Excerpt: Others have seen the latest experimental evidence on biophysically constrained energy storage coming, but they have remained relatively silent.
This is a deliberate attempt to increase the number of my tweet impressions to more than 80K since Christmas eve, during the same month that ~1000 more articles on microRNA-mediated energy storage were added to the PubMed database. On June 24, 2017, I joked about the claims of science journalist Philip Ball. His pseudoscientific nonsense about quantum common sensee led to my Christmas eve-and-beyond efforts to establish the facts outside the context of the song: “Here Comes Santa Claus.”
I suggest you see: Mechanisms of Recombination conference and link what is known to all serious scientists about biophysically constrained viral latency from the anti-entropic virucidal of sunlight to the creation of RNA and cell type stability via phosphorylation. Cell type stability is energy-dependent and biophysically constrained by changes in the microRNA/messenger RNA balance, but now we see experimental evidence that the biophysical constraints are not linked to random events and the pseudoscientific nonsense touted by theorists.
The phosphorylation-induced structures revealed in this study propose a conserved structural motif of GPCRs that enables β-arrestin to recognize dozens of GPCRs.
Link the energy-dependent creation of G protein-coupled receptors (GPCRs) to all biodiversity via the claims from 1964 in:
Also, see the claims in: Long-range coherence and energy storage in biological systems
Others have seen the latest experimental evidence on biophysically constrained energy storage coming, but they have remained relatively silent.
…honey bee colony-level social manipulations that decrease individual aggression attenuated the effects of oxidative phosphorylation inhibition on aggression, demonstrating a specific effect of the social environment on brain function. Because decreased neuronal oxidative phosphorylation is usually associated with brain disease, these findings provide a powerful context for understanding brain metabolic plasticity and naturally occurring behavioral plasticity.
In the context of the honeybee model organism, Institute for Genomic Biology director Gene Robinson claimed that:
When he and his colleagues looked at brain gene activity in honey bees after they had faced down an intruder, the team found that some metabolic genes were suppressed. These genes play a key role in the most efficient type of energy generation in cells, a process called oxidative phosphorylation.
It seems that he then became confused because the findings on the conserved molecular mechanisms were placed into the context of 300 million years of evolution that supposedly separated fruit flies and honey bees. Simply put, nothing known about the food energy-dependent pheromone-controlled physiology of biophysically constrained RNA-mediated cell type differentiation made sense if only phosphorylation and the RNA-mediated protein folding chemistry are required to differentiate the cell types of the species in the context of their supercoiled DNA.
However, serious scientists no longer share all the views that Dozhansky (1973) expressed in Nothing in Biology Makes Any Sense Except in the Light of Evolution.
It has become clear that the food energy-dependent RNA-mediated fixation of amino acid substitutions is linked from the pheromone-controlled physiology of reproduction in bacteria to biophysically constrained cell type differentiation via chromosomal rearrangements that protect organize genomes from the virus-driven degradation of messenger RNA that links mutations to all pathology. Indeed, that fact may explain why the President of the United States did not meet with the 2017 Nobel Prize Winners. The President seems to known that some or all of them are still lying about what is known to other serious scientists about energy-dependent RNA-mediated biodiversity.
Frank was among the 2017 Nobel Prize winners class for his work in chemistry, recognized for helping launch a medical imaging effort [cryo-EM] credited with making it easier to picture the biomolecular building blocks of life.
That picture became clearer in the context of works published by Michael Rosbash, who shared the 2017 Nobel Prize in Physiology or Medicine.
The conserved molecular mechanisms of food energy-dependent pheromone-controlled biophysically constrained RNA-mediated cell type differentiation began to be examined in the mid 1990’s by Rosbash and others, but any experimental evidence that refuted neo-Darwinian nonsense and “Big Bang” cosmology was ignored by Nobel Laureates like Joachim Frank. Why would President Donald Trump want to meet with scientists who are examples of human idiocy?
For example: Nobel Laureate, Richard P. Feynman placed nearly all physicists, chemists and biologists into his example of human idiocy. See: Food energy
Some of the 2017 Nobel Laureates are ashamed that their ignorance has led to the unnecessary suffering and premature death of millions during the past two decades. They know that Trump realizes some Noble Prize winners are part of a “broken system” of science.
See: Science is broken
Perverse incentives and the misuse of quantitative metrics have undermined the integrity of scientific research
Trump’s priority is fixing the problems, not to welcome and/or congratulate those who have caused the problems.
For a recent example, see: Growing up on an Amish farm protects children against asthma by reprogramming immune cells (2016).
For comparison to what is known about immune system reprograming, all aspects of biophysically constrained RNA-mediated cell type differentiation, which protects all organized genomes from virus-driven entropy, were placed into the context of claims about evolved proteins in: A null mutation in SERPINE1 protects against biological aging in humans.
See for comparison the report: Amish gene mutation makes some live 10 years longer: study
The report in the journal Science Advances is the latest clue in a decade-plus search for the secrets to healthy aging in this traditional, Christian community that balks at most modern technology.
…they are really talking about adaptation, not evolution. Nowhere do they describe how this extra-strong flagellum originated or how it evolved from another species.
Amino acid sequence variability in the central parts of FlgE proteins of C. jejuni strains was proposed to occur because of selection pressure during host invasion to generate variations in surface-exposed antigenic determinants. The variable regions do indeed correspond to the surface-exposed region of C. jejuni hook domains D3 and D4. The variability is tolerated because these regions are not essential for intra-molecular contacts that organize the hook.
Amino acid sequence variability ensures that fixation of nutrient energy-dependent RNA-mediated amino acid substitutions occurs in the context of the physiology of pheromone-controlled reproduction in all living genera.
In the context of attempts to discuss the weekend evolution of the bacterial flagellum on “The Battlefield” FB group, Larry Kisner Sr., and others realized that fluorescence was the obvious nutrient energy-dependent pheromone-controlled link from the molecular epigenetics of cell type differentiation in P. fluorescens to the fossil record via Mark Armitage‘s works.
I fully expect that President Donald Trump has no interest in meeting with any Nobel Laureate who has helped to bastardize the works of all serious scientists since the years before Schrodinger’s claims were made in “What is Life?” (1944) and the subsequent claim by Roger Penrose (1991)
See also: Innate Immunity and Asthma Risk in Amish and Hutterite Farm Children
See also: Scents and Sensibility and Richard Axel’s 2005 Scents and Sensibility: A Molecular Logic of Olfactory Perception (Nobel Lecture) and Unraveling the sense of smell (Nobel lecture)
Keep in mind that food energy-dependent pheromone-controlled feedback loops are the only obvious source of ecological adaptation, because without food, organisms die. See for details: Feedback loops link odor and pheromone signaling with reproduction
…geneticists don’t have an accurate understanding of how mutations behave in people who are not obviously sick. “This is a fascinating flashpoint in the field right now,” says Robert Green, a geneticist at Brigham and Women’s Hospital in Boston, Massachusetts. “Many people are deeply concerned that widespread screening of ostensibly healthy people could actually lead to harm.”
Indeed, in the case of higher animals we know the kind of orderliness they feed upon well enough, viz. the extremely well-ordered state of matter in more or less complicated organic compounds, which serve them as foodstuffs. After utilizing it they return it in a very much degraded form -not entirely degraded, however, for plants can still make use of it. (These, of course, have their most power supply of ‘negative entropy’ the sunlight.) (pp. 73 and 74)
The anti-entropic virucidal energy of sunlight is the obvious key to healthy longevity in all human populations. The link from a population in Central China to the Amish population in Berne, Indiana was placed into the context of this invited review of nutritional epigenetics.
Naturally occuring energy-dependent base editing, microRNA editing, and RNA editing were linked from fixation of a single amino acid substitution in the mouse model to the physiology of pheromone-controlled reproduction and epigenetically effected homologous changes in human morphological phenotypes.