavioral phenotypes.

For contrast, virus-driven energy theft is the link from messenger RNA degradation to negative supercoiling, constraint breaking mutations, and hecatombic evolution. The viral hecatomb links transgenerational epigenetic inheritance from archaea to Zika virus-damaged DNA, which typically is repaired by endogenous RNA interference and fixation of RNA-mediated amino acid substitutions in organized genomes.

Added support for the light-activated molecular epigenetics of autophagy:
Light-powering Escherichia coli with proteorhodopsin (2007)

…we quantify the coupling between light-driven and respiratory proton currents… and show that light-driven pumping by PR can fully replace respiration as a cellular energy source in some environmental conditions.

Structure of the Deactive State of Mammalian Respiratory Complex I (2018)

…the deactive state arises when critical structural elements that form the ubiquinone-binding site become disordered, and we propose reactivation is induced when substrate binding to the NADH-reduced enzyme templates their reordering. Our structure both rationalizes biochemical data on the deactive state and offers new insights into its physiological and cellular roles.

Global collective motions in the mammalian and bacterial respiratory complex I (2018)

…we identify here transitions between experimentally resolved structures of the mammalian complex I as low-frequency collective motions of the enzyme, highlighting similarities and differences between the bacterial and mammalian enzymes. Despite the reduced complexity of the smaller bacterial enzyme, our results suggest that the global dynamics of complex I is overall conserved.

The conservation of light-powered functional structures and energy-dependent proton gradients link the deactive state in critical structures to the active state via the creation of enzymes in species from bacteria to mammals. The energy-dependent creation of the enzymes links metabolism of the energy (e.g., food energy) from pheromones to biophysically constrained viral latency in the context of the physiology of reproduction.
The pheromone-controlled physiology of reproduction in species from microbes to humans links our visual perception of energy and mass in the context of how ecological variation must be linked to energy-dependent ecological adaptations in all living genera.
See: Olfaction Warps Visual Time Perception

Our perception of the world builds upon dynamic inputs from multiple senses with different temporal resolutions, and is threaded with the passing of subjective time. How time is extracted from multisensory inputs is scantly known. Utilizing psychophysical testing and electroencephalography, we show in healthy human adults that odors modulate object visibility around critical flicker-fusion frequency (CFF)-the limit at which chromatic flickers become perceived as a stable color-and effectively alter CFF in a congruency-based manner, despite that they afford no clear environmental temporal information. The behavioral gain produced by a congruent relative to an incongruent odor is accompanied by elevated neural oscillatory power around the object’s flicker frequency in the right temporal region ~150-300 ms after object onset, and is not mediated by visual awareness. In parallel, odors bias the subjective duration of visual objects without affecting one’s temporal sensitivity. These findings point to a neuronal network in the right temporal cortex that executes flexible temporal filtering of upstream visual inputs based on olfactory information. Moreover, they collectively indicate that the very process of sensory integration at the stage of object processing twists time perception, hence casting new insights into the neural timing of multisensory events.

See also: Odors Alter Subjective Time Experience Author: Dr. ZHOU Wen’s Research Group Update time: 2017/05/15

The brain is not a timepiece. Whereas it is equipped with senses like vision, audition, touch, smell, and taste, it has no direct access to or measure of the physical time (unless you read from a clock). Rather, it constructs the subjective “time” of an event from the dynamic multisensory inputs associated with that event. Yet different senses come with different temporal precisions. For instance, when standing near an apple tree, you can detect the falling of an apple much better with your eyes or ears than the nose. How does the brain coordinate multisensory signals entering different brain regions with different temporal resolutions, and come up with the subjective time?

A team at the Institute of Psychology at Chinese Academy of Sciences tackled this issue using odors and images. Specifically, Dr. Bin Zhou, the study’s lead author, and his colleagues examined whether odors could modulate one’s temporal sampling and subjective duration of visual objects. In their study, participants viewed two series of flickering isoluminant images in red and green (Figure 1A). One of the series contained opposite images of an apple or bananas; the other contained only images of red and green fields. When the images alternated at a frequency beyond 20 Hz, the participants started to have difficulty reporting which series contained an object. Indeed, for most people, chromatic flicker fusion frequency (CFF), the limit at which alternating colors become perceived as a stable fused color, falls somewhere between 20 and 25 Hz. Interestingly, the participants’ object detection accuracies around CFF were improved under the exposure of a congruent, as opposed to an incongruent, odor. In other words, the participants detected a rapidly flickering apple better when they smelled an apple odor rather than a banana odor, and vice versa (Figure 1B, left panel). In effect, the presence of a congruent odor facilitated the brain’s temporal sampling of a visual object and elevated its CFF (Figure 1B, right panel). Based on electrical activities recorded from the participants’ scalp, the researchers found that the integration between smell and vision strengthened the signals of the corresponding object in a brain region heavily implicated in object representations called the right temporal cortex, about 150-300 ms after object onset. They further showed that such integration lengthened one’s subjective duration of the corresponding object in a duration comparison task. The researchers concluded that subjective time is warped by the neural energy involved in representing multisensory inputs at subsecond scales.

Until Philip C. Ball mentioned that Nick Lane believed proton gradients came before the energy-dependent creation of RNA, I did not realize how little they knew about this link from differences in the energy of photons to consciousness.
See: What Affective Neuroscience Means for Science Of Consciousness (2013)

The coupling of the two circuits promotes an endogenous feedback that supports conscious processes. Within this framework, we present the defence that detailed study of both affective and cognitive processes, their interactions, as well of their respective brain networks, is necessary for a science of consciousness.

The coupling of the two circuits links differences in the energy of photons from the proton motive force to the light-activated endogenous feedback loops and Feedback loops link odor and pheromone signaling with reproduction.
It is extremely difficult for intelligent people to not link this experimental evidence to biophysically constrained viral latency in the context of reports that claim “Creatures’ Adaptability Begins with Their Sensors.”
But, see for comparison: David Attenborough on creationsim May, 2015

My comment on his nonsense: First steps to neutralizing Zika: How highly potent antibody neutralizes Zika infection discovered

This is framed within the context of energy-dependent changes in pH, which facilitate receptor-mediated entry of nutrients or viruses into specific cell types of species-specific tissues via stress-linked changes in hydrogen-atom transfer in DNA base pairs.

Virus-driven energy theft has been linked to all pathology in all living genera via the conserved molecular mechanisms of RNA-mediated polycombic protein folding chemistry compared to the hecatombic evolution of pathology manifested first in the differences between archaea and bacteria. Admitting that Carl Woese was wrong about the different domains of life is the first step towards understanding the difference between healthy longevity and the evolution of all virus-driven pathology.

Carl Woese was wrong

God did not create the viruses. He created the anti-entropic virucidal energy of sunlight, which protects all organized genomes from virus-driven entropy. Only the choices of our ancestors could have led to the increasing amout of virus-driven pathology during the past ~6000 years that pseudoscientists place into the context of millions of years of evolution. Then, they blame God, like these two pseudoscientists do. Darwin knew they would do that, which is why he insisted that others put conditions of life before natural selection. But they bastardized his theory anyway and taught their revision to anyone who was foolish enough to believe in it. It’s called the “Modern Synthesis” and was based on de Vries 1902 definition of “mutation.”

Celebrate Your Inner Virus

It is important that we understand the design present in viruses because God made them.

It is no wonder that Sir David Attenborough and many others like Philip C. Ball and Nick Lane are confused about the energy-dependent creation of healthy longevity and consciousness. Even some young earth creationists have failed to link the creation of the sun’s anti-entropic virucidal energy from changes in electrons to ecosystems via the proton motive force. That leaves every aspect of creation to be placed back into the context of ridiculous theories. The theories start with the virus-driven theft of quantized energy as information. The energy theft links mutations to all virus-driven pathology. The theft of quantized energy as information cannot be linked by serious scientists from beneficial mutations to the evolution of one species from another.
For comparison, pseudoscientists have no problem touting this confusing nonsense:
Sign of selection on mutation rate modifiers depends on population size (
1)  Genetic variation—the raw material for evolution—is ultimately generated by mutation.
2). …beneficial alleles never become deleterious and deleterious alleles never become beneficial.
Conclusion:

Whether these phenomena can be united in a single theoretical framework remains an open question that we are actively exploring. In any case, our results add to a growing appreciation of nonclassical population size dependence in evolution by natural selection (41, 42).

Funding for research that attempts to link natural selection to evolution via mutation-driven genetic variation should be used to link food odors and pheromones from the physiology of reproduction to biophysically constrained viral latency and ecological adaptations. It is time to stop creating more biologically uninformed theorists.

For God and Country

Diet-driven RNA interference and cancer prevention (4)

Excerpt: What I perceive as apathy can be attributed to the lack of empathy for anyone who suffers from the preventable or controlled virus-driven pathology that, sooner or later, kills us all.
In the case of our Vietnam veterans, naturally occurring prevention or effective treatment of glioblastoma might be achieved by dietary intervention with a curcumin supplement.
“micrornas”[MeSH Terms] OR “micrornas”[All Fields] OR “microrna”[All Fields] Items: 1 to 20 of 68871
See:  The tipping point (revisited): 68,000 publications
69,000 published works on microRNAs will be the next “tipping point.” Predictably, it will be reached during the same 28 day period in which my tweets (@jvkohl have received more than 70,000 impressions.
On 1/18/18: Tweet impressions 71.2K 602.0%
The 602.0% increase has not been accompanied by a significant increase in followers or a significant increase in engagements.
What I perceive as apathy can be attributed to the lack of empathy for anyone who suffers from the preventable or controlled virus-driven pathology that, sooner or later, kills us all.
In the case of our Vietnam veterans, naturally occurring prevention or effective treatment of glioblastoma might be achieved by dietary intervention with a curcumin supplement.
See: A curcumin-loaded polymeric micelle as a carrier of a microRNA-21 antisense-oligonucleotide for enhanced anti-tumor effects in a glioblastoma animal model

DP-Cur is an efficient carrier of miR21ASO and the combined delivery of miR21ASO and curcumin may be useful in the development of combination therapy for glioblastoma.

See also: Pharmacological blockade of ASCT2-dependent glutamine transport leads to antitumor efficacy in preclinical models

This is the first study, to our knowledge, to demonstrate the utility of a pharmacological inhibitor of glutamine transport in oncology, representing a new class of targeted therapy and laying a framework for paradigm-shifting therapies targeting cancer cell metabolism.

Reported as: Researchers find a way to ‘starve’ cancer

Glutamine is an essential amino acid for many cell functions including biosynthesis, cell signaling and protection against oxidative damage. Because cancer cells divide more rapidly than do normal cells, they need more glutamine.

A protein called ACST2 is the primary transporter of glutamine into cancer cells. Elevated ASCT2 levels have been linked to poor survival in many human cancers, including those of the lung, breast and colon. Genetic studies that silence the ACST2 gene in cancer cells have produced dramatic anti-tumor effects.

See also: MicroRNA[s] and glutamine Items: 1 to 20 of 65
The facts about food energy-dependent microRNA-mediated RNA-directed DNA methylation and fixation of RNA-mediated amino acid substitutions that differentiate all cell types in all individuals of all living genera were removed from this report. Use off the cryo-EM technology links energy-dependent changes in electrons to healthy longevity in all ecosystems. It is apparent that some researchers do not want more people to learn about that fact.
See: Structural basis of RNA polymerase III transcription initiation

The unwound DNA directly contacts both sides of the Pol III cleft. Topologically, the Pol III PIC resembles the Pol II PIC, whereas the Pol I PIC is more divergent. The structures presented unravel the molecular mechanisms underlying the first steps of Pol III transcription and also the general conserved mechanisms of gene transcription initiation.

The information that links the virus-driven theft of quantized energy from the negative supercoiling (unwinding) of supercoiled DNA was removed in this attempt to support the neo-Darwinian pseudoscientific nonsense about the three domains of life. The bastardization of the use of cryo-EM technology occurred in the following context(s).
1) There is no mention of the quantized anti-entropic virucidal energy as information that is required to create ATP and RNA.
2) The energy-dependent creation of ATP and the creation of RNA is not linked to healthy longevity in all living genera via the physiology of pheromone-controlled reproduction.
3) The fixation of RNA-mediated amino acid substitutions that stabilize the differentiated cell types of all living genera are viewed in the context of negative supercoiling that occurs in an ATP-independent manner.
4) A spontaneously formed transcription bubble links the energy-dependent stability of supercoiled DNA to cell type differentiation in species from bacteria to humans.
5) The claim that promoters can be opened without ATP hydrolysis is used to suggest that no energy-dependent supercoiling is required to link the three kingdoms of life — assuming that there are three kingdoms of life.
6) The fact that the virus-driven degradation of messenger RNA in humans causes them to become non-human primates and the fact that it also cause bacteria to archaea and L-forms is ignored.
See: Virus-mediated archaeal hecatomb in the deep seafloor

We show here for the first time the crucial role of viruses in controlling archaeal dynamics and therefore the functioning of deep-sea ecosystems, and suggest that virus-archaea interactions play a central role in global biogeochemical cycles.

By deliberately removing virus-archaea interactions from the representations reported as: Scientists zoom in to watch DNA code being read, pseudoscientists have reverted to promotion of their ridiculous gene-centric theories.
See for comparison: “Cytosis

A board game taking place inside a human cell! Players compete to build enzymes, hormones and receptors and fend off attacking Viruses!

See also: Attacked from All Sides: RNA Decay in Antiviral Defense

…RNA decay machinery plays important roles in antiviral defense. This can involve either direct effects on vRNA stability or indirect regulation of the intracellular milieu. Furthermore, an emerging theme suggests that many RNA binding proteins can be repurposed from their endogenous roles in the nucleus to antiviral roles in the cytoplasm. Future studies are necessary to further elucidate how these RNA binding proteins recognize foreign RNAs and how they interface with the RNA decay machinery to restrict vRNA replication.

Accurate representations of how natural selection for food energy-dependent codon optimality links the physiology of pheromone-controlled reproduction to the transgenerational epigenetic inheritance of healthy longevity will continue to be attacked from all sides.
Biologically uninformed theorists and philosophers can do nothing else but attack after proclaiming the nonsense of mutation-driven evolution during the past decades. They have failed to link their nonsense to the prevention of all pathology or to effective treatments via optimization of autophagy: the innate antiphage defense mechanism of all living genera.

A rendering of how changes in an electron's motion (bottom view) alter the scattering of light (top view), as measured in a new experiment that scattered more than 500 photons of light from a single electron. Previous experiments had managed to scatter no more than a few photons at a time. Credit: Extreme Light Laboratory|University of Nebraska-Lincoln

Exome Sequencing Impact in Routine Care

Summary: They placed the pseudoscientific nonsense about selection for beneficial mutations into the context of positive selection for mutations, which are caused by the virus-driven degradation of messenger RNA. The mutations have been linked to all pathology. It’s as if all theorists want to become known as “biologically uninformed science idiots” via their associations with others who have touted claims about “beneficial mutations.”

US Air Force Studying Impact of Exome Sequencing in Routine Care

Who, among my fellow veterans, and especially among others from The American Legion and The American Legion Riders, did not anticipate that the US Air Force would lead the way forward to prevention of all virus-driven pathology via the use of this technology?

The doctors will receive an educational primer in genomics and on-site genetic counseling support. After exome testing is performed on patients, their doctors will get a report listing the pathogenic and likely pathogenic variants related to dominant and recessive monogenic conditions, risks for complex diseases, and response to drugs. These results will be entered into the service members’ electronic medical records.

I was trained to become a medial laboratory scientist during the last 4 years of my 7 years in the United States Air Force (Dec. 1970-Aug. 1977).  I worked in the laboratory and examined the experimental evidence reported in published works, I learned that all pathogenic variants are caused by the virus-driven degradation of messenger RNA. I also learned that pharmacogenomic profiles have already been linked to effective treatments for virus-driven energy theft via my model of nutrient-dependent pheromone-controlled biodiversity.
See: Nutrient-dependent/pheromone-controlled adaptive evolution: a model
Conclusion:

…the model represented here is consistent with what is known about the epigenetic effects of ecologically important nutrients and pheromones on the adaptively evolved behavior of species from microbes to man. Minimally, this model can be compared to any other factual representations of epigenesis and epistasis for determination of the best scientific ‘fit’.

My model refuted every aspect of neo-Darwinian pseudoscientific nonsense, which may be why some doctors never heard about it, or why some of them don’t want to admit to what they know about effective treatments for all pathology.
During suicide prevention month, the National Commander of the American Legion focused on efforts to help reduce the number of suicides among veterans, which occur at ~ 22 each day. I was surprised to see how little response from the general public there has been since then. It’s as if no one has learned about experimental evidence of biologically-based cause and effect such as this:
Whole-transcriptome brain expression and exon-usage profiling in major depression and suicide: evidence for altered glial, endothelial and ATPase activity

Differences in miRNA expression or structural gene variants were not detected. Results lend further support for models in which deficits in microglial, endothelial (blood-brain barrier), ATPase activity and astrocytic cell functions contribute to MDD and suicide, and identify putative pathways and mechanisms for further study in these disorders.

The only obvious link from from energy-dependent ATPase activity to cell type function in all cell types of all living genera is the anti-entropic virucidal energy of sunlight, which biophysically constrains viral latency in the context of the pheromone-controlled physiology of reproduction. That fact suggests exome sequencing data must be linked to routine case via the creation of energy, the creation of ATP and the creation of RNA.
See: Dependence of RNA synthesis in isolated thymus nuclei on glycolysis, oxidative carbohydrate catabolism and a type of “oxidative phosphorylation”

The synthesis of RNA in isolated thymus nuclei is ATP dependent.

If the role of microRNAs is not examined in the context of virus-driven energy theft, the degradation of messenger RNA cannot be linked to all pathology. The suicide rate may never change, or it may not change until the virus-driven degradation of messenger RNA is linked to cancer and all other pathology in species from microbes to humans.
See also: exome sequencing microRNA  for examples like this:
Whole exome sequencing and single nucleotide polymorphism array analyses to identify germline alterations in genes associated with testosterone metabolism in a patient with androgen insensitivity syndrome and early-onset colorectal cancer.
If you do not agree that exome sequencing is the key to understanding the difference between energy-dependent healthy longevity and virus-driven pathology, please explain what you don’t like about the scientific approach to effective treatment and/or prevention of all pathology in the context of Precision Medicine.
See also: Energy as information and constrained endogenous RNA interference from the Labroots: Precision Medicine Virtual Conference February 22-23. 2017
Narrative: The term microRNA has been used in 58,000 indexed works. All the works support claims that link the anti-entropic virucidal energy of sunlight from endogenous RNA interference to biophysically constrained protein folding chemistry and cell type differentiation.

Abstract:

Feedback loops link quantized energy as information to biophysically constrained RNA-mediated protein folding chemistry. Light induced energy-dependent changes link angstroms to ecosystems from classical physics to chemistry/chirality and to molecular epigenetics/autophagy.

The National Microbiome Initiative links microbial quorum sensing to the physiology of reproduction via endogenous RNA interference and chromosomal rearrangements. The rearrangements link energy-dependent fixed amino acid substitutions to the Precision Medicine Initiative via genome wide inferences of natural selection.

This detailed representation of energy-dependent natural selection for codon optimality links biologically- based cause and effect from G protein-coupled receptors to RNA-mediated amino acid substitutions and the functional structure of supercoiled DNA. Energy-dependent polycombic ecological adaptations are manifested in supercoiled DNA. Chromosomal inheritance links the adaptations from morphological phenotypes to healthy longevity via behavioral phenotypes.

For contrast, virus-driven energy theft is the link from messenger RNA degradation to negative supercoiling, constraint breaking mutations, and hecatombic evolution. The viral hecatomb links transgenerational epigenetic inheritance from archaea to Zika virus-damaged DNA, which typically is repaired by endogenous RNA interference and fixation of RNA-mediated amino acid substitutions in organized genomes.

See for comparison: Evolutionary Analysis Reveals Number, Nature of Mutations Under Positive Selection in Cancer

The research shows that “across cancer types a relatively consistent small number of mutated genes is required to convert a single normal cell into a cancer cell, but that the specific genes chosen differ according to cancer type,” Sanger Institute Director Michael Stratton, a co-author on the study, said in a statement.

…the researchers identified almost 200 mutated genes under positive selection in cancer — a collection that included known cancer contributors and genes not previously implicated as cancer driver candidates.

They placed the pseudoscientific nonsense about selection for beneficial mutations into the context of positive selection for mutations, which are caused by the virus-driven degradation of messenger RNA. The mutations have been linked to all pathology. It’s as if all theorists want to become known as “biologically uninformed science idiots” via their associations with others who have touted claims about “beneficial mutations.”

Alternative splicing of pre-mRNA

Inventing "Transcriptome Trajectory Turning Points"

Summary: They invented the term “Transcriptome Trajectory Turning Points” to prevent others from learning that virus-driven energy theft is the cause of all pathology.
Scientists discover genetic timetable of brain’s aging process

The biggest reorganisation of genes occurs during young adulthood, peaking around age 26, the team found. These changes affected the same genes that are associated with schizophrenia.

The team says this could explain why people with schizophrenia do not show symptoms until young adulthood, even though the genetic changes responsible for the condition are present from birth.

See for comparison: microrna schizophrenia 
 
There is no such thing as a genetic timetable of aging outside the context of epigenetic effects on hormones that affect behavior.
 

Food energy-dependent pheromone-controlled changes in the microRNA/messenger RNA balance link fixation of experience-dependent RNA-mediated amino acid substitutions to supercoiled DNA, which protects us from the virus-driven degradation of messenger RNA.

See also:  A genomic lifespan program that reorganises the young adult brain is targeted in schizophrenia

They invented the term “Transcriptome Trajectory Turning Points.” That is typical of what pseudoscientists must do to prevent others from learning that virus-driven energy theft is the cause of all pathology.

See for comparison: Oppositional COMT Val158Met effects on resting state functional connectivity in adolescents and adults 

One amino acid substitution in supercoiled DNA can make the difference between healthy longevity and virus-driven pathology at any point in life. That is true for all individuals of all species and all serious scientists are using that fact as they continue Combating Evolution to Fight Disease.

See also: Microbial regulation of microRNA expression in the amygdala and prefrontal cortex

See also: Epigenetic Changes Caused by Occupational Stress in Humans Revealed through Noninvasive Assessment of DNA Methylation of the Tyrosine Hydroxylase Gene

See also: A new target for G protein signaling

The structure and mechanism of heterotrimeric G proteins has been studied at atomic resolution (Oldham and Hamm, 2008).

The energy-dependent de novo creation of G protein coupled receptors links the sense of smell in bacteria to our visual perception of mass and energy in the context of the physiology of pheromone-controlled reproduction and the time-space continuum. See: Olfaction Warps Visual Time Perception

See also: Nutrient-dependent pheromone-controlled ecological adaptations: from atoms to ecosystems

This atoms to ecosystems model of ecological adaptations links nutrient-dependent epigenetic effects on base pairs and amino acid substitutions to pheromone-controlled changes in the microRNA / messenger RNA balance and chromosomal rearrangements. The nutrient-dependent pheromone-controlled changes are required for the thermodynamic regulation of intracellular signaling, which enables biophysically constrained nutrient-dependent protein folding; experience-dependent receptor-mediated behaviors, and organism-level thermoregulation in ever-changing ecological niches and social niches. Nutrient-dependent pheromone-controlled ecological, social, neurogenic and socio-cognitive niche construction are manifested in increasing organismal complexity in species from microbes to man. Species diversity is a biologically-based nutrient-dependent morphological fact and species-specific pheromones control the physiology of reproduction. The reciprocal relationships of species-typical nutrient-dependent morphological and behavioral diversity are enabled by pheromone-controlled reproduction. Ecological variations and biophysically constrained natural selection of nutrients cause the behaviors that enable ecological adaptations. Species diversity is ecologically validated proof-of-concept. Ideas from population genetics, which exclude ecological factors, are integrated with an experimental evidence-based approach that establishes what is currently known. This is known: Olfactory/pheromonal input links food odors and social odors from the epigenetic landscape to the physical landscape of DNA in the organized genomes of species from microbes to man during their development.

"Evolution of Man. - Undoubtedly there once lived upon the earth races of men who were much lower in their mental organization than the present inhabitants.

Science vs Secularism: Molecular Mechanisms or Math?

Summary: An example from ancient knowledge of trigonometry links pattern recognition as the basis for the science of creationism, and pattern recognition also is the basis for molecular biology.
What form of virus-driven pathology would you most like to see eliminated from future consideration by serious scientists who know how energy-dependent RNA-mediated cell type differentiation occurs? In any case, a PubMed search for microRNA and your disease of choice will be enlightening. See for example: microRNA + Alzheimer’s or microRNA + fragile X syndrome; Parkinson’s disease; diabetes; cancer; malaria; and/or other human diseases
See:  Are scientists who speak out against religion hurting science? for discussion of Why religion is not going away and science will not destroy it

…science needs all the friends it can get. Its advocates would be well advised to stop fabricating an enemy out of religion, or insisting that the only path to a secure future lies in a marriage of science and secularism.

Serious scientists have met the enemies of science. One of them is the author of Quantum common sense

We don’t need a conscious mind to measure or look. With or without us, the Universe is always looking

More than 64,000 indexed publications on the PubMed site attest to the fact that the energy-dependent de novo creation of plant microRNAs is linked to all healthy longevity via the food energy-dependent pheromone-controlled physiology of reproduction in species from microbes to humans. Experimentally established facts about the virus-driven degradation of messenger RNA are linked to all pathology via changes in the microRNA/messenger RNA balance.

See: Cytosis: A Cell Biology Board Game

A board game taking place inside a human cell! Players compete to build enzymes, hormones and receptors and fend off attacking Viruses!

What form of virus-driven pathology would you most like to see eliminated from future consideration by serious scientists who know how energy-dependent RNA-mediated cell type differentiation occurs? In any case, a PubMed search for microRNA and your disease of choice will be enlightening. See for example: microRNA + Alzheimer’s or microRNA + fragile X syndrome; Parkinson’s disease; diabetes; cancer; malaria; and/or other human diseases
Role of miRNAs in development and disease: Lessons learnt from small organisms

MicroRNAs (miRNAs) constitute a class of small (18-22 nucleotides) non-coding RNAs that regulate gene expression at the post-transcriptional level. Caenorhabditis elegans, Drosophila melanogaster, and many other small organisms have been instrumental in deciphering the biological functions of miRNAs. While some miRNAs from small organisms are highly conserved across the taxa, others are organism specific. The miRNAs are known to play a crucial role during development and in various cellular functions such as cell survival, cell proliferation, and differentiation. The miRNAs associated with fragile X syndrome, Parkinson’s disease, Alzheimer’s disease, diabetes, cancer, malaria, infectious diseases and several other human diseases have been identified from small organisms. These organisms have been used as platforms in deciphering the functions of miRNAs in the pathogenesis of human diseases and to study miRNA biogenesis. Small organisms have also been used in the development of miRNA-based diagnostic, prognostic and therapeutic strategies. The molecular techniques such as genome sequencing, northern blot analysis, and quantitative RT-PCR, have been used in deciphering the functions of miRNAs in small organisms. How miRNAs from small organisms especially those from Drosophila and C. elegans regulate development and disease pathogenesis is the focus of this review. The outstanding questions raised by our current understanding are discussed.

See for comparison: Quantum Theory Rebuilt From Simple Physical Principles by Philip Ball

“What is needed is new mathematics that will render these notions scientific,” he said. Then, perhaps, we’ll understand what we’ve been arguing about for so long.”

I do not believe that new mathematics will end the arguments, and I do not believe anything Philip Ball claims. Does any intelligent person on Earth believe this claim? “We don’t need a conscious mind to measure or look. With or without us, the Universe is always looking”

For a historical perspective on the nonsense touted by theorists and so-called science journalists, like Philip Ball, see:

Secularism: This ancient Babylonian tablet may contain the first evidence of trigonometry

He and Wildberger concluded that the Babylonians expressed trigonometry in terms of exact ratios of the lengths of the sides of right triangles, rather than by angles, using their base 60 form of mathematics, they report today in Historia Mathematica. “This is a whole different way of looking at trigonometry,” Mansfield says. “We prefer sines and cosines … but we have to really get outside our own culture to see from their perspective to be able to understand it.”

When have serious scientists not gone outside our own culture to understand how the history of human behavioral development has been misrepresented by so-called experts.

See: Past 5,000 years prolific for changes to human genome

The findings confirm their earlier work suggesting that the majority of variants, including potentially harmful ones, were picked up during the past 5,000–10,000 years.

Simply put, the harmful variants probably contribute to our relative lack of intelligence compared to the intelligence of our ancestors, unless you think that a single-celled organism is one of your ancestors. Obviously, however, even if that is the case, you are somewhat more intelligent that pond scum. But, let me apologize in advance for referring to you as a “biologically uninformed science idiot” — in the context of the definition of “idiot” as someone with no professional expertise. Apologists might use the term “fool” in the context of this passage from the Holy Bible:

Thou fool, that which thou sowest is not quickened, except it die:”

Feynman used the term “human idiocy” in the context of representations made by theoretical physicists:

Prepare yourself to experience more insults from experts who have, during the past 5-10,000 years confirmed the links from energy to physics, chemistry, and molecular biology in the context of food energy and the biophysically constrained pheromone-controlled physiology of reproduction.

Apologetics:Indiana Banks and the Tablet of Trig

This story attracted my attention because it is yet more evidence against the Darwinian narrative of human history, which holds that we evolved from apes and have been steadily gaining in technology and science ever since. The reality is very different. The evidence often points to initial brilliance followed by decline, the pattern that creationists would expect. In this instance, extremely ancient people pioneered a form of trigonometry that is more exact than the form used by later Mesopotamian nations and by the Greeks, Romans, and later Western Civilization.

Pattern recognition is the basis for the science of creationism and pattern recognition is the basis for molecular biology.

See also: Olfaction Warps Visual Time Perception

In their concluding paragraph, the authors link irreverent representations of the space-time continuum (Hawking, 1988) to our visual perception of mass and energy. With no vague representations of untested theories, they suggest that neural energy represents multisensory input at subsecond scales.

If what they suggest is true, their published work is an unprecedented refutation of neo-Darwinian pseudoscientific nonsense and an unparalleled refutation of “Big Bang” cosmology. Simply put, they concurrently link the creation of energy to the energy-dependent creation of the sense of smell in bacteria. The sense of smell is linked to the pheromone-controlled physiology of reproduction in all living genera via representations that link neural energy from the epigenetic landscape to the physical landscape of supercoiled DNA.

For example, the sense of smell in bacteria is linked to the weekend resurrection of the bacterial flagellum.

See:Evolutionary Rewiring

Strong selective pressure can lead to rapid and reproducible evolution in bacteria.

Natural selection for food energy-dependent codon optimality was linked to the ability of P. fluorescens to find food, which was linked to their pheromone-controlled physiology of reproduction by everything known about quorum sensing. But wait, that fact defies attempts to put the refutation of all theories into the context of something as simple-minded as this claim:

We don’t need a conscious mind to measure or look. With or without us, the Universe is always looking

For more information on the mutation-driven “dumbing down” of you and your ancestors play the game “Cytosis” when it becomes available later this month and watch for more information on the game “Subatomic.” It is less difficult now than it ever has been to link energy-dependent changes from atoms to ecosystems by what is known to serious scientists. But first, you may need to dismiss the pseudoscientific nonsense touted by theorists.

See also: Nutrient-dependent pheromone-controlled ecological adaptations: from atoms to ecosystems

This atoms to ecosystems model of ecological adaptations links nutrient-dependent epigenetic effects on base pairs and amino acid substitutions to pheromone-controlled changes in the microRNA / messenger RNA balance and chromosomal rearrangements. The nutrient-dependent pheromone-controlled changes are required for the thermodynamic regulation of intracellular signaling, which enables biophysically constrained nutrient-dependent protein folding; experience-dependent receptor-mediated behaviors, and organism-level thermoregulation in ever-changing ecological niches and social niches. Nutrient-dependent pheromone-controlled ecological, social, neurogenic and socio-cognitive niche construction are manifested in increasing organismal complexity in species from microbes to man.

See also: Protecting 4 billion people from virus-driven entropy September 8, 2016
See also: Recurrence-Based Information Processing in Gene Regulatory Networks

We also show that the readout layer can learn to decode the information stored in the reservoir via standard evolutionary strategies. Our work thus suggests that recurrent dynamics is a key element for the processing of complex time-dependent information by cells.

What evolutionary strategies led to the recurrent dynamics of time-dependent information processing and the use of trigonometry ~5000 years ago?
Learning from Bacteria about Natural Information Processing

It seems that bacteria have some sort of collective memory by which they keep track of how they handled their previous encounters with antibiotics. They know how to collectively glean information from the environment, “talk” with each other, distribute tasks, generate collective memory, and turn their colony into a “cybernetic system”—a massive “brain” that can perform natural distributed information processing, learn from past experience, and possibly alter the genome organization or even create new genes to better cope with novel challenges.8–13,17,18

Physiology is rocking the foundations of evolutionary biology

Perhaps the elegant mathematics and the extraordinary reputation of the scientists involved blinded us to what now seems obvious: the organism should never have been relegated to the role of mere carrier of its genes.

 
 
 

Cytosis

God vs host-derived creation of virus-driven pathology

Summary: The virus-driven theft of quantized energy forces cells to compete for nutrient energy-dependent RNA-mediated reprogramming in the context of the structure of photons, one-carbon metabolism, autophagy, and the physiology of reproduction, which links energy-dependent changes in chirality from base pairs to RNA-mediated amino acid substitutions.

Host-derived viral transporter protein for nitrogen uptake in infected marine phytoplankton (with my emphasis)

Viruses often carry genes acquired from their host. In the present work, we show that a virus of a marine alga carries a gene encoding a transporter protein that mediates nutrient uptake. We confirm that the viral transporter protein is expressed during infection and show that the protein functions to take up sources of nitrogen. This is important because acquisition of nutrients often determines the ecological success of phytoplankton populations. This work demonstrates how a virus can amend host–viral dynamics by modulating acquisition of nutrients from the environment.

Reported as: Virus reprograms ocean plankton

The virus has stolen a gene from the phytoplankton, which has the surprising effect of making the infected plankton better at absorbing certain nutrients for a period – before the virus kills them.

Much of the planet’s carbon is stored in the sea by a process of algae dying and sinking to the ocean floor, and this research shows a new feature of that process.

“Availability of vitamins and nutrients determine how these phytoplankton function,” said Professor Thomas Richards, of the University of Exeter.

“We have shown that this virus reprogrammes how the phytoplankton obtain nutrients, which affects how they grow and is likely to affect how they absorb carbon dioxide.

“Cells that have the virus are more competitive in the short-term.

The virus-driven theft of quantized energy forces cells to compete for nutrient energy-dependent RNA-mediated reprogramming in the context of the structure of photons, quantum entanglement, one-carbon metabolism, autophagy, and the physiology of reproduction, which links energy-dependent changes in chirality from base pairs to RNA-mediated amino acid substitutions. The amino acid substitutions stabilize the organized genomes of all living genera. Virus-driven energy theft links amino acid substitutions to the stability of viruses at the expense of the stability of organized genomes in all living genera.
The significance of Host-derived viral transporter protein for nitrogen uptake in infected marine phytoplankton can be viewed in the context of prescient predictions made by young earth creationists and other serious scientists. Unfortunately, most of them failed to link energy-dependent RNA-mediated cell type differentiation to all biophysically constrained biodiversity via viral latency.

Pseudoscientists did not mention the likelihood that viruses cause the mutations, which all serious scientists have linked to all pathology. That may be the most recognizable difference between a pseudoscientist and a serious scientist.
See for information reported by serious scientists: Who rules the waves? – Viruses might just be bit players in the drama of the seas. Then again, they could be major actors (1996)

Most consider viruses to be a legion of cripples, sterilised by ultraviolet radiation and rendered impotent by hosts that are largely immune to their threat. But a few researchers take the opposite view. And if they turn out to be right, viruses could radically alter the balance of life in the oceans, ripping away huge parts of the food web that supports whales, sea birds and the fisheries on which many people rely.

See also: 1999 Did God Make Pathogenic Viruses? (1999)
See also: Where do viruses come from? (2004)

“…when virus-infected bacterial cells burst, their energy-rich cell contents spill into the water for other bacteria to scavenge. ‘Viruses tend to keep nutrients away from the big stuff and keep them going around in the little stuff,’ says Fuhrman. If so, viruses have shaped the entire structure of the ecosystem.”

See also: Viral Genome Junk Is Bunk (2015)

So, where do viruses come from that essentially share the same sequences as those found in their host genomes? Perhaps the evolutionists have placed the cart before the horse on this issue, as proposed by several creationist scientists.4,6 In fact, in an ironic twist, the evidence mentioned above indicates that viruses likely arose from their hosts and not the other way around. As molecular biologist and biochemist Peter Borger notes, “The most parsimonious answer is: the RNA viruses got their genes from their hosts.”6

See for comparison from 2017:
Overthrowing the Hegemony of the Culture of Margulis?
Asgard archaea illuminate the origin of eukaryotic cellular complexity
Mitochondria are not captive bacteria

Carl Woese failed to place his ideas about the three domains of life into the context of how biophysically constrained viral latency links the anti-entropic virucidal energy of sunlight from the physiology of pheromone controlled reproduction to all biodiversity. Woese was wrong about everything. There is one domain of life. In all living genera, the pheromone-controlled physiology of reproduction is energy-dependent and RNA-directed DNA methylation links amino acid substitutions in supercoiled DNA to all biodiversity.

See for comparison this example of human idiocy, On the Origin of Reverse Transcriptase-Using CRISPR-Cas Systems and Their Hyperdiverse, Enigmatic Spacer Repertoires

Only neo-Darwinian theorists insist on playing word games to link what they refer to as “enigmatic spacer repertoires” to biodiversity outside the context of energy-dependent changes in the microRNA/messenger RNA balance that link electrons to ecosystems via hydrogen-atom transfer in DNA base pairs in solution.

“Human idiocy” was the term used by Feynman before Roger Penrose reminded us that all organisms must eat. See: “How often do we still hear that quantum effects can have little relevance in the study of biology, or even that we eat food in order to gain energy?” (1991)

For comparison see: Fink et al., (2017) Cross-Cultural Investigation of Male Gait Perception in Relation to Physical Strength and Speed Fink also is a co-author of the award-winning review: Human pheromones: integrating neuroendocrinology and ethology (2001)
See for comparison: A BRIEF ESSAY ON HOW COMPARATIVE PSYCHOLOGY BECAME AN ENDANGERED SPECIES (link opens pdf)

Rather than continue to link food energy from the pheromone-controlled physiology of reproduction to all biodiversity in all living genera, Fink joined the pseudoscientists. He appears to be following the lead of people like Jay R. Feierman. As moderator of the International Society for Human Ethology’s Yahoo Group, Feierman has inadvertently eliminated all works of human ethologists from any further consideration, and he admits it.

See: 8/21/17 [HUMAN ETHOLOGY MODERATOR NOTE: I could write a similar essay on why human ethology is an endangered species but the causes would be different.  I’m old enough to have seen many academic disciplines disappear and new ones take their place. It is rather easy to put this process into a cultural evolution model. Academic disciplines are like species, most of the ones who have ever lived are now extinct. New species are born and old species die…. jrf]

On July 25, 2013, Feierman [jrf] wrote: Variation is not nutrient availability and the something that is doing the selecting is not the individual organism. A feature of an educated person is to realize what they do not know. Sadly, you don’t know that you have an incorrect understanding [of] Darwinian biological evolution.
Four years later, the concept of “new species are born and old species die” is divorced from the claims Jay R. Feierman made.
See for comparison: Linking mental health and the gut microbiome

The main idea of our review is that there is strong communication between the gastrointestinal tract and the brain, and that changes to the microbiome-gut-brain axis could be associated with the etiology of different neuropsychiatric disorders such as depression…

Food energy-dependent changes in the microbiome-gut-brain axis link nutrient stress and social stress from the de novo creation of microRNAs in plants to changes in the microRNA/messenger RNA balance of animals via links from food odors to pheromone-controlled ecological adaptations in species from microbes to humans.
See: Feedback loops link odor and pheromone signaling with reproduction
See for comparison: “I Am I and My Bacterial Circumstances”: Linking Gut Microbiome, Neurodevelopment, and Depression

A better perception of the significance of the MGB axis in the etiology of depression will help us to obtain a better understanding about the pathophysiology of this syndrome. Also, it opens the possibility to offer better treatment strategies to our patients. This will be possible only if we accomplish to decipher the genetic, anatomical, functional, and behavioral characteristics of the human microbiota. The most important limitation in the area of the MGB axis’ research lies in the fact that there is very little knowledge about the gut microbiome.

The claim that there is very little knowledge about the gut microbiome can be compared to what is known about the link from the virus-driven degradation of messenger RNA in soil bacteria to all pathology in all living genera. Everything known to serious scientists was detailed in the context of this report: The Bull Sperm MicroRNAome and the Effect of Fescue Toxicosis on Sperm MicroRNA Expression The changes in the microRNAome included the link to the transgenerational epigenetic inheritance of all pathology in all living genera. The links from the transgenerational epigenetic inheritance of cancer and the transgenerational epigenetic inheritance of behavioral disorders were place into the context of links from quantum physics to quantum souls.
See: Quantum Souls and Welcome to the official YouTube Channel of Quantum Souls.
Video interview about the death of Robin Williams
Superbugs, Bacteriophages and Phage Therapy: An Interview with James Kohl
Food Energy-Dependent Cell Type Differentiation Refutes Theory of Evolution
How to Treat Cancer as a Disorder of Energy Transfer
Charles Darwin Taught Conditions of Life, Not Mutations
Quantized Energy Links Olfaction from Angstroms to Ecosystems Part 1
Quantized Energy Links Olfaction from Angstroms to Ecosystems Part 2
When you next see someone claim that “…there is very little knowledge about the gut microbiome” you may associate that claim with the ignorance touted by neo-Darwinian theorists and compare it to what anyone 10 years-old or older will learn when they play the cell biology game “Cystosis.”

A board game taking place inside a human cell! Players compete to build enzymes, hormones and receptors and fend off attacking Viruses!

Amino acid modification FA_Epigenetics_Table1

Food energy-dependent cell type differentiation (2)

Summary: The concept of “faster-evolving DNA” regions in the context of nucleotide variation in both the 16S and 12S sequences is not consistent with any accurate representation of how the functional structure of supercoiled DNA must be linked from energy-dependent changes in angstroms to ecosystems in all living genera. Conserved molecular mechanisms link the sense of smell in bacteria from the de novo creation of olfactory receptor genes to the physiology of reproduction via the microRNA/messenger RNA balance and Feynman’s claim about the human idiocy of theoretical physicists who use different terms for their measurements of food energy.
See first: Food energy-dependent cell type differentiation
See also: Bacterial Communication And Relevance Of Quantum Theory
Thanks to antagonist Jay R. Feierman for calling this to my attention, See: Fwd: Bacterial Communication And Relevance Of Quantum Theory

The recent findings confirm that bacteria communicate each other through chemical and electrical signals. Bacteria use chemical signaling molecules which are called as quorum sensing molecules (QSMs) or autoinducers. Moreover, the ion channels in bacteria conduct a long-range electrical signaling within biofilm communities through propagated waves of potassium ions and biofilms attracts other bacterial species too. Both communication process are used by bacteria to make their own survival strategies. In this article, we model this bacterial communication mechanism by complex Ginzburg-Landau equation and discuss the formation of patterns depending on kinematic viscosity associated with internal noise. Again, the potassium wave propagation is described by the non-linear Schrodinger equation in a dissipative environment. By adding perturbation to non-linear Schrodinger equation one arrives at Complex Ginzburg-Landau equation. In this paper we emphasize that at the cellular level (bacteria) we use Complex Ginzburg-Landau equation as a perturbed Non-linear Schrodinger equation to understand the bacterial communication as well as pattern formation in biofilms for certain range of kinematic viscosity which can be tested in laboratory experiment. Here, the perturbation is due to the existence of nonthermal fluctuations associated to the finite size of the bacteria. It sheds new light on the relevance of quantum formalism in understanding the cell to cell communication.

For everyone who does not follow my posts on groups and in forums where they are not commonly edited or fail to appear because the moderators and administrators are biologically uninformed theorists, I reiterate:
Natural selection for energy-dependent codon optimality and nutrient energy-dependent quorum sensing have been linked from the pheromone-controlled physiology of reproduction in bacteria that naturally produce a uranium isotope to all morphological and behavioral biodiversity via an atoms to ecosystems model that refutes every aspect of neo-Darwinian theory and all theories linked to the claims of “Big Bang” cosmologists.
Clearly, Feedback loops link odor and pheromone signaling with reproduction (2005) in all living genera can be compared in the context of two claims, which were made by the moderator of the ISHE’s human ethology group, soon after I published Nutrient-dependent/pheromone-controlled adaptive evolution: a model (6/14/13)
7/25/13
Jay R. Feierman: Variation is not nutrient availability and the something that is doing the selecting is not the individual organism. A feature of an educated person is to realize what they do not know. Sadly, you don’t know that you have an incorrect understanding [of] Darwinian biological evolution.
7/26/13
Jay R. Feierman: I am absolutely certain that if you showed this statement to any professor of biology or genetics in any accredited university anywhere in the world that 100% of them would say that “Random mutations are the substrate upon which directional natural selection acts” is a correct and true statement.
See for comparison: Quantum Souls

The sun’s energy flows to Earth as information that is absorbed by energy-dependent organisms. Along with nutrient-dependency and pheromones, it effects all living genera and ensures reproduction. God’s “conditions of life,” described in part by Darwin, come before natural selection.

For additional evidence that links the anti-entropic virucidal energy of sunlight to all biodiversity and the concept of quantum souls, I reiterate:
Figure 4: Conceptual model of uranium roll-front deposit formation. — from Biogenic non-crystalline U(IV) revealed as major component in uranium ore deposits (open access)

Precursors and conditions favouring the formation of uraninite, biogenic uraninite and non-crystalline U(IV) are illustrated.

The nutrient energy-dependent pheromone-controlled physiology of reproduction of bacteria that live underground was linked from thermodynamic cycles of RNA-mediated protein folding chemistry to the production of uranium isotopes. The obvious link from the quantized energy of sunlight to the de novo creation of all biodiversity also was reported in the context of 16S rRNA microbial community analysis in fish. Most authors report this in the context of a “DNA-based” analysis. That way, there is no need to differentiate between abiogeneis and biophysically constrained biogenesis. Start with genes and you do not need to explain how DNA was created.

See for comparison: Evaluation of the 16S and 12S rRNA genes as universal markers for the identification of commercial fish species in South Africa

The nucleotide variation in both the 16S and 12S sequences was suitable for identifying the large majority of the examined fish specimens to at least the level of genus, but was found to be less useful for the explicit differentiation of certain congeneric fish species. It is recommended that one or more faster-evolving DNA regions be analysed to confirm the identities of closely-related fish species in South Africa.

The concept of “faster-evolving DNA” regions in the context of nucleotide variation in both the 16S and 12S sequences is not consistent with any accurate representation of how the functional structure of supercoiled DNA must be linked from energy-dependent changes in angstroms to ecosystems in all living genera. Conserved molecular mechanisms link the sense of smell in bacteria from the de novo creation of olfactory receptor genes to the physiology of reproduction via the microRNA/messenger RNA balance and Feynman’s claim about the human idiocy of theoretical physicists who use different terms for their measurements of food energy.
The amount of food energy, measured in calories, is linked to whether or not the organism starves to death before it reproduces. That’s how ecological variation in the supply of nutrients may lead to extinction of any species that fails to evolve into another species. So far, no experimental evidence of biologically-based cause and effect suggests that any species has ever evolved into another species.
Claims about the need for energy-dependent changes in supercoiled DNA to protect all organized genomes from the virus-driven degradation of messenger RNA, which is linked to mutations and all pathology may have have peaked with this publication:
Viral MicroRNAs, Host MicroRNAs Regulating Viruses, and Bacterial MicroRNA-Like RNAs (5/25/17)

Over the last decade, it has become increasingly apparent that miRNAs have many important roles in the development of disease and cancer. Recently, however, their role in viral and bacterial gene regulation as well as host gene regulation during disease progression has become a field of interest.

More than 61,000 works published peer-reviewed works show why differences in the types of microRNAs are the most important consideration to energy-dependent healthy longevity or to virus-driven pathology.
MicroRNA Items: 1 to 20 of 61426
See for comparison: It’s Time to Start Calling Evangelicals What They Are: The American Taliban

Atheistic hate-mongers like Magnus S. Magnusson continue to disseminate this nonsense and encourage attacks on any views that link Creationism to Americanism. The hate-mongers don’t know who created energy or how energy-dependent ecological adaptation is linked from changes in base pairs to all biodiversity, but they will claim that American evangelicals are like the Taliban.

See for comparison:  The in vivo structure of biological membranes and evidence for lipid domains

The structure and organization of the cell membrane are central to many biological functions, and although they have been extensively studied, there is still much that we don’t understand. A wealth of detailed information has been obtained from studies of model lipid membranes. However, these systems are often highly simplified in composition and always lack the active processes found in cells. The major obstacle to studying membranes in vivo in living cells has been that high-resolution physical methods used to investigate membrane structure are not compatible with living organisms. To overcome this obstacle, we employed a new in vivo approach that allows membrane structure to be observed directly in the gram-positive bacterium B. subtilis. This approach relies on tuning the isotopic content of hydrogen within the membrane, and other parts of the bacterium, to generate neutron scattering spectra exclusively from the membrane. Using this approach, we confirmed that the structure of the B. subtilis membrane is lamellar and has an average hydrophobic thickness of 23.9 ± 0.9 Ångstroms (Å). We were also able to observe nanoscopic lateral membrane structures, consistent with the notion of lipid rafts. This experimental approach will allow for a wide range of future structural studies of the cell membrane (and possibly other classes of biomolecules) without the need for extrinsic probes or labels. In this way, it fundamentally changes the scope of nanoscale structural questions that can be addressed in vivo.

Reported as: This Is The First Ever Nanoscale Image of a Living Cell Membrane 

They link the energy-dependent de novo creation of the cell wall in Bacillus subtilus, a Gram-positive, catalase-positive bacterium, found in soil and the gastrointestinal tract of ruminants and humans, to all biodiversity on Earth via differences in hydrogen ions, hydrogen atom transfer in DNA base pairs in solution, and the pheromone-controlled physiology of reproduction.

Hydrogen ions are made by the removal of one electron from atomic hydrogen. That fact supports the the claims of those who have linked energy-dependent changes from atoms to ecosystems in all living genera via what occurs at the level of changes in angstroms. The changes in angstroms are linked to the innate ability of all cell types to signal other cell types via changes in the membrane that biophysically constrains the contents of the cell.
Although it is important that these researchers showed how the role of quantized energy from the sun is linked to biophysically constrained hydrophobicity in supercoiled DNA, anyone who has ever performed a “catalase” test to distinguish between pathogenic and non-pathogenic strains of Staphlococcus and Streptococcus before testing for beta-lactamase and resistance to oxacillin/methicillin has observed the release of hydrogen caused by the breakdown of the cell membrane.

Catalase is a common enzyme found in nearly all living organisms exposed to oxygen (such as bacteria, plants, and animals). It catalyzes the decomposition of hydrogen peroxide to water and oxygen.[3]”

Beta-lactamase provides antibiotic resistance by breaking the antibiotics’ structure. These antibiotics all have a common element in their molecular structure: a four-atom ring known as a β-lactam. Through hydrolysis, the lactamase enzyme breaks the β-lactam ring open, deactivating the molecule’s antibacterial properties.”

Congratulate the researchers who have just refuted every aspect of neo-Darwinian theory as was predicted by any intelligent microbiologist who has ever needed to identify and perform susceptibility testing on a pathogen to help a physician keep the pathogen from killing the patient.

And, remember the Hippocratic Oath. First, do no harm. If you are a physician who thinks that people evolved from bacteria, learn something about cell type differentiation via a visit to the microbiology lab at a local hospital. Most medical laboratory scientists will be happy to help you stop killing people with your ignorance.

Serious scientists have forced theorists to change their claims about the gene editing technology called CRISPR Cas9 to reflect the fact that the reason the technology failed miserably. The technology was based on naturally occurring endogenous RNA interference. It is now being reported as CRISPRi in the context of identifying new genes but outside the context of their energy-dependent de novo creation.

See: High-throughput CRISPRi phenotyping identifies new essential genes in Streptococcus pneumoniae

Genome‐wide screens have discovered a large set of essential genes in the opportunistic human pathogen Streptococcus pneumoniae. However, the functions of many essential genes are still unknown, hampering vaccine development and drug discovery. Based on results from transposon sequencing (Tn‐seq), we refined the list of essential genes in S. pneumoniae serotype 2 strain D39. Next, we created a knockdown library targeting 348 potentially essential genes by CRISPR interference (CRISPRi) and show a growth phenotype for 254 of them (73%). Using high‐content microscopy screening, we searched for essential genes of unknown function with clear phenotypes in cell morphology upon CRISPRi‐based depletion. We show that SPD_1416 and SPD_1417 (renamed to MurT and GatD, respectively) are essential for peptidoglycan synthesis, and that SPD_1198 and SPD_1197 (renamed to TarP and TarQ, respectively) are responsible for the polymerization of teichoic acid (TA) precursors. This knowledge enabled us to reconstruct the unique pneumococcal TA biosynthetic pathway. CRISPRi was also employed to unravel the role of the essential Clp‐proteolytic system in regulation of competence development, and we show that ClpX is the essential ATPase responsible for ClpP‐dependent repression of competence. The CRISPRi library provides a valuable tool for characterization of pneumococcal genes and pathways and revealed several promising antibiotic targets.

The de novo creation of essential genes has been placed into the context of a problem with antibiotic sensitivity testing.

 
The problem was introduced into susceptibility testing by biologically uninformed theorists who still may not know the difference between energy-dependent ecological adaptation and mutation-driven evolution.

Cell-type-specific genome editing with a microRNA-responsive CRISPR-Cas9 switch

The transient and conditional expression of our system using synthetic RNA could provide genome editing as a potentially ‘one-shot therapy’ to treat numerous genetic diseases. In conclusion, our miR-Cas9 switch combined with a RNA-delivery approach can selectively engineer genomes of target cells by detecting an endogenous miRNA signature, with potential benefits for synthetic biology, genome editing field and future therapeutic applications.

The conditional expression of genes is linked from food energy-dependent pheromone-controlled biophysically constrained viral latency to healthy longevity or from virus-driven energy theft to constraint breaking mutations and all pathology.

People like Jay R. Feierman and Magnus S. Magnusson tout the pseudoscienitific nonsense of theories in books such as this one. The Biology of Religious Behavior: The Evolutionary Origins of Faith and Religion
Their atheistic agenda is the antithesis of any factual representation of anything known to serious scientists about biophysically constrained energy-dependent biologically-based cause and effect.
See for comparison:  Mechanism of transmembrane signaling by sensor histidine kinases reported as:Scientists investigate how the sense of smell works in bacteria

…the signaling and inactive states differ only very slightly at the nitrate-binding site – by 0.5-1 angstroms, which is approximately one fifth of the size of the ion itself (1 angstrom is 10-10 meters). However, when this ion binds to the sensor, it causes huge changes in the protein: The helices of different monomers begin to move in different directions, like pistons. These “pistons” transmit the small change of 0.5-1 angstroms through the membrane, and their outer ends shift by approximately 2.5 angstroms in different directions. Inside the cell, in the HAMP domain, these shifts are converted into the rotation of two parts of NarQ relative to each other. Ultimately, the positions of the output helices change by as much as 7 angstroms, thus completing the signal transmission.

See also: Eros is a novel transmembrane protein that controls the phagocyte respiratory burst and is essential for innate immunity
For a non-technical representation of everything currently known to serious scientists about the energy-dependent biophysically constrained physiology of pheromone-controlled biodiversity in all living genera see: The Scent of Eros: Mysteries of Odor in Human Sexuality (1995/2002)
Could any serious scientist fail to link the novel transmembrane protein “Eros” from what organism eat to innate immunity via the non-technical representations in The Scent of Eros? If you know someone who you think is a serious scientist ask them about the representations made in The Biology of Religious Behavior: The Evolutionary Origins of Faith and Religion. If you learn that they think Faith and Religion “evolved,” I will add them to my growing list of pseudoscientists who continue to tout ridiculous theories.
 

Amino acid modification FA_Epigenetics_Table1

Biologically uninformed biologists fight back and lose

Novel layers of RNA polymerase III control affecting tRNA gene transcription in eukaryotes 22 Feb 2017

A subset of tRNA genes shows low responsiveness to both environmental and cellular signals. Notably, this group contains at least one tRNA for each amino acid. Together these findings suggest the existence of a basal subset of housekeeping tRNA genes [36]. This concept is consistent with the mode of Maf1-mediated repression of actively transcribed tRNA genes in human cells subjected to serum starvation [104].

See also the citation to (with my emphasis): Kimura M, Ishihama A. 1995 Functional map of the alpha subunit of Escherichia coli RNA polymerase: amino acid substitution within the amino-terminal assembly domain. J. Mol. Biol. 254, 342–349.
The fact that an enzymatic reaction linked energy to the amino acid substitution seems to have been virtually ignored by theorists

See for example comparison: Richard Lenski – Evolution in a Flask

Published on 24 Feb 2017

Dr. Stan Maloy talks with Richard Lenski Ph.D., Hannah Professor of Microbial Ecology, Michigan State University, about his research into the evolution of bacteria and the new frontier of digital evolution.Episode 61 of MicrobeWorld Video, filmed at the American Association for the Advancement of Science Meeting in Vancouver, Canada on February 17th, 2012.

Lenski’s Long Term Evolution Experiment with E. coli has seen over 50,000 new generations since its inception in 1998. This has led to insights such as how viruses can evolve from types that don’t infect humans to ones that do.

Lenski’s work with E. coli has also led him into the digital world. Using computers, Lenski can achieve precise, rapid results by manipulating digital organisms. Software that evolves much like bacteria in the real world.

Lenski is optimistic about the future of evolution research. Applying the generalities that have resulted from his studies to any number of other microbial species. He also sees large potential in applying what he’s learned to the study of antibiotic resistance and bioengery.

The fact that Richard Lenski failed to acknowledge what was known about the nutrient energy-dependent RNA-mediated amino acid substitution that stabilized the organized genome of E. coli, his model organism, attests to how much pseudoscientific nonsense about mutations, natural selection, and evolution he has been touting for more than 2 decades.
For comparison, see: Measurements of translation initiation from all 64 codons in E. coli
Reported as: Start codons in DNA may be more numerous than previously thought
See also: Biodiversity is autocatalytic

…it was recently shown using the RAF algorithm that the metabolic network of Escherichia coli forms a large autocatalytic set of close to 1800 reactions (Sousa et al., 2015). As far as we know, this is the first formal proof that living organisms
(or at least essential parts thereof) are indeed autocatalytic sets.

Reported as: Autocatalytic biodiversity hypothesis aims to supplant Darwin’s ‘war of the species (February 9, 2017)

A species emerges from this environment and is an expression of those interactions. In other words, species are expressed and maintained by a complex interacting ecological network.

Contrary to Darwin’s beliefs, biodiversity, according to Dr. Cazzolla Gatti, does not derive “from the war of nature, from famine and death,” but from the power of life to enable other life; not from war, but from coexistence; not from competition but from the avoidance of it, e.g. from cooperation and facilitation, i.e., by autocatalysis.

The power of life to enable other life is nutrient energy-dependent and controlled by the physiology of reproduction. That fact explains why virus-driven energy theft is being linked to all pathology in the science news that is reported each day. The obfuscation is clear in the fact that there is no such thing as a genomic pathway outside the context of epigenetic effects that link metabolic networks to genetic networks in all living genera. When you see a report that does not link energy-dependent epigenetic effects to supercoiled DNA or to virus-driven pathology, you should learn to recognize the tactics that are used to frame experimental evidence of biologically-based cause and effect in the context of evolutionary theories about evolutionary pathways and/or genomic pathways.
Faulty genomic pathway linked to schizophrenia developing in utero, study finds

“This research shows that there is a common dysregulated gene program that may be impacting more than 1,000 genes and that the great majority of those genes are targeted by the dysregulated nuclear FGFR1,” Stachowiak said.

When even one of the many schizophrenia-linked genes undergoes mutation, by affecting the INFS it throws off the development of the brain as a whole, similar to the way that an entire orchestra can be affected by a musician playing just one wrong note, he said.

See the obfuscatory attempt in:

See also: Epigenome: The symphony in your cells
The “symphony” is energy-dependent and RNA-mediated via endogenous RNA interference in the context of the physiology of reproduction.

 
 
 

Alternative splicing of pre-mRNA

Bill Gates refutes theistic evolution (sequel)

See: Bill Gates refutes theistic evolution
See also: Gate-controlled conductance switching in DNA

Conclusion:

Our work demonstrates one can introduce an active control to DNA conductance by modifying a base with a redox group, and switch the DNA conductance reversibly between two levels by oxidizing or reducing the redox group with an EC gate. This strategy could be implemented in more sophisticated DNA nanostructures for active device building blocks. As the DNA conductance is an indicator of the molecule in the reduction or oxidation state, it is possible to study redox reaction kinetics at the single-molecule level by monitoring the DNA conductance.

Reported as: Switched-on DNA: Sparking nano-electronic applications

…the engineered DNA provides a nice tool to examine redox reaction kinetics, and thermodynamics the single molecule level…

This means they can examine virus-driven energy theft in the context of redox reaction kinetics and thermodynamics at the single molecule level, which links nutrient energy-dependent changes from angstroms to ecosystems via the physiology of pheromone-controlled reproduction in species from microbes to humans. Simply put, they can link virus-driven energy theft from mutations to all pathology in species from archaea to modern humans.
See for comparison: Actor Steven Kearney reads excerpts from Greg Bear‘s 1985 novel Blood Music.

The virus is made up of tiny biological computers called “noocytes,” where were intended to improve the human body — giving it routine maintenance and maximizing human potential. Instead, it wiped out most of North America.

See also: Donald Trump’s abortion funding ban condemned by Bill Gates

“The US is the number one donor in the work that we do. Government aid can’t be replaced by philanthropy,” the 61-year-old told the Guardian.

Under the order, which is also known as the Mexico City Policy after it was first unveiled at a UN conference there in 1984, no government funding for family planning services can be given to clinics or groups outside the US that offer abortion or counselling services.

Why is Bill Gates condemning any of President Trump’s foreign policies before the Bill and Melinda Gates foundation stops funding research that is irrelevant to prevention of the viral apocalypse. Does Bill Gates decide who gets the vaccine and who doesn’t at the time the apocalypse begins, or will other billionaires like George Soros dictate all foreign policies? Who are you going to trust with the lives of your loved ones?

See also: Leakers beware: Trump has utterly defeated the disloyal coteries of the US intelligence community with my emphasis

The Trump administration exposed the false flag terrorism in the media.

Donald Trump posed as a hit man. He made sure that the leakers in the IC knew that their actions were illegal. He WARNED them. Then he launched his sting.

Donald Trump gave a press conference in which he admitted to the sting. He said that the leaks are real, but the news is fake.

It was his tactic, and he had to expose how he used it. That exemplifies Trump’s brilliance. Any intelligent disloyal Democrat from the intelligence community should have seen it coming. That suggests none of them are intelligent adversaries.
The biased media reporting on the press conference attests to lack of intelligence among the media representatives who reported the claims of Trump’s ignorant adversaries. The media representatives continue to look more foolish every time they speak out against the President of the United States.
The media representatives won’t be charged with any crimes. How many disloyal Democrats from the intelligence community will be prosecuted for treason?
How will President Trump deal with disloyal billionaires and others who waste his time attempting to influence the people of the United States and cause them to challenge him on topics they know nothing about?
Who will be the next billionaire to inadvertently refute theistic evolution by linking what is known about nutrient energy-dependent RNA-mediated amino acid substitutions to healthy longevity and linking virus-driven energy theft to all pathology?
Will Mark Zuckerberg eliminate the false flag terrorist groups from Facebook?
Will Paul Allen stop funding brain research that does not link the speed of light on contact with water to all energy-dependent cell type differentiation in all living genera via biophotonics and optogenetics?
See also: Billionaires say they’ll end disease. Evolution suggests otherwise

Darwin introduced a viewpoint that was radically unsettling: we don’t progress to a more perfect form, but adapt to local environments. If humans are machines, then we can simply repair the broken parts. But if there is something more fundamental to the crisis of life than mere mechanisms of biology, then risk, and an element of danger, will always be with us.

Humans are not machines. Bill Gates probably knows that. And he probably knows that theistic evolution is the threat that can now be placed into the context of Non-theistic evolution

The major criticism of theistic evolution by non-theistic evolutionists focuses on its essential belief in a supernatural creator. These critics argue that by the application of Occam’s razor, sufficient explanation of the phenomena of evolution is provided by natural processes (in particular, natural selection), and the intervention or direction of a supernatural entity is not required.[42] Evolutionary biologist Richard Dawkins considers theistic evolution a superfluous attempt to “smuggle God in by the back door”.[43]

God doesn’t need to be smuggled in. He’s always been with those who believe. Believers know that natural selection for energy-dependent codon optimality occurs in the context of the physiology of pheromone-controlled reproduction. The physiology of energy-dependent reproduction links natural processes to fixation of amino acid substitutions in supercoiled DNA that differentiate the cell types of all living genera.

Supercoiled DNA protects all organized genomes from virus driven energy theft, which is linked to all pathology by mutations. Theistic evolutionists may continue to claim that they believe in mutation-driven evolution, but that’s because they known nothing about energy-dependent top-down causation.

Ask Bill Gates or a theistic evolutionist where the energy comes from, and see for comparison.

Charge-altering releasable transporters (CARTs) for the delivery and release of mRNA in living animals

CARTs are structurally unique and operate through an unprecedented mechanism, serving initially as oligo(alpha-amino ester) cations that complex, protect, and deliver mRNA and then change physical properties through a degradative, charge-neutralizing intramolecular rearrangement, leading to intracellular release of functional mRNA and highly efficient protein translation.

Reported as: A new way Forward for Gene Therapy

Sickle-cell disease is caused by a mutation that links the transgenerational epigenetic inheritance of virus-driven energy theft to failed nutrient energy-dependent RNA-mediated DNA repair. Hemoglobin S is a naturally occurring hemoglobin variant — one of more than 1200 other variants. The variants link RNA-mediated amino acid substitutions in the cell types of populations of ecologically adapted humans. Clearly, their lineages adapted to ecological variation in the parts of the world where they were raised. Researchers have delivered nutrient energy-dependent messenger RNA (mRNA) into cells that use the mRNA to make proteins. What’s missing from this report on gene therapy are facts about how nutrient energy-dependent viral latency must be linked to healthy longevity via energy-dependent changes in the microRNA/messenger RNA balance linked to amino acid substitutions in supercoiled DNA, or from virus-driven energy theft to all pathology.
I continue to encourage comments from those who are not Combating Evolution to Fight Disease, especially if they are willing to tell others what they like about virus-driven energy theft and all pathology. Now that Bill Gates has clearly stated that virus-driven energy theft is not likely to be a good thing for humanity, perhaps he will join the serious scientists and/or help to fund their works.
See for example: The 2000 T. H. Morgan Medal Essay: H. J. Muller and the Nature of the Gene and works published by Ruth Ann Luna.
For example,  The Brain-Gut-Microbiome Axis: What Role Does It Play in Autism Spectrum Disorder? and her presentation from February 22, 2017:
The Microbiome-Gut-Brain Axis: Linking Gastrointestinal and Neurobehavioral Processes in Autism Spectrum Disorder
She graciously answered these three questions:
Q: Is the gut microbiome the most likely link from nutrient energy-dependent metabolic networks to genetic networks and Precision Medicine via the National Microbiome Initiative?

Ruth Ann Luna PhD, MB (ASCP) CM

It’s certainly a key player in the crosstalk, but there’s still much to uncover about these pathways.

Q: Have you placed the 2016 publication of “Codon identity regulates mRNA stability and translation efficiency during the maternal-to-zygotic transition” into the context of natural selection for energy-dependent codon optimality and transgenerational epigenetic inheritance in your works?

Ruth Ann Luna PhD, MB (ASCP) CM

No we have not. We are working from functional gut microbiome up the gut-brain axis at this point and hoping to weave in as many other factors as possible.

Q: Who else is addressing the bidirectional communication besides your group?
Ruth Ann Luna PhD, MB (ASCP) CM

There are many other groups evaluating the gut-brain connection in general, but not necessarily exclusive to ASD. I’d suggest a quick search in Pubmed for the latest groups involved in this area.

See: Search Results for “autism” and Search results for “autism microrna”
Her expressed intent to “weave in other factors that already are known to me and to Teresa Binstock inspired me to perform this search for the terms autism and microRNA
See for example from February 17, 2017: Regulation of mRNA splicing by MeCP2 via epigenetic modifications in the brain
Conclusion:

Our analysis thus indicated that MeCP2-mediated alternative splicing might influence neuronal functions via two different strategies: one is to regulate protein diversity by coding exons, and another is to regulate protein expression by non-coding exons. Our studies not only systematically explore the mechanisms underlying MeCP2-mediated alternative splicing, but also provide insights into the roles of MeCP2-mediated alternative splicing, which could influence both protein diversity and protein expression level in neurons.

Our 1996 Hormones and Behavior review explored the molecular mechanisms of RNA-mediated alternative splicings and nutrient-dependent pheromone-controlled biophysically constrained protein folding chemistry in the context of the physiology of reproduction in species from microbes to humans.
See our molecular epigenetics section in From Fertilization to Adult Sexual Behavior

Small intranuclear proteins also participate in generating alternative splicing techniques of pre-mRNA and, by this mechanism, contribute to sexual differentiation in at least two species, Drosophila melanogaster and Caenorhabditis elegans (Adler and Hajduk, 1994; de Bono, Zarkower, and Hodgkin, 1995; Ge, Zuo, and Manley, 1991; Green, 1991; Parkhurst and Meneely, 1994; Wilkins, 1995; Wolfner, 1988). That similar proteins perform functions in humans suggests the possibility that some human sex differences may arise from alternative splicings of otherwise identical genes.

If my co-authors and I had been funded to link what was known about biologically-based cell type differentiation in all species to their origins and from ecological variation to ecological adaptations in all living genera, you would not need to ask whether or not some or all of your loved ones will survive the viral apocalypse.
Nutrient energy-dependent sexual differentiation in yeasts at the advent of sexual reproduction has been linked to all cell type differentiation in all individuals of all species via the conserved molecular mechanisms of pheromone-controlled reproduction that we began to detail two decades ago.
See also: Possible sexually dimorphic role of miRNA and other sncRNA in ASD brain

Our findings of sexual dimorphism in sncRNA levels underscore the importance of considering sex, in addition to age, when interpreting molecular findings on ASD brain.

The interpretation of molecular findings on ASD brain can be placed into the context of virus-driven energy theft and all pathology via the transgenerational epigenetic inheritance of Zika virus-damaged DNA in humans. For comparison see how Greg Bear used information on nutrient-dependent pheromone-controlled RNA-mediated protein folding chemistry to ecological adaptations in a new human subspecies.
See also: Association Between the Probability of Autism Spectrum Disorder and Normative Sex-Related Phenotypic Diversity in Brain Structure

…etiological models suggest that the biological male phenotype carries a higher intrinsic risk for ASD than the female phenotype. To our knowledge, this hypothesis has never been tested directly, and the neurobiological mechanisms that modulate ASD risk in male individuals and female individuals remain elusive.

The neurobiological mechanisms link sex differences in the cell types of yeasts to sex differences in virus-driven energy theft and all pathology.
Reviewed as: Evolution rising from the grave

Bear goes a little further in suggesting that such change can occur over about a generation, an idea that might be a little too radical at the moment. However, he does mention data suggesting that fruitflies can adapt to a new environment in just a few generations of selection.

Reviewed as: Living with the Neanderthals

Bear’s two Darwin novels were not written just to entertain. He also seeks to teach readers about science, to highlight our utilitarian politics and our inability to get along with each other, and to provide a quasi-rational basis for theology and morality. He advances a world view in which we are all part of the vast neural network of life, cutting across ethnic borders, species divides and the chasms between taxonomic kingdoms, in balance, and in two-way communication, with the ecosystem.

Bear qualifies to win the next Nobel Peace Prize, or minimally, the Prize for Literature. When you realize whose information is being used as a basis for the claims by Bill Gates that support young earth creationism, see also: Viral Genome Junk Is Bunk

…in an ironic twist, the evidence mentioned above indicates that viruses likely arose from their hosts and not the other way around. As molecular biologist and biochemist Peter Borger notes, “The most parsimonious answer is: the RNA viruses got their genes from their hosts. 6

Where else would viruses get their genes, and what else would force organisms to use the sun’s anti-entropic virucidal energy to adapt?

Alternative splicing of pre-mRNA

Bill Gates refutes theistic evolution

See: Bill Gates refutes theistic evolution (prequel)

See for comparison: Our 2017 Annual Letter Warren Buffett’s Best Investment

Reported as: Scientists create first stable semisynthetic organism

 “We can now get the light of life to stay on,” said Romesberg. “That suggests that all of life’s processes can be subject to manipulation.”

Life’s processes are manipulated by nutrient energy-dependent endogenous RNA interference in the context of the physiology of pheromone-controlled reproduction in all living genera. Supercoiled DNA protects all organized genomes from virus-driven energy theft and genomic entropy. But, someone will make billions of dollars on vaccines like this one, which will cost millions and be delivered only to those who can pay for them.

Alternatively, here’s another money-maker: Get Well in the RNAi Way-RNAi, A Billion Dollar Baby in Therapy 

But wait. What about nutrient energy-dependent endogenous RNA interference in the context of the physiology of pheromone-controlled reproduction in all living genera. As a computer software developer, Bill Gates knows what can go wrong when a virus steals the energy as information that is required to run the central processing unit, which has sometimes been compared to the human brain.

See also: Bill Gates warns tens of millions could be killed by bio-terrorism  February 18, 2017

The next epidemic could originate on the computer screen of a terrorist intent on using genetic engineering to create a synthetic version of the smallpox virus … or a super contagious and deadly strain of the flu.

The creation of a synthetic virus and/or the virus-driven energy theft that leads to the creation of a deadly strain of the flu links the failure of nutrient energy-dependent endogenous RNA interference to protect organized genomes from virus-driven energy theft.

For example see: Substitutions Near the Receptor Binding Site Determine Major Antigenic Change During Influenza Virus Evolution

The major antigenic changes of the influenza virus are primarily caused by a single amino acid near the receptor binding site.

I placed that claim into the context of The Quest to End the Flu with this comment.

SARCASM ALERT

The idea of biophysical constraints seems antithetical to the idea of nature somehow selecting mutations that cause amino acid substitutions. However, I am not a biophysicist or evolutionary theorist.

The problem may be my focus on nutrient-dependent receptor-mediated amino acid substitutions in species from bacteria to humans (non-viral organisms). Since I am not a virologist or physicist, I’m not sure that the laws of physics apply to viruses and their replication.

If they do, natural selection for random mutations is not likely to result in amino acid substitutions because the thermodynamics of changes in organism-level thermoregulation preclude such randomness. Stability of protein biosynthesis and degradation that probably depends on protein folding must somehow be controlled. Besides, I don’t know how random mutations in viruses could be naturally selected for inclusion in the human virome (or in the virome of any organism capable of thermoregulating its thermodynamic intercellular signaling).

If the Second Law of Thermodynamics does not apply to viruses, which means the chemical bonds that enable the amino acid substitutions can form at random and somehow be naturally selected, the details of biophysical constraints in this article seems out of place, since I do not think in terms of constrained random mutations and natural selection in mutation-driven evolution.

Hopefully, someone with a background in biophysics will address my confusion in case others are confused. In addition, I wonder if the consequences of understanding the evolutionary mechanisms that govern viruses extend to consequences important to understanding the evolution of species from bacteria to humans via constrained random mutations and natural selection?

People with a background in biophysics or computer models of biophysically constrained top-down causation have addressed the confusion about random mutations and natural selection in mutation-driven evolution. Simply put, there is no such thing as natural selection for random mutations, which means there no such thing as the evolution of one species from another.
Francis S. Collins, author of The Language of God: A Scientist Presents Evidence for Belief may not like the facts, but
See for comparison:The Darwin Code by Greg Bear

Perhaps the most intriguing method of gene swapping in bacteria is the bacteriophage, or bacterial virus. Bacteriophages–phages for short–can either kill large numbers of host bacteria, reproducing rapidly, or lie dormant in the bacterial chromosome until the time is right for expression and release.

Ask where Bill Gates got the idea that virus-driven energy theft could cause the death of 30 million people.
Also, see this Google search for “virus-driven energy theft.”
My claim follows the claims Greg Bear has been making during the past 2-3 decades. All energy-dependent changes, which link angstroms to ecosystems in all living genera, are biophysically constrained by the pheromone-controlled physiology of reproduction in species from microbes to humans.
Is it coincidental or providential that Bill Gates finally admits to what serious scientists have known for more than 2 decades about the forthcoming viral apocalypse?
The viral apocalypse will not be prevented by vaccines because viruses adapt to quickly. The facts about the energy-dependent adaptations of viruses compared to hosts are known to all serious scientists. For comparison, whose works have been funded by the Bill and Melinda Gates Foundation? Is philanthropy wasted on pseudoscientists?
See: Bill Gates refutes theistic evolution (sequel)