Unraveling the secrets of RNA-mediated events

Unraveling the Secrets of DNA


Belmont’s team will “rewire” chromosome regions to different nuclear locations and then determine the functional consequences of this rewiring.

My comment: The “rewiring” can be placed into the context of nutrient-dependent pheromone-controlled rewiring of the genome that led to a report of over-the-weekend” re-evolution of the bacterial flagellum. Two nutrient-dependent amino acid substitutions linked the metabolic networks to the genetic networks and the RNA-mediated substitutions led to a second-chance resurrection of a functional structure.
The amino acid substitutions stabilized the organized genome in the context of supercoiled DNA, which protects all organized genomes from virus-driven genomic entropy. They substitutions were reported as if they were mutations.
See: Evolutionary resurrection of flagellar motility via rewiring of the nitrogen regulation system
This video representation of biologically-based cause and effect will help to force serious scientists to report their findings in the context of what is currently known about how metabolic networks are linked to genetic networks via the physiology of reproduction.

The spurious claim that “bacteria evolve over a weekend” must be viewed as if the researchers were joking by serious scientists who joke about the pseudoscientists who seem to know nothing about how cell type differentiation occurs in the context of an atoms to ecosystems model that links the epigenetic landscape to the physical landscape of DNA in all living genera via RNA-mediated events.
See for example:

See also: Structural diversity of supercoiled DNA
See also: Inching toward the 3D genome
My comment:
Re: “…the nucleome structure changes as cells age, differentiate, and divide, and researchers want to understand how and why.”
Cell type differentiation is nutrient-dependent. RNA-directed DNA methylation links RNA-mediated amino acid substitutions to cell type differentiation via protein folding during life history transitions. Amino acid substitutions stabilize protein folding; mutations perturb it, during nutrient-dependent thermodynamic cycles of protein biosynthesis and degradation.
Life is physics and chemistry and communication — http://dx.doi.org/10.1111/nyas.12570
The metabolism of nutrients links metabolic networks to genetic networks via species-specific pheromones that control the physiology of reproduction. Simply put, pheromones link nutrient-dependent life via physics, chemistry, and the conserved molecular mechanisms of communication in species from microbes to man.
Until nutrient-dependent protein folding is linked via the conserved molecular mechanisms of amino acid substitutions and pheromone-controlled DNA stability in organized genomes, which links the epigenetic landscape to the physical landscape of DNA, researchers must take a piece-meal approach to integrating the requirements for life and successful life history transitions — despite the fact that life history transitions have been detailed in the context of the honeybee model organism. See: Honey bees as a model for understanding mechanisms of life history transitions http://www.ncbi.nlm.nih.gov/pubmed/15925525

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