The stability of organized genomes

Beyond neo-Darwinism—an epigenetic approach to evolution

Excerpt from 6/21/79

The evidence suggests… that a relative lack of natural selection may be the prerequisite for major evolutionary advance.

Nutrient-dependent/pheromone-controlled adaptive evolution: a model.
Excerpt from 6/14/13 (34 years later)

…the epigenetic ‘tweaking’ of the immense gene networks that occurs via exposure to nutrient chemicals and pheromones can now be modeled in the context of the microRNA/messenger RNA balance, receptor-mediated intracellular signaling, and the stochastic gene expression required for nutrient-dependent pheromone-controlled adaptive evolution.

The Surprising Origins of Evolutionary Complexity

Excerpt from 7/17/13

Others maintain that as random mutations arise, complexity emerges as a side effect, even without natural selection to help it along. Complexity, they say, is not purely the result of millions of years of fine-tuning through natural selection—the process that Richard Dawkins famously dubbed “the blind watchmaker.” To some extent, it just happens.

The New Genetics and Natural versus Artificial Genetic Modification

Excerpt from 11/4/13

RNA is now known to regulate gene expression through thousands of miRNAs in RNA interference universal to plants and animals (see previous section)(Bacteria and Archaebacteria too, have RNAi, but it works differently from eukaryotes [162]). MiRNAs are part of the nucleic acid intercommunication system of the body [163].

Roquin binds ​microRNA-146a and ​Argonaute2 to regulate microRNA homeostasis

Excerpt from 2/20/15

“Posttranscriptional gene regulation by trans-acting RNA-binding proteins is a rapid and efficient way to modify gene expression and cellular responses. Mutations in these trans-acting factors are often associated with pathology1.”

My comment: Does anyone know how mutations are linked to evolution in the context of anything known to serious scientists about RNA-mediated cell type differentiation?
RC3H1 post-transcriptionally regulates A20 mRNA and modulates the activity of the IKK/NF-kappaB pathway
Excerpt from 6/14/15 (2 years after publication of my 2013 review of RNA-mediated amino acid substitutions and biodiversity)

Post-transcriptional regulation of gene expression by RNA-binding proteins (RBPs) controls a variety of cellular processes. Especially, the modulation of messenger RNA (mRNA) stability is of critical importance for the dynamic regulation of genes such as transcription factors and cytokines that need to be switched on and off rapidly1,2.

Reported as: RNA-binding Protein Influences Key Mediator of Cellular Inflammation and Stress Responses

RC3H1/ROQUIN has already been described in previous studies as an RNA-binding protein that influences the stability of various mRNAs

My comment: They link the thermodynamics of stress responses to organism-level thermoregulation. During the past two years, no one has presented an alternative model of RNA-mediated cell type differentiation for comparison to what obviously occurs in the context of fixation of RNA-mediated amino acid substitutions in my model.  The only theory to be consistently put forth is the one in the book Mutation-Driven Evolution.
For example, see:
Jay R. Feierman: I am absolutely certain that if you showed this statement to any professor of biology or genetics in any accredited university anywhere in the world that 100% of them would say that “Random mutations are the substrate upon which directional natural selection acts” is a correct and true statement. 
Eugene Koonin: The entire evolution of the microbial world and the virus world, and the interaction between microbes and viruses and other life forms have been left out of the Modern Synthesis…
Jay R. Feierman: You really want us to believe that you are the expert on this topic when 100% of university level biology textbooks for Biology 101 and all biology and genetics professors will say the exact same sentence or something almost identical.
My comment: I am a medical laboratory scientist with expertise on RNA-mediated cell type differentiation. Eugene Koonin is an expert on viruses who claims that nothing known about their role in RNA-mediated cell type differentiation was included in the “Modern Synthesis.” If any university level biology textbooks, or any biology professor or genetic professor continues to make the same ridiculous statement that Jay R. Feierman and others have made during the past 50 years, despite no experimental evidence to support their claims, they should be promptly removed from their position of influence.  Instead, the history of all paradigm shifts predicts this attempt by Feierman to limit discussion to the dumbed-down dogma that he was taught to believe in.
[MODERATOR NOTE: I’m not going to post more from Kohl until he answers the very direct and simple question posed to him by anon, which is whether he (Kohl) believes that RNA splicing can change DNA.]
My comment: My beliefs have nothing to do with the dogma that has been touted by neo-Darwinian theorists. My beliefs are based on established scientific facts. Clearly, messenger RNA (mRNA) stability is linked from viruses and viral microRNAs to entropic elasticity and genomic entropy unless nutrient-dependent microRNAs stabilize the microRNA/messenger RNA balance. The stability of the microRNA/messenger RNA balance is linked from the physiology of reproduction and fixation of amino acid substitutions to RNA-mediated cell type differentiation and the stability of organized genomes in all living genera.
The RNA-mediated cell type differentiation that links the microRNA/messenger RNA balance to all cell type differentiation in all cells of all tissues of all organisms of all species is not based on my beliefs or any dogma. Others have repeatedly been provided with facts and most have ignored anything that links biologically-based cause and effect.
For example, the mapping strategy detailed in this video has no potential for use in medical practice without the understanding of the events that lead to the cell type differentiation.

The RNA-mediated events that lead to cell type differentiation during life history transitions of humans include experimental evidence of what occurs in the context of a single amino acid substitution: the Val158Met substitution in the context of “Oppositional COMT Val158Met effects on resting state functional connectivity in adolescents and adults.”
See also: The Biological Big Bang model for the major transitions in evolution.


A Biological Big Bang (BBB) model is proposed for the major transitions in life’s evolution. According to this model, each transition is a BBB such that new classes of biological entities emerge at the end of a rapid phase of evolution (inflation) that is characterized by extensive exchange of genetic information which takes distinct forms for different BBBs. The major types of new forms emerge independently, via a sampling process, from the pool of recombining entities of the preceding generation. This process is envisaged as being qualitatively different from tree-pattern cladogenesis.

My comment: Creationists have since linked the Biological Big Bang model to the Cosmological Big Bang model via the role of viruses in RNA-mediated cell type differentiation. Cell type differentiation is perturbed by the viral microRNAs, which clearly links viruses to all pathology and none of increasing organismal complexity manifested in the context of the biophysically constrained chemistry of nutrient-dependent protein folding.

Viral Genome Junk Is Bunk


So, where do viruses come from that essentially share the same sequences as those found in their host genomes? Perhaps the evolutionists have placed the cart before the horse on this issue, as proposed by several creationist scientists.4,6 In fact, in an ironic twist, the evidence mentioned above indicates that viruses likely arose from their hosts and not the other way around. As molecular biologist and biochemist Peter Borger notes, “The most parsimonious answer is: the RNA viruses got their genes from their hosts.”6

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See, instead, the discussion of Neanderthals had outsize effect on human biology on the Evolutionary Psychology News FaceBook group. Remember, the history of all paradigm shifts predicts attempts to limit discussion to the dumbed-down dogma that others have been taught to believe in.
See also, the discussion of 3D brain map reveals connections between cells in nano-scale on the Evolutionary Psychology News FaceBook group

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